Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(5), P. 535 - 535
Published: April 29, 2025
Peach,
apricot,
chokeberry,
blueberry,
cranberry,
raspberry,
and
wild
strawberry
fruits
were
used
to
create
a
polyphenolic
preparation
(PP)
after
enzyme-assisted
extraction,
ultrafiltration,
concentration.
The
composition
of
PP
was
determined
using
LC-MS.
Gelatin
jellies
produced
with
PP,
as
well
liquid
“digested”
in
an
vitro
model.
entrapment
the
gelatin
matrix
delayed
release
total
polyphenolics,
flavonoids,
flavanols,
condensed
tannins,
anthocyanins
(predominantly
during
“small
intestinal”
phase).
entrapped
jelly
more
effectively
(p
<
0.05)
decreased
activity
acetylcholinesterase,
butyrylcholinesterase,
cyclooxygenase-2
catalase
(during
However,
no
significant
effects
on
superoxide
dismutase,
glutathione
peroxidase,
reductase
activities
observed.
FRAP,
CUPRAC,
HORAC,
oxidation
linoleic
acid,
ABTS-reducing
higher
“intestinal”
phase;
however,
DPPH
test
β-carotene
bleaching
tests
did
not
confirm
these
results.
presented
findings
may
be
useful
for
designing
nutraceuticals
programmed
bioactive
compounds
digestion.
Antioxidants,
Journal Year:
2022,
Volume and Issue:
11(11), P. 2167 - 2167
Published: Oct. 31, 2022
Alzheimer’s
disease
(AD),
the
most
common
form
of
dementia,
has
increasing
incidence,
mortality
rates,
and
poses
a
huge
burden
on
healthcare.
None
currently
approved
drugs
for
treatment
AD
influence
progression.
Many
clinical
trials
aiming
at
inhibiting
amyloid
plaque
formation,
beta
clearance,
or
neurofibrillary
tangle
pathology
yielded
inconclusive
results
failed.
Meanwhile,
research
identified
many
interlinked
vicious
cascades
implicating
oxidative
stress,
mitochondrial
dysfunction,
chronic
neuroinflammation,
pointed
to
novel
therapeutic
targets
such
as
improving
bioenergetics
quality
control,
diminishing
modulating
neuroinflammatory
pathways.
molecules
tested
in
vitro
animal
models
have
proven
efficient,
but
their
translation
into
clinic
needs
further
regarding
appropriate
doses,
delivery
routes,
possible
side
effects.
Cell-based
therapies
extracellular
vesicle-mediated
messenger
RNAs
microRNAs
seem
also
promising
strategies
allowing
target
specific
signaling
pathways,
need
harvesting
culture
methods
well
control
tumorigenic
The
rapidly
developing
area
nanotechnology
could
improve
drug
be
used
early
diagnosis.
Frontiers in Neurology,
Journal Year:
2023,
Volume and Issue:
14
Published: Dec. 6, 2023
In
the
realm
of
Alzheimer's
disease,
most
prevalent
form
dementia,
impact
environmental
factors
has
ignited
intense
curiosity
due
to
its
substantial
burden
on
global
health.
Recent
investigations
have
unveiled
these
as
key
contributors,
shedding
new
light
their
profound
influence.
Notably,
emerging
evidence
highlights
detrimental
role
various
contaminants
in
incidence
and
progression
disease.
These
encompass
a
broad
spectrum,
including
air
pollutants
laden
with
ozone,
neurotoxic
metals
like
lead,
aluminum,
manganese,
cadmium,
pesticides
insidious
effects,
ubiquitous
presence
plastics
microplastics.
By
meticulously
delving
into
intricate
web
connecting
this
devastating
neurological
disorder,
comprehensive
chapter
takes
deep
dive
involvement
significant
risk
for
Furthermore,
it
explores
underlying
molecular
mechanisms
through
which
exert
influence,
aiming
unravel
complex
interactions
that
drive
pathogenesis
Additionally,
proposes
potential
strategies
mitigate
effects
brain
health,
ultimate
goal
restoring
preserving
typical
cognitive
function.
Through
exploration,
we
aim
enhance
our
understanding
multifaceted
relationship
between
neurotoxins
providing
solid
foundation
developing
innovative
in-vivo
models
advancing
knowledge
pathological
processes
debilitating
condition.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(1), P. 180 - 180
Published: Jan. 12, 2023
Alzheimer’s
disease
(AD)
is
a
neurodegenerative
disorder
characterized
by
progressive
memory
loss
and
cognitive
decline.
Although
substantial
research
has
been
conducted
to
elucidate
the
complex
pathophysiology
of
AD,
therapeutic
approach
still
limited
efficacy
in
clinical
practice.
Oxidative
stress
(OS)
established
as
an
early
driver
several
age-related
diseases,
including
neurodegeneration.
In
increased
levels
reactive
oxygen
species
mediate
neuronal
lipid,
protein,
nucleic
acid
peroxidation,
mitochondrial
dysfunction,
synaptic
damage,
inflammation.
Thus,
identification
novel
antioxidant
molecules
capable
detecting,
preventing,
counteracting
AD
onset
progression
utmost
importance.
