Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 215 - 242
Published: Oct. 4, 2024
Language: Английский
Pharmacological Research, Journal Year: 2024, Volume and Issue: 201, P. 107086 - 107086
Published: Jan. 29, 2024
The progress in human disease treatment can be greatly advanced through the implementation of nanomedicine. This approach involves targeted and cell-specific therapy, controlled drug release, personalized dosage forms, wearable delivery, companion diagnostics. By integrating cutting-edge technologies with delivery systems, greater precision achieved at tissue cellular levels use stimuli-responsive nanoparticles, development electrochemical sensor systems. targeting – by virtue nanotechnology allows for therapy to directed specifically affected tissues while reducing side effects on healthy tissues. As such, nanomedicine has potential transform conditions such as cancer, genetic diseases, chronic illnesses facilitating precise delivery. Additionally, forms devices offer ability tailor unique needs each patient, thereby increasing therapeutic effectiveness compliance. Companion diagnostics further enable efficient monitoring response, enabling customized adjustments plan. question whether all approaches outlined here are viable alternatives current treatments is also discussed. In general, application field biomedicine may provide a strong alternative existing several reasons. this review, we aim present evidence that, although early stages, fully merging technology innovative shows promise successful across various areas, including cancer or diseases.
Language: Английский
Citations
67
Materials Today Chemistry, Journal Year: 2024, Volume and Issue: 40, P. 102233 - 102233
Published: Aug. 5, 2024
Language: Английский
Citations
13
Nature Physics, Journal Year: 2025, Volume and Issue: 21(4), P. 590 - 598
Published: Feb. 21, 2025
Abstract The pursuit of targeted therapies capable overcoming biological barriers, including the blood–brain barrier, has spurred investigation stimuli-responsive microagents that can improve therapeutic efficacy and reduce undesirable side effects. Intravenously administered, ultrasound-responsive microbubbles are promising agents with demonstrated potential in clinical trials, but mechanism underlying drug absorption remains unclear. Here we show ultrasound-driven single puncture cell membrane induce uptake through stable cyclic microjets. Our theoretical models successfully reproduce observed bubble dynamic responses. We find jets arise from shape instabilities, as opposed to classical inertial driven by pressure gradients, enabling microjet formation at mild ultrasound pressures below 100 kPa. also establish a threshold for radial expansion beyond which microjets form facilitate cellular permeation stress generated microjetting outperforms previously suggested mechanisms least an order magnitude. Overall, this work elucidates physics behind microbubble-mediated delivery provides criteria its effective safe application.
Language: Английский
Citations
1
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 373, P. 929 - 951
Published: Aug. 8, 2024
Language: Английский
Citations
5
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown
Published: July 19, 2024
Abstract Accurately evaluating tumor neoangiogenesis and conducting precise interventions toward an immune‐favorable microenvironment are of significant clinical importance. In this study, a novel nanodroplet termed as the nanodroplet‐based ultrasound contrast agent therapeutic (NDs UCA/Tx ) is designed for imaging neoangiogenesis. Briefly, NDs shell constructed from engineered CMs containing antigen, vascular endothelial growth factor receptor 1 (VEGFR1) extracellular domain 2–3, CD93 ligand multimerin 2. The core composed perfluorohexane immune adjuvant R848. After injection, found to be enriched in vasculature with high expression CD93. When triggered by ultrasound, underwent acoustic droplet vaporization generated enhanced signal. Some microbubbles exploded resultant debris (with antigen R848) together adsorbed VEGF taken up nearby cells. This cleared local normalization, also served vaccine activate response. Using syngeneic mouse model, satisfactory performance activation confirmed. Thus, multifunctional successfully developed molecular remodeling microenvironment.
Language: Английский
Citations
4
Physics of Fluids, Journal Year: 2024, Volume and Issue: 36(8)
Published: Aug. 1, 2024
In this work, we experimentally studied bubble formation on the superhydrophobic surface (SHS) under a constant gas flow rate and at quasi-static regime. SHS with radius RSHS ranging from 4.2 to 19.0 mm was used. We observed two bubbling modes A B, depending RSHS. mode for small RSHS, contact line fixed rim of SHS, angle (θ) initially reduced, then maintained as constant, finally increased. B large continuously expanded, θ slowly reduced. For both modes, during necking, retracts, close equilibrium angle. Moreover, pinch-off early stage similar nozzle followed power-law relation Rneck ∼ τ0.54, where is minimum neck τ time detaching. Furthermore, calculated forces acting found balance between one lifting force (pressure force) retaining (surface tension buoyancy force). Last, waiting finite volume be detected The detached well predicted by Tate volume, which derived based function base radius.
Language: Английский
Citations
4
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(6)
Published: Nov. 1, 2024
Contrast-enhanced ultrasound is currently used worldwide with clinical indications in cardiology and radiology, it continues to evolve develop through innovative technological advancements. Clinically utilized contrast agents for consist of hydrophobic gas microbubbles stabilized a biocompatible shell. These are commonly echocardiography, emerging applications cancer diagnosis therapy. Microbubbles blood pool agent diameters between 1 10 μm, which precludes their use other extravascular applications. To expand the potential contrast-enhanced beyond intravascular applications, sub-micron agents, often called nanobubbles or ultra-fine bubbles, have recently emerged as promising tool. Combining principles imaging unique properties (high concentration small size), recent work has established potential. using these gain traction, new studies establishing novel We highlight achievements nonlinear nanobubble imaging, including discussion on formulations acoustic characteristics. Ultrasound still its early stages, but shown great preclinical research animal studies. unexplored areas where capabilities may offer advantages. As technology advances, this technique find various medicine, detection treatment, cardiovascular drug delivery.
Language: Английский
Citations
4
Droplet, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 5, 2025
Abstract We experimentally studied the effect of gas flow rate Q on bubble formation a superhydrophobic surface (SHS). varied in range 0.001 < Q/Q cr 0.35, where is critical value for transition from quasi‐static regime to dynamic regime. The geometrical parameters and forces acting were calculated. found that as increase, detached volume ( V d ) increased. After proper normalization, relationship between generally agreed with those observed bubbles detaching hydrophilic hydrophobic surfaces. Furthermore, we had minor impact shape duration necking due negligible momentum injected compared tension hydrostatic pressure. Lastly, explained primary reason larger at higher rates, which was increased during process. Our results enhanced fundamental understanding complex surfaces could provide potential solutions controlling generation extending application SHS drag reduction, anti‐fouling, heat mass transfer enhancement.
Language: Английский
Citations
0
Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: 106, P. 106740 - 106740
Published: Feb. 21, 2025
Language: Английский
Citations
0
Advanced Drug Delivery Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 115551 - 115551
Published: Feb. 1, 2025
Language: Английский
Citations
0