Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Дек. 16, 2022

Aging is a gradual and irreversible pathophysiological process. It presents with declines in tissue cell functions significant increases the risks of various aging-related diseases, including neurodegenerative cardiovascular metabolic musculoskeletal immune system diseases. Although development modern medicine has promoted human health greatly extended life expectancy, aging society, variety chronic diseases have gradually become most important causes disability death elderly individuals. Current research on focuses elucidating how endogenous exogenous stresses (such as genomic instability, telomere dysfunction, epigenetic alterations, loss proteostasis, compromise autophagy, mitochondrial cellular senescence, stem exhaustion, altered intercellular communication, deregulated nutrient sensing) participate regulation aging. Furthermore, thorough pathogenesis to identify interventions that promote longevity caloric restriction, microbiota transplantation, nutritional intervention) clinical treatment methods for (depletion senescent cells, therapy, antioxidative anti-inflammatory treatments, hormone replacement therapy) could decrease incidence turn healthy longevity.

Язык: Английский

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Recent Advances in the Development and Antimicrobial Applications of Metal–Phenolic Networks

Advanced Science, Год журнала: 2022, Номер 9(27)

Опубликована: Июль 25, 2022

Due to the abuse of antibiotics and emergence multidrug resistant microorganisms, medical devices, related biomaterials are at high risk microbial infection during use, placing a heavy burden on patients healthcare systems. Metal-phenolic networks (MPNs), an emerging organic-inorganic hybrid network system developed gradually in recent years, have exhibited excellent multifunctional properties such as anti-inflammatory, antioxidant, antibacterial by making use coordination between phenolic ligands metal ions. Further, MPNs received widespread attention antimicrobial infections due their facile synthesis process, biocompatibility, brought about polyphenols In this review, different categories based (nanoparticles, coatings, capsules, hydrogels) fabrication strategies summarized, research advances applications biomedical fields (e.g., skin repair, bone regeneration, etc.) highlighted.

Язык: Английский

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Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes

Free Radical Biology and Medicine, Год журнала: 2022, Номер 190, С. 234 - 246

Опубликована: Авг. 15, 2022

Iron overload is a common phenomenon in the elderly population. Many clinical studies have indicated an association between iron and incidence pathological progression of intervertebral disc degeneration (IVDD). However, role underlying mechanism by which participates IVDD has not yet been reported. In present study, we aimed to elucidate connection IVDD, explore mechanisms disease. Firstly, epidemiology study was conducted revealed that independent risk factor for human IVDD. To mouse model established, observed promoted cartilage endplate dose dependent manner. Endplate chondrocytes were further isolated treated with FAC mimic vitro. Excess significantly mineralization addition their via oxidative stress. Moreover, high excess ferroptosis. An chelator (DFO), antioxidant (NAC) ferroptosis inhibitor (Fer-1) demonstrated effective inhibition chondrocyte induced overload, our vivo DFO, NAC Fer-1 could rescue iron-induced calcification. conclusion, results indicate strongly associated onset development stress Inhibiting or therefore be promising therapeutic strategies overload.

Язык: Английский

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Fighting age-related orthopedic diseases: focusing on ferroptosis

Bone Research, Год журнала: 2023, Номер 11(1)

Опубликована: Март 1, 2023

Abstract Ferroptosis, a unique type of cell death, is characterized by iron-dependent accumulation and lipid peroxidation. It closely related to multiple biological processes, including iron metabolism, polyunsaturated fatty acid the biosynthesis compounds with antioxidant activities, glutathione. In past 10 years, increasing evidence has indicated potentially strong relationship between ferroptosis onset progression age-related orthopedic diseases, such as osteoporosis osteoarthritis. Therefore, in-depth knowledge regulatory mechanisms in diseases may help improve disease treatment prevention. This review provides an overview recent research on its influences bone cartilage homeostasis. begins brief systemic metabolism ferroptosis, particularly potential ferroptosis. presents discussion role promotion loss degradation inhibition osteogenesis. Finally, it focuses future targeting treat intention inspiring further clinical development therapeutic strategies.

Язык: Английский

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Mitochondrial dysfunction and neurological disorders: A narrative review and treatment overview

Life Sciences, Год журнала: 2023, Номер 334, С. 122257 - 122257

Опубликована: Ноя. 8, 2023

Язык: Английский

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The mechanisms of ferroptosis and its role in atherosclerosis

