International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(19), С. 10757 - 10757
Опубликована: Окт. 6, 2024
With
the
aging
of
global
population,
neurodegenerative
diseases
are
emerging
as
a
major
public
health
issue.
The
adoption
less
sedentary
lifestyle
has
been
shown
to
have
beneficial
effect
on
cognitive
decline,
but
molecular
mechanisms
responsible
clear.
Here
we
provide
detailed
analysis
complex
molecular,
cellular,
and
systemic
underlying
age-related
decline
how
choices
influence
these
processes.
A
review
evidence
from
animal
models,
human
studies,
postmortem
analyses
emphasizes
importance
integrating
physical
exercise
with
cognitive,
multisensory,
motor
stimulation
part
multifaceted
approach
mitigating
decline.
We
highlight
potential
non-pharmacological
interventions
address
key
hallmarks,
such
genomic
instability,
telomere
attrition,
neuroinflammation,
underscore
need
for
comprehensive
personalized
strategies
promote
resilience
healthy
aging.
Geriatrics,
Год журнала:
2020,
Номер
5(4), С. 80 - 80
Опубликована: Окт. 19, 2020
Due
to
demographic
changes,
the
number
of
older
drivers
is
steadily
increasing.
Mobility
highly
relevant
for
leading
an
independent
life
in
elderly.
It
largely
depends
on
car
driving,
which
a
complex
task
requiring
multitude
cognitive
and
motor
skills
vulnerable
age-
related
functional
deterioration.
The
almost
inevitable
effects
senescence
may
be
potentiated
by
age-related
diseases,
such
as
stroke
or
diabetes
mellitus.
Respective
pharmacological
treatment
cause
side
effects,
additionally
affecting
driving
safety.
present
article
reviews
impact
diseases
drug
these
conditions
fitness
elderly
drivers.
In
essence,
we
focus
visual
auditory
systems,
central
nervous
system
(i.e.,
stroke,
depression,
dementia
mild
disorder,
Parkinson’s
disease),
sleep
disorders,
well
cardiovascular
mellitus,
musculoskeletal
frailty.
We
will
outline
role
tests
assessment
behavior
(by
simulator
real
traffic),
clinical
interview
including
questions
about
frequency
(near)
accidents,
etc.
evaluation
also
address
polypharmacy
end
up
with
recommendations
physicians
caring
patients.
Biomedicines,
Год журнала:
2022,
Номер
10(8), С. 2043 - 2043
Опубликована: Авг. 21, 2022
Nuclear
factor
(erythroid-derived
2)-like
2
(NRF2)
is
a
redox-sensitive
transcription
that
binds
to
the
antioxidant
response
element
consensus
sequence,
decreasing
reactive
oxygen
species
and
regulating
of
wide
array
genes,
including
detoxifying
enzymes,
genes
involved
in
mitochondrial
function
biogenesis.
Moreover,
NRF2
has
been
shown
directly
regulate
expression
anti-inflammatory
mediators
reducing
pro-inflammatory
cytokines.
In
recent
years,
attention
turned
role
plays
brain
different
diseases
such
Alzheimer’s
disease,
Parkinson’s
Huntington’s
disease
others.
This
review
focused
on
evidence,
derived
vitro,
vivo
from
clinical
trials,
supporting
for
activation
maintaining
improving
cognitive
how
its
can
be
used
elicit
neuroprotection
lead
enhancement.
The
also
brings
critical
discussion
concerning
possible
prophylactic
and/or
therapeutic
use
activators
treating
impairment-related
conditions.
Frontiers in Aging Neuroscience,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 8, 2024
The
glucocorticoid
(GC)
hypothesis
posits
that
effects
of
stress
and
dysregulated
hypothalamic-pituitary-adrenal
axis
activity
accumulate
over
the
lifespan
contribute
to
impairment
neural
function
cognition
in
advanced
aging.
validity
GC
is
bolstered
by
a
wealth
studies
investigate
aging
hippocampus
decline
associated
mnemonic
functions.
prefrontal
cortex
(PFC)
mediates
working
memory
which
also
decreases
with
age.
While
PFC
susceptible
GCs,
few
have
formally
assessed
application
memory.
Using
parallel
behavioral
molecular
approaches,
we
compared
normal
versus
chronic
variable
(CVS)
on
expression
genes
encode
for
effectors
glutamate
GABA
signaling
male
F344
rats.
an
operant
delayed
match-to-sample
test
PFC-dependent
memory,
determined
CVS
each
significantly
impaired
accuracy
reduced
total
number
completed
trials.
