Metal natural product complex Ru-procyanidins with quadruple enzymatic activity combat infections from drug-resistant bacteria

Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(5), С. 2298 - 2316

Опубликована: Янв. 26, 2024

Bacterial infection hampers wound repair by impeding the healing process. Concurrently, inflammation at site triggers production of reactive oxygen species (ROS), causing oxidative stress and damage to proteins cells. This can lead chronic wounds, posing severe risks. Therefore, eliminating bacterial reducing ROS levels are crucial for effective healing. Nanozymes, possessing enzyme-like catalytic activity, convert endogenous substances into highly toxic substances, such as ROS, combat bacteria biofilms without inducing drug resistance. However, current nanozyme model with single enzyme activity falls short meeting complex requirements antimicrobial therapy. Thus, developing nanozymes multiple enzymatic activities is essential. Herein, we engineered a novel metalloenzyme called Ru-procyanidin nanoparticles (Ru-PC NPs) diverse aid infections. Under acidic conditions, due their glutathione (GSH) depletion peroxidase (POD)-like Ru-PC NPs combined H2O2 exhibit excellent antibacterial effects. in neutral environment, NPs, catalase (CAT) decompose O2, alleviating hypoxia ensuring sufficient supply. Furthermore, possess exceptional antioxidant capacity through superior superoxide dismutase (SOD) effectively scavenging excess nitrogen (RNS) environment. maintains balance system prevents inflammation. also promote polarization macrophages from M1 M2, facilitating More importantly, show good biosafety negligible toxicity. In vivo models have confirmed efficacy inhibiting promoting The focus this work highlights quadruple its potential reduce bacteria-infected

Язык: Английский

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A Multifunctional, Tough, Stretchable, and Transparent Curcumin Hydrogel with Potent Antimicrobial, Antioxidative, Anti-inflammatory, and Angiogenesis Capabilities for Diabetic Wound Healing

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(8), С. 9749 - 9767

Опубликована: Фев. 15, 2024

The treatment of diabetic chronic wounds is still faced with great challenges, mainly due to wound infection, excessive inflammation, and peripheral vascular disease in the area. Therefore, it importance develop a novel multifunctional hydrogel high efficiency accelerate healing. Curcumin (Cur), Chinese herbal, has shown potential enhancing healing because its immunomodulatory pro-angiogenic properties. However, low aqueous solubility, poor bioavailability, chemical instability have limited clinical applications. To address these current bottlenecks, poly(vinyl alcohol) (PVA)–chitosan (CS)/sodium alginate (SA)–Cur (PCSA) hydrogels were prepared for first time, they demonstrated all above intriguing performances by Michael addition reaction CS Cur. PCSA show multiple dynamic bonds, which possess strong mechanical properties (tensile stress: ∼0.980 MPa; toughness: ∼258.45 kJ/m3; compressive strength: ∼7.38 MPa at strain 80%). These provided an optimal microenvironment cell migration proliferation also promoted growth blood vessels, leading early angiogenesis. Importantly, experimental results that can effectively transform pro-inflammatory M1 macrophages into anti-inflammatory M2 without need additional ingredients vitro. Benefiting from characteristics, full-thickness rat model via ROS-scavenging, downregulation IL-1β, upregulation CD31 expression, resulting angiogenesis collagen deposition. This strategy not only provides simple safe Cur-based but highlights significant development high-performance biomaterials promoting using traditional medicine.

Язык: Английский

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Engineered bioadhesive Self-Healing nanocomposite hydrogel to fight infection and accelerate cutaneous wound healing

Chemical Engineering Journal, Год журнала: 2024, Номер 489, С. 150992 - 150992

Опубликована: Апрель 4, 2024

The emergence of multifunctional wound dressings for cutaneous tissue injuries represents a paradigm shift in care, offering advanced solutions that transcend traditional protection. Inspired by the recent advances nano-reinforcement and mussel-inspired chemistry, an innovative bioadhesive self-healing hydrogel was developed using dopamine-grafted oxidized sodium alginate/gelatin containing Myrtus communis L. extract@ZIF-8 NPs (MC@ZIF-8/DA-OSA/Gel) through dual cross-linking. resulting optimized demonstrated good physicochemical, hemostatic properties, rapid self-repair, firm adhesion to tissues. In vitro analysis confirmed excellent cytocompatibility cultured fibroblasts. Notably, incorporation MC@ZIF-8 into enhanced antioxidant antibacterial activities. Applying engineered at injury site significantly accelerated healing process mouse model injury, as evident increased thickness improved collagen disposition. Moreover, local increase CD31+ cells COL1A+ strands indicated vascularization, fibroblast proliferation compared other groups. Overall, our results demonstrate potential efficacy system wound-covering material, suggesting it could be effective treating various forms acute chronic wounds well.

Язык: Английский

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Hydrogel-based dressings designed to facilitate wound healing

Materials Advances, Год журнала: 2023, Номер 5(4), С. 1364 - 1394

Опубликована: Дек. 20, 2023

This review provides an overview of the functionalities hydrogel-based dressings and their role in promoting wound healing.

