Biologics, theranostics, and personalized medicine in drug delivery systems

Pharmacological Research, Год журнала: 2024, Номер 201, С. 107086 - 107086

Опубликована: Янв. 29, 2024

The progress in human disease treatment can be greatly advanced through the implementation of nanomedicine. This approach involves targeted and cell-specific therapy, controlled drug release, personalized dosage forms, wearable delivery, companion diagnostics. By integrating cutting-edge technologies with delivery systems, greater precision achieved at tissue cellular levels use stimuli-responsive nanoparticles, development electrochemical sensor systems. targeting – by virtue nanotechnology allows for therapy to directed specifically affected tissues while reducing side effects on healthy tissues. As such, nanomedicine has potential transform conditions such as cancer, genetic diseases, chronic illnesses facilitating precise delivery. Additionally, forms devices offer ability tailor unique needs each patient, thereby increasing therapeutic effectiveness compliance. Companion diagnostics further enable efficient monitoring response, enabling customized adjustments plan. question whether all approaches outlined here are viable alternatives current treatments is also discussed. In general, application field biomedicine may provide a strong alternative existing several reasons. this review, we aim present evidence that, although early stages, fully merging technology innovative shows promise successful across various areas, including cancer or diseases.

Язык: Английский

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Nanostructures and nanoparticles as medical diagnostic imaging contrast agents: A review

Materials Today Chemistry, Год журнала: 2024, Номер 40, С. 102233 - 102233

Опубликована: Авг. 5, 2024

Язык: Английский

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Cyclic jetting enables microbubble-mediated drug delivery

Nature Physics, Год журнала: 2025, Номер 21(4), С. 590 - 598

Опубликована: Фев. 21, 2025

Abstract The pursuit of targeted therapies capable overcoming biological barriers, including the blood–brain barrier, has spurred investigation stimuli-responsive microagents that can improve therapeutic efficacy and reduce undesirable side effects. Intravenously administered, ultrasound-responsive microbubbles are promising agents with demonstrated potential in clinical trials, but mechanism underlying drug absorption remains unclear. Here we show ultrasound-driven single puncture cell membrane induce uptake through stable cyclic microjets. Our theoretical models successfully reproduce observed bubble dynamic responses. We find jets arise from shape instabilities, as opposed to classical inertial driven by pressure gradients, enabling microjet formation at mild ultrasound pressures below 100 kPa. also establish a threshold for radial expansion beyond which microjets form facilitate cellular permeation stress generated microjetting outperforms previously suggested mechanisms least an order magnitude. Overall, this work elucidates physics behind microbubble-mediated delivery provides criteria its effective safe application.

Язык: Английский

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Designing intelligent bioorthogonal nanozymes: Recent advances of stimuli-responsive catalytic systems for biomedical applications

Journal of Controlled Release, Год журнала: 2024, Номер 373, С. 929 - 951

Опубликована: Авг. 8, 2024

Язык: Английский

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Dual‐Functional Nanodroplet for Tumor Vasculature Ultrasound Imaging and Tumor Immunosuppressive Microenvironment Remodeling

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Июль 19, 2024

Abstract Accurately evaluating tumor neoangiogenesis and conducting precise interventions toward an immune‐favorable microenvironment are of significant clinical importance. In this study, a novel nanodroplet termed as the nanodroplet‐based ultrasound contrast agent therapeutic (NDs UCA/Tx ) is designed for imaging neoangiogenesis. Briefly, NDs shell constructed from engineered CMs containing antigen, vascular endothelial growth factor receptor 1 (VEGFR1) extracellular domain 2–3, CD93 ligand multimerin 2. The core composed perfluorohexane immune adjuvant R848. After injection, found to be enriched in vasculature with high expression CD93. When triggered by ultrasound, underwent acoustic droplet vaporization generated enhanced signal. Some microbubbles exploded resultant debris (with antigen R848) together adsorbed VEGF taken up nearby cells. This cleared local normalization, also served vaccine activate response. Using syngeneic mouse model, satisfactory performance activation confirmed. Thus, multifunctional successfully developed molecular remodeling microenvironment.

