Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(20)
Published: May 7, 2023
Abstract
Liposomes
have
received
tremendous
attention
as
a
class
of
versatile
pharmaceutical
vehicles
great
potential
over
the
past
several
decades.
However,
application
liposomes
encounters
major
challenges
due
to
knowledge
gaps
in
their
vivo
delivery
process.
Immunoglobulin
M
(IgM)
displays
both
pervasiveness
and
complexity
regulating
biological
functions
well
eliciting
adverse
effects
liposomes.
Understanding,
mitigating,
exploiting
duality
IgM
are
prerequisites
for
achieving
various
biomedical
applications
In
this
review,
intricate
relationship
between
environments
has
been
summarized,
with
an
emphasis
on
regulatory
performance
Corresponding
solutions
also
discussed
evade
IgM‐mediated
opsonization
safe
efficient
drug
delivery.
Acta Pharmaceutica Sinica B,
Journal Year:
2021,
Volume and Issue:
12(2), P. 600 - 620
Published: Aug. 12, 2021
The
use
of
small
interfering
RNAs
(siRNAs)
has
been
under
investigation
for
the
treatment
several
unmet
medical
needs,
including
acute
lung
injury/acute
respiratory
distress
syndrome
(ALI/ARDS)
wherein
siRNA
may
be
implemented
to
modify
expression
pro-inflammatory
cytokines
and
chemokines
at
mRNA
level.
properties
such
as
clear
anatomy,
accessibility,
relatively
low
enzyme
activity
make
a
good
target
local
therapy.
However,
translation
is
restricted
by
inefficient
delivery
therapeutics
cells
due
naked
siRNA.
Thus,
this
review
will
focus
on
various
systems
that
can
used
different
barriers
need
surmounted
development
stable
inhalable
formulations
human
before
ALI/ARDS
become
available
in
clinic.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(3), P. 774 - 774
Published: Feb. 26, 2023
Nanomedicine
is
a
branch
of
medicine
using
nanotechnology
to
prevent
and
treat
diseases.
Nanotechnology
represents
one
the
most
effective
approaches
in
elevating
drug‘s
treatment
efficacy
reducing
toxicity
by
improving
drug
solubility,
altering
biodistribution,
controlling
release.
The
development
materials
has
brought
profound
revolution
medicine,
significantly
affecting
various
major
diseases
such
as
cancer,
injection,
cardiovascular
experienced
explosive
growth
past
few
years.
Although
clinical
transition
nanomedicine
not
very
satisfactory,
traditional
drugs
still
occupy
dominant
position
formulation
development,
but
increasingly
active
have
adopted
nanoscale
forms
limit
side
effects
improve
efficacy.
review
summarized
approved
nanomedicine,
its
indications,
properties
commonly
used
nanocarriers
nanotechnology.
Discover Nano,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Oct. 4, 2024
Nanomedicine
has
the
potential
to
transform
healthcare
by
offering
targeted
therapies,
precise
diagnostics,
and
enhanced
drug
delivery
systems.
The
National
Institutes
of
Health
coined
term
"nanomedicine"
describe
use
nanotechnology
in
biological
system
monitoring,
control,
diagnosis,
treatment.
continues
receive
increasing
interest
for
rationalized
therapeutics
pharmaceutical
agents
achieve
required
response
while
reducing
its
side
effects.
However,
as
advance,
concerns
about
toxicological
effects
have
also
grown.
This
review
explores
current
state
nanomedicine,
focusing
on
types
nanoparticles
used
their
associated
properties
that
contribute
nanotoxicity.
It
examines
mechanisms
through
which
exert
toxicity,
encompassing
various
cellular
molecular
interactions.
Furthermore,
it
discusses
assessment
methods
employed
evaluate
nanotoxicity,
in-vitro
in-vivo
models,
well
emerging
techniques.
addresses
regulatory
issues
surrounding
nanotoxicology,
highlighting
challenges
developing
standardized
guidelines
ensuring
secure
translation
nanomedicine
into
clinical
settings.
ethical
with
understanding
safety
profile
is
essential
effective
therapeutic
applications.
Acta Pharmaceutica Sinica B,
Journal Year:
2022,
Volume and Issue:
13(10), P. 4105 - 4126
Published: Nov. 30, 2022
Messenger
RNA
(mRNA)
is
the
template
for
protein
biosynthesis
and
emerging
as
an
essential
active
molecule
to
combat
various
diseases,
including
viral
infection
cancer.
