Supramolecular Assembly‐Enabled Transdermal Therapy of Hypertrophic Scarring Through Concurrent Ferroptosis‐Apoptosis DOI
Bin Zhao, Mengying Wei, Xiaomeng Zhou

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Abstract Hypertrophic scar (HS) remains a major challenge for clinicians due to unsatisfactory therapeutic performance. Although inducing apoptosis of HS fibroblasts (HSFs) has proved be an effective nonsurgical treatment strategy, potential chemotherapy resistance HSFs makes the development new and efficient strategies highly demanding. Herein, ferroptosis‐apoptosis combined strategy is developed through supramolecular self‐assembly between cucurbit[7]uril (CB[7]) two bioactive agents, dihydroartemisinin (DHA) gold nanoclusters (AuNCs). The resulting self‐assembled nanoparticles, named CAD NPs, showed high guest loading efficiency prominent pH‐responsive degradability in acidic lysosomes HSFs. Importantly, both DHA AuNCs act synergistically generate excessive reactive oxygen species lipid peroxidation, leading mitochondrial damage, ultimately concurrent ferroptosis on Upon further into hydrogel microneedles facilitate their transdermal delivery, these NPs superior antiscar effects shortening span 3 weeks improving appearance, as demonstrated at rabbit ear model HS. present assembly‐based provides innovative guideline efficiently treating well other diseases.

Language: Английский

Nanomaterials Enhanced Sonodynamic Therapy for Multiple Tumor Treatment DOI Creative Commons
Mengyao Yang, Xin Wang,

Mengke Peng

et al.

Nano-Micro Letters, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 24, 2025

Abstract Sonodynamic therapy (SDT) as an emerging modality for malignant tumors mainly involves in sonosensitizers and low-intensity ultrasound (US), which can safely penetrate the tissue without significant attenuation. SDT not only has advantages including high precision, non-invasiveness, minimal side effects, but also overcomes limitation of low penetration light to deep tumors. The cytotoxic reactive oxygen species be produced by utilization combined with US kill tumor cells. However, underlying mechanism been elucidated, its unsatisfactory efficiency retards further clinical application. Herein, we shed on main mechanisms types sonosensitizers, organic inorganic sonosensitizers. Due development nanotechnology, many novel nanoplatforms are utilized this arisen field solve barriers enable continuous innovation. This review highlights potential nanosonosensitizers focus enhanced based monotherapy or synergistic that difficult reach traditional treatment, especially orthotopic cancers.

Language: Английский

Citations

0
Photodynamically activated chlorogenic acid-based antimicrobial packaging films for cherry preservation DOI

Ximei Han,

Jiayi Chen, Qian Wang

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 479, P. 143857 - 143857

Published: March 11, 2025

Language: Английский

Citations

0
Chemo-Selective Transformation of Anthracene Derivative within Water-Soluble Coordination Cages Having Different Cavities DOI
Rinshad V. Abdul,

Shamsad Ali,

Neal Hickey

et al.

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Coordination cages with specific properties and functionalities are utilized as reaction vessels for the desired chemical transformation of substrates. The symmetry inherent cavity coordination can influence host–guest interactions outcome in their confined space. However, impact cage shape on different transformations remains unclear. In this chapter, we report chemo-selective anthracene derivative using three geometrically distinct Pd6 (CC2, CC3, CC4). Photoirradiation 9-bromoanthracene (G3) distorted double-square (CC2) yields anthracene-9,10-dione, while known (CC3) forms a [4 + 4] cycloaddition product. same bowl-shaped (CC4) resulted oxidized Through combination experimental computational studies, demonstrate that size significantly pathways encapsulated derivative, leading to chemo-selectivity. Furthermore, observe encapsulation cavities (CC2 CC4) leads significant enhancement rate photooxidation G3. This work underscores versatility water-soluble synthetic chemistry, offering interesting avenues transformation.

