Allergologia et Immunopathologia,
Journal Year:
2023,
Volume and Issue:
51(1), P. 140 - 145
Published: Jan. 1, 2023
Objective:
To
unravel
the
role
of
La
ribonucleoprotein
7
(LARP7),
a
transcriptional
regulator,
in
progression
psoriasis
and
underlying
molecular
mechanisms.
Methods:
The
psoriasis-like
mice
model
was
created
by
daily
administering
imiquimod
on
shaved
skin.
histological
analysis
skin
damage
were
evaluated
each
group.
inflammation
oxidative
stress
response
assessed
enzyme-linked-immunosorbent
serologic
immunoblot
assays.
involvement
silent
information
regulator
1
(mem-ber
Sirtuin
family;
SIRT1/nuclear
factor
kappa
B
(NF-κB)
signaling
pathway
LARP7-mediated
also
detected
assay.
Results:
LARP7
relieved
symptoms
model.
inhibited
expression
inflammatory
cytokines
as
well
chemokines
tissues.
Additionally,
suppressed
tissues
mice.
activation
SIRT1/NF-κB
pathway,
therefore
affected
psoriasis.
Conclusion:
regulating
pathway.
Cells,
Journal Year:
2023,
Volume and Issue:
12(1), P. 184 - 184
Published: Jan. 2, 2023
Immune
cells
and
commensal
microbes
in
the
human
intestine
constantly
communicate
with
react
to
each
other
a
stable
environment
order
maintain
healthy
immune
activities.
system-microbiota
cross-talk
relies
on
complex
network
of
pathways
that
sustain
balance
between
tolerance
immunogenicity.
Probiotic
bacteria
can
interact
stimulate
intestinal
microflora
modulate
specific
functions
homeostasis.
Growing
evidence
shows
probiotic
present
important
health-promoting
immunomodulatory
properties.
Thus,
use
probiotics
might
represent
promising
approach
for
improving
system
So
far,
few
studies
have
been
reported
beneficial
modulatory
effect
probiotics.
However,
many
others,
which
are
mainly
focused
their
metabolic/nutritional
properties,
published.
Therefore,
mechanisms
behind
interaction
host
only
partially
described.
The
review
aims
collect
summarize
most
recent
scientific
results
resulting
implications
how
improve
functions.
Hence,
description
currently
known
is
provided.
JDDG Journal der Deutschen Dermatologischen Gesellschaft,
Journal Year:
2023,
Volume and Issue:
21(4), P. 363 - 372
Published: April 1, 2023
Summary
The
study
of
psoriasis
has
yielded
fundamental
new
insights
into
immunologic
regulation
and
innovative
therapies
in
a
way
that
few
other
diseases
have.
In
this
review,
we
summarize
the
main
features
current
research
with
emphasis
on
pathophysiological
processes
milestones
approval
various
biologics
small
molecule
drugs.
Thus,
through
research,
are
gaining
better
understanding
interplay
between
components
innate
adaptive
immune
systems.
New
therapeutics
interfere
crucial
regulatory
networks.
Based
knowledge,
outline
what
believe
to
be
some
most
important
future
directions
therapeutic
clinical
developments
psoriasis.
These
span
multiple
areas,
ranging
from
genetic,
epigenetic,
cellular,
immunological
mechanisms
studies
particular
forms
psoriasis,
individual
systemic
effects
disease
its
treatment,
incorporation
large
connected
data
sets
artificial
intelligence.
goal
is
understand
holistically,
molecular
organismic
societal
levels,
order
develop
individualized
prevention
treatment
strategies.
Despite
impressive
progress,
must
continue
evolve
at
both
smallest
largest
scales
comprehensively
address
needs
physicians
patients.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2024,
Volume and Issue:
14
Published: Aug. 7, 2024
Psoriasis
is
one
of
the
most
common
autoimmune
skin
diseases.
Increasing
evidence
shows
that
alterations
in
diversity
and
function
microbiota
can
participate
pathogenesis
psoriasis
through
various
pathways
mechanisms.
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(8), P. 2441 - 2441
Published: April 22, 2024
Background:
The
care
of
psoriatic
patients
requires
a
multidisciplinary
approach
that
addresses
not
only
skin
involvement
but
also
cardiovascular
risk
factors.
Coordination
between
dermatology
and
internal
medicine
departments,
with
specific
focus
on
treatment
long-term
follow-up,
can
substantially
improve
the
course
disease
its
associated
complications.
Objective:
to
evaluate
effects
holistic
management
psoriasis
by
team
consisting
specialists.
Methods:
We
conducted
an
observational,
prospective,
single-center
case-control
study
October
2016
December
2019
in
San
Jorge
University
Hospital
(Huesca,
Spain).
Cases
included
undergoing
follow-up
combined
clinic.
control
group
consisted
equivalent
number
randomly
selected,
age-
sex-matched
moderate-to-severe
who
were
seen
general
department
same
hospital
during
time
period.
Main
outcomes
measures:
primary
outcome
was
factors
such
as
weight,
blood
pressure,
waist
circumference,
body
mass
index
(BMI),
SCORE
(Systematic
Coronary
Risk
Evaluation),
test
parameters,
well
diet,
physical
exercise,
habits
tobacco
alcohol
consumption.
To
compare
data
collected
over
time,
grouped
into
three
periods:
baseline
(t1),
intermediate
(t2),
final
(t3).
Results:
case
27
patients,
25
patients.
Multivariate
analysis
used
relationship
10-year
experiencing
event
(SCORE)
clinical
characteristics
analytical
variables
controls
(n
=
52).
significantly
higher
age
(OR,
1.33;
CI95%
1.21-1.50;
p
<
0.001);
smoking
5.05,
1.07-27.37;
0.047);
PASI
7.98,
2.32-35.86;
0.003);
BSA
1.22,
1.01-1.49;
0.044);
being
patient
3.26;
0.84-13.56;
0.029).
Conclusions:
Pharmacological
behavioral
interventions
carried
out
part
procedure
clinic
resulted
improvements
following
relative
group:
PASI,
BSA,
DLQI,
PSOLIFE,
lipid
profile,
insulin
HOMA-IR
GGT
levels,
vitamin
D
SCORE.
These
findings
indicate
beneficial
effect
clinic,
which
reduced
events
metabolic
comorbidities.