However,
although
studies
have
published,
comprehensive
up-to-date
overviews
principal
anti-AD
agents
harboring
properties
remain
scarce.
this
narrative
review,
we
summarize
role
vitamins,
minerals,
flavonoids,
non-flavonoids,
mitochondria-targeting
molecules,
organosulfur
compounds,
carotenoids
non-enzymatic
antioxidants
with
diagnostic,
preventative,
potential,
thereby
offering
insights
into
relationship
between
OS
Molecules,
Journal Year:
2025,
Volume and Issue:
30(1), P. 174 - 174
Published: Jan. 4, 2025
Inflammation,
oxidative
stress,
and
metabolic
diseases
are
intricately
linked
in
a
complex,
self-reinforcing
relationship.
Inflammation
can
induce
while
stress
trigger
inflammatory
responses,
creating
cycle
that
contributes
to
the
development
progression
of
disorders;
addition,
these
effects
be
observed
at
systemic
local
scales.
Both
processes
lead
cellular
damage,
mitochondrial
dysfunction,
insulin
resistance,
particularly
affecting
adipose
tissue,
liver,
muscles,
gastrointestinal
tract.
This
results
impaired
function
energy
production,
contributing
conditions
such
as
type
2
diabetes,
obesity,
syndrome.
Legumes
good
source
phenolic
compounds
anthocyanins
exert
an
antioxidant
effect—they
directly
neutralize
reactive
oxygen
species
free
radicals,
reducing
stress.
In
vivo,
vitro,
clinical
trial
studies
demonstrate
modulate
key
signaling
pathways
involved
inflammation
metabolism,
improving
sensitivity
regulating
lipid
glucose
metabolism.
They
also
anti-inflammatory
by
inhibiting
proinflammatory
enzymes
cytokines.
Additionally,
phenolics
may
positively
influence
gut
microbiome,
indirectly
metabolism
inflammation.
Evidence-based Complementary and Alternative Medicine,
Journal Year:
2023,
Volume and Issue:
2023(1)
Published: Jan. 1, 2023
The
liver
is
a
crucial
organ
that
involved
in
various
kinds
of
metabolic
activity
and
very
stable
accessory
gland
for
the
digestive
system.
Long‐term
or
persistent
inflammation
oxidative
stress
due
to
any
reasons
have
substantial
impact
on
beginning
continuation
chronic
diseases
such
as
hepatocellular
carcinoma,
cirrhosis,
fibrosis,
other
hepatic
conditions.
There
are
many
sources
which
can
help
be
healthy
enhance
its
potential
liver.
Since
diet
rich
origin
bioactive
along
with
antioxidant
chemicals
including
flavonoids
polyphenols,
it
control
different
stages
diseases.
Numerous
food
sources,
notably
vegetables,
nuts,
fruits,
cereals,
beverages,
herbal
medicinal
plants,
called
their
derivatives
like
Flavones,
Anthocyanins,
Iso‐flavonoid,
Flavanones,
Flavanols,
Flavan‐3‐ols.
Most
recently
occurred
research
has
demonstrated
they
regulate
hepatoprotective
properties.
This
because
essential
parts
pharmaceutical
nutraceutical
products
hepatoprotective,
antioxidative,
immune‐modulating
characteristics.
However,
characteristics
remain
unclear.
purpose
this
comprehensive
review
survey
flavonoid
structure
enriched
effects
concerning
toxicity
injury.
Journal of Neuroinflammation,
Journal Year:
2023,
Volume and Issue:
20(1)
Published: Nov. 17, 2023
Abstract
Cyanidin-3-O-glucoside
(C3G)
is
a
natural
anthocyanin
with
antioxidant,
anti-inflammatory,
and
antitumor
properties.
However,
as
the
effects
of
C3G
on
amyloidogenic
pathway,
autophagy,
tau
phosphorylation,
neuronal
cell
death,
synaptic
plasticity
in
Alzheimer’s
disease
models
have
not
been
reported,
we
attempted
to
investigate
same
brains
APPswe/PS1ΔE9
mice
were
analyzed.
After
oral
administration
(30
mg/kg/day)
for
16
weeks,
cortical
hippocampal
regions
treatment
reduced
levels
soluble
insoluble
Aβ
(Aβ40
Aβ42)
peptides
protein
expression
amyloid
precursor
protein,
presenilin-1,
β-secretase
regions.
And
upregulated
autophagy-related
markers,
LC3B-II,
LAMP-1,
TFEB,
PPAR-α
downregulated
that
SQSTM1/p62,
improving
autophagy
plaques
neurofibrillary
tangles.
In
addition,
increased
phosphorylated-AMPK/AMPK
Sirtuin
1
decreased
mitogen-activated
kinases,
such
phosphorylated-Akt/Akt
phosphorylated-ERK/ERK,
thus
demonstrating
its
neuroprotective
effects.
Furthermore,
regulated
PI3K/Akt/GSK3β
signaling
by
upregulating
phosphorylated-GSK3β/GSK3β
expression.
mitigated
phosphorylation
improved
function
synapse-associated
proteins
synaptophysin
postsynaptic
density
protein-95.
Although
potential
mouse
has
yet
shown
protect
brain
improve
cognitive
behavior.
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