Nanomaterials Enhanced Sonodynamic Therapy for Multiple Tumor Treatment

Nano-Micro Letters, Год журнала: 2025, Номер 17(1)

Опубликована: Фев. 24, 2025

Abstract Sonodynamic therapy (SDT) as an emerging modality for malignant tumors mainly involves in sonosensitizers and low-intensity ultrasound (US), which can safely penetrate the tissue without significant attenuation. SDT not only has advantages including high precision, non-invasiveness, minimal side effects, but also overcomes limitation of low penetration light to deep tumors. The cytotoxic reactive oxygen species be produced by utilization combined with US kill tumor cells. However, underlying mechanism been elucidated, its unsatisfactory efficiency retards further clinical application. Herein, we shed on main mechanisms types sonosensitizers, organic inorganic sonosensitizers. Due development nanotechnology, many novel nanoplatforms are utilized this arisen field solve barriers enable continuous innovation. This review highlights potential nanosonosensitizers focus enhanced based monotherapy or synergistic that difficult reach traditional treatment, especially orthotopic cancers.

Язык: Английский

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Photodynamically activated chlorogenic acid-based antimicrobial packaging films for cherry preservation

Food Chemistry, Год журнала: 2025, Номер 479, С. 143857 - 143857

Опубликована: Март 11, 2025

Язык: Английский

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Metallacage-crosslinked free-standing supramolecular networks via photo-induced copolymerization for photocatalytic water decontamination

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Март 19, 2025

The development of polymer materials for water decontamination makes a significant contribution to environmental protection and public health. Herein, we report the preparation metallacage-crosslinked free-standing supramolecular networks by photo-induced copolymerization acrylate metallacages butyl methacrylate decontamination. integration into endows good capability generating singlet oxygen via photosensitization, making them serve as type that can effectively eliminate diverse organic pollutants bacterial contaminants. This study not only provides mild effective strategy metallacage-cored but also explores their applications photocatalytic dye degradation killing, which will promote future metallacage-based applications. is important authors

Язык: Английский

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Nonemissive Iridium(III) Solvent Complex as a Self-Reporting Photosensitizer for Monitoring Phototherapeutic Efficacy in a “Signal on” Mode

Chemical & Biomedical Imaging, Год журнала: 2024, Номер 2(12), С. 808 - 816

Опубликована: Авг. 1, 2024

Photodynamic therapy (PDT) has long been receiving increasing attention for the minimally invasive treatment of cancer. The performance PDT depends on photophysical and biological properties photosensitizers (PSs). always-on fluorescence signal conventional PSs makes it difficult to real-time monitor phototherapeutic efficacy in process. Therefore, functional with good photodynamic effect self-reporting are highly desired. Here, two nonemissive iridium(III) solvent complexes, [(dfppy)2Ir(DMSO)]Cl (Ir-DMSO, dfppy = 2,4-difluorophenyl)pyridine, DMSO dimethyl sulfoxide) [(dfppy)2Ir(ACN)]Cl (Ir-ACN, ACN acetonitrile) as PSs, were synthesized. Both them exhibit intense high-energy absorption bands, low photoluminescence (PL) emission, dark toxicity. Thanks lower toxicity Ir-DMSO, we chose a PS further PDT. In this work, Ir-DMSO functions specific PL "signal on" therapeutic during its own Colocalization experiments indicated that accumulated endoplasmic reticulum mitochondria. Under light irradiation, not only exhibited ability kill cancer cells but also presented response toward cell death. During Ir-DMSO-induced PDT, death modality was investigated immunogenic revealed, which main hallmarks, including ROS generation, upregulation surface-exposed calreticulin, high-mobility group box 1, adenosine triphosphate secretion, observed. coordination reaction between histidine (His)/His-containing proteins, can be monitored real time without other probes. This work provides new promising strategy development ability, is great importance imaging-guided

Язык: Английский

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Hypocrellin-Mediated PDT: A Systematic Review of Its Efficacy, Applications, and Outcomes

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(9), С. 4038 - 4038

Опубликована: Апрель 24, 2025

Photodynamic therapy (PDT) is a light-activated treatment that generates reactive oxygen species (ROS) to induce microbial cell death. As resistance traditional antibiotics intensifies globally, PDT has emerged as promising alternative or adjunctive antimicrobial strategy. Among various photosensitizers, Hypocrellin, perylenequinone compound, shown high ROS yield and broad-spectrum activity against bacteria fungi. This systematic review evaluated the efficacy, safety, therapeutic potential of Hypocrellin-mediated photodynamic therapy. Following PRISMA 2020 guidelines, comprehensive literature search was conducted in PubMed, Embase, Scopus, Cochrane Library for studies published between 2015 2025. Eligible included vitro preclinical vivo research using Hypocrellin photosensitizer. Quality risk bias were assessed structured nine-item checklist. Ten eligible studies, all China, included. aPDT significantly reduced loads both planktonic biofilm states resistant pathogens such Candida albicans, auris, Cutibacterium acnes, Staphylococcus aureus. The acted via ROS-mediated apoptosis, membrane disruption, mitochondrial dysfunction, with minimal cytotoxicity mammalian cells. Studies also reported enhanced efficacy when incorporated into nanocarriers, polymeric scaffolds, combined chemodynamic photothermal therapies. However, substantial heterogeneity observed concentrations, irradiation parameters, outcome measures. Hypocrellin-based exhibits potent favorable safety settings, supporting its an conventional antibiotics. standardized protocols robust clinical trials are urgently needed validate long-term translational feasibility. These findings underscore broader promise addressing drug-resistant infections through mechanism unlikely resistance.

