The Chemical Record,
Год журнала:
2023,
Номер
23(5)
Опубликована: Апрель 3, 2023
Abstract
Rhodium
(Rh)
is
a
non‐toxic
transition
metal
used
as
various
nanomaterials
with
unique
structures
and
properties.
Rh‐based
nanozymes
can
mimic
the
activities
of
natural
enzymes,
overcome
limitation
application
scope
interact
biological
microenvironments
to
play
variety
functions.
be
synthesized
in
ways,
different
modification
regulation
methods
also
enable
users
control
catalytic
performance
by
adjusting
enzyme
active
sites.
The
construction
has
attracted
great
interest
biomedical
field
impacted
industry
other
areas.
This
paper
reviews
typical
synthesis
strategies,
properties,
applications,
challenges,
prospects
nanozymes.
Next,
features
are
emphasized,
including
adjustable
enzyme‐like
activity,
stability,
biocompatibility.
In
addition,
we
discuss
biosensors
detection,
therapy,
industrial
applications.
Finally,
future
challenges
proposed.
Bioactive Materials,
Год журнала:
2023,
Номер
33, С. 483 - 496
Опубликована: Дек. 3, 2023
Limited
by
low
tumor
immunogenicity
and
the
immunosuppressive
microenvironment
(TME),
triple-negative
breast
cancer
(TNBC)
has
been
poorly
responsive
to
immunotherapy
so
far.
Herein,
a
Ca
&
Mn
dual-ion
hybrid
nanostimulator
(CMS)
is
constructed
enhance
anti-tumor
immunity
through
ferroptosis
inducing
innate
awakening,
which
can
serve
as
inducer
immunoadjuvant
for
TNBC
concurrently.
On
one
hand,
glutathione
(GSH)
depletion
reactive
oxygen
species
(ROS)
generation
be
achieved
due
mixed
valence
state
of
in
CMS.
other
an
exotic
Ca2+
supplier,
CMS
causes
mitochondrial
overload,
further
amplifies
oxidative
stress.
Significantly,
cells
undergo
because
inactivation
peroxidase
4
(GPX4)
accumulation
lipid
peroxidation
(LPO).
More
impressively,
act
awaken
alleviating
intra-tumor
hypoxia
Mn2+-induced
activation
STING
signaling
pathway,
promotes
polarization
tumor-associated
macrophages
(TAMs)
dendritic
(DCs)
antigen
presentation
subsequent
infiltration
tumor-specific
cytotoxic
T
lymphocytes
(CTLs)
into
tissues.
Taken
together,
this
work
demonstrates
novel
strategy
simultaneously
awakening
immunity,
offering
new
perspective
effective
TNBC.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 19, 2024
Ferroptosis
is
a
form
of
regulated
cell
death
(RCD)
characterized
by
iron-dependent
lipid
peroxidation.
currently
proposed
as
one
the
most
promising
means
combating
tumor
resistance.
Nevertheless,
problem
ferroptosis
resistance
in
certain
cancer
cells
has
been
identified.
This
review
first,
investigates
mechanisms
induction
cells.
Next,
to
ferroptosis,
well
underlying
discussed.
Recently
discovered
ferroptosis-suppressing
biomarkers
have
described.
The
various
types
nanoparticles
that
can
induce
are
also
Given
ability
combine
multiple
agents,
this
proposes
nanoparticle-based
viable
method
circumventing
suggests
combining
with
other
forms
death,
such
apoptosis,
cuproptosis
and
autophagy.
It
immunotherapy.
