A shielded cascade of targeted nanocarriers spanning multiple microenvironmental barriers for inflammatory disease therapy DOI Creative Commons
Fengyi Liu, Xu Wang, Mingxing Ren

и другие.

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Дек. 23, 2024

The multi-biological barriers present in the inflammatory microenvironment severely limit targeted aggregation of anti-inflammatory drugs lesion area. However, conventional responsive drug carriers inevitably come into contact with several pro-responsive stimulatory mediators simultaneously, leading to premature release and loss most therapeutic effects. Breaking through multi-level is essential improve enrichment bioavailability drugs. In this study, we propose a novel two-stage structural strategy build shielded cascades nanocarriers (FA-PTP@Que) mediators, using cascade structures cross multiple environmental barriers. structure FA-PTP@Que exhibits ideal pathological microenvironmental response properties. has shown good macrophage regulation effects by efficiently targeting macrophages, scavenging intracellular reactive oxygen species (ROS), down-regulating secretion pro-inflammatory factors. Significantly, mice arthritis colitis, enriches targets macrophages at sites showing significant combines active chemotaxis tissues effector cells, acting precisely each barrier level different microenvironments responding overcoming microenvironment. This innovative can effectively break various potential application other diseases.

Язык: Английский

Responsive biomaterials: optimizing control of cancer immunotherapy DOI
Lulu Xue, Ajay S. Thatte, David Mai

и другие.

Nature Reviews Materials, Год журнала: 2023, Номер 9(2), С. 100 - 118

Опубликована: Дек. 22, 2023

Язык: Английский

Процитировано

54
Dual Barrier‐Penetrating Inhaled Nanoparticles for Enhanced Idiopathic Pulmonary Fibrosis Therapy DOI

Ming‐Yuan Yang,

Meng‐Meng Han, Tang Ling

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер 34(23)

Опубликована: Фев. 14, 2024

Abstract Idiopathic pulmonary fibrosis (IPF) is an age‐related interstitial disease with unclear etiology that poses a serious threat to human health. IPF interventions in clinical settings mainly involve oral medications, such as nintedanib (NIN), which exhibit limited accumulation the lungs and neglect epithelial micro‐environment. Inhalation efficient route for treatment of diseases. However, mucus barrier trachea extracellular matrix (ECM) interstitium are two main obstacles inhaled therapeutic agent delivery. Therefore, this study, dual barrier‐penetrating liposomes (AN‐TR) constructed utilizing tris‐(2‐carboxyethyl)‐phosphine (TCEP) l ‐arginine penetrate ECM barriers, respectively. This approach facilitates thorough uniform distribution NIN navitoclax (ABT‐263) across all five lung lobes. Furthermore, ABT‐263 can remove senescent cells alveoli, thereby improving efficiency treatment. study suggests noninvasive vehicles first‐line medications improve efficacy

Язык: Английский

Процитировано

11
Dendritic nanomedicine enhances chemo-immunotherapy by disturbing metabolism of cancer-associated fibroblasts for deep penetration and activating function of immune cells DOI Creative Commons
Yunkun Li,

Xiaoding Shen,

Ding Haitao

и другие.

Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(8), С. 3680 - 3696

Опубликована: Март 9, 2024

Inefficient drug penetration hurdled by the stroma in tumor tissue leads to a diminished therapeutic effect for drugs and reduced infiltration level of immune cells. Herein, we constructed PEGylated dendritic epirubicin (Epi) prodrug (Epi-P4D) regulate metabolism cancer-associated fibroblasts (CAFs), thus enhancing Epi into both multicellular spheroids (MTSs) tissues mouse colon cancer (CT26), breast (4T1) human (MDA-MB-231) models. Enhanced cytotoxicity against CT26 MTSs remarkable antitumor efficacy Epi-P4D were ascribed fibronectin, α-SMA, collagen secretion. Besides, thinning efficient eradication cells promoted immunogenic cell death (DC) maturation subsequent activation, including elevating CD4+ T population, reducing CD8+ hyperactivation exhaustion, amplifying natural killer (NK) proportion effectively activating them. As result, this nanomedicine thinned enhance facilitate elevated efficacy.

Язык: Английский

Процитировано

11
Inhaled nanoparticles for treating idiopathic pulmonary fibrosis by inhibiting honeycomb cyst and alveoli interstitium remodeling DOI
Meng‐Meng Han, Tang Ling, Bin Huang

и другие.

Journal of Controlled Release, Год журнала: 2024, Номер 366, С. 732 - 745

Опубликована: Янв. 20, 2024

Язык: Английский

Процитировано

10
Reactive Oxygen Species‐Responsive Nanoparticles Toward Extracellular Matrix Normalization for Pancreatic Fibrosis Regression DOI Creative Commons
Liang Qi,

Bo‐Wen Duan,

Hui Wang

и другие.