Especially,
mRNA-based
vaccines,
a
new
type
of
vaccine,
have
played
leading
role
in
fighting
against
current
global
pandemic
COVID-19.
However,
inherent
drawbacks,
large
size,
negative
charge,
instability,
hinder
its
use
therapeutic
agent.
Lipid
carriers
are
distinguishable
promising
vehicles
mRNA
delivery,
owning
capacity
encapsulate
deliver
negatively
charged
drugs
targeted
tissues
release
cargoes
at
desired
time.
Here,
we
first
summarized
structure
properties
different
lipid
carriers,
such
liposomes,
liposome-like
nanoparticles,
solid
lipid-polymer
hybrid
nanoemulsions,
exosomes
lipoprotein
particles,
their
applications
delivering
mRNA.
Then,
development
lipid-based
formulations
vaccine
delivery
systems
was
discussed
highlighted.
Recent
advancements
COVID-19
were
emphasized.
Finally,
described
our
future
vision
perspectives
this
field.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
34(38)
Published: May 18, 2022
Abstract
Globally,
liver
cancer,
which
is
one
of
the
major
cancers
worldwide,
has
attracted
growing
attention
technological
researchers
for
its
high
mortality
and
limited
treatment
options.
Hydrogels
are
soft
3D
network
materials
containing
a
large
number
hydrophilic
monomers.
By
adding
moieties
such
as
nitrobenzyl
groups
to
structure
cross‐linked
nanocomposite
hydrogel,
click
reaction
improves
drug‐release
efficiency
in
vivo,
survival
rate
prolongs
time
cancer
patients.
The
application
hydrogel
drug
delivery
system
can
not
only
enrich
concentration
at
tumor
site
long
but
also
effectively
prevents
distant
metastasis
residual
cells.
At
present,
researches
have
been
working
toward
construction
responsive
systems,
there
few
comprehensive
articles
systematically
summarize
these
discoveries.
Here,
this
systematic
review
summarizes
synthesis
methods
related
applications
hydrogels
with
actions
external
or
internal
physiological
stimuli.
With
different
physical
chemical
stimuli,
structural
unit
rearrangement
controlled
release
drugs
be
used
states.
Polymers,
Journal Year:
2023,
Volume and Issue:
15(21), P. 4327 - 4327
Published: Nov. 5, 2023
In
recent
years,
there
has
been
a
growing
interest
in
the
use
of
gelatin
nanoparticles
(GNPs)
for
treatment
infectious
diseases.
The
inherent
properties
these
make
them
attractive
options
drug
delivery.
Their
biocompatibility
ensures
that
they
can
interact
with
biological
systems
without
causing
adverse
reactions,
while
their
biodegradability
break
down
harmlessly
body
once
function
is
performed.
Furthermore,
capacity
controlled
release
therapeutic
agents
be
delivered
over
sustained
period,
thereby
enhancing
efficacy.
This
review
examines
current
landscape
GNP-based
delivery,
specific
focus
on
its
potential
applications
and
challenges
context
Key
include
controlling
rates,
ensuring
nanoparticle
stability
under
physiological
conditions,
scaling
up
production
maintaining
quality,
mitigating
immunogenic
optimizing
loading
efficiency,
tracking
biodistribution
clearance
GNPs
body.
Despite
hurdles,
hold
promising
realm
disease
treatment.
Ongoing
research
innovation
are
essential
to
overcome
obstacles
completely
harness
clinical
applications.
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
14(11), P. 4683 - 4716
Published: Sept. 2, 2024
About
40%
of
approved
drugs
and
nearly
90%
drug
candidates
are
poorly
water-soluble
drugs.
Low
solubility
reduces
the
drugability.
Effectively
improving
bioavailability
is
a
critical
issue
that
needs
to
be
urgently
addressed
in
development
application.
This
review
briefly
introduces
conventional
solubilization
techniques
such
as
solubilizers,
hydrotropes,
cosolvents,
prodrugs,
salt
modification,
micronization,
cyclodextrin
inclusion,
solid
dispersions,
details
crystallization
strategies,
ionic
liquids,
polymer-based,
lipid-based,
inorganic-based
carriers
bioavailability.
Some
most
commonly
used
carrier
materials
for
presented.
Several
using
summarized.
Furthermore,
this
summarizes
mechanism
each
technique,
reviews
latest
research
advances
challenges,
evaluates
potential
clinical
translation.
could
guide
selection
approach,
dosage
form,
administration
route
Moreover,
we
discuss
several
promising
attracting
increasing
attention
worldwide.
