Life Sciences, Год журнала: 2024, Номер 354, С. 122947 - 122947
Опубликована: Авг. 8, 2024
Язык: Английский
Chemical Engineering Journal, Год журнала: 2023, Номер 468, С. 143826 - 143826
Опубликована: Май 30, 2023
Язык: Английский
Процитировано
21
Applied Materials Today, Год журнала: 2024, Номер 37, С. 102084 - 102084
Опубликована: Фев. 3, 2024
Extracellular vesicles (EVs) are biologically active nanoparticles secreted by cells, which have a variety of physiological functions, such as promoting cell proliferation, regulating immunity, anti-inflammation, and facilitating angiogenesis. However, the application EVs is limited defects low therapeutic efficiency, lack targeting, unstable effects. In recent years, various engineering methods been developed to enhance function EVs. addition, research on isolation mechanisms has also made significant progress. this paper, we review biogenesis, composition, techniques EVs, summarize potential natural well strategies for EV modification, highlight advances in tissue regeneration. Finally, discuss EVs' current problems future perspectives regenerative medicine.
Язык: Английский
Процитировано
6
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 3233 - 3257
Опубликована: Апрель 1, 2024
Abstract: Extracellular vesicles (EVs) can deliver various bioactive molecules among cells, making them promising diagnostic and therapeutic alternatives in diseases. Mesenchymal stem cell-derived EVs (MSC-EVs) have shown potential similar to MSCs but with drawbacks such as lower yield, reduced biological activities, off-target effects, shorter half-lives. Improving strategies utilizing biotechniques pretreat enhance the properties of released EVs, well modifying MSC-EVs targeting abilities achieve controlled release, shows for overcoming application limitations enhancing effects treating bone-related This review focuses on recent advances functionalizing treat Firstly, we underscore significance facilitating crosstalk between cells within skeletal environment. Secondly, highlight functional-modified We explore pretreatment using resulting diverse approaches modify targeted delivery release. Finally, address challenges opportunities further research Keywords: extracellular vesicles, mesenchymal functional modification, diseases
Язык: Английский
Процитировано
6
Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12
Опубликована: Апрель 18, 2024
Degenerative orthopaedic diseases pose a notable worldwide public health issue attributable to the global aging population. Conventional medical approaches, encompassing physical therapy, pharmaceutical interventions, and surgical methods, face obstacles in halting or reversing degenerative process. In recent times, exosome-based therapy has gained widespread acceptance popularity as an effective treatment for diseases. This therapeutic approach holds potential "cell-free" tissue regeneration. Exosomes, membranous vesicles resulting from fusion of intracellular multivesicles with cell membrane, are released into extracellular matrix. Addressing challenges such rapid elimination natural exosomes vivo limitation drug concentration can be effectively achieved through various strategies, including engineering modification, gene overexpression biomaterial binding. review provides concise overview source, classification, preparation methods exosomes, followed by in-depth analysis their functions applications. Furthermore, explores strategies utilizing diseases, overexpression, The primary objective is provide fresh viewpoint on utilization addressing bone conditions support practical application theranosis
Язык: Английский
Процитировано
6
Journal of Extracellular Vesicles, Год журнала: 2024, Номер 13(7)
Опубликована: Июнь 28, 2024
Abstract Extracellular vesicles have gained wide momentum as potential therapeutics for osteoarthritis, a highly prevalent chronic disease that still lacks an approved treatment. The membrane‐bound are secreted by all cells carrying different cargos can serve both biomarkers and modifiers. Nonetheless, despite significant peak in research regarding EVs OA therapeutics, clinical implementation seems distant. In addition to scalability standardization challenges, researchers often omit focus on consider the proper tropism of vesicles, practicality relevance their source, low native therapeutic efficacy, whether they address whole. These considerations necessary better understand light been comprehensively discussed ultimately summarized this review into conceptualized framework termed nanodiamond concept. Future perspectives also discussed, alternatives presented some challenges concerns.
Язык: Английский
Процитировано
6
Biomaterials Advances, Год журнала: 2022, Номер 144, С. 213232 - 213232
Опубликована: Дек. 5, 2022
Язык: Английский
Процитировано
26
Genes & Diseases, Год журнала: 2023, Номер 11(3), С. 100986 - 100986
Опубликована: Июнь 19, 2023
Osteoarthritis and psoriasis arthritis are two degenerative forms of that share similar yet also different manifestations at the histological, cellular, clinical levels. Rheumatologists have marked them as entirely distinct arthropathies. Given recent discoveries in disease initiation progression, potential mechanisms, cellular signaling pathways, ongoing therapeutics, there now more opportunities for discovering osteoarthritis drugs. This review summarized crosstalk between BMP, WNT, TGF-β, VEGF, TLR, FGF biomarkers, anatomical pathologies. Through bench research, we demonstrated regenerative medicine is a promising alternative treating by highlighting significant scientific on entheses, multiple blockers, novel molecules such immunoglobulin new antigen receptors targeted drug evaluation. Furthermore, offered valuable therapeutic approaches with multidisciplinary strategy to treat patients or coming future clinic.
Язык: Английский
Процитировано
15
Materials Today Bio, Год журнала: 2023, Номер 23, С. 100840 - 100840
Опубликована: Ноя. 2, 2023
The repair of bone defects remains a huge clinical challenge. M2 macrophage-derived exosomes (M2-Exos) can act as immunomodulators to promote fracture healing; however, how retain the sustained release target area Here, we report composite hydrogel loaded with M2-Exos aiming accelerate defect healing. It was verified that F127/HA-NB had dense network structure, tissue adhesiveness, and dual sensitivity temperature light. (M2-Exos@F127/HA-NB) exhibited good biocompatibility achieved for up two weeks. study showed both M0-Exos M2-Exos@F127/HA-NB significantly promoted osteogenic differentiation rat marrow mesenchymal stem cells. mechanism implied activates Wnt/β-catenin signaling pathway BMSCs. Finally, evaluated osteogenetic effects in cranial model, results superior regeneration-promoting effects. This provides new strategy cell-free treatment defects.
Язык: Английский
Процитировано
15
Chemical Engineering Journal, Год журнала: 2023, Номер 477, С. 147146 - 147146
Опубликована: Ноя. 4, 2023
Язык: Английский
Процитировано
14
Gels, Год журнала: 2024, Номер 10(2), С. 114 - 114
Опубликована: Фев. 1, 2024
Meniscus tissue engineering (MTE) has emerged as a promising strategy for meniscus repair and regeneration. As versatile platforms, hydrogels have gained significant attention in this field, they possess tunable properties that allow them to mimic native extracellular matrices provide suitable microenvironment. Additionally, can be minimally invasively injected adjusted match the shape of implant site. They conveniently effectively deliver bioactive additives demonstrate good compatibility with other functional materials. These inherent qualities made hydrogel candidate therapeutic approaches This article provides comprehensive review advancements research on application engineering. Firstly, biomaterials crosslinking strategies used formation are summarized analyzed. Subsequently, role additives, including cells, growth factors, active products, facilitating regeneration is thoroughly discussed. Furthermore, we summarize key issues designing MTE. Finally, conclude current challenges encountered by applications suggest potential solutions addressing these field We hope resource researchers practitioners interested thereby exploration new design possibilities.
Язык: Английский
Процитировано
5