Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 10, 2024
Abstract
Simultaneously
endowing
carbon
nanofibers
(CNFs)
with
flexibility,
flame‐resistant
properties,
and
high
sonoelectric/mechanical‐electric
energy
conversion
efficiency
is
quite
challenging,
restricting
their
wide
application
to
smart
fabrics.
Herein,
a
carbon‐based
nanofiber
prepared
by
electrospinning
subsequent
carbonization
the
formation
of
Bi
20
TiO
32
(BT),
followed
in
situ
growth
hydrothermally
produced
2
S
3
(B)
MoS
(M)
successively.
Compared
pure
CNF,
synthesized
carbon/Bi
/MoS
/Bi
(CBT/M/B)
fiber
exhibited
not
only
enhanced
flexibility
antiflaming
performance
but
also
sensitive
ability
mechanical
power
into
electricity.
Its
due
its
micro/nanostructure
interactions
between
grain
boundaries.
Importantly,
CBT/M/B
achieved
realization
relying
on
unique
human
motion
provide
convert
it
piezoelectric
manner,
thus
exhibiting
satisfactory
antibacterial
effects.
This
research
provides
valuable
insights
wearable
fibers
characterized
flexible,
antiflaming,
mechanosensitive
functions.
Biomaterials Science,
Год журнала:
2024,
Номер
12(7), С. 1788 - 1800
Опубликована: Янв. 1, 2024
A
bi-functional
antibiofilm
nanoplatform
was
developed
based
on
a
complex
of
quercetin
and
copper
integrating
bactericidal
anti-quorum
sensing
properties.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(11), С. 13353 - 13383
Опубликована: Март 11, 2024
Biofilm
contamination
presents
a
significant
threat
to
public
health,
the
food
industry,
and
aquatic/marine-related
applications.
In
recent
decades,
although
various
methods
have
emerged
combat
biofilm
contamination,
intricate
persistent
nature
of
biofilms
makes
complete
eradication
challenging.
Therefore,
innovative
alternative
solutions
are
imperative
for
addressing
formation.
Instead
solely
focusing
on
mature
biofilms,
strategically
advantageous
measures
involve
delay
or
prevention
formation
surfaces.
Quorum
sensing,
communication
system
enabling
bacteria
coordinate
their
behavior
based
population
density,
plays
pivotal
role
in
numerous
microbial
species.
Materials
possessing
antibiofilm
properties
that
target
quorum
sensing
gained
considerable
attention
potential
prevent
This
Review
consolidates
research
progress
utilization
materials
with
antiquorum
combating
These
can
be
categorized
into
three
distinct
types:
(i)
nanomaterials,
(ii)
surfaces,
(iii)
hydrogels
capabilities.
Finally,
concludes
brief
discussion
current
challenges
outlines
avenues
future
research.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(31)
Опубликована: Авг. 22, 2024
The
prevalence
of
drug-resistant
bacterial
infections
has
emerged
as
a
grave
threat
to
clinical
treatment
and
global
human
health,
presenting
one
the
foremost
challenges
in
medical
care.
Thus,
there
is
an
urgent
imperative
develop
safe
efficacious
novel
antimicrobial
strategies.
Nitric
oxide
(NO)
recognized
endogenous
signaling
molecule,
which
plays
pivotal
role
numerous
pathological
processes.
Currently,
NO
garnered
significant
interest
antibacterial
agent
due
its
capability
eradicate
bacteria,
disrupt
biofilms,
facilitate
wound
healing,
all
while
circumventing
emergence
drug
resistance.
However,
inherently
unstable
characteristic
therapeutic
gas
renders
controlled
administration
gases
exceedingly
challenging.
Hence,
this
review,
current
challenge
infection
discussed;
then
it
briefly
elucidated
mechanism
comprehensively
delineate
recent
advancements
stimulus-responsive
delivery
platforms,
along
with
their
merits,
obstacles,
prospective
avenues
for
application.
This
review
offers
guidance
future
NO-medicated
anti-infection
therapy
hoped.
Biofilms
significantly
impede
the
efficacy
of
conventional
antimicrobial
agents,
particularly
in
multidrug-resistant
(MDR)
infections.
In
this
work,
we
developed
a
size-adaptive,
bismuth-based
nanomicrobicide
encapsulated
with
neutrophil
membranes
(Bi2S3/SNP@CM),
designed
to
selectively
generate
nitric
oxide
(NO)
within
acidic
biofilms
under
near-infrared
(NIR)
irradiation.
The
nanomicrobicide's
adaptive
size
ensures
deeper
biofilm
penetration
and
accumulation,
while
membrane
coating
enhances
biocompatibility
targeting
at
infection
sites.
Upon
NIR
irradiation,
localized
heating
NO
release
synergistically
eradicate
MDR
biofilms.
