An overview of recent advancements in 4D printing of alginate hydrogels for tissue regeneration DOI

Y. Liu,

Aixiang Ding

Journal of Biomaterials Science Polymer Edition, Год журнала: 2025, Номер unknown, С. 1 - 34

Опубликована: Май 24, 2025

4D printing of alginate hydrogels has emerged as a transformative strategy in tissue engineering, enabling the fabrication stimuli-responsive scaffolds that recapitulate temporal and spatial complexities native tissues. Leveraging alginate's tunable crosslinking, biocompatibility, easy modification, recent research demonstrated successful design constructs capable programmable shape morphing response to physiological stimuli. This review highlights advances polymer design, including methacrylated, oxidized, ligand-functionalized derivatives, cutting-edge technologies such extrusion-based photopolymerization-based technologies. Notably, these systems have shown promising outcomes regenerating cartilage, bone, vascular, neural However, key challenges remain, standardization shape-morphing quantification, enhancement mechanical robustness, improvement host integration, replication complexity. concludes with critical evaluation current limitations future directions, highlighting potential integrating hydrogel emerging artificial intelligence, machine learning, organoid models, bioelectronic interfaces accelerate innovation broaden their application engineering. By synthesizing advancements offering insights into implementation hydrogels, this aims stimulate continued progress rapidly evolving field.

Язык: Английский

Extracellular vesicle-loaded hydrogels for tissue repair and regeneration DOI Creative Commons

Yikun Ju,

Yue Hu, Yang Pu

и другие.

Materials Today Bio, Год журнала: 2022, Номер 18, С. 100522 - 100522

Опубликована: Дек. 21, 2022

Extracellular vesicles (EVs) are a collective term for nanoscale or microscale secreted by cells that play important biological roles. Mesenchymal stem class of with the potential self-healing and multidirectional differentiation. In recent years, numerous studies have shown EVs, especially those mesenchymal cells, can promote repair regeneration various tissues and, thus, significant in regenerative medicine. However, due to rapid clearance capacity circulatory system, EVs barely able act persistently at specific sites target tissues. Hydrogels good biocompatibility loose porous structural properties allow them serve as EV carriers, thereby prolonging retention certain areas slowing release EVs. When needed function sites, EV-loaded hydrogels stand an excellent approach. this review, we first introduce sources, roles, extraction characterization methods describe their current application status. We then review different types discuss factors influencing abilities carry summarize several strategies loading into characterizing hydrogels. Furthermore, applications tissue repair. This article concludes summary state research on outlook future directions, which hope will provide promising ideas researchers.

Язык: Английский

Процитировано

282

Novel Trends in Hydrogel Development for Biomedical Applications: A Review DOI Open Access
Pablo Sánchez‐Cid, Mercedes Jiménez‐Rosado, Alberto Romero

и другие.

Polymers, Год журнала: 2022, Номер 14(15), С. 3023 - 3023

Опубликована: Июль 26, 2022

Nowadays, there are still numerous challenges for well-known biomedical applications, such as tissue engineering (TE), wound healing and controlled drug delivery, which must be faced solved. Hydrogels have been proposed excellent candidates these they promising properties the mentioned including biocompatibility, biodegradability, great absorption capacity tunable mechanical properties. However, depending on material or manufacturing method, resulting hydrogel may not up to specific task it is designed, thus different approaches enhance performance requirements of application in question. The main purpose this review article was summarize most recent trends technology, going through used polymeric materials popular synthesis methods years, strategies enhancing hydrogels' properties, cross-linking manufacture composite hydrogels. In addition, secondary objective briefly discuss other novel applications hydrogels that past few years drawn a lot attention.

Язык: Английский

Процитировано

209

Alginate-Based Biomaterials in Tissue Engineering and Regenerative Medicine DOI Creative Commons
Nima Farshidfar, Siavash Iravani, Rajender S. Varma

и другие.

Marine Drugs, Год журнала: 2023, Номер 21(3), С. 189 - 189

Опубликована: Март 18, 2023

Today, with the salient advancements of modern and smart technologies related to tissue engineering regenerative medicine (TE-RM), use sustainable biodegradable materials biocompatibility cost-effective advantages have been investigated more than before. Alginate as a naturally occurring anionic polymer can be obtained from brown seaweed develop wide variety composites for TE, drug delivery, wound healing, cancer therapy. This renewable biomaterial displays several fascinating properties such high biocompatibility, low toxicity, cost-effectiveness, mild gelation by inserting divalent cations (e.g., Ca2+). In this context, challenges still exist in relation solubility viscosity high-molecular weight alginate, density intra- inter-molecular hydrogen bonding, polyelectrolyte nature aqueous solution, lack suitable organic solvents. Herein, TE-RM applications alginate-based are deliberated, focusing on current trends, important challenges, future prospects.

