Best Practice & Research Clinical Rheumatology, Год журнала: 2024, Номер unknown, С. 102030 - 102030
Опубликована: Дек. 1, 2024
Язык: Английский
Heliyon, Год журнала: 2025, Номер unknown, С. e42938 - e42938
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Cellular & Molecular Biology Letters, Год журнала: 2024, Номер 29(1)
Опубликована: Окт. 29, 2024
Abstract Chronic pain dramatically affects life qualities of the sufferers. It has posed a heavy burden to both patients and health care system. However, current treatments for chronic are usually insufficient cause many unwanted side effects. Chemokine C–X–C motif ligand 13 (CXCL13), formerly recognized as B cell chemokine, binds with cognate receptor CXCR5, G-protein-coupled (GPCR), participate in immune recruitments modulations. Recent studies further demonstrated that CXCL13–CXCR5 signaling is implicated via promoting neuroimmune interaction neuroinflammation sensory In addition, some latest work also pointed out involvement pathogenesis certain neurological diseases, including ischemic stroke amyotrophic lateral sclerosis. Therefore, we aim outline recent findings regard well focus on how this chemokine contributes these diseases regulating neuroinflammation. Strategies can specifically target distinct locations may provide new therapeutic options diseases.
Язык: Английский
Процитировано
3
Cellular and Molecular Life Sciences, Год журнала: 2024, Номер 81(1)
Опубликована: Июнь 17, 2024
Heterotopic ossification (HO) occurs as a common complication after injury, while its risk factor and mechanism remain unclear, which restricts the development of pharmacological treatment. Clinical research suggests that diabetes mellitus (DM) patients are prone to developing HO in tendon, but solid evidence mechanical still needed. Here, we combined clinical samples DM mice model identify disordered glycolipid metabolism aggravates senescence tendon-derived stem cells (TSCs) promotes osteogenic differentiation. Then, combining RNA-seq results aging detected abnormally activated autocrine CXCL13-CXCR5 axis TSCs cultured high fat, glucose (HFHG) environment also aged tendon. Genetic inhibition CXCL13 successfully alleviated formation mice, providing potential therapeutic target for suppressing trauma or surgery.
Язык: Английский
Процитировано
1
Clinical and Experimental Medicine, Год журнала: 2024, Номер 24(1)
Опубликована: Окт. 24, 2024
CXCL13 is a chemokine that plays an important role in the regulation and development of secondary lymphoid organs. also involved pathological processes, particularly inflammatory responses, many diseases. The function varies depending on condition host. In healthy condition, mainly secreted by mouse stromal cells or human follicular helper T cells, whereas diseases conditions, they are produced peripheral macrophages non-lymphoid tissues; this termed ectopic expression CXCL13. Ectopic pathogenesis various immune-mediated as it regulates migration B lymphocytes, other immune sites well influences factors. Additionally, key organ formation. review, we focused sources different conditions its regulatory mechanisms diseases, providing novel ideas for further research targeting treatment
Язык: Английский
Процитировано
1
Journal of Cosmetic Dermatology, Год журнала: 2024, Номер unknown
Опубликована: Окт. 31, 2024
ABSTRACT Aim To compare and evaluate the differences between EGCG phosphatidylcholine‐encapsulated in terms of their anti‐inflammatory antioxidant capacities. Methods In this study, transdermal absorption experiments were conducted to capacity EGCG. Subsequently, disparity efficacy evaluated through cytotoxicity experiments, as well determination cellular inflammatory factors measurement ROS content under different treatment conditions. Results The concentration EGCG, encapsulated phosphatidylcholine, porcine skin is 40.76 ± 1.29 μg/cm 2 , which significantly higher than alone (31.62 2.01 ). Also, ability suppress such tumor necrosis factor‐α (TNF‐α), cyclooxygenase‐2 (COX‐2), prostaglandin E2 (PGE2) was notably superior that alone. Both showed excellent scavenging capacity. Conclusion percutaneous impact within phosphatidylcholine substantially enhanced when compared by itself. Additionally, both formulations exhibited capacities, albeit variance them not pronounced. These insights furnish a vital theoretical underpinning for utilization cosmetic applications, specifically fostering products with benefits.
Язык: Английский
Процитировано
1
Journal of Advanced Research, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Colonic fibrosis is a long-term complication of inflammatory bowel disease (IBD), often leading to functional impairment, intestinal obstruction, and surgery. Adiponectin (APN) an adipokine derived from adipocytes that plays pleiotropic role in regulation, depending on tissue cell type specific or context, but its colonic remains unclear.
Язык: Английский
Процитировано
1
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0
Best Practice & Research Clinical Rheumatology, Год журнала: 2024, Номер unknown, С. 102030 - 102030
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0