Versatility of Caenorhabditis elegans as a Model Organism for Evaluating Foodborne Neurotoxins and Food Bioactive Compounds in Nutritional Neuroscience

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 25, 2025

Язык: Английский

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The Link between Oxidative Stress, Mitochondrial Dysfunction and Neuroinflammation in the Pathophysiology of Alzheimer’s Disease: Therapeutic Implications and Future Perspectives

Antioxidants, Год журнала: 2022, Номер 11(11), С. 2167 - 2167

Опубликована: Окт. 31, 2022

Alzheimer’s disease (AD), the most common form of dementia, has increasing incidence, mortality rates, and poses a huge burden on healthcare. None currently approved drugs for treatment AD influence progression. Many clinical trials aiming at inhibiting amyloid plaque formation, beta clearance, or neurofibrillary tangle pathology yielded inconclusive results failed. Meanwhile, research identified many interlinked vicious cascades implicating oxidative stress, mitochondrial dysfunction, chronic neuroinflammation, pointed to novel therapeutic targets such as improving bioenergetics quality control, diminishing modulating neuroinflammatory pathways. molecules tested in vitro animal models have proven efficient, but their translation into clinic needs further regarding appropriate doses, delivery routes, possible side effects. Cell-based therapies extracellular vesicle-mediated messenger RNAs microRNAs seem also promising strategies allowing target specific signaling pathways, need harvesting culture methods well control tumorigenic The rapidly developing area nanotechnology could improve drug be used early diagnosis.

Язык: Английский

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Alzheimer’s disease: the role of extrinsic factors in its development, an investigation of the environmental enigma

Frontiers in Neurology, Год журнала: 2023, Номер 14

Опубликована: Дек. 6, 2023

In the realm of Alzheimer's disease, most prevalent form dementia, impact environmental factors has ignited intense curiosity due to its substantial burden on global health. Recent investigations have unveiled these as key contributors, shedding new light their profound influence. Notably, emerging evidence highlights detrimental role various contaminants in incidence and progression disease. These encompass a broad spectrum, including air pollutants laden with ozone, neurotoxic metals like lead, aluminum, manganese, cadmium, pesticides insidious effects, ubiquitous presence plastics microplastics. By meticulously delving into intricate web connecting this devastating neurological disorder, comprehensive chapter takes deep dive involvement significant risk for Furthermore, it explores underlying molecular mechanisms through which exert influence, aiming unravel complex interactions that drive pathogenesis Additionally, proposes potential strategies mitigate effects brain health, ultimate goal restoring preserving typical cognitive function. Through exploration, we aim enhance our understanding multifaceted relationship between neurotoxins providing solid foundation developing innovative in-vivo models advancing knowledge pathological processes debilitating condition.

Язык: Английский

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Non-Enzymatic Antioxidants against Alzheimer’s Disease: Prevention, Diagnosis and Therapy

Antioxidants, Год журнала: 2023, Номер 12(1), С. 180 - 180

Опубликована: Янв. 12, 2023

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive memory loss and cognitive decline. Although substantial research has been conducted to elucidate the complex pathophysiology of AD, therapeutic approach still limited efficacy in clinical practice. Oxidative stress (OS) established as an early driver several age-related diseases, including neurodegeneration. In increased levels reactive oxygen species mediate neuronal lipid, protein, nucleic acid peroxidation, mitochondrial dysfunction, synaptic damage, inflammation. Thus, identification novel antioxidant molecules capable detecting, preventing, counteracting AD onset progression utmost importance. However, although studies have published, comprehensive up-to-date overviews principal anti-AD agents harboring properties remain scarce. this narrative review, we summarize role vitamins, minerals, flavonoids, non-flavonoids, mitochondria-targeting molecules, organosulfur compounds, carotenoids non-enzymatic antioxidants with diagnostic, preventative, potential, thereby offering insights into relationship between OS

Язык: Английский

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Pharmacodynamics, pharmacokinetics, and cell signaling pathways of pomegranate peel extract

Phytochemistry Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

Язык: Английский

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Bisphenol A exposure links to exacerbation of memory and cognitive impairment: A systematic review of the literature

Neuroscience & Biobehavioral Reviews, Год журнала: 2022, Номер 143, С. 104939 - 104939

