Liquid biopsy in lung cancer: significance in diagnostics, prediction, and treatment monitoring

Molecular Cancer, Год журнала: 2022, Номер 21(1)

Опубликована: Янв. 20, 2022

Primary lung cancer is one of the most common malignant tumors in China. Approximately 60% patients have distant metastasis at initial diagnosis, so it necessary to find new tumor markers for early diagnosis and individualized treatment. Tumor contribute play important roles detection treatment, as well precision medicine, efficacy monitoring, prognosis prediction. The pathological small biopsy specimens determines whether there are cells type. Because traumatic compliance with multiple biopsies poor, liquid has become a hot research direction. Liquid advantageous because they nontraumatic, easy obtain, reflect overall state tumor, allow real-time monitoring. At present, mainly include circulating cells, DNA, exosomes, microRNA, RNA, platelets, endothelial cells. This review introduces progress clinical application prospect technology cancer.

Язык: Английский

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Advances and challenges in the treatment of lung cancer

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 169, С. 115891 - 115891

Опубликована: Ноя. 16, 2023

Lung cancer accounts for a relatively high proportion of malignant tumors. As the most prevalent type lung cancer, non-small cell (NSCLC) is characterized by morbidity and mortality. Presently, arsenal treatment strategies encompasses surgical resection, chemotherapy, targeted therapy radiotherapy. However, despite these options, prognosis remains distressingly poor with low 5-year survival rate. Therefore, it urgent to pursue paradigm shift in methodologies. In recent years, advent sophisticated biotechnologies interdisciplinary integration has provided innovative approaches cancer. This article reviews cutting-edge developments nano drug delivery system, molecular photothermal strategy, immunotherapy Overall, systematically summarizing critically analyzing latest progress current challenges we aim provide theoretical basis development novel drugs treatment, thus improve therapeutic outcomes patients.

Язык: Английский

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Advances in Non-Small Cell Lung Cancer: Current Insights and Future Directions

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(14), С. 4189 - 4189

Опубликована: Июль 18, 2024

The leading cause of cancer deaths worldwide is attributed to non-small cell lung (NSCLC), necessitating a continual focus on improving the diagnosis and treatment this disease. In review, latest breakthroughs emerging trends in managing NSCLC are highlighted. Major advancements diagnostic methods, including better imaging technologies utilization molecular biomarkers, discussed. These have greatly enhanced early detection personalized plans. Significant improvements patient outcomes been achieved by new targeted therapies immunotherapies, providing hope for individuals with advanced NSCLC. This review discusses persistent challenges accessing treatments their associated costs despite recent progress. Promising research into therapies, such as CAR-T therapy oncolytic viruses, which could further revolutionize treatment, also aims inform inspire continued efforts improve patients globally, offering comprehensive overview current state future possibilities.

Язык: Английский

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A Pluripotential Neutrophil-Mimic Nanovehicle Modulates Immune Microenvironment with Targeted Drug Delivery for Augmented Antitumor Chemotherapy

ACS Nano, Год журнала: 2024, Номер unknown

Опубликована: Фев. 9, 2024

The limited therapeutic outcomes and severe systemic toxicity of chemotherapy remain major challenges to the current clinical antitumor regimen. Tumor-targeted drug delivery that diminishes undifferentiated distribution is a practical solution ameliorating toxicity. However, tumor adaptive immune microenvironment still poses great threat compromises efficacy by promoting tolerance cells. Herein, pluripotential neutrophil-mimic nanovehicle (Neutrosome(L)) composed an activated neutrophil membrane-incorporated liposome proposed modulate synergize chemotherapy. prominent targeting capability inherited from neutrophils improved penetration ability Neutrosome(L) enable considerable accumulation in tissues (more than sixfold free drug). Importantly, can restricting infiltration tissue, which may be attributed neutralization inflammatory cytokines, thus potentiating As consequence, treatment cisplatin-loaded performs suppression effects, reduces toxicity, prolongs survival period tumor-bearing mice. this study not only enhance chemotherapeutics but also microenvironment, providing compendious strategy for augmented

Язык: Английский

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Advances in pharmacological effects and mechanism of action of cinnamaldehyde

