Safety of COVID-19 Vaccines in Patients with Autoimmune Diseases, in Patients with Cardiac Issues, and in the Healthy Population DOI Creative Commons
Loredana Frasca, Giuseppe Ocone,

Raffaella Palazzo

и другие.

Pathogens, Год журнала: 2023, Номер 12(2), С. 233 - 233

Опубликована: Фев. 2, 2023

The coronavirus disease 2019 (COVID-19) has been a challenge for the whole world since beginning of 2020, and COVID-19 vaccines were considered crucial eradication. Instead producing classic vaccines, some companies pointed to develop products that mainly function by inducing, into host, production antigenic protein SARS-CoV-2 called Spike, injecting an instruction based on RNA or DNA sequence. Here, we aim give overview safety profile actual known adverse effects these in relationship with their mechanism action. We discuss use at-risk people, especially those autoimmune diseases previously reported myocarditis, but also general population. debate real necessity administering unclear long-term people conditions, as well healthy at time omicron variants. This, considering existence therapeutic interventions, much more clearly assessed present compared past, relatively lower aggressive nature new viral

Язык: Английский

Understanding COVID-19-associated coagulopathy DOI Open Access
Edward M. Conway, Nigel Mackman, Ronald Q. Warren

и другие.

Nature reviews. Immunology, Год журнала: 2022, Номер 22(10), С. 639 - 649

Опубликована: Авг. 5, 2022

Язык: Английский

Процитировано

252
Covid-19 a triggering factor of autoimmune and multi-inflammatory diseases DOI Creative Commons

Emina Karahmet Sher,

Adnan Ćosović,

Amina Džidić-Krivić

и другие.

Life Sciences, Год журнала: 2023, Номер 319, С. 121531 - 121531

Опубликована: Фев. 27, 2023

SARS-CoV-2 virus has attracted a lot of attention globally due to the autoimmune and inflammatory processes that were observed during development Covid-19 disease. Excessive activation immune response triggering autoantibodies synthesis as well an excessive cytokines onset cytokine storm vital role in disease outcome occurring complications. This scenario is reminiscent infiltration lymphocytes monocytes specific organs increased production chemoattractants noted other diseases. The main goal this study investigate complex occur find similarities with diseases such multiple sclerosis (MS), acute respiratory distress syndrome (ARDS), rheumatoid arthritis (RA) Kawasaki advance existing diagnostic therapeutic protocols. therapy Interferon-gamma (IFN-γ) use S1P receptor modulators showed promising results. However, there are many unknowns about these mechanisms possible novel therapies. Therefore, inflammation autoimmunity triggered by should be further investigated improve procedures protocols for Covid-19.

Язык: Английский

Процитировано

44
Tissue‐resident memory T cells and lung immunopathology DOI Creative Commons
In Su Cheon, Young Min Son, Jie Sun

и другие.

Immunological Reviews, Год журнала: 2023, Номер 316(1), С. 63 - 83

Опубликована: Апрель 4, 2023

Rapid reaction to microbes invading mucosal tissues is key protect the host against disease. Respiratory tissue-resident memory T (T

Язык: Английский

Процитировано

34
Long-term effects of SARS-CoV-2 infection on human brain and memory DOI Creative Commons

Qiulu Ding,

H T Zhao

Cell Death Discovery, Год журнала: 2023, Номер 9(1)

Опубликована: Июнь 29, 2023

Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have caused several waves of outbreaks. From the ancestral strain to Omicron variant, SARS-CoV-2 has evolved with high transmissibility and increased immune escape against vaccines. Because multiple basic amino acids in S1-S2 junction spike protein, widespread distribution angiotensin-converting enzyme (ACE2) receptor human body transmissibility, can infect organs led over 0.7 billion infectious cases. Studies showed that infection cause more than 10% patients Long-COVID syndrome, including pathological changes brains. This review mainly provides molecular foundations for understanding mechanism invading brain basis interfering memory, which are associated dysfunction, syncytia-induced cell death, persistence infection, microclots biopsychosocial aspects. We also discuss strategies reducing syndrome. Further studies analysis shared researches will allow further clarity regarding long-term health consequences.

Язык: Английский

Процитировано

28
Prevalent and persistent new-onset autoantibodies in mild to severe COVID-19 DOI Creative Commons
August Jernbom Falk,

Lovisa Skoglund,

Elisa Pin

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Окт. 16, 2024

Autoantibodies have been shown to be implied in COVID-19 but the emerging autoantibody repertoire remains largely unexplored. We investigated new-onset 525 healthcare workers and hospitalized patients at five time points over a 16-month period 2020 2021 using proteome-wide targeted protein peptide arrays. Our results show that prevalent autoantibodies against wide range of antigens emerged following SARS-CoV-2 infection relation pre-infectious baseline samples remained elevated for least 12 months. found an increased prevalence after severe demonstrated associations between distinct neuropsychiatric symptoms post-COVID-19. Using epitope mapping, we determined main epitopes selected autoantibodies, validated them independent cohorts neuro-COVID pre-pandemic healthy controls, identified sequence similarities suggestive molecular mimicry conserved fusion Spike glycoprotein. work describes complexity dynamics with supports need continued analysis elucidate mechanisms post-COVID-19 condition.

Язык: Английский

Процитировано

9
Dengue and COVID-19: two sides of the same coin DOI Creative Commons
Gathsaurie Neelika Malavige, Chandima Jeewandara, Graham S. Ogg

и другие.