Язык: Английский

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Chemo-Selective Transformation of Anthracene Derivative within Water-Soluble Coordination Cages Having Different Cavities

Inorganic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Coordination cages with specific properties and functionalities are utilized as reaction vessels for the desired chemical transformation of substrates. The symmetry inherent cavity coordination can influence host–guest interactions outcome in their confined space. However, impact cage shape on different transformations remains unclear. In this chapter, we report chemo-selective anthracene derivative using three geometrically distinct Pd6 (CC2, CC3, CC4). Photoirradiation 9-bromoanthracene (G3) distorted double-square (CC2) yields anthracene-9,10-dione, while known (CC3) forms a [4 + 4] cycloaddition product. same bowl-shaped (CC4) resulted oxidized Through combination experimental computational studies, demonstrate that size significantly pathways encapsulated derivative, leading to chemo-selectivity. Furthermore, observe encapsulation cavities (CC2 CC4) leads significant enhancement rate photooxidation G3. This work underscores versatility water-soluble synthetic chemistry, offering interesting avenues transformation.

Язык: Английский

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Highly Emissive Platinum(II) Metallacage in the Near-Infrared Region for Synergistic Chemo-Photodynamic Therapy

Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Highly emissive metallacages that generate reactive oxygen species (ROS) are important to synergistic cancer therapy, but it is still challenging balance the emission and phototheranostic properties. Herein, a metallacage of DTPABT-Mc prepared. It observed in near-infrared region from 600 1000 nm with high photoluminescence quantum yield value 7.92% solids recorded for DTPABT-Mc. In addition, ability produce both type I II ROS under light irradiation also observed, leading potential application photodynamic therapy (PDT) chemotherapy. After that, 4T1@DTPABT-Mc-NPs, covering nanoparticles 4T1 cell membranes, prepared enhance their tumor-targeting ability. This finally results effective therapeutic performance vivo, effectively inhibiting tumor growth. These suggest DTPABT-Mc-NPs exhibit excellent effects by combining PDT chemotherapy, providing new ideas design agents diagnosis future.

Язык: Английский

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Multicomponent Metallacages via the Integrative Self-Assembly of Pt(II) Nodes with Multiple Pyridyl and Carboxylate Ligands

Accounts of Chemical Research, Год журнала: 2025, Номер unknown

Опубликована: Май 2, 2025

ConspectusIn recent years, multicomponent self-assembly has emerged as a pivotal strategy in supramolecular chemistry, enabling the construction of artificial systems with enhanced functionalities that surpass those individual molecular components. These assemblies have garnered significant interest due to their potential applications recognition, catalysis, and biomedical engineering. However, achieving precise control over assembly process remains challenge, increased structural complexity often results thermodynamic mixtures, limiting practical applications. In this context, metal-coordination-driven promising strategy, moderate strength good directionality metal-ligand bonds ensure formation discrete architectures well-defined structures geometries. Notably, integration pyridyl carboxylate donors cis-Pt(II) nodes offers an effective approach for constructing metallacages. This method is particularly attractive its ability enable heteroleptic assembly, along accessibility tunability ligands, which impart desirable photophysical properties anticancer activities.This Account provides comprehensive overview our work on design, preparation, functionalization metallacages via ligands nodes. By strategically tailoring ligand adjusting number coordination sites, we successfully constructed diverse geometries, including tetragonal hexagonal prisms, triple-cavity ladders, truncated octahedra, cyclic bis[2]catenanes, etc. particular, highlight use functional such tetraphenylethylene, hexaphenylbenzene, perylene diimide, porphyrin derivatives, explore these Tetraphenylethylene hexaphenylbenzene derivatives are propeller-shaped molecules aggregation-induced emission properties, enhancing both solution solid state. Perylene diimide electron-deficient, planar conjugated structures, contribute strong solution, thereby improving host-guest chemistry luminescent Porphyrin owing excellent photosensitivity, endow photocatalytic capabilities. Additionally, other phenanthroline triazine been employed antibacterial SO2 adsorption respectively, Furthermore, metallacage-cross-linked networks exhibit mechanical superior processability, making them candidates materials. At conclusion Account, address challenges future perspectives development We believe ongoing research field will significantly advance understanding metal-coordination

Язык: Английский

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Metallacage-Crosslinked Free-Standing Supramolecular Networks via Photo-induced Copolymerization for Photocatalytic Water Decontamination

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Авг. 21, 2024

The development of polymer materials for water decontamination makes a significant contribution to environmental protection and public health. Herein, we report the preparation metallacage-crosslinked free-standing supramolecular networks by photo-induced copolymerization acrylate metallacages butyl methacrylate decontamination. integration into endows good capability generating singlet oxygen via photosensitization, making them serve as type that can effectively eliminate diverse organic pollutants bacterial contaminants. This study not only provides mild effective strategy metallacage-cored but also explores their applications photocatalytic dye degradation killing, which will promote future metallacage-based applications.

Язык: Английский

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Heterometallic [2]Catenane‐Crosslinked Supramolecular Networks with Improved Antibacterial Activity

Chemistry - A European Journal, Год журнала: 2024, Номер unknown

Опубликована: Окт. 24, 2024

Abstract The construction of supramolecular networks with novel crosslinks is great significance in expanding their chemical structures and exploring advanced functions. Herein, we prepare a type [2]catenane‐cored based on the crosslinking polyethylene glycol (PEG) using heterometallic [2]catenane unit. By adjusting molecular weight PEG, solubility can be tuned gels are formed low PEG. introduction offers good antibacterial properties owing to synergistic antimicrobial activity Pt(II) Cu(I) ions [2]catenane. This study provides simple efficient strategy for constructing topological as materials, which will promote structural design biological applications networks.

Язык: Английский

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