Utilizing dual-responsive iridium(III) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy DOI

JinYu Guo,

Yandai Lin, Shaohua He

et al.

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: 35(9), P. 109537 - 109537

Published: Jan. 21, 2024

Language: Английский

Ultrafine Ru clusters with GOx enable glucose-activated cascaded reaction for bacterial-infected diabetic wound healing DOI
Lu Zhang, Shuangqi Cai,

Yujie Zhai

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 488, P. 150991 - 150991

Published: April 7, 2024

Language: Английский

Citations

13
Dual-Coordinated atomically dispersed Pt nanozymes evoke efficient pyroptosis for cancer immunotherapy DOI
Jingqi Chen, Yanping Tang,

Lin Yan

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 483, P. 149312 - 149312

Published: Feb. 5, 2024

Language: Английский

Citations

10
ML162 derivatives incorporating a naphthoquinone unit as ferroptosis/apoptosis inducers: Design, synthesis, anti-cancer activity, and drug-resistance reversal evaluation DOI

Furong Ma,

Yulong Li,

Mao-Hua Cai

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 270, P. 116387 - 116387

Published: April 1, 2024

Language: Английский

Citations

10
Photothermal and ferroptosis synergistic therapy for liver cancer using iron-doped polydopamine nanozymes DOI
Yun‐Chun Li,

Linqun Qian,

Zhouping Yang

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 239, P. 113911 - 113911

Published: April 11, 2024

Language: Английский

Citations

10
Ca & Mn dual-ion hybrid nanostimulator boosting anti-tumor immunity via ferroptosis and innate immunity awakening DOI Creative Commons

Xi Deng,

Tianzhi Liu,

Yutong Zhu

et al.

Bioactive Materials, Journal Year: 2023, Volume and Issue: 33, P. 483 - 496

Published: Dec. 3, 2023

Limited by low tumor immunogenicity and the immunosuppressive microenvironment (TME), triple-negative breast cancer (TNBC) has been poorly responsive to immunotherapy so far. Herein, a Ca & Mn dual-ion hybrid nanostimulator (CMS) is constructed enhance anti-tumor immunity through ferroptosis inducing innate awakening, which can serve as inducer immunoadjuvant for TNBC concurrently. On one hand, glutathione (GSH) depletion reactive oxygen species (ROS) generation be achieved due mixed valence state of in CMS. other an exotic Ca2+ supplier, CMS causes mitochondrial overload, further amplifies oxidative stress. Significantly, cells undergo because inactivation peroxidase 4 (GPX4) accumulation lipid peroxidation (LPO). More impressively, act awaken alleviating intra-tumor hypoxia Mn2+-induced activation STING signaling pathway, promotes polarization tumor-associated macrophages (TAMs) dendritic (DCs) antigen presentation subsequent infiltration tumor-specific cytotoxic T lymphocytes (CTLs) into tissues. Taken together, this work demonstrates novel strategy simultaneously awakening immunity, offering new perspective effective TNBC.

Language: Английский

Citations

20
Coordination engineering of FeCo dual single-atom nanozymes with photothermal-enhanced cascaded catalysis for efficient pancreatic cancer immunotherapy DOI

Wen-kuan Huang,

Zeyuan Zhang,

Jingqi Chen

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 496, P. 154203 - 154203

Published: July 21, 2024

Language: Английский

Citations

8
Orchestrating apoptosis and ferroptosis through enhanced sonodynamic therapy using amorphous UIO-66-CoOx DOI

Xiuxin Lu,

Yang Zheng,

Yan Liu

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 667, P. 91 - 100

Published: April 10, 2024

Language: Английский

Citations

7
Applications of amorphous inorganics as novel functional materials DOI Creative Commons
Zhengxi Guo, Zhaoming Liu, Ruikang Tang

et al.

Materials Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 8(7), P. 1703 - 1730

Published: Jan. 1, 2024

Amorphous inorganics have attracted much attention because of their long-range disordered structure with advantageous functional properties.

Language: Английский

Citations

6
Dual Enzyme-Driven Cascade Reactions Modulate Immunosuppressive Tumor Microenvironment for Catalytic Therapy and Immune Activation DOI
Hengke Liu, Shanshan Jiang, Meng Li

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(44), P. 30345 - 30359

Published: Oct. 21, 2024

Lactate-enriched tumor microenvironment (TME) fosters an immunosuppressive milieu to hamper the functionality of tumor-associated macrophages (TAMs). However, tackling effects wrought by lactate accumulation is still a big challenge. Herein, we construct dual enzyme-driven cascade reaction platform (ILH) with TME modulation for photoacoustic (PA) imaging-guided catalytic therapy and immune activation. The ILH composed iridium (Ir) metallene nanozyme, oxidase (LOx), hyaluronic acid (HA). combination Ir nanozyme LOx can not only efficiently consume reverse into immunoreactive one promoting polarization TAMs from M2 M1 phenotype, thus enhancing antitumor defense, but also alleviate hypoxia as well induce strong oxidative stress, triggering immunogenic cell death (ICD) activating immunity. Furthermore, photothermal performance strengthen ability endow PA response. Based on changes in signals endogenous molecules, three-dimensional multispectral imaging was utilized track process vivo. This work provides nanoplatform activation regulating TME.

Language: Английский

Citations

5
Interfacial strong interaction-enabling cascade nanozymes for apoptosis-ferroptosis synergistic therapy DOI

Lineng Wei,

Ziyu Wang,

Xiuxin Lu

et al.

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 653, P. 20 - 29

Published: Sept. 7, 2023

Language: Английский

Citations

13