Comparison of In Vitro and In Vivo Antioxidant Activities of Six Flavonoids with Similar Structures DOI Creative Commons

Yixiu Zeng,

Jiajia Song, Meimei Zhang

et al.

Antioxidants, Journal Year: 2020, Volume and Issue: 9(8), P. 732 - 732

Published: Aug. 11, 2020

The in vitro and vivo antioxidant activities of six flavonoids with similar structures, including epicatechin (EC), epigallocatechin (EGC), procyanidin B2 (P), quercetin (Q), taxifolin (T), rutin (R) were compared. structures the their scavenging for 2,2-diphenyl-1-picrylhydrazyl (DPPH•) 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS+) radicals closely related. decreased serum contents malondialdehyde (MDA) nitric oxide (NO), increased total antioxidative capacity (T-AOC), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) levels to different degrees d-galactose-treated mice. changes mRNA expression liver GSH-Px1, CAT, SOD1, SOD2 by d-galactose dissimilarly restored flavonoids. Moreover, differentially prevented inflammatory response caused oxidative stress inhibiting interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α levels, restoring IL-10 levels. These from two subclasses revealed following capability: P > EC, EGC Q T, R. Our results indicate that (1) pyrogallol, dimerization, C2=C3 double bonds enhanced activity (2) C3 glycosylation attenuated capacity.

Language: Английский

Association between composite dietary antioxidant index and handgrip strength in American adults: Data from National Health and Nutrition Examination Survey (NHANES, 2011-2014) DOI Creative Commons
Dongzhe Wu, Hao Wang, Wendi Wang

et al.

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: March 31, 2023

The Composite Dietary Antioxidant Index (CDAI), a composite score of multiple dietary antioxidants (including vitamin A, C, and E, selenium, zinc, carotenoids), represents an individual's comprehensive antioxidant intake profile. CDAI was developed based on its combined effect pro-inflammatory markers Tumor Necrosis Factor-α (TNF-α) anti-inflammatory effects Interleukin-1β (IL-1β), which are associated with many health outcomes, including depression, all-cause mortality, colorectal cancer, etc. Handgrip strength is used as simple measure muscle strength, not only it highly correlated overall but also serves diagnostic tool for adverse sarcopenia frailty syndromes.

Language: Английский

Citations

46
Antioxidant Metabolism Pathways in Vitamins, Polyphenols, and Selenium: Parallels and Divergences DOI Open Access
Celia María Curieses Andrés, José Manuel Pérez de la Lastra, Celia Andrés

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2600 - 2600

Published: Feb. 23, 2024

Free radicals (FRs) are unstable molecules that cause reactive stress (RS), an imbalance between oxygen and nitrogen species in the body its ability to neutralize them. These generated by both internal external factors can damage cellular lipids, proteins, DNA. Antioxidants prevent or slow down oxidation process interrupting transfer of electrons substances agents. This is particularly important at level because reactions lead formation FR contribute various diseases. As we age, RS accumulates leads organ dysfunction age-related disorders. Polyphenols; vitamins A, C, E; selenoproteins possess antioxidant properties may have a role preventing treating certain human diseases associated with RS. In this review, explore current evidence on potential benefits dietary supplementation investigate intricate connection SIRT1, crucial regulator aging longevity; transcription factor NRF2; polyphenols, vitamins, selenium. Finally, discuss positive effects molecules, such as reducing RS, their slowing several

Language: Английский

Citations

36
Progress in chitin/chitosan and their derivatives for biomedical applications: Where we stand DOI

Lanxin Mu,

Liqin Wu, Shuangquan Wu

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 343, P. 122233 - 122233

Published: May 4, 2024

Language: Английский

Citations

25
Preparation, characterization and antioxidant activity of protocatechuic acid grafted carboxymethyl chitosan and its hydrogel DOI
Chao Xu, Shui Guan, Jianqiang Xu

et al.

Carbohydrate Polymers, Journal Year: 2020, Volume and Issue: 252, P. 117210 - 117210

Published: Oct. 13, 2020

Language: Английский

Citations

136
Comparison of In Vitro and In Vivo Antioxidant Activities of Six Flavonoids with Similar Structures DOI Creative Commons

Yixiu Zeng,

Jiajia Song, Meimei Zhang

et al.

Antioxidants, Journal Year: 2020, Volume and Issue: 9(8), P. 732 - 732

Published: Aug. 11, 2020

The in vitro and vivo antioxidant activities of six flavonoids with similar structures, including epicatechin (EC), epigallocatechin (EGC), procyanidin B2 (P), quercetin (Q), taxifolin (T), rutin (R) were compared. structures the their scavenging for 2,2-diphenyl-1-picrylhydrazyl (DPPH•) 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS+) radicals closely related. decreased serum contents malondialdehyde (MDA) nitric oxide (NO), increased total antioxidative capacity (T-AOC), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) levels to different degrees d-galactose-treated mice. changes mRNA expression liver GSH-Px1, CAT, SOD1, SOD2 by d-galactose dissimilarly restored flavonoids. Moreover, differentially prevented inflammatory response caused oxidative stress inhibiting interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α levels, restoring IL-10 levels. These from two subclasses revealed following capability: P > EC, EGC Q T, R. Our results indicate that (1) pyrogallol, dimerization, C2=C3 double bonds enhanced activity (2) C3 glycosylation attenuated capacity.

Language: Английский

Citations

117