Perspectives on recent advancements in energy harvesting, sensing and bio-medical applications of piezoelectric gels

Chemical Society Reviews, Год журнала: 2023, Номер 52(17), С. 6191 - 6220

Опубликована: Янв. 1, 2023

This review highlights the recent progress in piezoelectric gels (also known as PiezoGels) comprised of polymers, ceramic oxides and supramolecular materials used for energy harvesting, sensing wound dressing.

Язык: Английский

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A stretchable, biocompatible, and self-powered hydrogel multichannel wireless sensor system based on piezoelectric barium titanate nanoparticles for health monitoring

Nano Energy, Год журнала: 2023, Номер 114, С. 108617 - 108617

Опубликована: Июнь 20, 2023

Язык: Английский

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Ultrasound Stimulation of Piezoelectric Nanocomposite Hydrogels Boosts Chondrogenic Differentiation in Vitro, in Both a Normal and Inflammatory Milieu

ACS Nano, Год журнала: 2024, Номер 18(3), С. 2047 - 2065

Опубликована: Янв. 2, 2024

The use of piezoelectric nanomaterials combined with ultrasound stimulation is emerging as a promising approach for wirelessly triggering the regeneration different tissue types. However, it has never been explored boosting chondrogenesis. Furthermore, parameters used are often not adequately controlled. In this study, we show that adipose-tissue-derived mesenchymal stromal cells embedded in nanocomposite hydrogel containing barium titanate nanoparticles and graphene oxide nanoflakes stimulated waves precisely controlled (1 MHz 250 mW/cm2, 5 min once every 2 days 10 days) dramatically boost chondrogenic cell commitment vitro. Moreover, fibrotic catabolic factors strongly down-modulated: proteomic analyses reveal such influences biological processes involved cytoskeleton extracellular matrix organization, collagen fibril metabolic processes. optimal regimen also considerable anti-inflammatory effect keeps its ability to chondrogenesis vitro, even an inflammatory milieu. An analytical model predict voltage generated by invested proposed, together computational tool takes into consideration nanoparticle clustering within vacuoles predicts electric field streamline distribution cytoplasm. proposed shows good injectability adhesion cartilage ex vivo, well excellent biocompatibility according ISO 10993. Future perspectives will involve preclinical testing paradigm regeneration.

Язык: Английский

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Injectable ultrasound-powered bone-adhesive nanocomposite hydrogel for electrically accelerated irregular bone defect healing

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Фев. 7, 2024

The treatment of critical-size bone defects with irregular shapes remains a major challenge in the field orthopedics. Bone implants adaptability to complex morphological defects, bone-adhesive properties, and potent osteogenic capacity are necessary. Here, shape-adaptive, highly bone-adhesive, ultrasound-powered injectable nanocomposite hydrogel is developed via dynamic covalent crosslinking amine-modified piezoelectric nanoparticles biopolymer networks for electrically accelerated healing. Depending on inorganic-organic interaction between amino-modified bio-adhesive network, adhesive strength prepared exhibited an approximately 3-fold increase. In response ultrasound radiation, could generate controllable electrical output (-41.16 61.82 mV) enhance effect vitro vivo significantly. Rat calvarial defect repair validates addition, bioinformatics analysis reveals that ultrasound-responsive enhanced differentiation mesenchymal stem cells by increasing calcium ion influx up-regulating PI3K/AKT MEK/ERK signaling pathways. Overall, present work novel wireless broadens therapeutic horizons defects.

Язык: Английский

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Optimized strategies of ROS-based nanodynamic therapies for tumor theranostics

Biomaterials, Год журнала: 2023, Номер 303, С. 122391 - 122391

Опубликована: Ноя. 15, 2023

Язык: Английский

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Pyroelectric Janus nanomotors to promote cell internalization and synergistic tumor therapy

Journal of Controlled Release, Год журнала: 2023, Номер 357, С. 342 - 355

Опубликована: Апрель 10, 2023

Язык: Английский

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Solution blow spun bilayer chitosan/polylactic acid nanofibrous patch with antibacterial and anti-inflammatory properties for accelerating acne healing

Carbohydrate Polymers, Год журнала: 2023, Номер 326, С. 121618 - 121618

Опубликована: Ноя. 24, 2023

Язык: Английский

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Piezoelectric Nanomaterials Activated by Ultrasound in Disease Treatment

Pharmaceutics, Год журнала: 2023, Номер 15(5), С. 1338 - 1338

Опубликована: Апрель 26, 2023

Electric stimulation has been used in changing the morphology, status, membrane permeability, and life cycle of cells to treat certain diseases such as trauma, degenerative disease, tumor, infection. To minimize side effects invasive electric stimulation, recent studies attempt apply ultrasound control piezoelectric effect nano material. This method not only generates an field but also utilizes benefits non-invasive mechanical effects. In this review, important elements system, piezoelectricity nanomaterial ultrasound, are first analyzed. Then, we summarize categorized into five kinds, nervous system treatment, musculoskeletal tissues cancer anti-bacteria therapy, others, prove two main mechanics under activated piezoelectricity: one is biological change on a cellular level, other piezo-chemical reaction. However, there still technical problems be solved regulation processes completed before widespread use. The core include how accurately measure properties, concisely electricity release through complex energy transfer processes, deeper understanding related bioeffects. If these conquered future, nanomaterials by will provide new pathway realize application disease treatment.

Язык: Английский

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Piezoelectric Bioactive Glasses Composite Promotes Angiogenesis by the Synergistic Effect of Wireless Electrical Stimulation and Active Ions

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(17)

Опубликована: Фев. 28, 2023

Abstract Insufficient angiogenesis frequently occurs after the implantation of orthopedic materials, which greatly increases risk bone defect reconstruction failure. Therefore, development implant with improved angiogenic properties is great importance. Mimicking extracellular matrix clues provides a more direct and effective strategy to modulate angiogenesis. Herein, inspired by bioelectrical characteristics microenvironment, piezoelectric bioactive glasses composite (P‐KNN/BG) based on incorporation polarized potassium sodium niobate constructed, could effectively promote It found that P‐KNN/BG has exceptional wireless electrical stimulation performance sustained active ions release. In vitro cell experiments reveal enhances endothelial adhesion, migration, differentiation via activating eNOS/NO signaling pathway, might be contributed membrane hyperpolarization induced increase influx into cells. vivo chick chorioallantoic experiment demonstrates shows excellent pro‐angiogenic capacity biocompatibility. This work broadens current understanding materials bionic properties, brings new insights clinical treatment repair.

Язык: Английский

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Semiconductive Biomaterials for Pathological Bone Repair and Regeneration

Advanced Functional Materials, Год журнала: 2024, Номер 34(24)

Опубликована: Фев. 19, 2024

Abstract Bone implant biomaterials are among the most used materials for clinical application. Despite significant advances in biocompatibility and osteoconductivity, conventional lack ability to cope with pathological microenvironment (inflammation, infection, residual tumors, etc.) during bone repair. Semiconductor have unique electrical, optical, ultrasound, thermal response properties, which facilitate non‐invasively controllably dynamic repair of defects. In this review, design synthesis a new generation semiconductor‐driven summarized, mechanism action semiconductive biomaterials' functional interfaces process tissues discussed, strategies problems encountered osseointegration is provided. Finally, review outlooks future implants defect

Язык: Английский

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