Plant flavonoids: Classification, distribution, biosynthesis, and antioxidant activity

Food Chemistry, Год журнала: 2022, Номер 383, С. 132531 - 132531

Опубликована: Фев. 23, 2022

Язык: Английский

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The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice

Nature Metabolism, Год журнала: 2021, Номер 3(12), С. 1706 - 1726

Опубликована: Дек. 6, 2021

Abstract Ageing-associated functional decline of organs and increased risk for age-related chronic pathologies is driven in part by the accumulation senescent cells, which develop senescence-associated secretory phenotype (SASP). Here we show that procyanidin C1 (PCC1), a polyphenolic component grape seed extract (GSE), increases healthspan lifespan mice through its action on cells. By screening library natural products, find GSE, PCC1 as one active components, have specific effects At low concentrations, appears to inhibit SASP formation, whereas it selectively kills cells at higher possibly promoting production reactive oxygen species mitochondrial dysfunction. In rodent models, depletes treatment-damaged tumour microenvironment enhances therapeutic efficacy when co-administered with chemotherapy. Intermittent administration either irradiated, cell-implanted or naturally aged old alleviates physical dysfunction prolongs survival. We identify senotherapeutic agent vivo activity high potential further development clinical intervention delay, alleviate prevent pathologies.

Язык: Английский

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The Role of Oxidative Stress and Natural Antioxidants in Ovarian Aging

Frontiers in Pharmacology, Год журнала: 2021, Номер 11

Опубликована: Янв. 14, 2021

The ovarian system comprises vital organs in females and is of great significance for the maintenance reproductive potential endocrine stability. Although complex pathogenesis undoubtedly contributes to aging, increasing attention being paid extensive influence oxidative stress. However, role stress aging yet be fully elucidated. Exploring stress-related processes might a promising strategy against aging. In this review, compelling evidence shown that plays etiology promotes development other aging-related etiologies, including telomere shortening, mitochondrial dysfunction, apoptosis, inflammation. addition, some natural antioxidants such as quercetin, resveratrol, curcumin have protective ovaries through multiple mechanisms. These findings raise prospect modulator-natural therapeutic interventions delaying

Язык: Английский

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A Comparative Study of Hesperetin, Hesperidin and Hesperidin Glucoside: Antioxidant, Anti-Inflammatory, and Antibacterial Activities In Vitro

Antioxidants, Год журнала: 2022, Номер 11(8), С. 1618 - 1618

Опубликована: Авг. 20, 2022

The antioxidant, anti-inflammatory and antibacterial activities of hesperetin, hesperidin glucoside with different solubility were compared in vitro. Hesperetin was prepared by enzymatic hydrolysis from hesperidin, composed mono-glucoside through transglycosylation. Solubility the compounds different: partition coefficient (log P) 2.85 ± 0.02 for 2.01 -3.04 0.03 glucoside. showed a higher effect than on radical scavenging activity antioxidant assays, while similar activity. Cytotoxicity low order glucoside, hesperetin murine macrophage RAW264.7 cells. Treatment cells each compound reduced levels inflammatory mediators, nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-α) interleukin-6 (IL-6). most effective at relatively concentrations, however, also concentration. both Gram-positive -negative bacteria, similarly depending bacterial strain. In conclusion, form aglycone more potent biological However, highly soluble form, has been shown to increase poorly hesperidin.

Язык: Английский

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Comparison of Flavonoid O-Glycoside, C-Glycoside and Their Aglycones on Antioxidant Capacity and Metabolism during In Vitro Digestion and In Vivo

Foods, Год журнала: 2022, Номер 11(6), С. 882 - 882

Опубликована: Март 20, 2022

Flavonoids are well known for their extensive health benefits. However, few studies compared the differences between flavonoid O-glycoside and C-glycoside. In this work, (isoquercitrin), C-glycoside (orientin), aglycones (quercetin luteolin) were chosen to compare on antioxidant activities metabolism during in vitro digestion vivo. digestion, initial activity of two was very high; however, they both decreased more sharply than glycosides intestinal phase. The glycosidic bond broken gastric stage, while remained unchanged. vivo, plasma elevated activity; urine higher O-glycoside. These results indicate that closely related structural characteristics different samples. Aglycones possessed but unstable structures. On contrary, sugar substituents reduced flavonoids improving stability helping maintain after digestion. Especially stable because C-C is C-O bond, which contributes difference absorption This study provided a new perspective comparing O-glycoside, C-glycoside, structure-activity relationship metabolism.

