Advanced Drug Delivery Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 115578 - 115578
Published: April 1, 2025
Language: Английский
Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 183, P. 114177 - 114177
Published: March 1, 2022
Language: Английский
Citations
115
Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 353, P. 699 - 712
Published: Dec. 15, 2022
Language: Английский
Citations
109
European Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 193, P. 106688 - 106688
Published: Jan. 1, 2024
The limitations of conventional cancer treatment are driving the emergence and development nanomedicines. Research in liposomal nanomedicine for therapy is rapidly increasing, opening up new horizons treatment. Liposomal nanomedicine, which focuses on targeted drug delivery to improve therapeutic effect while reducing damage normal tissues cells, has great potential field therapy. This review aims clarify advantages systems We describe recent understanding spatiotemporal fate liposomes organism after different routes administration. Meanwhile, various types liposome-based that exert their respective side effects were discussed. Moreover, combination agents with other therapies (such as photodynamic photothermal therapy) demonstrated enhanced tumor-targeting efficiency efficacy. Finally, opportunities challenges faced by liposome nanoformulations entering clinical highlighted.
Language: Английский
Citations
52
Nano Today, Journal Year: 2024, Volume and Issue: 55, P. 102151 - 102151
Published: Jan. 9, 2024
Smart nanomaterials, thanks to their stimuli-responsive properties, represent a promising class of nanostructures for biomedical applications. Their ability undergo structural or functional changes in response specific external cues has been exploited the manipulation cellular activities as potential treatment various health disorders. Despite rather interesting properties and applications, most smart are composed inorganic materials, thus limiting translatability clinical applications due toxicity long-term accumulation concerns. Polydopamine can overcome limitations posed by nanomaterials high biocompatibility, biodegradability, antioxidant effects, pH-responsiveness, tunability, surface reactivity, photothermal conversion act photoacoustic contrast agents. In this review, we will present general analysis polydopamine Our aim is provide reader with state art concerning use organic nanoplatforms nanomedicine, also providing an current connected translation solutions these challenges.
Language: Английский
Citations
35
Vaccines, Journal Year: 2023, Volume and Issue: 11(7), P. 1172 - 1172
Published: June 29, 2023
Ever since the development of first vaccine, vaccination has had great impact on global health, leading to decrease in burden numerous infectious diseases. However, there is a constant need improve existing vaccines and develop new strategies vaccine platforms that induce broader immune response compared traditional vaccines. Modern tend rely certain nanotechnology but are still expected be readily available easy for large-scale manufacturing durable response. In this review, we present an overview most promising nanoadjuvants nanoparticulate delivery systems discuss their benefits from tehchnological immunological standpoints as well objective drawbacks possible side effects. The presented nano alums, silica clay nanoparticles, nanoemulsions, adenoviral-vectored systems, adeno-associated viral vectors, vesicular stomatitis lentiviral virus-like particles (including bacteriophage-based ones) virosomes indicate developers can now choose different adjuvants and/or per requirement, specific combatting
Language: Английский
Citations
34
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 375, P. 366 - 388
Published: Sept. 18, 2024
Recent advancements in RNA therapeutics highlight the critical need for precision gene delivery systems that target specific organs and cells. Lipid nanoparticles (LNPs) have emerged as key vectors delivering mRNA siRNA, offering protection against enzymatic degradation, enabling targeted cellular uptake, facilitating cargo release into cytosol. This review discusses development optimization of organ- cell-specific LNPs, focusing on their design, mechanisms action, therapeutic applications. We explore innovations such DNA/RNA barcoding, which facilitates high-throughput screening precise adjustments formulations. address major challenges, including improving endosomal escape, minimizing off-target effects, enhancing efficiencies. Notable clinical trials recent FDA approvals illustrate practical applications future potential LNP-based therapies. Our findings suggest while considerable progress has been made, continued research is essential to resolve existing limitations bridge gap between pre-clinical evaluation safety efficacy therapeutics. highlights dynamic LNP research. It outlines a roadmap RNA-based medicine.
Language: Английский
Citations
17
Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)
Published: May 14, 2024
The flourishing progress in nanotechnology offers boundless opportunities for agriculture, particularly the realm of nanopesticides research and development. However, concerns have been raised regarding human environmental safety issues stemming from unrestrained use non-therapeutic nanomaterials nanopesticides. It is also important to consider whether current development strategy based on nanocarriers can strike a balance between investment return, if complex material composition genuinely improves efficiency, safety, circularity Herein, we introduced concept with minimizing carriers (NMC) prepared through prodrug design molecular self-assembly emerging as practical tools address limitations, compared it employing (NNC). We further summarized NMC examined potential challenges its preparation, performance, production. Overall, asserted that systems serve innovative driving force catalyzing green efficient revolution nanopesticides, offering way out predicament.
Language: Английский
Citations
16
Pharmacological Research, Journal Year: 2024, Volume and Issue: 203, P. 107150 - 107150
Published: March 21, 2024
Cancer, with its diversity, heterogeneity, and complexity, is a significant contributor to global morbidity, disability, mortality, highlighting the necessity for transformative treatment approaches. Photodynamic therapy (PDT) has aroused continuous interest as viable alternative conventional cancer treatments that encounter drug resistance. Nanotechnology brought new advances in medicine shown great potential delivery treatment. For precise efficient therapeutic utilization of such tumor approach high spatiotemporal selectivity minimal invasiveness, carrier-free noncovalent nanoparticles (NPs) based on chemo-photodynamic combination essential. Utilizing natural products foundation nanodrug development offers unparalleled advantages, including exceptional pharmacological activity, easy functionalization/modification, well biocompatibility. The natural-product-based, carrier-free, NPs revealed excellent synergistic anticancer activity comparison free photosensitizers bioactive products, representing an favorable avenue improve efficacy. Herein, comprehensive summary current strategies representative application examples past decade (such paclitaxel, 10-hydroxycamptothecin, doxorubicin, etoposide, combretastatin A4, epigallocatechin gallate, curcumin) therapy. We highlight insightful design synthesis smart aim enhance PDT Meanwhile, we discuss future challenges opportunities associated these provide enlightenment, spur innovative ideas, facilitate PDT-mediated clinical transformation.
Language: Английский
Citations
15
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 651, P. 123763 - 123763
Published: Jan. 2, 2024
Nanomaterials' application in cancer therapy has been driven by their ability to encapsulate chemotherapeutic drugs as well reach the tumor site. Nevertheless, nanomedicines' translation limited due lack of specificity towards cells. Although nanomaterials' surface can be coated with targeting ligands, such mostly achieved through non-covalent functionalization strategies that are prone premature detachment. Notwithstanding, cells often establish resistance mechanisms impair effect loaded drugs. This bottleneck may addressed using near-infrared (NIR)-light responsive nanomaterials. The NIR-light triggered hyperthermic generated these nanomaterials cause irreversible damage or sensitize them chemotherapeutics' action. Herein, a novel covalently functionalized targeted NIR-absorbing nanomaterial for chemo-photothermal was developed. For such, dopamine-reduced graphene oxide were bonded hyaluronic acid, and then doxorubicin (DOX/HA-DOPA-rGO). produced showed suitable physicochemical properties, high encapsulation efficiency, photothermal capacity. vitro studies revealed cytocompatible display an improved uptake CD44-overexpressing breast Importantly, combination DOX/HA-DOPA-rGO NIR light reduced cells' viability just 23 %, showcasing potential therapy.
Language: Английский
Citations
9
Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 457, P. 141226 - 141226
Published: Dec. 29, 2022
Language: Английский
Citations
31