ACS Applied Nano Materials,
Год журнала:
2024,
Номер
7(13), С. 15446 - 15458
Опубликована: Июнь 26, 2024
In
recent
years,
the
application
of
hollow
mesoporous
silicon
nanoparticles
in
biomedical
field
has
attracted
much
attention
because
their
excellent
features.
this
study,
sonosensitizer
curcumin
(Cur),
chemotherapy
drug
doxorubicin
(Dox),
and
perfluoropropane
(C3F8)
gas
were
loaded
into
a
multifunctional
silica
nanoparticle
(MHMSN).
The
surface
MHMSN
was
modified
with
biotin
molecule
acid-sensitive
groups
(cis-aconitic
anhydride-polyethylene
glycol,
CDM-PEG).
as-prepared
(CDF-MHMSN)
demonstrates
improved
therapeutic
efficacy
enhanced
tumor
contrast
ultrasound
performance.
Surface-modified
CDM-PEG
can
improve
blood
circulation
ability
peel
off
acidic
microenvironment,
which
enhance
endocytosis
cancer
cells.
As
sonosensitizer,
Cur
could
generate
reactive
oxygen
species
(ROS)
under
stimulation
to
kill
cells
reduce
multidrug
resistance
Dox
by
inhibiting
expression
P-glycoprotein.
Overall,
CDF-MHMSN
exhibits
good
biocompatibility,
imaging
capability,
effective
antitumor
ability,
may
contribute
improving
treatment
strategy
for
hepatocellular
carcinoma.
Pharmaceutics,
Год журнала:
2023,
Номер
15(2), С. 678 - 678
Опубликована: Фев. 17, 2023
Orally
administered
antipsychotic
drugs
are
the
first-line
treatment
for
psychotic
disorders,
such
as
schizophrenia
and
bipolar
disorder.
Nevertheless,
adverse
drug
reactions
jeopardize
clinical
outcomes,
resulting
in
patient
non-compliance.
The
design
formulation
strategies
enhancing
brain
delivery
has
been
a
major
challenge,
mainly
due
to
restrictive
properties
of
blood-brain
barrier.
However,
recent
pharmacokinetic
pharmacodynamic
vivo
assays
confirmed
advantage
intranasal
route
when
compared
oral
intravenous
administration,
it
allows
direct
nose-to-brain
transport
via
neuronal
pathways,
reducing
systemic
side
effects
maximizing
therapeutic
outcomes.
In
addition,
incorporation
into
nanosystems
polymeric
nanoparticles,
mixed
micelles,
solid
lipid
nanostructured
carriers,
nanoemulsions,
nanoemulgels,
nanosuspensions,
niosomes
spanlastics,
proven
be
quite
promising.
developed
nanosystems,
having
small
homogeneous
particle
size
(ideal
delivery),
high
encapsulation
efficiency
good
stability,
resulted
improved
bioavailability
therapeutic-like
animal
models.
Hence,
although
is
essential
continue
research
this
field,
schizophrenia,
disorder
other
related
disorders
promising,
opening
path
future
therapies
with
higher
efficacy.
Theranostics,
Год журнала:
2022,
Номер
13(1), С. 40 - 58
Опубликована: Ноя. 29, 2022
Immunotherapies
are
now
emerging
as
an
efficient
anticancer
therapeutic
strategy.
Cancer
immunotherapy
utilizes
the
host's
immune
system
to
fight
against
cancer
cells
and
has
gained
increasing
interest
due
its
durable
efficacy
low
toxicity
compared
traditional
antitumor
treatments,
such
chemotherapy
radiotherapy
(RT).
Although
combination
of
RT
drawn
extensive
attention
in
clinical
setting,
overall
response
rates
still
low.
Therefore,
strategies
for
further
improvement
urgently
needed.
Nanotechnology
been
used
target
not
only
but
also
tumor
microenvironment
(TME),
thereby
helping
generate
a
long-term
response.
Nanomaterials
can
be
effective
delivery
strong
autophagy
inducer,
with
ability
elevate
very
high
levels.
Interestingly,
could
play
critical
role
optimal
function,
mediating
cell-extrinsic
homeostatic
effects
through
regulation
danger
signaling
neoplastic
under
immunogenic
and/or
RT.
In
this
review,
we
summarize
preclinical
development
therapy
highlight
latest
progress
nanotechnology
augmenting
The
underlying
mechanisms
nanomaterial-triggered
TME
discussed
depth.
Finally,
suggest
implications
these
three
combined
together
achieve
goal
maximizing
advantages
show
recent
advances
biomarkers
evaluation
those
therapies.
