Pharmaceutics,
Год журнала:
2024,
Номер
16(4), С. 524 - 524
Опубликована: Апрель 10, 2024
The
skin
is
the
largest
organ
of
body,
and
it
acts
as
a
protective
barrier
against
external
factors.
Chronic
wounds
affect
millions
people
worldwide
are
associated
with
significant
morbidity
reduced
quality
life.
One
main
factors
involved
in
delayed
wound
healing
oxidative
injury,
which
triggered
by
overproduction
reactive
oxygen
species.
Oxidative
stress
has
been
implicated
pathogenesis
chronic
wounds,
where
known
to
impair
causing
damage
cellular
components,
delaying
inflammatory
phase
healing,
inhibiting
formation
new
blood
vessels.
Thereby,
treatment
requires
multidisciplinary
approach
that
addresses
underlying
causes
wound,
provides
optimal
care,
promotes
healing.
Among
promising
approaches
taking
care
antioxidants
gaining
interest
since
they
offer
multiple
benefits
related
health.
Therefore,
this
review,
we
will
highlight
latest
advances
use
natural
polymers
generate
tissue
regeneration
microenvironments
for
Materials Today Bio,
Год журнала:
2022,
Номер
18, С. 100522 - 100522
Опубликована: Дек. 21, 2022
Extracellular
vesicles
(EVs)
are
a
collective
term
for
nanoscale
or
microscale
secreted
by
cells
that
play
important
biological
roles.
Mesenchymal
stem
class
of
with
the
potential
self-healing
and
multidirectional
differentiation.
In
recent
years,
numerous
studies
have
shown
EVs,
especially
those
mesenchymal
cells,
can
promote
repair
regeneration
various
tissues
and,
thus,
significant
in
regenerative
medicine.
However,
due
to
rapid
clearance
capacity
circulatory
system,
EVs
barely
able
act
persistently
at
specific
sites
target
tissues.
Hydrogels
good
biocompatibility
loose
porous
structural
properties
allow
them
serve
as
EV
carriers,
thereby
prolonging
retention
certain
areas
slowing
release
EVs.
When
needed
function
sites,
EV-loaded
hydrogels
stand
an
excellent
approach.
this
review,
we
first
introduce
sources,
roles,
extraction
characterization
methods
describe
their
current
application
status.
We
then
review
different
types
discuss
factors
influencing
abilities
carry
summarize
several
strategies
loading
into
characterizing
hydrogels.
Furthermore,
applications
tissue
repair.
This
article
concludes
summary
state
research
on
outlook
future
directions,
which
hope
will
provide
promising
ideas
researchers.
Molecules,
Год журнала:
2023,
Номер
28(3), С. 1473 - 1473
Опубликована: Фев. 3, 2023
The
design
of
new
hemostatic
materials
to
mitigate
uncontrolled
bleeding
in
emergencies
is
challenging.
Chitosan-based
hydrogels
have
frequently
been
used
for
hemostasis
due
their
unique
biocompatibility,
tunable
mechanical
properties,
injectability,
and
ease
handling.
Moreover,
chitosan
(CS)
absorbs
red
blood
cells
activates
platelets
promote
hemostasis.
Benefiting
from
these
desired
the
application
CS
attracting
ever-increasing
research
attention.
This
paper
reviews
recent
progress
CS-based
advantageous
characteristics
compared
traditional
materials.
effects
mechanism,
deacetylation
degree,
relative
molecular
mass,
chemical
modification
on
performance
are
summarized.
Meanwhile,
some
typical
applications
introduced
provide
references
preparation
efficient
hydrogels.
Finally,
future
perspectives
presented.
Materials,
Год журнала:
2023,
Номер
16(15), С. 5459 - 5459
Опубликована: Авг. 3, 2023
The
treatment
of
skin
wounds
caused
by
trauma
and
pathophysiological
disorders
has
been
a
growing
healthcare
challenge,
posing
great
economic
burden
worldwide.
use
appropriate
wound
dressings
can
help
to
facilitate
the
repair
healing
rate
defective
skin.
Natural
polymer
biomaterials
such
as
collagen
hyaluronic
acid
with
excellent
biocompatibility
have
shown
promote
restoration
However,
low
mechanical
properties
fast
degradation
limited
their
applications.
Skin
based
on
biodegradable
biocompatible
synthetic
polymers
not
only
overcome
shortcomings
natural
but
also
possess
favorable
for
applications
in
wounds.