Language: Английский

Citations

0
Highly Emissive Platinum(II) Metallacage in the Near-Infrared Region for Synergistic Chemo-Photodynamic Therapy DOI

Qifei Shen,

Kai Gao, Peijuan Zhang

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Highly emissive metallacages that generate reactive oxygen species (ROS) are important to synergistic cancer therapy, but it is still challenging balance the emission and phototheranostic properties. Herein, a metallacage of DTPABT-Mc prepared. It observed in near-infrared region from 600 1000 nm with high photoluminescence quantum yield value 7.92% solids recorded for DTPABT-Mc. In addition, ability produce both type I II ROS under light irradiation also observed, leading potential application photodynamic therapy (PDT) chemotherapy. After that, 4T1@DTPABT-Mc-NPs, covering nanoparticles 4T1 cell membranes, prepared enhance their tumor-targeting ability. This finally results effective therapeutic performance vivo, effectively inhibiting tumor growth. These suggest DTPABT-Mc-NPs exhibit excellent effects by combining PDT chemotherapy, providing new ideas design agents diagnosis future.

Language: Английский

Citations

0
Nonemissive Iridium(III) Solvent Complex as a Self-Reporting Photosensitizer for Monitoring Phototherapeutic Efficacy in a “Signal on” Mode DOI Creative Commons

Manping Qian,

Ke Wang, Peng Yang

et al.

Chemical & Biomedical Imaging, Journal Year: 2024, Volume and Issue: 2(12), P. 808 - 816

Published: Aug. 1, 2024

Photodynamic therapy (PDT) has long been receiving increasing attention for the minimally invasive treatment of cancer. The performance PDT depends on photophysical and biological properties photosensitizers (PSs). always-on fluorescence signal conventional PSs makes it difficult to real-time monitor phototherapeutic efficacy in process. Therefore, functional with good photodynamic effect self-reporting are highly desired. Here, two nonemissive iridium(III) solvent complexes, [(dfppy)2Ir(DMSO)]Cl (Ir-DMSO, dfppy = 2,4-difluorophenyl)pyridine, DMSO dimethyl sulfoxide) [(dfppy)2Ir(ACN)]Cl (Ir-ACN, ACN acetonitrile) as PSs, were synthesized. Both them exhibit intense high-energy absorption bands, low photoluminescence (PL) emission, dark toxicity. Thanks lower toxicity Ir-DMSO, we chose a PS further PDT. In this work, Ir-DMSO functions specific PL "signal on" therapeutic during its own Colocalization experiments indicated that accumulated endoplasmic reticulum mitochondria. Under light irradiation, not only exhibited ability kill cancer cells but also presented response toward cell death. During Ir-DMSO-induced PDT, death modality was investigated immunogenic revealed, which main hallmarks, including ROS generation, upregulation surface-exposed calreticulin, high-mobility group box 1, adenosine triphosphate secretion, observed. coordination reaction between histidine (His)/His-containing proteins, can be monitored real time without other probes. This work provides new promising strategy development ability, is great importance imaging-guided

Language: Английский

Citations

4
Metallacage-crosslinked free-standing supramolecular networks via photo-induced copolymerization for photocatalytic water decontamination DOI Creative Commons
Rongrong Li, Haixin Zhang,

Yali Hou

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 19, 2025

The development of polymer materials for water decontamination makes a significant contribution to environmental protection and public health. Herein, we report the preparation metallacage-crosslinked free-standing supramolecular networks by photo-induced copolymerization acrylate metallacages butyl methacrylate decontamination. integration into endows good capability generating singlet oxygen via photosensitization, making them serve as type that can effectively eliminate diverse organic pollutants bacterial contaminants. This study not only provides mild effective strategy metallacage-cored but also explores their applications photocatalytic dye degradation killing, which will promote future metallacage-based applications. is important authors

Language: Английский

Citations

0
Perylene‐ and Perylene Diimide‐based Framework Materials Constructed through Metal Coordination DOI Open Access
Junxiao Wang,

Haoxuan Wei,

Guan Jun

et al.