Journal of Biomedical Science, Год журнала: 2022, Номер 29(1)

Опубликована: Июль 3, 2022

Many countries in Asia and Latin America are currently facing a double burden of outbreaks due to dengue COVID-19. Here we discuss the similarities differences between two infections so that lessons learnt far from studying both will be helpful further understanding their immunopathogenesis develop therapeutic interventions.

Язык: Английский

Процитировано

35
The Past, Present, and Future in Antinuclear Antibodies (ANA) DOI Creative Commons
Juan Irure‐Ventura, Marcos López‐Hoyos

Diagnostics, Год журнала: 2022, Номер 12(3), С. 647 - 647

Опубликована: Март 7, 2022

Autoantibodies are a hallmark of autoimmunity and, specifically, antinuclear antibodies (ANAs) the most relevant autoantibodies present in systemic autoimmune rheumatic diseases (SARDs). Over years, different methods from LE cell to HEp-2 indirect immunofluorescence (IIF), solid-phase assays (SPAs), and finally multianalyte technologies have been developed study ANA-associated SARDs. All them provide complementary information that is important clinically valuable information. The identification new biomarkers together with platforms will help close so-called “seronegative gap” correctly classify diagnose patients Finally, artificial intelligence machine learning an area still be exploited but next future extract patterns within patient data, exploit these predict outcomes for improved clinical management.

Язык: Английский

Процитировано

30
Cell-Specific Mechanisms in the Heart of COVID-19 Patients DOI Creative Commons
Emily J. Tsai, Daniela Čiháková, Nathan R. Tucker

и другие.

Circulation Research, Год журнала: 2023, Номер 132(10), С. 1290 - 1301

Опубликована: Май 11, 2023

From the onset of pandemic, evidence cardiac involvement in acute COVID-19 abounded. Cardiac presentations ranged from arrhythmias to ischemia, myopericarditis/myocarditis, ventricular dysfunction heart failure, and even cardiogenic shock. Elevated serum troponin levels were prevalent among hospitalized patients with COVID-19; higher magnitude elevation, greater illness severity in-hospital death risk. Whether these consequences due direct SARS-CoV-2 infection cells or secondary inflammatory responses steered early autopsy studies. was reportedly detected endothelial cells, myocytes, within extracellular space. However, findings inconsistent different methodologies had their limitations. Initial reports suggested that myocarditis common, setting off studies find phenotype infiltrates heart. Nonetheless, subsequent rarely myocarditis. Microthrombi, cardiomyocyte necrosis, without damage much more common. In vitro ex vivo experimental platforms have assessed cellular tropism elucidated mechanisms viral entry into replication cells. Data point pericytes as primary target Infection can account for observed pericyte cell death, innate immune response, immunothrombosis commonly hearts. These processes are bidirectional synergistic, rendering a definitive order events elusive. Single-cell/nucleus analyses myocardial tissue isolated provided granular data about composition type-specific transcriptomic signatures microthrombi-positive Still, remains unknown needed. This review seeks provide an overview current understanding pathophysiology. Cell such insights will be highlighted. Given unprecedented pace research, mechanistic details sure emerge since writing this review. Importantly, our knowledge offers significant clues pathophysiology long COVID-19, increased postrecovery risk events, thus, future landscape cardiovascular disease.

Язык: Английский

Процитировано

17
Early immune factors associated with the development of post-acute sequelae of SARS-CoV-2 infection in hospitalized and non-hospitalized individuals DOI Creative Commons
Jacqueline M. Leung, Michelle J. Wu,

Pouya Kheradpour

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Янв. 22, 2024

Infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to post-acute sequelae of SARS-CoV-2 (PASC) that persist for weeks years following initial viral infection. Clinical manifestations PASC are heterogeneous and often involve multiple organs. While many hypotheses have been made on the mechanisms its associated symptoms, biological drivers still unknown. We enrolled 494 patients with COVID-19 at their presentation a hospital or clinic followed them longitudinally determine development PASC. From 341 patients, we conducted multi-omic profiling peripheral blood samples collected shortly after study enrollment investigate early immune signatures During first week COVID-19, observed large number differences in profile individuals who were hospitalized compared those not hospitalized. Differences between did later develop were, comparison, more limited, but included significant autoantibodies epigenetic transcriptional double-negative 1 B cells, particular. found indicators incident nuanced, molecular signals manifesting predominantly robust hospitalization during COVID-19. The emerging cell phenotypes, especially highlight potentially important role these cells

Язык: Английский

Процитировано

7
Coronavirus disease 2019 (COVID-19) pandemic and autoimmune rheumatic diseases: Outcomes and prospects DOI Creative Commons
Е. Л. Насонов

Rheumatology Science and Practice, Год журнала: 2024, Номер 62(1), С. 32 - 54

Опубликована: Фев. 29, 2024

The pandemic of coronavirus disease 2019 (COVID-19), etiologically related to the SARS-CoV-2 virus (severe acute respiratory syndrome coronavirus-2), has drawn attention new clinical and fundamental problems in immunopathology human diseases associated with virus-induced autoimmunity autoinflammation. provision that “the experience gained rheumatology process studying pathogenetic mechanisms pharmacotherapy immunoinflammatory rheumatic as most common severe forms autoimmune autoinflammatory pathology humans will be demand for deciphering nature pathological processes underlying COVID-19 developing approaches effective pharmacotherapy” was confirmed numerous studies conducted over next 3 years midst pandemic. main focus on a critical analysis data regarding role inflammation, which basis pathogenesis immune-mediated context COVID-19.

Язык: Английский

Процитировано

7