Advanced Science, Год журнала: 2024, Номер 11(19)

Опубликована: Март 14, 2024

Abstract Pancreatic fibrosis (PF) is primarily characterized by aberrant production and degradation modes of extracellular matrix (ECM) components, resulting from the activation pancreatic stellate cells (PSCs) pathological cross‐linking ECM mediated lysyl oxidase (LOX) family members. The excessively deposited increases stiffness, over‐accumulated reactive oxygen species (ROS) induces oxidative stress, which further stimulates continuous PSCs advancing PF; challenging strategy toward normalizing homeostasis for regression PF. Herein, ROS‐responsive Vitamin A (VA) decorated micelles (named LR‐SSVA) to reverse imbalanced ameliorating PF are designed synthesized. Specifically, LR‐SSVA selectively targets via VA, thereby effectively delivering siLOXL1 resveratrol (RES) into pancreas. released RES inhibits overproduction eliminating ROS inactivating PSCs, meanwhile, decreased expression LOXL1 ameliorates cross‐linked collagen easier collagenase jointly normalizes alleviates This research shows that a safe efficient ROS‐response PSC‐targeted drug‐delivery system normalization, will propose an innovative ideal platform reversal

Язык: Английский

Процитировано

9
Curvature-mediated rapid extravasation and penetration of nanoparticles against interstitial fluid pressure for improved drug delivery DOI Creative Commons

Xiaohe Jiang,

Sai Xu,

Yunqiu Miao

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(22)

Опубликована: Май 20, 2024

Elevated interstitial fluid pressure (IFP) within pathological tissues (e.g., tumors, obstructed kidneys, and cirrhotic livers) creates a significant hindrance to the transport of nanomedicine, ultimately impairing therapeutic efficiency. Among these tissues, solid tumors present most challenging scenario. While several strategies through reducing tumor IFP have been devised enhance nanoparticle delivery, few approaches focus on modulating intrinsic properties nanoparticles effectively counteract during extravasation penetration, which are precisely stages by elevated IFP. Herein, we propose an innovative solution engineering with fusiform shape high curvature, enabling efficient surmounting barriers penetration tissues. Through experimental theoretical analyses, demonstrate that elongated highest mean curvature outperform spherical rod-shaped counterparts against IFP, leading superior intratumoral accumulation antitumor efficacy. Super-resolution microscopy molecular dynamics simulations uncover underlying mechanisms in contributes diminished drag force high-pressure differentials extravasation. Simultaneously, facilitated rotational movement augments hopping frequency penetration. This study addresses limitations posed impediments, uncovers mutual interactions between physical NPs their environment, presents promising avenue for advancing cancer treatment nanomedicine.

Язык: Английский

Процитировано

5
Mitochondrial endogenous substance transport-inspired nanomaterials for mitochondria-targeted gene delivery DOI
Yi Wang, Jingsong Yang, Min Zhao

и другие.

Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 211, С. 115355 - 115355

Опубликована: Июнь 5, 2024

Язык: Английский

Процитировано

4
Neurological insights into brain-targeted cancer therapy and bioinspired microrobots DOI
Shampa Ghosh, Rakesh Bhaskar,

Richa Mishra

и другие.

Drug Discovery Today, Год журнала: 2024, Номер 29(9), С. 104105 - 104105

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

4
Modulating Fibrotic Mechanical Microenvironment for Idiopathic Pulmonary Fibrosis Therapy DOI

Xue‐Na Li,

Ya‐Ping Lin, Meng‐Meng Han

и другие.

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 12, 2024

Idiopathic pulmonary fibrosis (IPF) is exacerbated by injurious mechanical forces that destabilize the microenvironment homeostasis, leading to alveolar dysfunction and exacerbating disease severity. However, given inherent mechanosensitivity of fibrotic lungs, where type II epithelial cells (AEC IIs) are subjected persistent stretching overactivated myofibroblasts experience malignant interactions during mechanotransduction, it becomes imperative develop effective strategies modulate microenvironment. Herein, cyclo (RGDfC) peptide-decorated zeolitic imidazolate framework-8 nanoparticles (named ZDFPR NPs) constructed target repair aberrant force levels in pathological lungs. Specifically, reduces tension AEC IIs pH-responsive NPs release zinc ions 7, 8-dihydroxyflavone promote differentiation. Meanwhile, between myofibroblast contractility extracellular matrix stiffness mechanotransduction disrupted fasudil inhibition ROCK signaling pathway. The results show successfully restored homeostasis terminated process bleomycin-induced mice. This study not only presents a promising strategy for modulating but also pioneers novel avenue IPF treatment.

Язык: Английский

Процитировано

4
A PDGFRβ-targeting nanodrill system for pancreatic fibrosis therapy DOI
Han Han,

Bi‐Te Chen,

Jiarong Ding

и другие.

Chinese Chemical Letters, Год журнала: 2024, Номер 35(10), С. 109583 - 109583

Опубликована: Фев. 1, 2024

Язык: Английский

Процитировано

3