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Metal-organic frameworks (MOFs) are a class of materials composed coordinative interactions between metal ions and organic linkers, encompassing two-dimensional (2D), three-dimensional (3D) architectures. cages (MOCs), special case these species, discrete molecular "capsules" with zero-dimensional (0D) structures. Over the last two decades, MOFs MOCs perylene (P) diimide (PDI) linkers have gained much attention due to their versatile properties, which can be further enhanced after incorporation into frameworks. This minireview highlights recent progress in construction application P/PDI-based coordination framework materials. The text offers an overview synthesis P/PDI proceeds integration different dimensionalities - 2D 3D MOFs, 0D MOCs, then explores potential applications. These include sensing, photocatalysis, electrochemical devices photothermal conversion focus on apparent structure-property relationships. Finally, challenges future prospects P/PDI-derived will addressed.

Language: Английский

Citations

0
Metallacage-Crosslinked Free-Standing Supramolecular Networks via Photo-induced Copolymerization for Photocatalytic Water Decontamination DOI Creative Commons
Mingming Zhang, Rongrong Li, Haixin Zhang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 21, 2024

Abstract The development of polymer materials for water decontamination makes a significant contribution to environmental protection and public health. Herein, we report the preparation metallacage-crosslinked free-standing supramolecular networks by photo-induced copolymerization acrylate metallacages butyl methacrylate decontamination. integration into endows good capability generating singlet oxygen via photosensitization, making them serve as type that can effectively eliminate diverse organic pollutants bacterial contaminants. This study not only provides mild effective strategy metallacage-cored but also explores their applications photocatalytic dye degradation killing, which will promote future metallacage-based applications.

Language: Английский

Citations

0
Heterometallic [2]Catenane‐Crosslinked Supramolecular Networks with Improved Antibacterial Activity DOI
Qian Feng, Rui Ding, Mingming Zhang

et al.

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

Abstract The construction of supramolecular networks with novel crosslinks is great significance in expanding their chemical structures and exploring advanced functions. Herein, we prepare a type [2]catenane‐cored based on the crosslinking polyethylene glycol (PEG) using heterometallic [2]catenane unit. By adjusting molecular weight PEG, solubility can be tuned gels are formed low PEG. introduction offers good antibacterial properties owing to synergistic antimicrobial activity Pt(II) Cu(I) ions [2]catenane. This study provides simple efficient strategy for constructing topological as materials, which will promote structural design biological applications networks.

Language: Английский

Citations

0
Supramolecular Assembly‐Enabled Transdermal Therapy of Hypertrophic Scarring Through Concurrent Ferroptosis‐Apoptosis DOI
Bin Zhao, Mengying Wei, Xiaomeng Zhou

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Abstract Hypertrophic scar (HS) remains a major challenge for clinicians due to unsatisfactory therapeutic performance. Although inducing apoptosis of HS fibroblasts (HSFs) has proved be an effective nonsurgical treatment strategy, potential chemotherapy resistance HSFs makes the development new and efficient strategies highly demanding. Herein, ferroptosis‐apoptosis combined strategy is developed through supramolecular self‐assembly between cucurbit[7]uril (CB[7]) two bioactive agents, dihydroartemisinin (DHA) gold nanoclusters (AuNCs). The resulting self‐assembled nanoparticles, named CAD NPs, showed high guest loading efficiency prominent pH‐responsive degradability in acidic lysosomes HSFs. Importantly, both DHA AuNCs act synergistically generate excessive reactive oxygen species lipid peroxidation, leading mitochondrial damage, ultimately concurrent ferroptosis on Upon further into hydrogel microneedles facilitate their transdermal delivery, these NPs superior antiscar effects shortening span 3 weeks improving appearance, as demonstrated at rabbit ear model HS. present assembly‐based provides innovative guideline efficiently treating well other diseases.

Language: Английский

Citations

0