Опубликована: Ноя. 1, 2022

Язык: Английский

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A Comprehensive Review of the Pharmacological Importance of Dietary Flavonoids as Hepatoprotective Agents

Evidence-based Complementary and Alternative Medicine, Год журнала: 2023, Номер 2023(1)

Опубликована: Янв. 1, 2023

The liver is a crucial organ that involved in various kinds of metabolic activity and very stable accessory gland for the digestive system. Long‐term or persistent inflammation oxidative stress due to any reasons have substantial impact on beginning continuation chronic diseases such as hepatocellular carcinoma, cirrhosis, fibrosis, other hepatic conditions. There are many sources which can help be healthy enhance its potential liver. Since diet rich origin bioactive along with antioxidant chemicals including flavonoids polyphenols, it control different stages diseases. Numerous food sources, notably vegetables, nuts, fruits, cereals, beverages, herbal medicinal plants, called their derivatives like Flavones, Anthocyanins, Iso‐flavonoid, Flavanones, Flavanols, Flavan‐3‐ols. Most recently occurred research has demonstrated they regulate hepatoprotective properties. This because essential parts pharmaceutical nutraceutical products hepatoprotective, antioxidative, immune‐modulating characteristics. However, characteristics remain unclear. purpose this comprehensive review survey flavonoid structure enriched effects concerning toxicity injury.

Язык: Английский

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Ozone-induced neurotoxicity: In vitro and in vivo evidence

Ageing Research Reviews, Год журнала: 2023, Номер 91, С. 102045 - 102045

Опубликована: Авг. 29, 2023

Язык: Английский

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Cyanidin-3-O-glucoside protects the brain and improves cognitive function in APPswe/PS1ΔE9 transgenic mice model

Journal of Neuroinflammation, Год журнала: 2023, Номер 20(1)

Опубликована: Ноя. 17, 2023

Abstract Cyanidin-3-O-glucoside (C3G) is a natural anthocyanin with antioxidant, anti-inflammatory, and antitumor properties. However, as the effects of C3G on amyloidogenic pathway, autophagy, tau phosphorylation, neuronal cell death, synaptic plasticity in Alzheimer’s disease models have not been reported, we attempted to investigate same brains APPswe/PS1ΔE9 mice were analyzed. After oral administration (30 mg/kg/day) for 16 weeks, cortical hippocampal regions treatment reduced levels soluble insoluble Aβ (Aβ40 Aβ42) peptides protein expression amyloid precursor protein, presenilin-1, β-secretase regions. And upregulated autophagy-related markers, LC3B-II, LAMP-1, TFEB, PPAR-α downregulated that SQSTM1/p62, improving autophagy plaques neurofibrillary tangles. In addition, increased phosphorylated-AMPK/AMPK Sirtuin 1 decreased mitogen-activated kinases, such phosphorylated-Akt/Akt phosphorylated-ERK/ERK, thus demonstrating its neuroprotective effects. Furthermore, regulated PI3K/Akt/GSK3β signaling by upregulating phosphorylated-GSK3β/GSK3β expression. mitigated phosphorylation improved function synapse-associated proteins synaptophysin postsynaptic density protein-95. Although potential mouse has yet shown protect brain improve cognitive behavior. Graphical

Язык: Английский

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Dietary Sources, Stabilization, Health Benefits, and Industrial Application of Anthocyanins—A Review

Foods, Год журнала: 2024, Номер 13(8), С. 1227 - 1227

Опубликована: Апрель 17, 2024

Natural phytochemicals are well known to protect against numerous metabolic disorders. Anthocyanins vacuolar pigments belonging the parent class of flavonoids. They for their potent antioxidant and gut microbiome-modulating properties, primarily responsible minimizing risk cardiovascular diseases, diabetes, obesity, neurodegenerative cancer, several other diseases associated with syndromes. Berries primary source anthocyanin in diet. The color stability anthocyanins substantially influenced by external environmental conditions, constraining applications foods. Furthermore, significantly low bioavailability greatly diminishes extent actual health benefits linked these bioactive compounds. Multiple strategies have been successfully developed utilized enhance anthocyanins. This review provides a comprehensive view recent advancements chemistry, biosynthesis, dietary sources, stabilization, bioavailability, industrial applications, Finally, we summarize prospects challenges

Язык: Английский

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