Comparison of In Vitro and In Vivo Antioxidant Activities of Six Flavonoids with Similar Structures DOI Creative Commons

Yixiu Zeng,

Jiajia Song, Meimei Zhang

и другие.

Antioxidants, Год журнала: 2020, Номер 9(8), С. 732 - 732

Опубликована: Авг. 11, 2020

The in vitro and vivo antioxidant activities of six flavonoids with similar structures, including epicatechin (EC), epigallocatechin (EGC), procyanidin B2 (P), quercetin (Q), taxifolin (T), rutin (R) were compared. structures the their scavenging for 2,2-diphenyl-1-picrylhydrazyl (DPPH•) 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS+) radicals closely related. decreased serum contents malondialdehyde (MDA) nitric oxide (NO), increased total antioxidative capacity (T-AOC), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) levels to different degrees d-galactose-treated mice. changes mRNA expression liver GSH-Px1, CAT, SOD1, SOD2 by d-galactose dissimilarly restored flavonoids. Moreover, differentially prevented inflammatory response caused oxidative stress inhibiting interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α levels, restoring IL-10 levels. These from two subclasses revealed following capability: P > EC, EGC Q T, R. Our results indicate that (1) pyrogallol, dimerization, C2=C3 double bonds enhanced activity (2) C3 glycosylation attenuated capacity.

Язык: Английский

Association between composite dietary antioxidant index and handgrip strength in American adults: Data from National Health and Nutrition Examination Survey (NHANES, 2011-2014) DOI Creative Commons
Dongzhe Wu, Hao Wang, Wendi Wang

и другие.

Frontiers in Nutrition, Год журнала: 2023, Номер 10

Опубликована: Март 31, 2023

The Composite Dietary Antioxidant Index (CDAI), a composite score of multiple dietary antioxidants (including vitamin A, C, and E, selenium, zinc, carotenoids), represents an individual's comprehensive antioxidant intake profile. CDAI was developed based on its combined effect pro-inflammatory markers Tumor Necrosis Factor-α (TNF-α) anti-inflammatory effects Interleukin-1β (IL-1β), which are associated with many health outcomes, including depression, all-cause mortality, colorectal cancer, etc. Handgrip strength is used as simple measure muscle strength, not only it highly correlated overall but also serves diagnostic tool for adverse sarcopenia frailty syndromes.

Язык: Английский

Процитировано

46

Antioxidant Metabolism Pathways in Vitamins, Polyphenols, and Selenium: Parallels and Divergences DOI Open Access
Celia María Curieses Andrés, José Manuel Pérez de la Lastra, Celia Andrés

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 2600 - 2600

Опубликована: Фев. 23, 2024

Free radicals (FRs) are unstable molecules that cause reactive stress (RS), an imbalance between oxygen and nitrogen species in the body its ability to neutralize them. These generated by both internal external factors can damage cellular lipids, proteins, DNA. Antioxidants prevent or slow down oxidation process interrupting transfer of electrons substances agents. This is particularly important at level because reactions lead formation FR contribute various diseases. As we age, RS accumulates leads organ dysfunction age-related disorders. Polyphenols; vitamins A, C, E; selenoproteins possess antioxidant properties may have a role preventing treating certain human diseases associated with RS. In this review, explore current evidence on potential benefits dietary supplementation investigate intricate connection SIRT1, crucial regulator aging longevity; transcription factor NRF2; polyphenols, vitamins, selenium. Finally, discuss positive effects molecules, such as reducing RS, their slowing several

Язык: Английский

Процитировано

36

Progress in chitin/chitosan and their derivatives for biomedical applications: Where we stand DOI

Lanxin Mu,

Liqin Wu, Shuangquan Wu

и другие.

Carbohydrate Polymers, Год журнала: 2024, Номер 343, С. 122233 - 122233

Опубликована: Май 4, 2024

Язык: Английский

Процитировано

25

Preparation, characterization and antioxidant activity of protocatechuic acid grafted carboxymethyl chitosan and its hydrogel DOI
Chao Xu, Shui Guan, Jianqiang Xu

и другие.

Carbohydrate Polymers, Год журнала: 2020, Номер 252, С. 117210 - 117210

Опубликована: Окт. 13, 2020

Язык: Английский

Процитировано

136

Comparison of In Vitro and In Vivo Antioxidant Activities of Six Flavonoids with Similar Structures DOI Creative Commons

Yixiu Zeng,

Jiajia Song, Meimei Zhang

и другие.

Antioxidants, Год журнала: 2020, Номер 9(8), С. 732 - 732

Опубликована: Авг. 11, 2020

The in vitro and vivo antioxidant activities of six flavonoids with similar structures, including epicatechin (EC), epigallocatechin (EGC), procyanidin B2 (P), quercetin (Q), taxifolin (T), rutin (R) were compared. structures the their scavenging for 2,2-diphenyl-1-picrylhydrazyl (DPPH•) 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS+) radicals closely related. decreased serum contents malondialdehyde (MDA) nitric oxide (NO), increased total antioxidative capacity (T-AOC), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) levels to different degrees d-galactose-treated mice. changes mRNA expression liver GSH-Px1, CAT, SOD1, SOD2 by d-galactose dissimilarly restored flavonoids. Moreover, differentially prevented inflammatory response caused oxidative stress inhibiting interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α levels, restoring IL-10 levels. These from two subclasses revealed following capability: P > EC, EGC Q T, R. Our results indicate that (1) pyrogallol, dimerization, C2=C3 double bonds enhanced activity (2) C3 glycosylation attenuated capacity.

Язык: Английский

Процитировано

117