The Hidden Dangers of Sedentary Living: Insights into Molecular, Cellular, and Systemic Mechanisms DOI Open Access
Daniel Guerreiro Diniz, João Bento‐Torres, Victor Oliveira da Costa

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10757 - 10757

Published: Oct. 6, 2024

With the aging of global population, neurodegenerative diseases are emerging as a major public health issue. The adoption less sedentary lifestyle has been shown to have beneficial effect on cognitive decline, but molecular mechanisms responsible clear. Here we provide detailed analysis complex molecular, cellular, and systemic underlying age-related decline how choices influence these processes. A review evidence from animal models, human studies, postmortem analyses emphasizes importance integrating physical exercise with cognitive, multisensory, motor stimulation part multifaceted approach mitigating decline. We highlight potential non-pharmacological interventions address key hallmarks, such genomic instability, telomere attrition, neuroinflammation, underscore need for comprehensive personalized strategies promote resilience healthy aging.

Language: Английский

The multifactorial nature of healthy brain ageing: Brain changes, functional decline and protective factors DOI
Sonia Turrini, Bonnie Wong, Mark C. Eldaief

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 88, P. 101939 - 101939

Published: April 27, 2023

Language: Английский

Citations

34
Combining non-invasive brain stimulation techniques and EEG markers analysis: an innovative approach to cognitive health in aging DOI
Chiara Pappalettera,

Anna Fabbrocino,

Francesca Miraglia

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Language: Английский

Citations

1
EEG entropy insights in the context of physiological aging and Alzheimer’s and Parkinson’s diseases: a comprehensive review DOI
Alessia Cacciotti, Chiara Pappalettera, Francesca Miraglia

et al.

GeroScience, Journal Year: 2024, Volume and Issue: 46(6), P. 5537 - 5557

Published: May 22, 2024

Language: Английский

Citations

7
Age-Related Diseases and Driving Safety DOI Creative Commons
Michael Falkenstein, Melanie Karthaus,

Ute Brüne-Cohrs

et al.

Geriatrics, Journal Year: 2020, Volume and Issue: 5(4), P. 80 - 80

Published: Oct. 19, 2020

Due to demographic changes, the number of older drivers is steadily increasing. Mobility highly relevant for leading an independent life in elderly. It largely depends on car driving, which a complex task requiring multitude cognitive and motor skills vulnerable age- related functional deterioration. The almost inevitable effects senescence may be potentiated by age-related diseases, such as stroke or diabetes mellitus. Respective pharmacological treatment cause side effects, additionally affecting driving safety. present article reviews impact diseases drug these conditions fitness elderly drivers. In essence, we focus visual auditory systems, central nervous system (i.e., stroke, depression, dementia mild disorder, Parkinson’s disease), sleep disorders, well cardiovascular mellitus, musculoskeletal frailty. We will outline role tests assessment behavior (by simulator real traffic), clinical interview including questions about frequency (near) accidents, etc. evaluation also address polypharmacy end up with recommendations physicians caring patients.

Language: Английский

Citations

38
The Role of the NRF2 Pathway in Maintaining and Improving Cognitive Function DOI Creative Commons
Nora E. Gray, Marcelo Farina, Paolo Tucci

et al.

Biomedicines, Journal Year: 2022, Volume and Issue: 10(8), P. 2043 - 2043

Published: Aug. 21, 2022

Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a redox-sensitive transcription that binds to the antioxidant response element consensus sequence, decreasing reactive oxygen species and regulating of wide array genes, including detoxifying enzymes, genes involved in mitochondrial function biogenesis. Moreover, NRF2 has been shown directly regulate expression anti-inflammatory mediators reducing pro-inflammatory cytokines. In recent years, attention turned role plays brain different diseases such Alzheimer’s disease, Parkinson’s Huntington’s disease others. This review focused on evidence, derived vitro, vivo from clinical trials, supporting for activation maintaining improving cognitive how its can be used elicit neuroprotection lead enhancement. The also brings critical discussion concerning possible prophylactic and/or therapeutic use activators treating impairment-related conditions.

