Advanced Powder Technology, Год журнала: 2025, Номер 36(6), С. 104895 - 104895
Опубликована: Апрель 25, 2025
Язык: Английский
Acta Pharmaceutica Sinica B, Год журнала: 2021, Номер 12(2), С. 600 - 620
Опубликована: Авг. 12, 2021
The use of small interfering RNAs (siRNAs) has been under investigation for the treatment several unmet medical needs, including acute lung injury/acute respiratory distress syndrome (ALI/ARDS) wherein siRNA may be implemented to modify expression pro-inflammatory cytokines and chemokines at mRNA level. properties such as clear anatomy, accessibility, relatively low enzyme activity make a good target local therapy. However, translation is restricted by inefficient delivery therapeutics cells due naked siRNA. Thus, this review will focus on various systems that can used different barriers need surmounted development stable inhalable formulations human before ALI/ARDS become available in clinic.
Язык: Английский
Процитировано
186
Pharmaceutics, Год журнала: 2023, Номер 15(3), С. 774 - 774
Опубликована: Фев. 26, 2023
Nanomedicine is a branch of medicine using nanotechnology to prevent and treat diseases. Nanotechnology represents one the most effective approaches in elevating drug‘s treatment efficacy reducing toxicity by improving drug solubility, altering biodistribution, controlling release. The development materials has brought profound revolution medicine, significantly affecting various major diseases such as cancer, injection, cardiovascular experienced explosive growth past few years. Although clinical transition nanomedicine not very satisfactory, traditional drugs still occupy dominant position formulation development, but increasingly active have adopted nanoscale forms limit side effects improve efficacy. review summarized approved nanomedicine, its indications, properties commonly used nanocarriers nanotechnology.
Язык: Английский
Процитировано
63
Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(11), С. 4683 - 4716
Опубликована: Сен. 2, 2024
About 40% of approved drugs and nearly 90% drug candidates are poorly water-soluble drugs. Low solubility reduces the drugability. Effectively improving bioavailability is a critical issue that needs to be urgently addressed in development application. This review briefly introduces conventional solubilization techniques such as solubilizers, hydrotropes, cosolvents, prodrugs, salt modification, micronization, cyclodextrin inclusion, solid dispersions, details crystallization strategies, ionic liquids, polymer-based, lipid-based, inorganic-based carriers bioavailability. Some most commonly used carrier materials for presented. Several using summarized. Furthermore, this summarizes mechanism each technique, reviews latest research advances challenges, evaluates potential clinical translation. could guide selection approach, dosage form, administration route Moreover, we discuss several promising attracting increasing attention worldwide.
Язык: Английский
Процитировано
21
Discover Nano, Год журнала: 2024, Номер 19(1)
Опубликована: Окт. 4, 2024
Nanomedicine has the potential to transform healthcare by offering targeted therapies, precise diagnostics, and enhanced drug delivery systems. The National Institutes of Health coined term "nanomedicine" describe use nanotechnology in biological system monitoring, control, diagnosis, treatment. continues receive increasing interest for rationalized therapeutics pharmaceutical agents achieve required response while reducing its side effects. However, as advance, concerns about toxicological effects have also grown. This review explores current state nanomedicine, focusing on types nanoparticles used their associated properties that contribute nanotoxicity. It examines mechanisms through which exert toxicity, encompassing various cellular molecular interactions. Furthermore, it discusses assessment methods employed evaluate nanotoxicity, in-vitro in-vivo models, well emerging techniques. addresses regulatory issues surrounding nanotoxicology, highlighting challenges developing standardized guidelines ensuring secure translation nanomedicine into clinical settings. ethical with understanding safety profile is essential effective therapeutic applications.
Язык: Английский
Процитировано
20
Acta Pharmaceutica Sinica B, Год журнала: 2022, Номер 13(10), С. 4105 - 4126
Опубликована: Ноя. 30, 2022
Messenger RNA (mRNA) is the template for protein biosynthesis and emerging as an essential active molecule to combat various diseases, including viral infection cancer. Especially, mRNA-based vaccines, a new type of vaccine, have played leading role in fighting against current global pandemic COVID-19. However, inherent drawbacks, large size, negative charge, instability, hinder its use therapeutic agent. Lipid carriers are distinguishable promising vehicles mRNA delivery, owning capacity encapsulate deliver negatively charged drugs targeted tissues release cargoes at desired time. Here, we first summarized structure properties different lipid carriers, such liposomes, liposome-like nanoparticles, solid lipid-polymer hybrid nanoemulsions, exosomes lipoprotein particles, their applications delivering mRNA. Then, development lipid-based formulations vaccine delivery systems was discussed highlighted. Recent advancements COVID-19 were emphasized. Finally, described our future vision perspectives this field.
Язык: Английский
Процитировано
70
Advanced Materials, Год журнала: 2022, Номер 34(38)
Опубликована: Май 18, 2022
Abstract Globally, liver cancer, which is one of the major cancers worldwide, has attracted growing attention technological researchers for its high mortality and limited treatment options. Hydrogels are soft 3D network materials containing a large number hydrophilic monomers. By adding moieties such as nitrobenzyl groups to structure cross‐linked nanocomposite hydrogel, click reaction improves drug‐release efficiency in vivo, survival rate prolongs time cancer patients. The application hydrogel drug delivery system can not only enrich concentration at tumor site long but also effectively prevents distant metastasis residual cells. At present, researches have been working toward construction responsive systems, there few comprehensive articles systematically summarize these discoveries. Here, this systematic review summarizes synthesis methods related applications hydrogels with actions external or internal physiological stimuli. With different physical chemical stimuli, structural unit rearrangement controlled release drugs be used states.
Язык: Английский
Процитировано
56
Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 198, С. 114874 - 114874
Опубликована: Май 19, 2023
Язык: Английский
Процитировано
32
Journal of Controlled Release, Год журнала: 2023, Номер 362, С. 728 - 754
Опубликована: Сен. 21, 2023
Язык: Английский
Процитировано
32
Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 200, С. 115007 - 115007
Опубликована: Июль 16, 2023
Язык: Английский
Процитировано
28
Polymers, Год журнала: 2023, Номер 15(21), С. 4327 - 4327
Опубликована: Ноя. 5, 2023
In recent years, there has been a growing interest in the use of gelatin nanoparticles (GNPs) for treatment infectious diseases. The inherent properties these make them attractive options drug delivery. Their biocompatibility ensures that they can interact with biological systems without causing adverse reactions, while their biodegradability break down harmlessly body once function is performed. Furthermore, capacity controlled release therapeutic agents be delivered over sustained period, thereby enhancing efficacy. This review examines current landscape GNP-based delivery, specific focus on its potential applications and challenges context Key include controlling rates, ensuring nanoparticle stability under physiological conditions, scaling up production maintaining quality, mitigating immunogenic optimizing loading efficiency, tracking biodistribution clearance GNPs body. Despite hurdles, hold promising realm disease treatment. Ongoing research innovation are essential to overcome obstacles completely harness clinical applications.
Язык: Английский
Процитировано
27