Cancer Metabolism: The Role of ROS in DNA Damage and Induction of Apoptosis in Cancer Cells

Metabolites, Год журнала: 2023, Номер 13(7), С. 796 - 796

Опубликована: Июнь 27, 2023

Cancer is a huge challenge for people worldwide. High reactive oxygen species (ROS) levels are recognized hallmark of cancer and an important aspect treatment research. Abnormally elevated ROS often attributable to alterations in cellular metabolic activities increased oxidative stress, which affects both the development maintenance cancer. Moderately high beneficial maintain tumor cell genesis development, while toxic have been shown be force destroying cells. has become anticancer target based on proapoptotic effect ROS. Therefore, this review summarizes role DNA damage apoptosis cells caused by changes metabolism, as well various therapies targeting generation, order provide references generation.

Язык: Английский

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An Emerging Family of Piezocatalysts: 2D Piezoelectric Materials

Small, Год журнала: 2023, Номер 19(44)

Опубликована: Июнь 29, 2023

Abstract Piezocatalysis is an emerging technique that holds great promise for the conversion of ubiquitous mechanical energy into electrochemical through piezoelectric effect. However, energies in natural environment (such as wind energy, water flow and noise) are typically tiny, scattered, featured with low frequency power. Therefore, a high response to these tiny critical achieving piezocatalytic performance. In comparison nanoparticles or 1D materials, 2D materials possess characteristics such flexibility, easy deformation, large surface area, rich active sites, showing more future practical applications. this review, state‐of‐the‐art research progresses on their applications piezocatalysis provided. First, detailed description offered. Then comprehensive summary presented examines various fields, including environmental remediation, small‐molecule catalysis, biomedicine. Finally, main challenges prospects discussed. It expected review can fuel application piezocatalysis.

Язык: Английский

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Piezoelectric Biomaterials Inspired by Nature for Applications in Biomedicine and Nanotechnology

Advanced Materials, Год журнала: 2024, Номер 36(35)

Опубликована: Июнь 22, 2024

Bioelectricity provides electrostimulation to regulate cell/tissue behaviors and functions. In the human body, bioelectricity can be generated in electromechanically responsive tissues organs, as well biomolecular building blocks that exhibit piezoelectricity, with a phenomenon known piezoelectric effect. Inspired by natural bio-piezoelectric phenomenon, efforts have been devoted exploiting high-performance synthetic biomaterials, including molecular materials, polymeric ceramic composite materials. Notably, biomaterials polarize under mechanical strain generate electrical potentials, which used fabricate electronic devices. Herein, review article is proposed summarize design research progress of devices toward bionanotechnology. First, functions regulating electrophysiological activity from cellular tissue level are introduced. Next, recent advances structure-property relationship various provided detail. following part, applications engineering, drug delivery, biosensing, energy harvesting, catalysis systematically classified discussed. Finally, challenges future prospects presented. It believed this will provide inspiration for development innovative fields biomedicine nanotechnology.

Язык: Английский

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A Distinctive Insight into Inorganic Sonosensitizers: Design Principles and Application Domains

Small, Год журнала: 2024, Номер 20(25)

Опубликована: Янв. 15, 2024

Abstract Sonodynamic therapy (SDT) as a promising non‐invasive anti‐tumor means features the preferable penetration depth, which nevertheless, usually can't work without sonosensitizers. Sonosensitizers produce reactive oxygen species (ROS) in presence of ultrasound to directly kill tumor cells, and concurrently activate immunity especially after integration with microenvironment (TME)‐engineered nanobiotechnologies combined therapy. Current sonosensitizers are classified into organic inorganic ones, current most reviews only cover highlighted their applications. However, there have few specific that focus on including design principles, regulation, etc. In this review, first according rationales rather than composition, action underlying chemistry highlighted. Afterward, what how TME is regulated based sonosensitizers‐based SDT nanoplatform an emphasis targets‐engineered elucidated. Additionally, applications non‐cancer diseases also outlined. Finally, setbacks challenges, proposed potential solutions future directions pointed out. This review provides comprehensive detailed horizon sonosensitizers, will arouse more attentions SDT.