Furthermore,
interactions
between
glutathione,
as
well
reactions
ROS,
disrupt
intracellular
redox
balance,
further
amplifying
antibacterial
efficacy.
This
innovative
design
affords
promising
for
effectively
treating
Bioactive Materials,
Год журнала:
2023,
Номер
33, С. 341 - 354
Опубликована: Ноя. 25, 2023
Nitric
oxide
(NO)
enhanced
photodynamic
therapy
(PDT)
is
a
promising
approach
to
overcome
drug
tolerance
and
resistance
biofilm
but
limited
by
its
short
excitation
wavelengths
low
yield
of
reactive
oxygen
species
(ROS).
Herein,
we
develop
compelling
degradable
polymer-based
near-infrared
II
(NIR-II,
1000-1700
nm)
photosensitizer
(PNIR-II),
which
can
maintain
50
%
PDT
efficacy
even
under
2.6
cm
tissue
barrier.
Remarkably,
PNIR-II
synthesized
alternately
connecting
the
electron
donor
thiophene
acceptors
diketopyrrolopyrrole
(DPP)
boron
dipyrromethene
(BODIPY),
where
intramolecular
charge
transfer
properties
be
tuned
increase
intersystem
crossover
rate
decrease
internal
conversion
rate,
thereby
stabilizing
NIR-II
rather
than
photothermal
effect.
For
exerting
combination
eradicate
multidrug-resistant
biofilms,
further
assembled
into
nanoparticles
(NPs)
with
synthetic
glutathione-triggered
NO
polymer.
Under
1064
nm
laser
radiation,
NPs
precisely
release
ROS
that
triggered
over-expressed
GSH
in
microenvironment,
forming
more
bactericidal
nitrogen
(RNS)
vitro
vivo
mice
model
orderly
destroy
Staphylococcus
aureus
cultures
from
clinical
patients.
It
thus
provides
new
outlook
for
deep
tissues.
Coordination Chemistry Reviews,
Год журнала:
2024,
Номер
515, С. 215921 - 215921
Опубликована: Май 21, 2024
Nitric
oxide
(NO)
is
an
important
biochemical
molecule
that
endogenously
produced
to
act
for
instance
as
neurotransmitter,
effect
cell
growth,
or
regulate
the
immune
response.
Therapeutic
treatment
with
exogeneous
NO
difficult
owing
its
gaseous
and
reactive
nature
and,
not
surprising,
specific
molecules
deliver
have
been
developed.
Amongst
various
triggers
deliberately
release
from
these
NO-releasing
molecules,
light
most
elegant
allows
a
high
degree
of
control
over
time
location
NO-release.
For
therapeutic
applications,
it
necessary
use
long-wavelength
light,
preferably
in
red
near
infrared
region,
which
challenging
achieve.
This
review
gives
overview
on
approaches
red-shift
activation
wavelength
light-activated
NO-release
nitrosoamines,
o-substituted
nitroarenes,
L-arginine,
cupferron,
nitrosyl
metal
complexes.
While
focusing
single
photon
excitation
events,
direct
mechanisms
are
covered
well
photoelectron
transfer,
energy
chemiluminescence
photothermal
light-triggered
oxidation
pathways.
each
NO-releaser
class,
photochemical
mechanism
discussed,
biological
applications
mentioned.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(24), С. 30915 - 30928
Опубликована: Июнь 7, 2024
Multidrug-resistant
(MDR)
bacteria
pose
serious
threats
to
public
health
due
the
lack
of
effective
and
biocompatible
drugs
kill
MDR
bacteria.
Photodynamic
antibacterial
therapy
has
been
widely
studied
its
low
induction
resistance.
However,
photosensitizers
that
can
efficiently
generate
reactive
oxygen
species
(ROS)
through
both
type
I
II
mechanisms
have
capability
multiple
modes
action
are
rarely
reported.
Addressing
this
issue,
we
developed
a
near-infrared-emitting
triphenylamine
indole
iodoethane
(TTII)
silver(I)
self-assembled
(TTIIS)
aggregation-induced
emission
(AIE)
photosensitizer
for
multimode
bacterial
infection
therapy.
TTII
produce
Type
ROS
•OH
1O2.
Interestingly,
Ag(I)−π
interaction
contributed
in
TTIIS
efficiency
promotion
generation
Moreover,
by
releasing
Ag+,
enabled
photodynamic-Ag(I)
dual-mode
sterilization.
As
result,
achieved
an
enhancement
activity,
with
1–2-fold
boost
against
multidrug-resistant
Escherichia
coli
(MDR
E.
coli).
Both
at
concentration
as
0.55
μg
mL–1
more
than
98%
methicillin
resistant
Staphylococcus
aureus
(MRSA)
on
MRSA-infected
full-thickness
defect
wounds
mouse,
were
eliminating
promoting
wound
healing.
