Nanotechnology Reviews, Год журнала: 2023, Номер 12(1)
Опубликована: Янв. 1, 2023
Graphical abstract
Язык: Английский
Micromachines, Год журнала: 2022, Номер 13(9), С. 1395 - 1395
Опубликована: Авг. 26, 2022
With the development of cross-fertilisation in various disciplines, flexible wearable sensing technologies have emerged, bringing together many such as biomedicine, materials science, control and communication technology. Over past few years, multiple types devices that are widely used for detection human physiological signals has proven strong biocompatibility a great potential further development. These include electronic skin patches, soft robots, bio-batteries, personalised medical devices. In this review, we present an updated overview emerging sensor biomedical applications comprehensive summary research progress sensors. First, describe selection fabrication their excellent electrochemical properties. We evaluate mechanisms by which these work, then categorise compare unique advantages variety from perspective vitro vivo sensing, well some exciting body. Finally, summarise opportunities challenges field
Язык: Английский
Процитировано
48
Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 203, С. 115116 - 115116
Опубликована: Окт. 21, 2023
Язык: Английский
Процитировано
28
ACS Applied Bio Materials, Год журнала: 2024, Номер 7(3), С. 1336 - 1361
Опубликована: Фев. 27, 2024
Over the past decade, nanotechnology has seen extensive integration into biomedical applications, playing a crucial role in biodetection, drug delivery, and diagnostic imaging. This is especially important reproductive health care, which become an emerging significant area of research. Global concerns have intensified around disorders such as infertility, endometriosis, ectopic pregnancy, erectile dysfunction, benign prostate hyperplasia, sexually transmitted infections, cancers. Nanotechnology presents promising solutions to address these by introducing innovative tools techniques, facilitating early detection, targeted improved imaging capabilities. Through utilization nanoscale materials devices, researchers can craft treatments that are not only more precise but also effective, significantly enhancing outcomes healthcare. Looking forward, future medicine holds immense potential for reshaping diagnostics, personalized therapies, fertility preservation. The nanotechnology-driven delivery systems anticipated elevate treatment effectiveness, minimize side effects, offer patients therapies efficient. review aims delve various types, properties, preparation techniques nanocarriers specifically designed context disorders, shedding light on current landscape directions this dynamic field.
Язык: Английский
Процитировано
15
Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(11)
Опубликована: Март 4, 2024
Lipid nanoparticle (LNP) formulations are a proven method for the delivery of nucleic acids gene therapy as exemplified by worldwide rollout LNP-based RNAi therapeutics and mRNA vaccines. However, targeting specific tissues or cells is still major challenge. After LNP administration, LNPs interact with biological fluids (i.e., blood), components which adsorb onto surface forming layer biomolecules termed “biomolecular corona (BMC)” affects stability, biodistribution, tissue tropism. The mechanisms BMC influences tissue- cell-specific remains largely unknown, due to technical challenges in isolating their from complex media. In this study, we present new technique that utilizes magnetic isolate LNP–corona complexes unbound proteins human serum. First, developed formulation, containing >40 superparamagnetic iron oxide nanoparticles (IONPs)/LNP, resulting (IOLNPs) displayed similar particle size morphology loaded acids. We further demonstrated isolation IOLNPs corresponding using separation (MS) system. profile MS system was compared exclusion column chromatography analyzed via mass spectrometry, revealing differences protein abundances. This approach enabled mild versatile its corona, while maintaining structural integrity. identification associated an intact provides insight into interactions fluids.
Язык: Английский
Процитировано
13
Advanced Materials, Год журнала: 2024, Номер 36(35)
Опубликована: Июнь 21, 2024
Inhibition of disease-causing mutations using RNA interference (RNAi) has resulted in clinically approved medicines with additional candidates late stage trials. However, targetable tissues currently preclinical development are limited to liver following systemic intravenous (IV) administration because predictable delivery siRNA non-liver remains an unsolved challenge. Here, evidence durable extrahepatic gene silencing enabled by Selective ORgan Targeting lipid nanoparticles (siRNA SORT LNPs) the kidneys, lungs, and spleen is provided. LNPs excel at dose-dependent tissue-enriched endogenous targets resulting 60%-80% maximal knockdown after a single IV injection up 88% downregulation protein expression mouse lungs two doses. To examine potency unbiased organ targeting, B6.129
Язык: Английский
Процитировано
12
Journal of Orthopaedic Translation, Год журнала: 2024, Номер 49, С. 181 - 206
Опубликована: Окт. 16, 2024
Язык: Английский
Процитировано
11
ACS Applied Bio Materials, Год журнала: 2024, Номер 7(6), С. 3535 - 3555
Опубликована: Май 20, 2024
Alzheimer's disease (AD) is a neurological condition currently with 47 million people suffering from it globally. AD might have many reasons such as genetic issues, environmental factors, and Aβ accumulation, which the biomarker of disease. Since primary reason unknown, there no targeted treatment at moment, but ongoing research aims to slow its progression by managing amyloid-beta peptide production rather than symptomatic improvement. phytochemicals been demonstrated possess antioxidant, anti-inflammatory, neuroprotective properties, they may target multiple pathological factors can reduce risk Curcumin, phytochemical found in turmeric known for free radical scavenging an antiamyloid treating AD, has come under investigation. Although low bioavailability limits efficacy, prominent drug delivery system (DDS) desired overcome it. Hence, potency lipid-based nanoparticles encapsulating curcumin (LNPs-CUR) considered this study promising DDS. In vivo studies animal models indicate LNPs-CUR effectively amyloid plaque formation, leading cognitive enhancement reduced toxicity compared CUR. However, deeper understanding CUR's pharmacokinetics safety profile crucial before be medicine. Future investigations explore combination NPs other therapeutic agents increase their efficacy cases. This review provides current position CUR therapy paradigm, DDS suggestions CUR, previous point analytical view focused on advantages challenges.
Язык: Английский
Процитировано
10
Journal of Controlled Release, Год журнала: 2024, Номер 372, С. 113 - 140
Опубликована: Июнь 15, 2024
Язык: Английский
Процитировано
10
Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 207, С. 115194 - 115194
Опубликована: Фев. 10, 2024
Язык: Английский
Процитировано
9
RNA Biology, Год журнала: 2024, Номер 21(1), С. 1 - 27
Опубликована: Март 26, 2024
Adjuvanticity and delivery are crucial facets of mRNA vaccine design. In modern vaccines, adjuvant functions integrated into nanoparticles, allowing the co-delivery antigen adjuvants in a unified, all-in-one formulation. this formulation, many vaccines utilize immunostimulating properties carrier components, including lipids polymers, as adjuvants. However, careful design is necessary, excessive adjuvanticity activation improper innate immune signalling can conversely hinder vaccination efficacy trigger adverse effects. also require systems to achieve expression antigen-presenting cells (APCs) within lymphoid organs. Some directly target APCs organs, while others rely on migration draining lymph nodes after taking up vaccines. This review explores current mechanistic understanding these processes ongoing efforts improve safety based understanding.
Язык: Английский
Процитировано
9