We
then
increased
Slc6a11,
encodes
GAT-3
transporter
expressed
astrocytes,
prelimbic
(PrL)
subregion
PFC.
PrL
glutamatergic
synapses:
Grin2b
GluN2B
subunit
NMDA
receptor,
Grm4
metabotropic
receptor
4
(mGluR4),
Plcb1
phospholipase
C
beta
1,
intracellular
enzyme
transduces
Group
I
mGluRs.
Beyond
identification
specific
were
differentially
between
or
CVS,
examination
Log2
fold-changes
all
revealed
positive
association
phenotypes
but
no
infralimbic
subregion.
Consistent
predictions
hypothesis,
glutamate/GABA
gene
demonstrate
comparable
sensitivity
stress.
However,
changes
affiliated
regulation
extracellular
vs.
encoding
during
suggest
presence
unique
manifestations
imbalanced
inhibitory
excitatory
Frontiers in Psychology,
Год журнала:
2024,
Номер
15
Опубликована: Май 9, 2024
Introduction
Cognitive
functions
play
a
crucial
role
in
individual’s
life
since
they
represent
the
mental
abilities
necessary
to
perform
any
activity.
During
working
life,
having
healthy
cognitive
functioning
is
essential
for
proper
performance
of
work,
but
it
especially
preserving
and
thus
ensuring
aging
after
retirement.
The
aim
this
paper
was
systematically
review
scientific
literature
related
effects
work
on
assess
which
work-related
factors
most
adversely
affect
them.
Method
We
queried
PubMed
Scopus
electronic
databases,
February
2023,
according
PRISMA
guidelines
(PROSPERO
ID
number
=
CRD42023439172),
articles
were
included
if
met
all
inclusion
criteria
survived
quality
assessment.
From
an
initial
pool
61,781
papers,
we
retained
final
sample
64
articles,
divided
into
5
categories
based
factors:
shift
(
n
39),
sedentary
7),
occupational
stress
12),
prolonged
hours
3),
expertise
3).
Results
results
showed
that
stress,
and,
probably,
have
detrimental
functioning;
instead,
are
inconclusive
extremely
miscellaneous.
Discussion
Therefore,
workplace
health
well-being
promotion
should
consider
reducing
or
rescheduling
night
shift,
creation
less
demanding
more
resourceful
environments
use
micro-breaks
preserve
workers’
both
before
Systematic
registration
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023439172
,
identifier
CRD42023439172.
European Journal of Neuroscience,
Год журнала:
2025,
Номер
61(3)
Опубликована: Фев. 1, 2025
ABSTRACT
Working
memory,
which
tends
to
be
the
most
vulnerable
cognitive
domain
aging,
is
thought
depend
on
a
functional
brain
network
for
efficient
communication.
The
dynamic
communication
within
this
represented
by
segregation
and
integration.
This
study
aimed
investigate
healthy
aging
examining
age
effect
outcomes
of
graph
theory
analysis
during
visual
short‐term
memory
binding
(VSTMB)
task.
VSTMB
tasks
rely
integration
features
are
less
sensitive
semantic
verbal
strategies.
Effects
neuropsychological
test
scores,
along
with
EEG
graph‐theoretical
integration,
global
organization
metrics
in
frequencies
from
delta
gamma
band
were
investigated.
Neuropsychological
assessment
showed
low
sensitivity
as
measure
age‐related
changes.
results
indicated
that
architecture
changed
more
effectively
middle
age,
while
effectiveness
appears
vanish
or
show
compensatory
mechanisms
elderly.
These
differences
further
found
related
scores.
first
demonstrate
working
across
broad
range.
Perceptual and Motor Skills,
Год журнала:
2016,
Номер
122(1), С. 165 - 192
Опубликована: Фев. 1, 2016
Aging
is
accompanied
by
declines
in
cognitive
and
sensorimotor
functions.
However,
at
present,
the
interrelation
between
attentional
processes
dexterity
aging
has
not
been
thoroughly
addressed.
This
study
explored
relationship
executive
function,
working
memory,
performance
15
young
healthy
elderly,
right-handed
participants.
A
modified
version
of
Purdue
Pegboard
Test
was
used
for
assessment.
Two
subtasks
were
selected
to
calculate
temporal
kinematic
parameters
reaching,
grasping,
transport,
insertion
pegs.
Evaluation
function
memory
performed
using
neuropsychological
tests.
The
outcomes
also
examined.
Results
showed
that
prehensile
movements
involved
grasping
their
speed
significantly
differed
groups
correlated
with
group.
For
elderly
adults,
variability
hand
turned
out
be
associated
abilities.
