Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Фев. 21, 2024

Abstract Inflammation-associated diseases encompass a range of infectious and non-infectious inflammatory diseases, which continuously pose one the most serious threats to human health, attributed factors such as emergence new pathogens, increasing drug resistance, changes in living environments lifestyles, aging population. Despite rapid advancements mechanistic research development for these current treatments often have limited efficacy notable side effects, necessitating more effective targeted anti-inflammatory therapies. In recent years, nanotechnology has provided crucial technological support prevention, treatment, detection inflammation-associated diseases. Various types nanoparticles (NPs) play significant roles, serving vaccine vehicles enhance immunogenicity carriers improve targeting bioavailability. NPs can also directly combat pathogens inflammation. addition, facilitated biosensors pathogen imaging techniques This review categorizes characterizes different NPs, summarizes their applications It discusses challenges associated with clinical translation this field explores latest developments prospects. conclusion, opens up possibilities comprehensive management

Язык: Английский

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Nanoparticle-Mediated Multiple Modulation of Bone Microenvironment To Tackle Osteoarthritis

ACS Nano, Год журнала: 2024, Номер 18(15), С. 10625 - 10641

Опубликована: Апрель 2, 2024

Development of nanomedicines that can collaboratively scavenge reactive oxygen species (ROS) and inhibit inflammatory cytokines, along with osteogenesis promotion, is essential for efficient osteoarthritis (OA) treatment. Herein, we report the design a ROS-responsive nanomedicine formulation based on fibronectin (FN)-coated polymer nanoparticles (NPs) loaded azabisdimethylphoaphonate-terminated phosphorus dendrimers (G4-TBP). The constructed G4-TBP NPs-FN size 268 nm are stable under physiological conditions, be specifically taken up by macrophages through FN-mediated targeting, dissociated in oxidative microenvironment. dendrimer having intrinsic anti-inflammatory property FN both antioxidative properties display integrated functions ROS scavenging, hypoxia attenuation, macrophage M2 polarization, thus protecting from apoptosis creating designed bone immune microenvironment stem cell osteogenic differentiation. These characteristics lead to their effective treatment an OA model vivo reduce pathological changes joints including synovitis inhibition cartilage matrix degradation simultaneously promote differentiation repair. developed combining advantages bioactive treat may immunomodulatory therapy different diseases.

Язык: Английский

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Emerging application of nanomedicine-based therapy in acute respiratory distress syndrome

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 237, С. 113869 - 113869

Опубликована: Март 21, 2024

Язык: Английский

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Crosstalk between ROS-inflammatory gene expression axis in the progression of lung disorders

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown

Опубликована: Авг. 28, 2024

Язык: Английский

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NO-releasing double-crosslinked responsive hydrogels accelerate the treatment and repair of ischemic stroke

Acta Pharmaceutica Sinica B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Stroke is a global disease that seriously threatens human life. The pathological mechanisms of ischemic stroke include neuroinflammation, oxidative stress, and the destruction blood vessels at lesion site. Here, biocompatible in situ hydrogel platform was designed to target multiple pathogenic post-stroke, including anti-inflammation, anti-oxidant, promotion angiogenesis. Double-crosslinked responsive multifunctional hydrogels could quickly respond microenvironment damage site mediate delivery nitric oxide (NO) ISO-1 (inhibitor macrophage migration inhibitory factor, MIF). demonstrated good biocompatibility scavenge reactive oxygen species (ROS) inflammatory cytokines, such as interleukin-6 (IL-6), interleukin-10 (IL-10), MIF. In mouse model, hydrogels, when situated within cerebral infarction characterized by weak acidity elevated ROS release, would release anti-inflammatory nanoparticles rapidly exert an effect. Concurrently, NO sustained facilitate angiogenesis provide neuroprotective effects. Neurological function significantly improved treated mice assessed modified neurological severity score, rotarod test, open field test. These findings indicate held promise for alleviate injury responding brain's microenvironment.

Язык: Английский

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Inflammatory Microenvironment-Responsive Nanomicelles for Acute Lung Injury Therapy: ROS-Scavenging and Macrophage Repolarization

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101622 - 101622

Опубликована: Фев. 27, 2025

Язык: Английский

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Advances in acute respiratory distress syndrome: focusing on heterogeneity, pathophysiology, and therapeutic strategies

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Март 7, 2025

In recent years, the incidence of acute respiratory distress syndrome (ARDS) has been gradually increasing. Despite advances in supportive care, ARDS remains a significant cause morbidity and mortality critically ill patients. is characterized by hypoxaemic failure with diffuse pulmonary inflammation bilateral edema due to excessive alveolocapillary permeability patients non-cardiogenic diseases. Over past seven decades, our understanding pathology clinical characteristics evolved significantly, yet it an area active research discovery. highly heterogeneous, including diverse pathological causes, presentations, treatment responses, presenting challenge for clinicians researchers. this review, we comprehensively discuss latest advancements research, focusing on its heterogeneity, pathophysiological mechanisms, emerging therapeutic approaches, such as cellular therapy, immunotherapy, targeted therapy. Moreover, also examine COVID-19-related corresponding approaches. face challenges posed offer hope improved patient outcomes. Further essential translate these findings into effective interventions personalized approaches ARDS, ultimately leading better outcomes suffering from ARDS.

Язык: Английский

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Dual delivery of an NF-κB inhibitor and IL-10 through supramolecular hydrogels polarizes macrophages and promotes cardiac repair after myocardial infarction

Acta Biomaterialia, Год журнала: 2023, Номер 164, С. 111 - 123

Опубликована: Март 29, 2023

Язык: Английский

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Bilirubin Nanoparticles Alleviate Sepsis-Induced Acute Lung Injury by Protecting Pulmonary Endothelia Glycocalyx and Reducing Inflammation

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(16), С. 18566 - 18578

Опубликована: Апрель 30, 2024

Acute lung injury (ALI) remains one of the most common complications sepsis. Although many potential effective pharmacologic and ventilatory treatment strategies have been reported, there is still a lack means sepsis-induced ALI in clinic. The aim this study to develop an easy-made endogenous bilirubin nanoparticle (BRNP) that could treat investigate its underlying therapeutic mechanism. We prepared BRNP by (BR) self-assembly bovine serum albumin (BSA) coating with simple one-pot nanoprecipitation method. holds good physical stability release BR sustained manner neutral medium but initiate burst either acidic or oxidative conditions. In sepsis murine model, substantially alleviate injury, as evidenced reduced histopathological changes tissues also inflammation development. Mechanically, glycocalyx damage, inhibit NF-κB pathway, reduce proinflammatory factor vivo. This provides robust ALI, which may pave way design multifunctional nanomedicine for clinical translation.

Язык: Английский

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Revolutionizing eye care: the game-changing applications of nano-antioxidants in ophthalmology

Nanoscale, Год журнала: 2024, Номер 16(15), С. 7307 - 7322

Опубликована: Янв. 1, 2024

Since the theory of free radical-induced aging was proposed in 1956, it has been constantly proven that reactive oxygen species (ROS) produced by oxidative stress play a vital role occurrence and progression eye diseases. However, inherent limitations traditional drug therapy hindered development ophthalmic disease treatment. In recent years, great achievements have made research nanomedicine, which promotes rapid safe theranostics ophthalmology. this review, we focus on applications antioxidant nanomedicine treatment The diseases were mainly classified into two categories: ocular surface posterior each part, first introduced pathology specific about stress, then presented representative application examples nano-antioxidants therapy. Meanwhile, nanocarriers used, mechanism function, therapeutic effect also presented. Finally, summarized latest progress for put forward prospects future development.

Язык: Английский

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