Language: Английский

Citations

19
Aging or chronic stress impairs working memory and modulates GABA and glutamate gene expression in prelimbic cortex DOI Creative Commons

Hannah M. Gandy,

Fiona Hollis, Caesar M. Hernandez

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 8, 2024

The glucocorticoid (GC) hypothesis posits that effects of stress and dysregulated hypothalamic-pituitary-adrenal axis activity accumulate over the lifespan contribute to impairment neural function cognition in advanced aging. validity GC is bolstered by a wealth studies investigate aging hippocampus decline associated mnemonic functions. prefrontal cortex (PFC) mediates working memory which also decreases with age. While PFC susceptible GCs, few have formally assessed application memory. Using parallel behavioral molecular approaches, we compared normal versus chronic variable (CVS) on expression genes encode for effectors glutamate GABA signaling male F344 rats. an operant delayed match-to-sample test PFC-dependent memory, determined CVS each significantly impaired accuracy reduced total number completed trials. We then increased Slc6a11, encodes GAT-3 transporter expressed astrocytes, prelimbic (PrL) subregion PFC. PrL glutamatergic synapses: Grin2b GluN2B subunit NMDA receptor, Grm4 metabotropic receptor 4 (mGluR4), Plcb1 phospholipase C beta 1, intracellular enzyme transduces Group I mGluRs. Beyond identification specific were differentially between or CVS, examination Log2 fold-changes all revealed positive association phenotypes but no infralimbic subregion. Consistent predictions hypothesis, glutamate/GABA gene demonstrate comparable sensitivity stress. However, changes affiliated regulation extracellular vs. encoding during suggest presence unique manifestations imbalanced inhibitory excitatory

Language: Английский

Citations

4
The effects of work on cognitive functions: a systematic review DOI Creative Commons
Pasquale Bufano, Cristina Di Tecco, Alice Fattori

et al.

Frontiers in Psychology, Journal Year: 2024, Volume and Issue: 15

Published: May 9, 2024

Introduction Cognitive functions play a crucial role in individual’s life since they represent the mental abilities necessary to perform any activity. During working life, having healthy cognitive functioning is essential for proper performance of work, but it especially preserving and thus ensuring aging after retirement. The aim this paper was systematically review scientific literature related effects work on assess which work-related factors most adversely affect them. Method We queried PubMed Scopus electronic databases, February 2023, according PRISMA guidelines (PROSPERO ID number = CRD42023439172), articles were included if met all inclusion criteria survived quality assessment. From an initial pool 61,781 papers, we retained final sample 64 articles, divided into 5 categories based factors: shift ( n 39), sedentary 7), occupational stress 12), prolonged hours 3), expertise 3). Results results showed that stress, and, probably, have detrimental functioning; instead, are inconclusive extremely miscellaneous. Discussion Therefore, workplace health well-being promotion should consider reducing or rescheduling night shift, creation less demanding more resourceful environments use micro-breaks preserve workers’ both before Systematic registration https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023439172 , identifier CRD42023439172.

Language: Английский

Citations

4
Network Segregation and Integration Changes in Healthy Aging: Evidence From EEG Subbands During the Visual Short‐Term Memory Binding Task DOI Creative Commons
Ezgi Fide, Emre Bora, Görsev Yener

et al.

European Journal of Neuroscience, Journal Year: 2025, Volume and Issue: 61(3)

Published: Feb. 1, 2025

ABSTRACT Working memory, which tends to be the most vulnerable cognitive domain aging, is thought depend on a functional brain network for efficient communication. The dynamic communication within this represented by segregation and integration. This study aimed investigate healthy aging examining age effect outcomes of graph theory analysis during visual short‐term memory binding (VSTMB) task. VSTMB tasks rely integration features are less sensitive semantic verbal strategies. Effects neuropsychological test scores, along with EEG graph‐theoretical integration, global organization metrics in frequencies from delta gamma band were investigated. Neuropsychological assessment showed low sensitivity as measure age‐related changes. results indicated that architecture changed more effectively middle age, while effectiveness appears vanish or show compensatory mechanisms elderly. These differences further found related scores. first demonstrate working across broad range.

Language: Английский

Citations

0
Systemic Rejuvenating Interventions: Perspectives on Neuroinflammation and Blood–Brain Barrier Integrity DOI
Victória Linden de Rezende, Maiara de Aguiar da Costa, Carla Damasio Martins

et al.

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(2)

Published: March 4, 2025

Language: Английский

Citations

0
Association Between Executive Functions, Working Memory, and Manual Dexterity in Young and Healthy Older Adults DOI
Claudia Rodríguez‐Aranda, Matthias Mittner, Olena Vasylenko

et al.

Perceptual and Motor Skills, Journal Year: 2016, Volume and Issue: 122(1), P. 165 - 192

Published: Feb. 1, 2016

Aging is accompanied by declines in cognitive and sensorimotor functions. However, at present, the interrelation between attentional processes dexterity aging has not been thoroughly addressed. This study explored relationship executive function, working memory, performance 15 young healthy elderly, right-handed participants. A modified version of Purdue Pegboard Test was used for assessment. Two subtasks were selected to calculate temporal kinematic parameters reaching, grasping, transport, insertion pegs. Evaluation function memory performed using neuropsychological tests. The outcomes also examined. Results showed that prehensile movements involved grasping their speed significantly differed groups correlated with group. For elderly adults, variability hand turned out be associated abilities.

Language: Английский

Citations

32