Язык: Английский

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Oxygen‐Supplying Piezocatalytic Therapy of Hypoxic Tumors by Intratumoral Delivery of pH‐Responsive Multicompartmental Carriers with Sequential Drug Release Capability

Advanced Functional Materials, Год журнала: 2024, Номер 34(21)

Опубликована: Янв. 14, 2024

Abstract Piezocatalytic cancer therapy, in which piezoelectric nanomaterials generate reactive oxygen species (ROS) via piezocatalytic redox reactions under mechanical stress, has emerged as an effective strategy for treatment. However, the inherent hypoxia tumor microenvironments enormously restricts its efficacy. To address this issue, acid‐degradable Janus‐type multicompartmental carriers able to separately encapsulate gold nanoparticle‐coated poly(ethylene glycol)‐modified zinc oxide nanorods (Au@P‐ZnO NRs) and O 2 ‐generating catalase (CAT) are fabricated study using stop‐flow lithography (SFL). The CAT Au@P‐ZnO NRs sequentially released by modulating composition ratios of acid‐cleavable monomers precursor solution during SFL. sequential release Janus significantly increased intracellular ROS levels conditions upon ultrasound irradiation owing supplied CAT. An vivo showed that a single intratumoral injection particles encapsulating efficiently alleviated substantially suppressed growth. This demonstrates pH‐responsive, ‐generating, have high potential therapy hypoxic tumors offers insights into pH‐responsive efficient hypoxia‐relieving cascade oxygenation generation.

Язык: Английский

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Piezoelectric Nanomaterials Activated by Ultrasound in Disease Treatment

Pharmaceutics, Год журнала: 2023, Номер 15(5), С. 1338 - 1338

Опубликована: Апрель 26, 2023

Electric stimulation has been used in changing the morphology, status, membrane permeability, and life cycle of cells to treat certain diseases such as trauma, degenerative disease, tumor, infection. To minimize side effects invasive electric stimulation, recent studies attempt apply ultrasound control piezoelectric effect nano material. This method not only generates an field but also utilizes benefits non-invasive mechanical effects. In this review, important elements system, piezoelectricity nanomaterial ultrasound, are first analyzed. Then, we summarize categorized into five kinds, nervous system treatment, musculoskeletal tissues cancer anti-bacteria therapy, others, prove two main mechanics under activated piezoelectricity: one is biological change on a cellular level, other piezo-chemical reaction. However, there still technical problems be solved regulation processes completed before widespread use. The core include how accurately measure properties, concisely electricity release through complex energy transfer processes, deeper understanding related bioeffects. If these conquered future, nanomaterials by will provide new pathway realize application disease treatment.

Язык: Английский

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Exploration of Ultrasound‐Sensitive Biomaterials in Cancer Theranostics

Advanced Functional Materials, Год журнала: 2024, Номер 34(21)

Опубликована: Янв. 6, 2024

Abstract Cancer is a serious health problem to be solved. With the development of biomaterials, enhanced diagnostic and controllable therapeutic strategies for cancer have emerged, revealing encouraging results with promising future. Due its outstanding tissue penetration controllability, along series bioeffects on tissues, ultrasound (US), as common medical technology, has been regarded an effective tool against cancer, use promoted exploration US‐sensitive biomaterials. In this review, US are first introduced then main biomaterials (containing cavitation nuclei, sonosensitizers, US‐responsive macromolecular systems) used treat followed by summary several applications based from diagnosis therapy. Finally, emerging challenges in field that need overcome highlighted. This review reports progress providing new possibilities theranostics thus benefiting patients.

