Antioxidants,
Год журнала:
2025,
Номер
14(5), С. 535 - 535
Опубликована: Апрель 29, 2025
Peach,
apricot,
chokeberry,
blueberry,
cranberry,
raspberry,
and
wild
strawberry
fruits
were
used
to
create
a
polyphenolic
preparation
(PP)
after
enzyme-assisted
extraction,
ultrafiltration,
concentration.
The
composition
of
PP
was
determined
using
LC-MS.
Gelatin
jellies
produced
with
PP,
as
well
liquid
“digested”
in
an
vitro
model.
entrapment
the
gelatin
matrix
delayed
release
total
polyphenolics,
flavonoids,
flavanols,
condensed
tannins,
anthocyanins
(predominantly
during
“small
intestinal”
phase).
entrapped
jelly
more
effectively
(p
<
0.05)
decreased
activity
acetylcholinesterase,
butyrylcholinesterase,
cyclooxygenase-2
catalase
(during
However,
no
significant
effects
on
superoxide
dismutase,
glutathione
peroxidase,
reductase
activities
observed.
FRAP,
CUPRAC,
HORAC,
oxidation
linoleic
acid,
ABTS-reducing
higher
“intestinal”
phase;
however,
DPPH
test
β-carotene
bleaching
tests
did
not
confirm
these
results.
presented
findings
may
be
useful
for
designing
nutraceuticals
programmed
bioactive
compounds
digestion.
Foods,
Год журнала:
2024,
Номер
13(8), С. 1227 - 1227
Опубликована: Апрель 17, 2024
Natural
phytochemicals
are
well
known
to
protect
against
numerous
metabolic
disorders.
Anthocyanins
vacuolar
pigments
belonging
the
parent
class
of
flavonoids.
They
for
their
potent
antioxidant
and
gut
microbiome-modulating
properties,
primarily
responsible
minimizing
risk
cardiovascular
diseases,
diabetes,
obesity,
neurodegenerative
cancer,
several
other
diseases
associated
with
syndromes.
Berries
primary
source
anthocyanin
in
diet.
The
color
stability
anthocyanins
substantially
influenced
by
external
environmental
conditions,
constraining
applications
foods.
Furthermore,
significantly
low
bioavailability
greatly
diminishes
extent
actual
health
benefits
linked
these
bioactive
compounds.
Multiple
strategies
have
been
successfully
developed
utilized
enhance
anthocyanins.
This
review
provides
a
comprehensive
view
recent
advancements
chemistry,
biosynthesis,
dietary
sources,
stabilization,
bioavailability,
industrial
applications,
Finally,
we
summarize
prospects
challenges
Current Drug Discovery Technologies,
Год журнала:
2024,
Номер
21(2)
Опубликована: Янв. 26, 2024
Background:
Bisphenol
A
(BPA)
is
a
known
neurotoxic
compound
with
potentially
harmful
effects
on
the
nervous
system.
Cyanidin
(CYN)
has
shown
promise
as
neuroprotective
agent.
Objective:
The
current
study
aims
to
determine
efficacy
of
CYN
against
BPA-induced
neuropathology.
Methods:
In
vitro
experiments
utilized
PC12
cells
were
pre-treated
gradient
doses
and
further
stimulated
10ng/ml
BPA.
DPPH
radical
scavenging
activity,
catalase
total
ROS
nitric
oxide
activity
done.
vivo
assessments
employed
doublecortin
immunohistochemistry
brain
in
BPA-exposed
Sprague-Dawley
rats.
Further,
silico
molecular
docking
all
proteins
involved
canonical
Wnt
signaling
was
performed
using
Autodock
v4.2
tool
BIOVIA
Discovery
Studio
Visualizer.
Results:
IC50
values
ascorbic
acid
determined
dose-response
curves,
it
found
be
24.68
±
0.563µg/ml
20.69
1.591µg/ml,
respectively.
BPA-stimulated
pretreated
showed
comparable
(p=0.0287).
reactive
species
production
by
CYN-treated
significantly
decreased
compared
(p<0.0001).