Язык: Английский

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Hydrogel Wound Dressings Accelerating Healing Process of Wounds in Movable Parts

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(12), С. 6610 - 6610

Опубликована: Июнь 15, 2024

Skin is the largest organ in human body and requires proper dressing to facilitate healing after an injury. Wounds on movable parts, such as elbow, knee, wrist, neck, usually undergo delayed inefficient due frequent movements. To better accommodate wounds, a variety of functional hydrogels have been successfully developed used flexible wound dressings. On one hand, mechanical properties, adhesion, stretchability, self-healing, make these suitable for mobile wounds promote process; other bioactivities, antibacterial antioxidant performance, could further accelerate process. In this review, we focus recent advances hydrogel-based dressings propose challenges perspectives

Язык: Английский

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Advancements and Challenges in Self-Healing Hydrogels for Wound Care

Gels, Год журнала: 2024, Номер 10(4), С. 241 - 241

Опубликована: Апрель 1, 2024

This manuscript explores self-healing hydrogels as innovative solutions for diverse wound management challenges. Addressing antibiotic resistance and tailored care, these exhibit promising outcomes, including accelerated closure tissue regeneration. Advancements in multifunctional with controlled drug release, antimicrobial properties, real-time assessment capabilities signal a significant leap toward patient-centered treatments. However, challenges such scalability, long-term safety evaluation, variability clinical outcomes persist. Future directions emphasize personalized medicine, manufacturing innovation, rigorous evaluation through trials, interdisciplinary collaboration. features the ongoing pursuit of effective, adaptable, comprehensive care to transform medical treatments improve patient outcomes.

Язык: Английский

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Cowberry extract loaded chitosan hydrogel with photothermal and antioxidant properties promotes infected wound healing

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 262, С. 129988 - 129988

Опубликована: Фев. 5, 2024

Язык: Английский

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Natural blackcurrant extract contained gelatin hydrogel with photothermal and antioxidant properties for infected burn wound healing

Materials Today Bio, Год журнала: 2024, Номер 26, С. 101113 - 101113

Опубликована: Июнь 1, 2024

Burns represent a prevalent global health concern and are particularly susceptible to bacterial infections. Severe infections may lead serious complications, posing life-threatening risk. Near-infrared (NIR)-assisted photothermal antibacterial combined with antioxidant hydrogel has shown significant potential in the healing of infected wounds. However, existing agents typically metal-based, complicated synthesize, or pose biosafety hazards. In this study, we utilized plant-derived blackcurrant extract (B) as natural source for both properties. By incorporating B into G-O crosslinked through Schiff base reaction between gelatin (G) oxidized pullulan (O), resulting G-

Язык: Английский

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Proanthocyanidin Capsules Remodel the ROS Microenvironment via Regulating MAPK Signaling for Accelerating Diabetic Wound Healing

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101467 - 101467

Опубликована: Янв. 8, 2025

Defective diabetic wound healing is a major clinical challenge, where hyperglycemia at the site induces excessive reactive oxygen species (ROS) which activate MAPK pathway (particularly p38 MAPK), resulting in sustained release of inflammatory factors and cellular damage/apoptosis. Polyphenols are efficient ROS scavengers reduce level inflammation promote healing, but low bioavailability limits their biomedical application. This study developed simple highly method for preparing proanthocyanidin (PC) capsules through hydrogen bonding hydrophobic interactions among PC molecules. can continuously scavenge free radicals proanthocyanidins, significantly enhancing bioavailability. A single dose accelerates mice by regulating signaling cascade, reducing mediator concentration, inhibiting cell apoptosis, remodeling microenvironment. research makes an important contribution to field polyphenol reveals potential modulating treating other oxidative stress-related diseases.

Язык: Английский

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Double‐Dynamic‐Bond Cross‐Linked Hydrogel Adhesive with Cohesion‐Adhesion Enhancement for Emergency Tissue Closure and Infected Wound Healing

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Abstract The hydrogel adhesives with strong tissue adhesion and biological characteristics adhm202404447are urgently needed for injury sealing repair. However, the negative correlation between mechanical strength poses a challenge their practical application. Herein, bio‐inspired cohesive enhancement strategy is developed to prepare adhesive simultaneously enhanced adhesion. double cross‐linked network achieved through cooperation polyacrylic acid grafted N‐hydroxy succinimide crosslinked by tannic cohesion‐enhanced ion crosslinking of sodium alginate Ca 2+ . Such unique structure endows resultant excellent strength. capable various organs in vitro, exhibits satisfactory on‐demand removability, antibacterial, antioxidant properties. As proof concept, not only effectively halts non‐compressible hemorrhages beating heart femoral artery models rats, but also accelerates healing infected wound inhibiting bacteria reducing inflammation. Overall, this advanced promising as an emergency rescue that enables robust closure, timely controlling bleeding, promoting damaged healing.

Язык: Английский

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