Materials Today Bio,
Год журнала:
2022,
Номер
18, С. 100522 - 100522
Опубликована: Дек. 21, 2022
Extracellular
vesicles
(EVs)
are
a
collective
term
for
nanoscale
or
microscale
secreted
by
cells
that
play
important
biological
roles.
Mesenchymal
stem
class
of
with
the
potential
self-healing
and
multidirectional
differentiation.
In
recent
years,
numerous
studies
have
shown
EVs,
especially
those
mesenchymal
cells,
can
promote
repair
regeneration
various
tissues
and,
thus,
significant
in
regenerative
medicine.
However,
due
to
rapid
clearance
capacity
circulatory
system,
EVs
barely
able
act
persistently
at
specific
sites
target
tissues.
Hydrogels
good
biocompatibility
loose
porous
structural
properties
allow
them
serve
as
EV
carriers,
thereby
prolonging
retention
certain
areas
slowing
release
EVs.
When
needed
function
sites,
EV-loaded
hydrogels
stand
an
excellent
approach.
this
review,
we
first
introduce
sources,
roles,
extraction
characterization
methods
describe
their
current
application
status.
We
then
review
different
types
discuss
factors
influencing
abilities
carry
summarize
several
strategies
loading
into
characterizing
hydrogels.
Furthermore,
applications
tissue
repair.
This
article
concludes
summary
state
research
on
outlook
future
directions,
which
hope
will
provide
promising
ideas
researchers.
Polymers,
Год журнала:
2022,
Номер
14(15), С. 3023 - 3023
Опубликована: Июль 26, 2022
Nowadays,
there
are
still
numerous
challenges
for
well-known
biomedical
applications,
such
as
tissue
engineering
(TE),
wound
healing
and
controlled
drug
delivery,
which
must
be
faced
solved.
Hydrogels
have
been
proposed
excellent
candidates
these
they
promising
properties
the
mentioned
including
biocompatibility,
biodegradability,
great
absorption
capacity
tunable
mechanical
properties.
However,
depending
on
material
or
manufacturing
method,
resulting
hydrogel
may
not
up
to
specific
task
it
is
designed,
thus
different
approaches
enhance
performance
requirements
of
application
in
question.
The
main
purpose
this
review
article
was
summarize
most
recent
trends
technology,
going
through
used
polymeric
materials
popular
synthesis
methods
years,
strategies
enhancing
hydrogels'
properties,
cross-linking
manufacture
composite
hydrogels.
In
addition,
secondary
objective
briefly
discuss
other
novel
applications
hydrogels
that
past
few
years
drawn
a
lot
attention.
Marine Drugs,
Год журнала:
2023,
Номер
21(3), С. 189 - 189
Опубликована: Март 18, 2023
Today,
with
the
salient
advancements
of
modern
and
smart
technologies
related
to
tissue
engineering
regenerative
medicine
(TE-RM),
use
sustainable
biodegradable
materials
biocompatibility
cost-effective
advantages
have
been
investigated
more
than
before.
Alginate
as
a
naturally
occurring
anionic
polymer
can
be
obtained
from
brown
seaweed
develop
wide
variety
composites
for
TE,
drug
delivery,
wound
healing,
cancer
therapy.
This
renewable
biomaterial
displays
several
fascinating
properties
such
high
biocompatibility,
low
toxicity,
cost-effectiveness,
mild
gelation
by
inserting
divalent
cations
(e.g.,
Ca2+).
In
this
context,
challenges
still
exist
in
relation
solubility
viscosity
high-molecular
weight
alginate,
density
intra-
inter-molecular
hydrogen
bonding,
polyelectrolyte
nature
aqueous
solution,
lack
suitable
organic
solvents.
Herein,
TE-RM
applications
alginate-based
are
deliberated,
focusing
on
current
trends,
important
challenges,
future
prospects.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(3), С. 1147 - 1147
Опубликована: Янв. 20, 2022
The
articular
cartilage
has
insufficient
intrinsic
healing
abilities,
and
injuries
often
progress
to
osteoarthritis.
