International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(19), С. 10757 - 10757
Опубликована: Окт. 6, 2024
With
the
aging
of
global
population,
neurodegenerative
diseases
are
emerging
as
a
major
public
health
issue.
The
adoption
less
sedentary
lifestyle
has
been
shown
to
have
beneficial
effect
on
cognitive
decline,
but
molecular
mechanisms
responsible
clear.
Here
we
provide
detailed
analysis
complex
molecular,
cellular,
and
systemic
underlying
age-related
decline
how
choices
influence
these
processes.
A
review
evidence
from
animal
models,
human
studies,
postmortem
analyses
emphasizes
importance
integrating
physical
exercise
with
cognitive,
multisensory,
motor
stimulation
part
multifaceted
approach
mitigating
decline.
We
highlight
potential
non-pharmacological
interventions
address
key
hallmarks,
such
genomic
instability,
telomere
attrition,
neuroinflammation,
underscore
need
for
comprehensive
personalized
strategies
promote
resilience
healthy
aging.
International Journal of Environmental Research and Public Health,
Год журнала:
2022,
Номер
19(12), С. 7483 - 7483
Опубликована: Июнь 18, 2022
The
deterioration
of
physical
and
cognitive
functioning
in
the
elderly
is
an
impairment
to
their
independent
self-management
improving
ability
perform
daily
functions.
Nurses
should
support
experience
a
healthy
successful
aging
process
by
preventing
dependence
on
understanding
care
assistance
that
such
persons
need.
This
study
aimed
gain
insight
into
evidence
effectiveness
multicomponent
intervention
activities
living
(ADL)
instrumental
(IADL)
among
community-dwelling
without
impairment.
design
systematic
review
randomized
controlled
trial.
language
published
literature
was
English,
search
period
from
January
2000
December
2020.
Articles
were
included
under
PICO
(population,
intervention,
comparison,
outcome)
framework
for:
(a)
impairment;
(b)
intervention;
(c)
comparison
group
who
did
not
receive
(d)
measurement
effect
ADL
IADL.
A
total
4413
references
found,
6
studies
included.
Most
(n
=
5)
reported
exerted
beneficial
Only
one
showed
highest
methodology
reporting
quality
Cochrane
review.
Common
components
programs
included:
occupational
therapy,
exercise,
memory
training,
cognitive–behavioral
interdisciplinary
training.
Multicomponent
may
be
way
improve
IADL
as
important
area
functional
evaluation
elderly.
Considering
condition
elderly,
interventions,
including
activity,
especially
individually
customized
coaching
related
useful.
Journal of Cellular Physiology,
Год журнала:
2024,
Номер
239(8)
Опубликована: Май 5, 2024
Liver,
an
important
regulator
of
metabolic
homeostasis,
is
critical
for
healthy
brain
function.
In
particular,
age-related
neurodegenerative
diseases
seriously
reduce
the
quality
life
elderly.
As
population
aging
progresses
rapidly,
unraveling
mechanisms
that
effectively
delay
has
become
critical.
Appropriate
exercise
reported
to
improve
aging-related
cognitive
impairment.
Whereas
current
studies
focused
on
exploring
effect
itself,
ignoring
persistent
effects
peripheral
organs
through
blood
circulation.
The
aim
this
paper
summarize
communication
and
processes
liver
emphasize
liver-brain
axis
about
ameliorating
diseases.
A
comprehensive
understanding
potential
improving
adaptation
changes
formulating
effective
interventions
against
decline.
Journal of Alzheimer s Disease,
Год журнала:
2024,
Номер
99(4), С. 1187 - 1205
Опубликована: Май 17, 2024
Dementia
is
a
syndrome
characterized
by
cognitive
and
neuropsychiatric
symptoms
associated
with
progressive
functional
decline
(FD).
FD
core
diagnostic
criterion
for
dementia,
setting
the
threshold
between
its
prodromal
stages
full-blown
disease.
The
operationalization
of
continues
to
generate
great
deal
controversy.
For
instance,
diagnosis
dementia
varies
across
criteria,
supporting
need
standardization
this
construct.
Moreover,
there
reconsider
how
we
are
measuring
set
boundaries
normal
aging,
mild
impairment,
dementia.
In
paper,
propose
multidimensional
framework
that
addresses
outstanding
issues
in
assessment
FD:
i)
What
activities
daily
living
(ADLs)
necessary
sustain
an
independent
aging?
ii)
How
assess
individuals
suspected
neurocognitive
disorders?
iii)
To
whom
directed?
iv)
much
does
differentiate
healthy
aging
from
major
Importantly,
Whom
Question
introduces
person-centered
approach
regards
patients
caregivers
as
active
agents
process
FD.
Thus,
once
impaired
ADLs
have
been
identified,
can
indicate
significant
such
impairments
them
life.
We
envisage
new
will
guide
future
strategies
enhance
treatment
their
caregivers.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(19), С. 10757 - 10757
Опубликована: Окт. 6, 2024
With
the
aging
of
global
population,
neurodegenerative
diseases
are
emerging
as
a
major
public
health
issue.
The
adoption
less
sedentary
lifestyle
has
been
shown
to
have
beneficial
effect
on
cognitive
decline,
but
molecular
mechanisms
responsible
clear.
Here
we
provide
detailed
analysis
complex
molecular,
cellular,
and
systemic
underlying
age-related
decline
how
choices
influence
these
processes.
A
review
evidence
from
animal
models,
human
studies,
postmortem
analyses
emphasizes
importance
integrating
physical
exercise
with
cognitive,
multisensory,
motor
stimulation
part
multifaceted
approach
mitigating
decline.
We
highlight
potential
non-pharmacological
interventions
address
key
hallmarks,
such
genomic
instability,
telomere
attrition,
neuroinflammation,
underscore
need
for
comprehensive
personalized
strategies
promote
resilience
healthy
aging.