Herein,
we
listed
several
used
dressing
materials,
PVA,
PCL,
PLA,
PLGA,
PU,
PEO/PEG,
focusing
composition,
fabrication
techniques,
functions
promoting
healing.
Additionally,
future
development
prospects
polymer-based
are
put
forward.
Our
review
aims
provide
new
insights
further
using
polymers.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Фев. 16, 2023
When
hydrogel
materials
with
excellent
biocompatibility
and
biodegradability
are
used
as
new
drug
carriers
in
the
treatment
of
cancer,
they
confer
following
three
advantages.
First,
can
be
a
precise
controlled
release
systems,
which
continuously
sequentially
chemotherapeutic
drugs,
radionuclides,
immunosuppressants,
hyperthermia
agents,
phototherapy
agents
other
substances
widely
cancer
through
radiotherapy,
chemotherapy,
immunotherapy,
hyperthermia,
photodynamic
therapy
photothermal
therapy.
Second,
have
multiple
sizes
delivery
routes,
targeted
to
different
locations
types
cancer.
This
greatly
improves
targeting
thereby
reducing
dose
drugs
improving
effectiveness.
Finally,
intelligently
respond
environmental
changes
according
internal
external
stimuli
so
that
anti-cancer
active
remotely
released
on
demand.
Combining
abovementioned
advantages,
transformed
into
hit
field
treatment,
bringing
hope
further
increase
survival
rate
quality
life
patients
Biomacromolecules,
Год журнала:
2023,
Номер
24(6), С. 2928 - 2941
Опубликована: Май 22, 2023
Gelatin
methacryloyl
(GelMA)
hydrogels
have
been
extensively
used
for
drug
delivery
and
tissue
engineering
applications
due
to
their
good
biocompatibility,
biodegradability,
controllable
photocurable
efficiency.
Phosphate
buffer
solution
(PBS)
is
the
most
widely
reaction
system
GelMA
synthesis.
However,
carbonate–bicarbonate
(CBS)
has
tried
recently
synthesizing
its
high
there
a
lack
of
systematic
investigation
into
possible
differences
in
structure
properties
synthesized
PBS
CBS,
respectively.
Therefore,
current
study,
molecules
with
two
degrees
methacryloylation
(∼20
∼80%)
were
under
CBS
systems,
respectively,
comparable
conditions.
The
results
showed
that
because
functionalization
methacrylate
groups
gelatin
chains,
which
could
interfere
intrachain
interchain
interactions,
such
as
hydrogen
bonding,
had
distinct
physical
structures
exhibited
different
comparison
those
produced
CBS.
higher
gel–sol
transition
temperatures
better
efficiencies,
mechanical
strength,
biological
properties.
In
contrast,
advantages
swelling
performance
microstructures,
pore
sizes
porosities.
addition,
possessing
degree
(the
"GelMA-PH"
polymer)
great
potential
three-dimensional
(3D)
bioprinting.
This
focused
study
gained
helpful
new
insights
can
provide
guidance
on
application
3D
printing
engineering.
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
263, С. 129858 - 129858
Опубликована: Фев. 29, 2024
Tissue
engineering
(TE)
demands
scaffolds
that
have
the
necessary
resistance
to
withstand
mechanical
stresses
once
implanted
in
our
body,
as
well
excellent
biocompatibility.
Hydrogels
are
postulated
interesting
materials
for
this
purpose,
especially
those
made
from
biopolymers.
In
study,
microstructure
and
rheological
performance,
functional
biological
properties
of
chitosan
collagen
hydrogels
(CH/CG)
crosslinked
with
different
coupling
agents,
both
natural
such
d-Fructose
(F),
genipin
(G)
transglutaminase
(T)
synthetic,
using
a
combination
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide
hydrochloride
N-hydroxysuccinimide
(EDC/NHS)
will
be
assessed.
FTIR
tests
were
carried
out
determine
if
proposed
crosslinking
reactions
each
agent
occurred
expected,
obtaining
positive
results
aspect.
Regarding
characterization
system,
two
main
trends
observed,
which
it
could
established
G
EDC-NHS
turned
more
effective
beneficial
than
other
producing
significant
improvements
respect
base
CH/CG
hydrogel.
addition,
vitro
demonstrated
potential
application
TE
these
systems,
G,
T
EDC-NHS.
