Biomaterials Advances, Год журнала: 2023, Номер 154, С. 213580 - 213580
Опубликована: Авг. 6, 2023
Язык: Английский
Nature Reviews Rheumatology, Год журнала: 2023, Номер 19(7), С. 403 - 416
Опубликована: Июнь 9, 2023
Язык: Английский
Процитировано
112
Frontiers in Immunology, Год журнала: 2022, Номер 13
Опубликована: Янв. 26, 2022
Mechanical damage is one of the predisposing factors inflammation, and it runs through entire inflammatory pathological process. Repeated or persistent damaging mechanical irritation leads to chronic diseases. The mechanism how forces induce inflammation not fully understood. Piezo1 a newly discovered mechanically sensitive ion channel. channel opens in response stimuli, transducing signals into an cascade cell leading tissue inflammation. A large amount evidence shows that plays vital role occurrence progression This mini-review briefly presents new responds different stresses trigger various tissues. discovery provides insights for treatment diseases related stress. Inhibiting transduction can inhibit improve outcome at early stage. pharmacology has shown bright prospects. development tissue-specific drugs clinical use may be target treating
Язык: Английский
Процитировано
99
Exploration, Год журнала: 2023, Номер 3(4)
Опубликована: Июль 12, 2023
Repairing articular osteochondral defects present considerable challenges in self-repair due to the complex tissue structure and low proliferation of chondrocytes. Conventional clinical therapies have not shown significant efficacy, including microfracture, autologous/allograft transplantation, cell-based techniques. Therefore, engineering has been widely explored repairing by leveraging natural regenerative potential biomaterials control cell functions. However, is a gradient with smooth transition from cartilage subchondral bone, involving changes chondrocyte morphologies phenotypes, extracellular matrix components, collagen type orientation, cytokines. Bioinspired scaffolds developed simulating characteristics heterogeneous tissues, such as pores, osteochondrogenesis-inducing factors, satisfy anisotropic features matrices. repair altering microenvironments growth induce osteochondrogenesis promote formation interfaces compared homogeneous scaffolds. This review outlines meaningful strategies for based on predicts pros cons prospective translation into practice.
Язык: Английский
Процитировано
86
Advanced Functional Materials, Год журнала: 2023, Номер 33(10)
Опубликована: Янв. 4, 2023
Abstract Articular cartilage defects bring about disability and worldwide socioeconomic loss, therefore, articular repair regeneration is recognized as a global issue. However, due to its avascular nearly acellular characteristic, tissue ability limited some extent. Despite the availability of various treatment methods, including palliative drugs surgical regenerative therapy, still face major challenges lack appropriate methods materials. Smart biomaterials can regulate cell behavior provide excellent microenvironment, thus inducing regeneration. This process adjusted by controlling drug/bioactive factors release via responding exogenous/endogenous stimuli, tailoring materials’ structure function similar native or providing physiochemical physical signaling factors. Herein, smart biomaterials, recently applied in regeneration, are elaborated from two aspects: drug system scaffolds. Furthermore, advanced manufacturing techniques discussed brief. Finally, perspectives for used presented clinical translation emphasized.
Язык: Английский
Процитировано
65
Bioactive Materials, Год журнала: 2023, Номер 26, С. 77 - 87
Опубликована: Фев. 24, 2023
Knee osteoarthritis is a chronic disease caused by the deterioration of knee joint due to various factors such as aging, trauma, and obesity, nonrenewable nature injured cartilage makes treatment challenging. Here, we present three-dimensional (3D) printed porous multilayer scaffold based on cold-water fish skin gelatin for osteoarticular regeneration. To make scaffold, was combined with sodium alginate increase viscosity, printability, mechanical strength, hybrid hydrogel according pre-designed specific structure using 3D printing technology. Then, scaffolds underwent double-crosslinking process enhance their strength even further. These mimic original network in way that allows chondrocytes adhere, proliferate, communicate each other, transport nutrients, prevent further damage joint. More importantly, found were nonimmunogenic, nontoxic, biodegradable. We also implanted into defective rat 12 weeks achieved satisfactory repair results this animal model. Thus, may have broad application potential regenerative medicine.
Язык: Английский
Процитировано
61
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(12), С. 9841 - 9841
Опубликована: Июнь 7, 2023
Collagens serve essential mechanical functions throughout the body, particularly in connective tissues. In articular cartilage, collagens provide most of biomechanical properties extracellular matrix for its function. Collagen plays a very important role maintaining cartilage and stability ECM. Noteworthily, many pathogenic factors course osteoarthritis rheumatoid arthritis, such as injury, inflammation, senescence, are involved irreversible degradation collagen, leading to progressive destruction cartilage. The collagen can generate new biochemical markers with ability monitor disease progression facilitate drug development. addition, also be used biomaterial excellent low immunogenicity, biodegradability, biocompatibility, hydrophilicity. This review not only provides systematic description analyzes structural characteristics mechanisms damage states but detailed characterization biomarkers production repair, providing ideas techniques clinical diagnosis treatment.
Язык: Английский
Процитировано
42
Journal of Manufacturing Processes, Год журнала: 2024, Номер 123, С. 112 - 127
Опубликована: Июнь 5, 2024
Язык: Английский
Процитировано
37
Redox Biology, Год журнала: 2022, Номер 55, С. 102411 - 102411
Опубликована: Июль 19, 2022
Язык: Английский
Процитировано
68
Materials Today Bio, Год журнала: 2022, Номер 17, С. 100495 - 100495
Опубликована: Ноя. 13, 2022
Язык: Английский
Процитировано
66
Bioactive Materials, Год журнала: 2022, Номер 20, С. 221 - 242
Опубликована: Май 31, 2022
Osteochondral defects (OCD) cannot be efficiently repaired due to the unique physical architecture and pathological microenvironment including enhanced oxidative stress inflammation. Conventional strategies, such as control of implant microstructure or introduction growth factors, have limited functions failing manage these complex environments. Here we developed a multifunctional silk-based hydrogel incorporated with metal-organic framework nanozymes (CuTA@SF) provide suitable for OCD regeneration. The incorporation CuTA endowed SF uniform elevated hydrophilicity. In vitro cultivation mesenchymal stem cells (MSCs) chondrocytes showed that CuTA@SF accelerated cell proliferation viability, well had antioxidant antibacterial properties. Under inflammatory environment stimulation IL-1β, still possessed potential promote MSC osteogenesis deposition cartilage-specific extracellular matrix (ECM). proteomics analysis further confirmed promoted ECM synthesis. full-thickness model rabbit, displayed successfully in situ regeneration, evidenced by micro-CT, histology (HE, S/O, toluidine blue staining) immunohistochemistry (Col I aggrecan immunostaining). Therefore, is promising biomaterial targeted at regeneration OCD.
Язык: Английский
Процитировано
60