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 171, С. 116112 - 116112

Опубликована: Янв. 2, 2024

Ferroptosis is a newly identified form of non-apoptotic programmed cell death, characterized by the iron-dependent accumulation lethal lipid reactive oxygen species (ROS) and peroxidation membrane polyunsaturated fatty acid phospholipids (PUFA-PLs). unique among other death modalities in many aspects. It initiated excessive oxidative damage due to iron overload compromised antioxidant defense systems, including system Xc-/ glutathione (GSH)/glutathione peroxidase 4 (GPX4) pathway GPX4-independent pathways. In past ten years, ferroptosis was reported play critical role pathogenesis various cardiovascular diseases, e.g., atherosclerosis (AS), arrhythmia, heart failure, diabetic cardiomyopathy, myocardial ischemia-reperfusion injury. Studies have dysfunctional metabolism abnormal expression profiles ferroptosis-related factors, iron, GSH, GPX4, ferroportin (FPN), SLC7A11 (xCT), as indicators for atherogenesis. Moreover, plaque cells, i.e., vascular endothelial (VEC), macrophage, smooth muscle (VSMC), positively correlate with atherosclerotic development. Many macromolecules, drugs, Chinese herbs, food extracts can inhibit atherogenic process suppressing cells. contrast, some inducers significant pro-atherogenic effects. However, mechanisms through which affects progression AS still need be well-known. This review summarizes molecular their emerging AS, aimed at providing novel, promising druggable targets anti-AS therapy.

Язык: Английский

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Iron homeostasis in older adults: balancing nutritional requirements and health risks

The journal of nutrition health & aging, Год журнала: 2024, Номер 28(5), С. 100212 - 100212

Опубликована: Март 14, 2024

Iron plays a crucial role in many physiological processes, including oxygen transport, bioenergetics, and immune function. is assimilated from food also recycled senescent red blood cells. exists two dietary forms: heme (animal based) non-heme (mostly plant based). The body uses iron for metabolic purposes, stores the excess mainly splenic hepatic macrophages. Physiologically, excretion humans inefficient not highly regulated, so regulation of intestinal absorption maintains homeostasis. losses occur at steady rate via turnover epithelium, loss, exfoliation dead skin cells, but overall homeostasis tightly controlled cellular systemic levels. Aging can have profound impact on induce dyshomeostasis where deficiency or overload (sometimes both simultaneously) occur, potentially leading to several disorders pathologies. To maintain physiologically balanced levels, reduce risk disease, promote healthy aging, it advisable older adults follow recommended daily intake guidelines periodically assess Clinicians evaluate status using different techniques selecting an assessment method primarily depends condition being examined. This review provides comprehensive overview forms, sources, metabolism iron, associated dyshomeostasis, levels adults, nutritional strategies balance adults.

Язык: Английский

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Antioxidant Systems as Modulators of Ferroptosis: Focus on Transcription Factors

Antioxidants, Год журнала: 2024, Номер 13(3), С. 298 - 298

Опубликована: Фев. 28, 2024

Ferroptosis is a type of programmed cell death that differs from apoptosis, autophagy, and necrosis related to several physio-pathological processes, including tumorigenesis, neurodegeneration, senescence, blood diseases, kidney disorders, ischemia–reperfusion injuries. linked iron accumulation, eliciting dysfunction antioxidant systems, which favor the production lipid peroxides, membrane damage, ultimately, death. Thus, signaling pathways evoking ferroptosis are strongly associated with those protecting cells against excess and/or lipid-derived ROS. Here, we discuss interaction between metabolic particular focus on transcription factors implicated in regulation ferroptosis, either as triggers peroxidation or defense pathways.

Язык: Английский

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Iron Metabolism in Aging and Age-Related Diseases

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(7), С. 3612 - 3612

Опубликована: Март 25, 2022

Iron is a trace metal element necessary to maintain life and also involved in variety of biological processes. Aging refers the natural process which physiological functions various systems, organs, tissues decline, affected by genetic environmental factors. Therefore, it imperative investigate relationship between iron metabolism aging-related diseases, including neurodegenerative diseases. During aging, accumulation nonheme destroys stability intracellular environment. The destruction homeostasis can induce cell damage producing hydroxyl free radicals, leading mitochondrial dysfunction, brain even organismal aging. In this review, we have briefly summarized role metabolic body, then discussed recent developments aging age-related finally, explored some chelators as treatment strategies for those disorders. Understanding roles diseases will fill knowledge gap field. This review could provide new insights into research on

Язык: Английский

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Defective NCOA4-dependent ferroptosis in senescent fibroblasts retards diabetic wound healing

Cell Death Discovery, Год журнала: 2023, Номер 9(1)

Опубликована: Апрель 28, 2023

Cellular senescence describes a state of permanent proliferative arrest in cells. Studies have demonstrated that diabetes promotes the pathological accumulation senescent cells, which turn impairs cell movement and proliferation. Historically, has been perceived to be detrimental consequence chronic wound healing. However, underlying mechanism causes cells remain diabetic wounds is yet elucidated. Ferroptosis ferritinophagy observed are due iron metabolism disorders, directly associated with initiation progression diabetes. Herein, we reveal fibroblasts resistant ferroptosis impaired may contributing cause. Further, expression NCOA4, key factor influences ferritinophagy, decreased both tissue high glucose-induced fibroblasts. Moreover, NCOA4 overexpression could render more vulnerable ferroptosis. A faster healing process was also linked induction Thus, resistance impedes removal fibroblasts; promoting reverse this process, significant implications for management wounds.

Язык: Английский

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