Язык: Английский

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PDK4-dependent hypercatabolism and lactate production of senescent cells promotes cancer malignancy

Nature Metabolism, Год журнала: 2023, Номер 5(11), С. 1887 - 1910

Опубликована: Окт. 30, 2023

Abstract Senescent cells remain metabolically active, but their metabolic landscape and resulting implications underexplored. Here, we report upregulation of pyruvate dehydrogenase kinase 4 (PDK4) upon senescence, particularly in some stromal cell lines. display a PDK4-dependent increase aerobic glycolysis enhanced lactate production maintain mitochondrial respiration redox activity, thus adopting special form reprogramming. Medium from PDK4 + promotes the malignancy recipient cancer vitro, whereas inhibition causes tumor regression vivo. We find that reactive oxygen species via NOX1 to drive senescence-associated secretory phenotype, suppression reduces DNA damage severity restrains phenotype. In preclinical trials, alleviates physical dysfunction prevents age-associated frailty. Together, our study confirms hypercatabolic nature senescent reveals link between cellular production, possibly, age-related pathologies, including not limited cancer.

Язык: Английский

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An insight into novel therapeutic potentials of taxifolin

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Май 12, 2023

Taxifolin is a flavonoid compound, originally isolated from the bark of Douglas fir trees, which often found in foods such as onions and olive oil, also used commercial preparations, has attracted interest nutritionists medicinal chemists due to its broad range health-promoting effects. It powerful antioxidant with excellent antioxidant, anti-inflammatory, anti-microbial other pharmacological activities. This review focuses on breakthroughs taxifolin for treatment diseases 2019 2022 according various systems human body, nervous system, immune digestive basis this review, we summarize problems current research try suggest solutions future directions.

Язык: Английский

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Polyphenol assisted nano-reinforced chitosan films with antioxidant and antimicrobial properties

Food Hydrocolloids, Год журнала: 2024, Номер 153, С. 110010 - 110010

Опубликована: Март 19, 2024

Язык: Английский

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A Comparative Study of Rutin and Rutin Glycoside: Antioxidant Activity, Anti-Inflammatory Effect, Effect on Platelet Aggregation and Blood Coagulation

Antioxidants, Год журнала: 2021, Номер 10(11), С. 1696 - 1696

Опубликована: Окт. 27, 2021

The effects of rutin and glycoside with different solubility were compared on antioxidant activity anti-inflammatory in vitro the platelet aggregation blood coagulation vivo. Rutin (consisting mono-glucoside di-glucoside) was prepared via enzymatic transglycosylation from rutin. showed a higher effect than radical scavenging assays. toxicity murine macrophage RAW264.7 cells. They had similar levels nitric oxide (NO), prostaglandin E (PGE) 2 pro-inflammatory cytokines (such as tumor necrosis factor (TNF)-α, interleukin (IL)-6) Both glycosides similarly reduced rate to controls vitro. also delayed prothrombin time (PT) activated partial thromboplastin (APTT) an test. repeated administration evaluated vivo using SD rats. administered group significantly decreased that control group. On other hand, PT APTT not In conclusion, differences activities vitro, while they reduction NO, PGE2, TNF-α IL-6 rates, both condition. Comparing vivo, effective but only coagulation.

Язык: Английский

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A review on benefits of quercetin in hyperuricemia and gouty arthritis

Saudi Pharmaceutical Journal, Год журнала: 2022, Номер 30(7), С. 918 - 926

Опубликована: Апрель 30, 2022

Hyperuricemia becomes a public health problem worldwide. It is not only major risk factor for gout but also associated with the development of life-threatening diseases such as chronic kidney disease and cardiovascular diseases. Although there are several available therapeutic drugs, some serious adverse effects contraindications concerned. These drive search an alternative therapy that effective safe. Quercetin particular interesting since it has been reported numerous pharmacological activities, especially anti-hyperuricemia, antioxidant, anti-inflammation amelioration metabolic syndromes which comorbidities hyperuricemia gout. In addition, quercetin widely used supplement many however, use indicated. Therefore, this review aims to gather summarize published data regarding efficacy in preclinical clinical studies along possible mechanism action, safety aspect order support dietary prevention management gouty arthritis and/or or combination minimize side conventional drugs.

Язык: Английский

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