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Июнь 6, 2024

Cinnamaldehyde is extracted from Cinnamomum cassia and other species, providing diverse sources for varying chemical properties therapeutic effects. Besides natural extraction, synthetic production biotechnological methods like microbial fermentation offer scalable sustainable alternatives. Cinnamaldehyd demonstrates a broad pharmacological range, impacting various diseases through detailed mechanisms. This review aims to encapsulate the effects of cinnamaldehyde, its molecular interactions, potential in clinical applications. Drawing on recent scientific studies databases Web Science, PubMed, ScienceDirect, this outlines cinnamaldehyde’s efficacy treating inflammatory conditions, bacterial infections, cancer, diabetes, cardiovascular kidney diseases. It primarily operates by inhibiting NF-κB pathway modulating pro-inflammatory mediators, alongside disrupting cells inducing apoptosis cancer cells. The compound enhances metabolic health improving glucose uptake insulin sensitivity offers protection anti-inflammatory lipid-lowering Additionally, it promotes autophagy disease management. Preclinical research supports potential, underscoring need further investigation into mechanisms safety develop new drugs based cinnamaldehyde.

Язык: Английский

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LncRNA DGUOK-AS1 facilitates non-small cell lung cancer growth and metastasis through increasing TRPM7 stability via m6A modification

Translational Oncology, Год журнала: 2023, Номер 32, С. 101661 - 101661

Опубликована: Апрель 8, 2023

N6-methyladenosine (m6A) modification plays key roles in tumor progression. LncRNA deoxyguanosine kinase antisense RNA 1 (DGUOK-AS1) has been reported as a promoter tumors, but its role and mechanism non-small cell lung cancer (NSCLC) development remain uncertain.

Язык: Английский

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ALKBH5 regulates paclitaxel resistance in NSCLC via inhibiting CEMIP-mediated EMT

Toxicology and Applied Pharmacology, Год журнала: 2024, Номер 483, С. 116807 - 116807

Опубликована: Янв. 9, 2024

Язык: Английский

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Molecular map of disulfidptosis-related genes in lung adenocarcinoma: the perspective toward immune microenvironment and prognosis

Clinical Epigenetics, Год журнала: 2024, Номер 16(1)

Опубликована: Фев. 11, 2024

Abstract Background Disulfidptosis is a recently discovered form of programmed cell death that could impact cancer development. Nevertheless, the prognostic significance disulfidptosis-related genes (DRGs) in lung adenocarcinoma (LUAD) requires further clarification. Methods This study systematically explores genetic and transcriptional variability, relevance, expression profiles DRGs. Clusters related to disulfidptosis were identified through consensus clustering. We used single-sample gene set enrichment analysis ESTIMATE assess tumor microenvironment (TME) different subgroups. conducted functional differentially expressed between subgroups, which involved ontology, Kyoto encyclopedia genomes, variation analysis, order elucidate their status. Prognostic risk models developed using univariate Cox regression least absolute shrinkage selection operator regression. Additionally, single-cell clustering communication enhance understanding importance signature genes. Lastly, qRT-PCR was employed validate model. Results Two clearly defined DRG clusters consensus-based, unsupervised analysis. Observations made concerning correlation changes multilayer various clinical characteristics, prognosis, infiltration TME cells. A well-executed assessment model, known as score, predict prognosis LUAD patients. high score indicates increased infiltration, higher mutation burden, elevated scores, poorer prognosis. showed significant with burden immune dysfunction exclusion score. Subsequently, nomogram established for facilitating application showing good predictive ability calibration. crucial DRGs validated by sequencing data. Finally, immunohistochemistry. Conclusion Our new can landscape LUAD. It also serves reference LUAD's immunotherapy chemotherapy.

Язык: Английский

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Efficacy of first-line chemotherapy combined with immunotherapy or anti-angiogenic therapy in advanced KRAS-mutant non-small cell lung cancer

Translational Oncology, Год журнала: 2025, Номер 53, С. 102317 - 102317

Опубликована: Фев. 3, 2025

Язык: Английский

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Deep Clustering-Based Metabolic Stratification of Non-Small Cell Lung Cancer Patients Through Integration of Somatic Mutation Profile and Network Propagation Algorithm

Interdisciplinary Sciences Computational Life Sciences, Год журнала: 2025, Номер unknown

Опубликована: Март 18, 2025

Язык: Английский

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