Язык: Английский

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Dynamics of bubble formation on superhydrophobic surface under a constant gas flow rate at quasi-static regime

Physics of Fluids, Год журнала: 2024, Номер 36(8)

Опубликована: Авг. 1, 2024

In this work, we experimentally studied bubble formation on the superhydrophobic surface (SHS) under a constant gas flow rate and at quasi-static regime. SHS with radius RSHS ranging from 4.2 to 19.0 mm was used. We observed two bubbling modes A B, depending RSHS. mode for small RSHS, contact line fixed rim of SHS, angle (θ) initially reduced, then maintained as constant, finally increased. B large continuously expanded, θ slowly reduced. For both modes, during necking, retracts, close equilibrium angle. Moreover, pinch-off early stage similar nozzle followed power-law relation Rneck ∼ τ0.54, where is minimum neck τ time detaching. Furthermore, calculated forces acting found balance between one lifting force (pressure force) retaining (surface tension buoyancy force). Last, waiting finite volume be detected The detached well predicted by Tate volume, which derived based function base radius.

Язык: Английский

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Nanobubble Contrast Enhanced Ultrasound Imaging: A Review

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Год журнала: 2024, Номер 16(6)

Опубликована: Ноя. 1, 2024

Contrast-enhanced ultrasound is currently used worldwide with clinical indications in cardiology and radiology, it continues to evolve develop through innovative technological advancements. Clinically utilized contrast agents for consist of hydrophobic gas microbubbles stabilized a biocompatible shell. These are commonly echocardiography, emerging applications cancer diagnosis therapy. Microbubbles blood pool agent diameters between 1 10 μm, which precludes their use other extravascular applications. To expand the potential contrast-enhanced beyond intravascular applications, sub-micron agents, often called nanobubbles or ultra-fine bubbles, have recently emerged as promising tool. Combining principles imaging unique properties (high concentration small size), recent work has established potential. using these gain traction, new studies establishing novel We highlight achievements nonlinear nanobubble imaging, including discussion on formulations acoustic characteristics. Ultrasound still its early stages, but shown great preclinical research animal studies. unexplored areas where capabilities may offer advantages. As technology advances, this technique find various medicine, detection treatment, cardiovascular drug delivery.

Язык: Английский

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Effect of gas flow rate on bubble formation on superhydrophobic surface

Droplet, Год журнала: 2025, Номер unknown

Опубликована: Янв. 5, 2025

Abstract We experimentally studied the effect of gas flow rate Q on bubble formation a superhydrophobic surface (SHS). varied in range 0.001 < Q/Q cr 0.35, where is critical value for transition from quasi‐static regime to dynamic regime. The geometrical parameters and forces acting were calculated. found that as increase, detached volume ( V d ) increased. After proper normalization, relationship between generally agreed with those observed bubbles detaching hydrophilic hydrophobic surfaces. Furthermore, we had minor impact shape duration necking due negligible momentum injected compared tension hydrostatic pressure. Lastly, explained primary reason larger at higher rates, which was increased during process. Our results enhanced fundamental understanding complex surfaces could provide potential solutions controlling generation extending application SHS drag reduction, anti‐fouling, heat mass transfer enhancement.

Язык: Английский

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Fertile Ground for Homeostatic Reformation: Engineered Release Platforms for Enhanced Regenerative Outcomes

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер 106, С. 106740 - 106740

Опубликована: Фев. 21, 2025

Язык: Английский

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Acoustic tweezers for targeted drug delivery

Advanced Drug Delivery Reviews, Год журнала: 2025, Номер unknown, С. 115551 - 115551

Опубликована: Фев. 1, 2025

Язык: Английский

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