ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(26), С. 33169 - 33181
Опубликована: Июнь 25, 2024
Inducing
immunogenic
cell
death
(ICD)
is
a
promising
strategy
for
cancer
immunotherapy.
Shikonin
(SHK),
naphthoquinone
compound
from
Lithospermum
erythrorhizon,
can
stimulate
antitumor
immunity
by
inducing
ICD.
Nevertheless,
the
immunogenicity
of
tumor
cells
killed
SHK
weak.
Endoplasmic
reticulum
(ER)
stress
an
important
intracellular
pathway
ICD
effect.
Curcumin
(CUR)
directly
induce
ER
disrupting
Ca2+
homeostasis,
which
might
enhance
SHK-induced
A
self-delivery
effect
nanobooster
(CS-PEG
NPs)
was
developed
self-assembly
(ICD
inducer)
and
CUR
enhancer)
with
assistance
DSPE-PEG2K
chemoimmunotherapy.
CS-PEG
NPs
possessed
effective
CT26
cellular
uptake
accumulation
ability.
Moreover,
enhanced
cytotoxicity
against
apoptosis
promotion
were
achieved
due
to
synergistic
SHK.
Notably,
induced
obvious
homeostasis
disruption,
stress,
Subsequently,
neoantigens
produced
robust
in
vivo
promoted
dendritic
maturation,
further
recruited
activated
cytotoxic
T
lymphocytes.
Superior
efficacy
systemic
observed
CT26-bearing
BALB/c
mouse
model
without
side
effects
major
organs.
This
study
offers
strong
European Journal of Pharmaceutical Sciences,
Год журнала:
2024,
Номер
193, С. 106688 - 106688
Опубликована: Янв. 1, 2024
The
limitations
of
conventional
cancer
treatment
are
driving
the
emergence
and
development
nanomedicines.
Research
in
liposomal
nanomedicine
for
therapy
is
rapidly
increasing,
opening
up
new
horizons
treatment.
Liposomal
nanomedicine,
which
focuses
on
targeted
drug
delivery
to
improve
therapeutic
effect
while
reducing
damage
normal
tissues
cells,
has
great
potential
field
therapy.
This
review
aims
clarify
advantages
systems
We
describe
recent
understanding
spatiotemporal
fate
liposomes
organism
after
different
routes
administration.
Meanwhile,
various
types
liposome-based
that
exert
their
respective
side
effects
were
discussed.
Moreover,
combination
agents
with
other
therapies
(such
as
photodynamic
photothermal
therapy)
demonstrated
enhanced
tumor-targeting
efficiency
efficacy.
Finally,
opportunities
challenges
faced
by
liposome
nanoformulations
entering
clinical
highlighted.
Nano Today,
Год журнала:
2024,
Номер
55, С. 102151 - 102151
Опубликована: Янв. 9, 2024
Smart
nanomaterials,
thanks
to
their
stimuli-responsive
properties,
represent
a
promising
class
of
nanostructures
for
biomedical
applications.
Their
ability
undergo
structural
or
functional
changes
in
response
specific
external
cues
has
been
exploited
the
manipulation
cellular
activities
as
potential
treatment
various
health
disorders.
Despite
rather
interesting
properties
and
applications,
most
smart
are
composed
inorganic
materials,
thus
limiting
translatability
clinical
applications
due
toxicity
long-term
accumulation
concerns.
Polydopamine
can
overcome
limitations
posed
by
nanomaterials
high
biocompatibility,
biodegradability,
antioxidant
effects,
pH-responsiveness,
tunability,
surface
reactivity,
photothermal
conversion
act
photoacoustic
contrast
agents.
In
this
review,
we
will
present
general
analysis
polydopamine
Our
aim
is
provide
reader
with
state
art
concerning
use
organic
nanoplatforms
nanomedicine,
also
providing
an
current
connected
translation
solutions
these
challenges.
Nano-Micro Letters,
Год журнала:
2024,
Номер
16(1)
Опубликована: Май 14, 2024
The
flourishing
progress
in
nanotechnology
offers
boundless
opportunities
for
agriculture,
particularly
the
realm
of
nanopesticides
research
and
development.
However,
concerns
have
been
raised
regarding
human
environmental
safety
issues
stemming
from
unrestrained
use
non-therapeutic
nanomaterials
nanopesticides.
It
is
also
important
to
consider
whether
current
development
strategy
based
on
nanocarriers
can
strike
a
balance
between
investment
return,
if
complex
material
composition
genuinely
improves
efficiency,
safety,
circularity
Herein,
we
introduced
concept
with
minimizing
carriers
(NMC)
prepared
through
prodrug
design
molecular
self-assembly
emerging
as
practical
tools
address
limitations,
compared
it
employing
(NNC).
We
further
summarized
NMC
examined
potential
challenges
its
preparation,
performance,
production.
Overall,
asserted
that
systems
serve
innovative
driving
force
catalyzing
green
efficient
revolution
nanopesticides,
offering
way
out
predicament.
Vaccines,
Год журнала:
2023,
Номер
11(7), С. 1172 - 1172
Опубликована: Июнь 29, 2023
Ever
since
the
development
of
first
vaccine,
vaccination
has
had
great
impact
on
global
health,
leading
to
decrease
in
burden
numerous
infectious
diseases.
However,
there
is
a
constant
need
improve
existing
vaccines
and
develop
new
strategies
vaccine
platforms
that
induce
broader
immune
response
compared
traditional
vaccines.
Modern
tend
rely
certain
nanotechnology
but
are
still
expected
be
readily
available
easy
for
large-scale
manufacturing
durable
response.