Язык: Английский

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Boosting Energy Deprivation by Synchronous Interventions of Glycolysis and Oxidative Phosphorylation for Bioenergetic Therapy Synergetic with Chemodynamic/Photothermal Therapy

Advanced Science, Год журнала: 2024, Номер 11(23)

Опубликована: Март 15, 2024

Abstract Bioenergetic therapy is emerging as a promising therapeutic approach. However, its effectiveness restricted by metabolic plasticity, tumor cells switch phenotypes between glycolysis and oxidative phosphorylation (OXPHOS) to compensate for energy. Herein, Metformin (MET) BAY‐876 (BAY) co‐loaded CuFe 2 O 4 (CF) nanoplatform (CFMB) developed boost energy deprivation synchronous interventions of OXPHOS bioenergetic synergetic with chemodynamic/photothermal (CDT/PTT). The MET can simultaneously restrain inhibiting hexokinase (HK2) activity damaging mitochondrial function deprive energy, respectively. Besides, BAY blocks glucose uptake transporter 1 (GLUT1) expression, further potentiating the repression thus achieving much more depletion tumorigenic sources. Interestingly, upregulated antioxidant glutathione (GSH) in cancer triggers CFMB degradation release Cu + /Fe 2+ catalyzing tumor‐overexpressed H hydroxyl radical (∙OH), both impairing GSH‐depletion amplified CDT. Furthermore, upon near‐infrared (NIR) light irradiation, has photothermal conversion capacity kill PTT improve ∙OH production enhanced In vivo experiments have manifested that remarkably suppressed growth mice without systemic toxicity. This study provides new modality paradigm bioenergetic‐related therapies.

Язык: Английский

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Piezocatalytic Schottky Junction Treats Atherosclerosis by a Biomimetic Trojan Horse Strategy

Advanced Materials, Год журнала: 2024, Номер 36(19)

Опубликована: Янв. 30, 2024

The atherosclerotic vulnerable plaque is characterized by the foamy macrophage burden, involving impaired cholesterol efflux and deficient efferocytosis. Correspondingly, piezocatalytic therapy an emerging solution for eliminating burden with satisfactory spatiotemporal controllability deep penetration depth. Herein, a biomimetic Trojan horse (Au-ZnO@MM) engineered coating membrane (MM) onto surface of rod-like Au-ZnO Schottky Junction to effectively relieve progression. These horses MM are actively transported into subsistent macrophages generate abundant reactive oxygen species (ROS) via ultrasound-activated piezocatalysis. ROS-initiated autophagy mitochondrial dysfunction induce substantial cell apoptosis, alleviating macrophages. resulting apoptotic fragments further significantly facilitate excretion trigger efferocytosis intraplaque fresh Ultimately, Au-ZnO@MM piezocatalyst not only inhibits foaming capacity macrophages, but also improves function removing debris, which can stabilize plaque. Meanwhile, plasmon resonance effect integrated gold nanoparticles enables favorable photoacoustic molecular imaging real-time image-guided therapy. This proposed strategy provides paradigm employing methodology enhanced theranostics.

Язык: Английский

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Ultrasound-triggered and glycosylation inhibition-enhanced tumor piezocatalytic immunotherapy

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Окт. 18, 2024

Nanocatalytic immunotherapy holds excellent potential for future cancer therapy due to its rapid activation of the immune system attack tumor cells. However, a high level N-glycosylation can protect cells, compromising anticancer immunity nanocatalytic immunotherapy. Here, we show 2-deoxyglucose (2-DG) and bismuth ferrite co-loaded gel (DBG) scaffold enhanced piezocatalytic After implantation in tumor, DBG generates both reactive oxygen species (ROS) piezoelectric signals when excited with ultrasound irradiation, significantly promoting immunity. Meanwhile, 2-DG released from ROS-sensitive disrupts N-glycans synthesis, further overcoming immunosuppressive microenvironment tumors. The synergy effects ultrasound-triggered glycosylation inhibition are demonstrated on four mouse models. A "hot" tumor-immunity niche is produced inhibit progress lung metastasis elicit strong memory effects. This work provides promising malignant solid tumors featuring low immunogenicity levels N-glycosylation.

Язык: Английский

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