Alginate-based
scaffolds
are
attractive
biomaterials
for
repair
regeneration,
allowing
the
delivery
of
cells
therapeutic
drugs
gene
sequences.
In
light
heterogeneity
findings
reporting
benefits
using
alginate
a
better
understanding
alginate-based
systems
is
needed
in
order
improve
approaches
aiming
enhance
regeneration
with
this
compound.
This
review
provides
an
in-depth
evaluation
literature,
focusing
on
manipulation
as
tool
support
processes
involved
demonstrate
how
such
material,
used
direct
compound
or
combined
cell
therapy
scaffold-guided
transfer
procedures,
may
assist
optimal
manner
future
applications
patients.
Advanced Functional Materials,
Год журнала:
2022,
Номер
33(6)
Опубликована: Ноя. 28, 2022
Marine
organisms
provide
novel
and
broad
sources
for
the
preparations
applications
of
biomaterials.
Since
urgent
requirement
bio‐hydrogels
to
mimic
tissue
extracellular
matrix
(ECM),
natural
biomacromolecule
hydrogels
derived
from
marine
have
received
increasing
attention.
Benefiting
their
outstanding
bioactivity
biocompatibility,
many
attempts
been
made
reconstruct
ECM
components
by
applying
marine‐derived
hydrogels.
Moreover,
successfully
applied
in
biomedicine
means
microfluidics,
electrospray,
bioprinting.
In
this
review,
classification
characteristics
are
summarized.
particular,
role
development
biomaterials
is
also
introduced.
Then,
recent
advances
bio‐fabrication
strategies
various
hydrogel
materials
focused
upon.
Besides,
influences
types
on
functions
biomedical
discussed
depth.
Finally,
critical
reflections
limitations
future
presented.
ACS Applied Materials & Interfaces,
Год журнала:
2022,
Номер
14(19), С. 21800 - 21813
Опубликована: Май 9, 2022
In
this
study,
we
developed
three-dimensional
(3D)
printed
annular
ring-like
scaffolds
of
hydrogel
(gelatin-alginate)
constructs
encapsulated
with
a
mixture
human
cardiac
AC16
cardiomyocytes
(CMs),
fibroblasts
(CFs),
and
microvascular
endothelial
cells
(ECs)
as
organoid
models
in
preparation
for
investigating
the
role
microgravity
cardiovascular
disease
initiation
development.
We
studied
mechanical
properties
acellular
confirmed
their
cell
compatibility
well
heterocellular
coupling
tissue
engineering.
Rheological
analysis
performed
on
showed
to
be
elastogenic
elastic
modulus
within
range
native
Advances in Colloid and Interface Science,
Год журнала:
2023,
Номер
321, С. 103030 - 103030
Опубликована: Окт. 20, 2023
The
impairment
of
articular
cartilage
due
to
traumatic
incidents
or
osteoarthritis
has
posed
significant
challenges
for
healthcare
practitioners,
researchers,
and
individuals
suffering
from
these
conditions.
Due
the
absence
an
approved
treatment
strategy
complete
restoration
defects
their
native
state,
tissue
condition
often
deteriorates
over
time,
leading
osteoarthritic
(OA).
However,
recent
advancements
in
field
regenerative
medicine
have
unveiled
promising
prospects
through
utilization
injectable
hydrogels.
This
versatile
class
biomaterials,
characterized
by
ability
emulate
characteristics
cartilage,
offers
distinct
advantage
minimally
invasive
administration
directly
site
damage.
These
hydrogels
can
also
serve
as
ideal
delivery
vehicles
a
diverse
range
bioactive
agents,
including
growth
factors,
anti-inflammatory
drugs,
steroids,
cells.
controlled
release
such
biologically
active
molecules
hydrogel
scaffolds
accelerate
healing,
stimulate
chondrogenesis,
modulate
inflammatory
microenvironment
halt
progression.
present
review
aims
describe
methods
used
design
hydrogels,
expound
upon
applications
molecules,
provide
update
on
advances
leveraging
systems
foster
regeneration.