Moreover,
inhibited
BPA
control
vivo,
positively
affected
immature
neuron
quantity,
correlating
dosage.
During
analysis,
exhibited
binding
affinity
>
-7Kcal/mol
key
associated
Wnt/β-catenin
cascade.
Conclusion:
Conclusively,
our
finding
suggests
that
counteracting
BPAinduced
oxidative
stress,
improving
compromised
neurogenesis
hippocampal
cortical
regions,
displaying
notable
interactions
proteins.
Thereby,
could
render
its
potential
neuropathology
Horticulturae,
Год журнала:
2024,
Номер
10(1), С. 105 - 105
Опубликована: Янв. 22, 2024
Blueberries
are
recognized
worldwide
as
one
of
the
most
important
healthy
foods
due
to
their
anthocyanins,
which
have
special
antioxidant
properties.
They
become
a
highly
produced
and
valuable
fruit
crop.
Most
blueberry
varieties
rich
in
impart
beautiful
blue
color;
however,
there
currently
several
with
different
colors
worldwide,
these
special-colored
key
analyzing
coloring
mechanism
fruit.
Fruit
color
could
be
seen
an
nutritional
quality
trait
terms
marketing.
In
this
study,
combination
transcriptomic
metabolomic
analyses
was
performed
on
three
representative
(‘Pink
Popcorn’,
‘Chandler’,
‘Black
Pearl’)
pink,
blue,
black
fruits,
respectively.
The
results
showed
that
delphinium
pigment
is
dominant
anthocyanin,
prerequisite
for
formation
blueberries.
We
identified
18
candidate
structural
genes
anthocyanin
biosynthesis
pathway
were
significantly
up-regulated
during
stages
ripening
Pearl’
but
not
found
expressed
‘Pink
Popcorn’
after
combining
analysis
results.
non-expression
VcANS
gene
may
lead
pink
mature
Popcorn’.
phylogenetic
tree,
heatmap
analysis,
WGCNA
transcription
factor,
VcMYBA,
regulate
differences
between
fruits
blueberries
by
regulating
expression
level
multiple
pathway.
These
provide
new
insights
into
mechanisms
accumulation
coloration
can
help
support
production
practices
improve
characteristics.
among
potential
enhance
properties
characteristics
through
future
genomic
editing.
Frontiers in Bioscience-Elite,
Год журнала:
2022,
Номер
14(4), С. 27 - 27
Опубликована: Окт. 9, 2022
The
aim
of
this
review
is
to
highlight
the
beneficial
attributes
flavonoids,
a
diverse
family
widely-distributed
polyphenolic
phytochemicals
that
have
cell
and
tissue
protective
properties.
Phytochemicals
are
widely
distributed
in
plants,
herbs
shrubs
used
traditional
complimentary
medical
formulations
for
centuries.
bioactive
components
convey
medicinal
effects
these
complex
herbal
preparations
now
being
identified
using
network
pharmacology
molecular
docking
procedures
identify
their
targets.
Flavonoids
anti-oxidant,
anti-inflammatory,
antiviral,
antibacterial
anti-cancer
properties
inspired
development
potent
multifunctional
derivatised
flavonoids
improved
efficacy.
antiviral
emergence
severe
acute
respiratory
syndrome
(SARS-CoV-2)
pandemic
has
resulted
resurgence
interest
search
efficacious
compounds
can
prevent
viral
infection
or
replication,
with
many
promising
plant
identified.
Promising
semi-synthetic
flavonoid
derivatives
also
been
developed
inhibit
multiple
pathological
neurodegenerative
processes;
offer
considerable
promise
treatment
diseases
cognitive
decline.
Clinical
trials
currently
undertaken
evaluate
efficacy
dietary
supplements
rich
virally-mediated
diseases.
Such
expected
be
harnessed
biomedical
applications
may
serve
as
supportive
adjunctive
conventional
anti-viral
drug
therapies
against
such
COVID-19.