Язык: Английский

Процитировано

113

Electroactive injectable hydrogel based on oxidized sodium alginate and carboxymethyl chitosan for wound healing DOI
Lin Zhao,

Zhipan Feng,

Yang Lyu

и другие.

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 230, С. 123231 - 123231

Опубликована: Янв. 11, 2023

Язык: Английский

Процитировано

70

Application of Alginate Hydrogels for Next-Generation Articular Cartilage Regeneration DOI Open Access
Wei Liu, Henning Madry, Magali Cucchiarini

и другие.

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(3), С. 1147 - 1147

Опубликована: Янв. 20, 2022

The articular cartilage has insufficient intrinsic healing abilities, and injuries often progress to osteoarthritis. Alginate-based scaffolds are attractive biomaterials for repair regeneration, allowing the delivery of cells therapeutic drugs gene sequences. In light heterogeneity findings reporting benefits using alginate a better understanding alginate-based systems is needed in order improve approaches aiming enhance regeneration with this compound. This review provides an in-depth evaluation literature, focusing on manipulation as tool support processes involved demonstrate how such material, used direct compound or combined cell therapy scaffold-guided transfer procedures, may assist optimal manner future applications patients.

Язык: Английский

Процитировано

68

Marine‐Derived Hydrogels for Biomedical Applications DOI
Xiang Lin, Jinglin Wang,

Xiangyi Wu

и другие.

Advanced Functional Materials, Год журнала: 2022, Номер 33(6)

Опубликована: Ноя. 28, 2022

Marine organisms provide novel and broad sources for the preparations applications of biomaterials. Since urgent requirement bio‐hydrogels to mimic tissue extracellular matrix (ECM), natural biomacromolecule hydrogels derived from marine have received increasing attention. Benefiting their outstanding bioactivity biocompatibility, many attempts been made reconstruct ECM components by applying marine‐derived hydrogels. Moreover, successfully applied in biomedicine means microfluidics, electrospray, bioprinting. In this review, classification characteristics are summarized. particular, role development biomaterials is also introduced. Then, recent advances bio‐fabrication strategies various hydrogel materials focused upon. Besides, influences types on functions biomedical discussed depth. Finally, critical reflections limitations future presented.

Язык: Английский

Процитировано

41

3D Biofabrication of a Cardiac Tissue Construct for Sustained Longevity and Function DOI
Matthew Alonzo,

Raven El Khoury,

Naveen Nagiah

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2022, Номер 14(19), С. 21800 - 21813

Опубликована: Май 9, 2022

In this study, we developed three-dimensional (3D) printed annular ring-like scaffolds of hydrogel (gelatin-alginate) constructs encapsulated with a mixture human cardiac AC16 cardiomyocytes (CMs), fibroblasts (CFs), and microvascular endothelial cells (ECs) as organoid models in preparation for investigating the role microgravity cardiovascular disease initiation development. We studied mechanical properties acellular confirmed their cell compatibility well heterocellular coupling tissue engineering. Rheological analysis performed on showed to be elastogenic elastic modulus within range native

Язык: Английский

Процитировано

40

Injectable hydrogels: An emerging therapeutic strategy for cartilage regeneration DOI Creative Commons

Arjan Atwal,

Tina P. Dale, Martyn Snow

и другие.

Advances in Colloid and Interface Science, Год журнала: 2023, Номер 321, С. 103030 - 103030

Опубликована: Окт. 20, 2023

The impairment of articular cartilage due to traumatic incidents or osteoarthritis has posed significant challenges for healthcare practitioners, researchers, and individuals suffering from these conditions. Due the absence an approved treatment strategy complete restoration defects their native state, tissue condition often deteriorates over time, leading osteoarthritic (OA). However, recent advancements in field regenerative medicine have unveiled promising prospects through utilization injectable hydrogels. This versatile class biomaterials, characterized by ability emulate characteristics cartilage, offers distinct advantage minimally invasive administration directly site damage. These hydrogels can also serve as ideal delivery vehicles a diverse range bioactive agents, including growth factors, anti-inflammatory drugs, steroids, cells. controlled release such biologically active molecules hydrogel scaffolds accelerate healing, stimulate chondrogenesis, modulate inflammatory microenvironment halt progression. present review aims describe methods used design hydrogels, expound upon applications molecules, provide update on advances leveraging systems foster regeneration.

Язык: Английский

Процитировано

40

Alginate-based biomaterial-mediated regulation of macrophages in bone tissue engineering DOI
Yuanyuan Li, Zhengyi Xu, Jian Wang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 230, С. 123246 - 123246

Опубликована: Янв. 14, 2023

Язык: Английский

Процитировано

32

Recent advances on stimuli-responsive biopolymer-based nanocomposites for drug delivery DOI

Renhua Xiao,

Guangying Zhou,

Yuming Wen

и другие.

Composites Part B Engineering, Год журнала: 2023, Номер 266, С. 111018 - 111018

Опубликована: Сен. 21, 2023

Язык: Английский

Процитировано

32