In
this
review,
we
present
an
overview
most
promising
nanoadjuvants
nanoparticulate
delivery
systems
discuss
their
benefits
from
tehchnological
immunological
standpoints
as
well
objective
drawbacks
possible
side
effects.
The
presented
nano
alums,
silica
clay
nanoparticles,
nanoemulsions,
adenoviral-vectored
systems,
adeno-associated
viral
vectors,
vesicular
stomatitis
lentiviral
virus-like
particles
(including
bacteriophage-based
ones)
virosomes
indicate
developers
can
now
choose
different
adjuvants
and/or
per
requirement,
specific
combatting
Journal of Controlled Release,
Год журнала:
2024,
Номер
375, С. 366 - 388
Опубликована: Сен. 18, 2024
Recent
advancements
in
RNA
therapeutics
highlight
the
critical
need
for
precision
gene
delivery
systems
that
target
specific
organs
and
cells.
Lipid
nanoparticles
(LNPs)
have
emerged
as
key
vectors
delivering
mRNA
siRNA,
offering
protection
against
enzymatic
degradation,
enabling
targeted
cellular
uptake,
facilitating
cargo
release
into
cytosol.
This
review
discusses
development
optimization
of
organ-
cell-specific
LNPs,
focusing
on
their
design,
mechanisms
action,
therapeutic
applications.
We
explore
innovations
such
DNA/RNA
barcoding,
which
facilitates
high-throughput
screening
precise
adjustments
formulations.
address
major
challenges,
including
improving
endosomal
escape,
minimizing
off-target
effects,
enhancing
efficiencies.
Notable
clinical
trials
recent
FDA
approvals
illustrate
practical
applications
future
potential
LNP-based
therapies.
Our
findings
suggest
while
considerable
progress
has
been
made,
continued
research
is
essential
to
resolve
existing
limitations
bridge
gap
between
pre-clinical
evaluation
safety
efficacy
therapeutics.
highlights
dynamic
LNP
research.
It
outlines
a
roadmap
RNA-based
medicine.
Pharmacological Research,
Год журнала:
2024,
Номер
203, С. 107150 - 107150
Опубликована: Март 21, 2024
Cancer,
with
its
diversity,
heterogeneity,
and
complexity,
is
a
significant
contributor
to
global
morbidity,
disability,
mortality,
highlighting
the
necessity
for
transformative
treatment
approaches.
Photodynamic
therapy
(PDT)
has
aroused
continuous
interest
as
viable
alternative
conventional
cancer
treatments
that
encounter
drug
resistance.
Nanotechnology
brought
new
advances
in
medicine
shown
great
potential
delivery
treatment.
For
precise
efficient
therapeutic
utilization
of
such
tumor
approach
high
spatiotemporal
selectivity
minimal
invasiveness,
carrier-free
noncovalent
nanoparticles
(NPs)
based
on
chemo-photodynamic
combination
essential.
Utilizing
natural
products
foundation
nanodrug
development
offers
unparalleled
advantages,
including
exceptional
pharmacological
activity,
easy
functionalization/modification,
well
biocompatibility.
The
natural-product-based,
carrier-free,
NPs
revealed
excellent
synergistic
anticancer
activity
comparison
free
photosensitizers
bioactive
products,
representing
an
favorable
avenue
improve
efficacy.
Herein,
comprehensive
summary
current
strategies
representative
application
examples
past
decade
(such
paclitaxel,
10-hydroxycamptothecin,
doxorubicin,
etoposide,
combretastatin
A4,
epigallocatechin
gallate,
curcumin)
therapy.
We
highlight
insightful
design
synthesis
smart
aim
enhance
PDT
Meanwhile,
we
discuss
future
challenges
opportunities
associated
these
provide
enlightenment,
spur
innovative
ideas,
facilitate
PDT-mediated
clinical
transformation.
International Journal of Pharmaceutics,
Год журнала:
2024,
Номер
651, С. 123763 - 123763
Опубликована: Янв. 2, 2024
Nanomaterials'
application
in
cancer
therapy
has
been
driven
by
their
ability
to
encapsulate
chemotherapeutic
drugs
as
well
reach
the
tumor
site.
Nevertheless,
nanomedicines'
translation
limited
due
lack
of
specificity
towards
cells.
Although
nanomaterials'
surface
can
be
coated
with
targeting
ligands,
such
mostly
achieved
through
non-covalent
functionalization
strategies
that
are
prone
premature
detachment.
Notwithstanding,
cells
often
establish
resistance
mechanisms
impair
effect
loaded
drugs.
This
bottleneck
may
addressed
using
near-infrared
(NIR)-light
responsive
nanomaterials.
The
NIR-light
triggered
hyperthermic
generated
these
nanomaterials
cause
irreversible
damage
or
sensitize
them
chemotherapeutics'
action.
Herein,
a
novel
covalently
functionalized
targeted
NIR-absorbing
nanomaterial
for
chemo-photothermal
was
developed.
For
such,
dopamine-reduced
graphene
oxide
were
bonded
hyaluronic
acid,
and
then
doxorubicin
(DOX/HA-DOPA-rGO).
produced
showed
suitable
physicochemical
properties,
high
encapsulation
efficiency,
photothermal
capacity.
vitro
studies
revealed
cytocompatible
display
an
improved
uptake
CD44-overexpressing
breast
Importantly,
combination
DOX/HA-DOPA-rGO
NIR
light
reduced
cells'
viability
just
23
%,
showcasing
potential
therapy.