Pharmaceutics,
Год журнала:
2023,
Номер
15(7), С. 1821 - 1821
Опубликована: Июнь 26, 2023
Cancer
immunotherapy
can
significantly
prevent
tumor
growth
and
metastasis
by
activating
the
autoimmune
system
without
destroying
normal
cells.
Although
cancer
has
made
some
achievements
in
clinical
treatment,
it
is
still
restricted
systemic
immunotoxicity,
immune
cell
dysfunction,
heterogeneity,
immunosuppressive
microenvironment
(ITME).
Biomimetic
cell-derived
nanoparticles
are
attracting
considerable
interest
due
to
their
better
biocompatibility
lower
immunogenicity.
Moreover,
biomimetic
achieve
different
preferred
biological
effects
inherent
abundant
source
cell-relevant
functions.
This
review
summarizes
latest
developments
for
immunotherapy,
discusses
applications
of
each
analyzes
challenges
transformation.
Combinations
of
chemotherapeutic
agents
comprise
a
clinically
feasible
approach
to
combat
cancers
that
possess
resistance
treatment.
Type
II
endometrial
cancer
is
typically
associated
with
poor
outcomes
and
the
emergence
chemoresistance.
To
overcome
this
challenge,
combination
therapy
developed
comprising
novel
ciprofloxacin
derivative-loaded
PEGylated
polymeric
nanoparticles
(CIP2b-NPs)
paclitaxel
(PTX)
against
human
type-II
(Hec50co
loss
function
p53).
Cytotoxicity
studies
reveal
strong
synergy
between
CIP2b
PTX
Hec50co,
significant
reduction
in
IC
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 23, 2024
ABSTRACT
Endometrial
cancer
is
one
of
the
most
common
gynecological
cancers
in
world,
with
an
estimated
382,000
new
cases
and
90,000
deaths
each
year.
There
no
specific
treatment,
as
underlying
causes
endometrial
neoplasia
are
poorly
understood.
This
study
focuses
on
development
validation
a
three-dimensional
(3D)
vitro
multilayer,
multicellularhydrogel
that
facilitates
drug
screening
analysis.
We
hypothesized
combination
natural
(collagen
type
I
IV,
fibrinogen,
fibronectin,
Laminin)
synthetic
(GELMA,
PEGDA)
polymers
would
maximize
microvessel
formation
cell
invasion.
The
3D
model
incorporates
human
microvascular
endothelial
cells
(hMVEC)
(HEC-1A)
atop
hydrogel
formulations
mimicking
cell-specific
extracellular
matrix
components.
Using
D-optimal
experimental
design,
45
combinations
were
generated.
predicted
formulation
to
all
responses
enhanced
higher
invasion
compared
gold
standard
Matrigel.
Subsequent
emphasizes
importance
disease-specific
crosstalk
maximizing
optimized
adeptly
captures
variances
among
lines
from
distinct
stages.
Finally,
platform
employed
compare
viability,
formation,
across
Ishikawa,
KLE,
HEC-1A
after
Paclitaxel
exposure,
delivered
both
free
loaded
poly(caprolactone)
(PCL)
nanoparticles.
Overall,
this
provides
valuable
tool
for
exploring
intricate
interactions
within
tumor
microenvironment,
offering
holistic
understanding
fostering
targeted
therapeutic
strategies
cancer.
Langmuir,
Год журнала:
2023,
Номер
39(23), С. 8109 - 8119
Опубликована: Июнь 3, 2023
Tuning
surface
properties
of
nanoparticles
by
introducing
charge,
functionalization,
or
polymer
grafting
is
central
to
their
stability
and
applications.
Here,
we
show
that
non-DLVO
forces
like
steric
hydrophobic
effects
in
charged
silica
nanoparticle
suspensions
through
interaction
with
a
nonionic
surfactant
brings
about
interesting
modulations
interparticle
phase
behavior.
The
Ludox
TM-40
negatively
thus
exhibit
liquid-liquid
separation
driven
the
onset
attraction
system
presence
triblock
copolymer
Pluronic
P123.
observed
separations
are
thermoresponsive
nature,
as
they
associated
lower
consolute
temperatures
re-entrant
behavior
function
temperature.
nanoparticle-Pluronic
undergoes
transformation
from
one-phase
two-phase
then
back
monotonic
increase
Evolution
composite
investigated
dynamic
light
scattering
(DLS),
small
angle
neutron
(SANS),
zeta
potential,
rheological,
fluorescence
spectroscopy
studies.
Zeta
potential
studies
charge
partially
mitigated
adsorption
micellar
layer
on
surfaces.
Contrast-matching
SANS
suggest
interactions
between
adsorbed
bring
system.
results
unique
not
reported
hitherto
systems.
