Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 23, 2024
Abstract
Osteoarthritis
(OA)
is
the
most
common
degenerative
joint
disease,
causing
pain,
disability,
and
economic
strain.
Combining
nanozymes
with
dopamine
(DOPA)‐based
adhesives
offers
a
promising
approach
to
effectively
modulate
microenvironment
of
OA‐affected
tissues.
However,
traditional
fabrication
methods
DOPA‐based
often
involve
external
oxidants
or
curing
agents,
which
can
introduce
additional
oxidative
stress,
posing
systemic
risks.
Here,
different
enzyme‐catalyzed
activities
platinum–copper
(PtCu)
at
pH
values
are
utilized
directly
catalyze
cross‐linking
DOPA‐modified
hyaluronic
acid
(HAD),
representing
new
polymerization
method
for
phenol‐based
bioadhesives.
The
resulting
adhesive
(HAD/PtCu/platelet‐rich
plasma
(PRP)),
when
combined
PRP,
mitigates
generation
proinflammatory
factors,
scavenges
reactive
oxygen
species,
boosts
hypoxic
chemotaxis
chondrocytes,
stimulates
chondrocyte
proliferation
migration,
protects
interleukin‐1β‐treated
human
articular
C28/I2
cells
from
further
OA
advancement.
Additionally,
in
vivo
assessments
show
that
HAD/PtCu/PRP
significantly
alleviates
pain
improves
knee
osteoarthritic
rats.
These
findings
suggest
provides
alternative
therapy.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(33), С. 43156 - 43170
Опубликована: Авг. 12, 2024
Metal-organic
frameworks
(MOFs)
are
composite
crystalline
materials
created
through
the
coordination
of
metal
ions
and
organic
ligands.
MOFs
have
attracted
extensive
attention
in
biomedical
field
based
on
advantages
internal
porosity,
customizable
facile
surface
modification.
This
review
examines
utilization
drug
delivery
systems,
focusing
research
progress
from
aspects
coloading
intelligent
responsive
carriers,
biological
macromolecule
stabilizers,
self-driving
micro/nanomotors,
multifunctional
living
carriers.
In
addition,
current
challenges
faces
also
discussed.
The
aims
to
provide
a
reference
for
further
application
as
advanced
systems.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(12), С. 14385 - 14404
Опубликована: Март 15, 2024
Bacterial
infectious
diseases
pose
a
significant
global
challenge.
However,
conventional
antibacterial
agents
exhibit
limited
therapeutic
effectiveness
due
to
the
emergence
of
drug
resistance,
necessitating
exploration
novel
strategies.
Nanozymes
have
emerged
as
highly
promising
alternative
antibiotics,
owing
their
particular
catalytic
activities
against
pathogens.
Herein,
we
synthesized
ultrasmall-sized
MnFe2O4
nanozymes
with
different
charges
(MnFe2O4–COOH,
MnFe2O4–PEG,
MnFe2O4–NH2)
and
assessed
capabilities.
It
was
found
that
exhibited
both
antibiofilm
properties
attributed
excellent
peroxidase-like
small
sizes,
enabling
them
penetrate
biofilms
interact
bacteria.
Moreover,
effectively
expedite
wound
healing
within
12
days
facilitate
tissue
repair
regeneration
while
concurrently
reducing
inflammation.
MnFe2O4–COOH
displayed
favorable
activity
Gram-positive
bacteria,
80%
bacterial
removal
efficiency
MRSA
by
interacting
phosphatidylglycerol
(PG)
cardiolipin
(CL)
membrane.
By
negatively
charged
bacteria
surfaces,
MnFe2O4–NH2
demonstrated
most
broad-spectrum
activity,
95
85%
methicillin-resistant
Staphylococcus
aureus
(MRSA)
P.
aeruginosa,
respectively.
MnFe2O4–PEG
dissipated
membrane
potential
reduced
ATP
levels
in
showing
relatively
activity.
To
conclude,
offer
approach
for
treating
infections.
Nanozymes,
nanomaterials
exhibiting
enzyme‐mimicking
activities,
have
gained
considerable
interest
in
biomedicine
due
to
their
stability,
adjustability,
and
cost‐efficiency.
Among
these,
metal–organic
framework
(MOF)‐based
nanozymes
distinguish
themselves
by
distinct
structure
customizable
characteristics.
Researchers
explored
MOF‐based
as
a
platform
for
developing
stimuli‐responsive
behaviors.
This
work
first
presents
the
categorization
of
nanozymes,
which
are
designed
mimic
catalytic
functions
oxidases,
peroxidases,
catalase,
superoxide
dismutase,
hydrolases,
multifunctional
enzymes.
Crafting
includes
customizing
reactions
particular
stimuli,
including
pH,
temperature,
light,
or
biomolecular
triggers,
ensuring
enhanced
specificity
potency
performance
amid
environmental
changes.
Moreover,
these
exhibit
immense
potential
biomedical
applications,
playing
crucial
roles
therapeutic
interventions
like
cancer
therapy
tissue
regeneration.
Finally,
article
delves
into
future
opportunities
challenges
within
emerging
research
frontiers.
These
offer
novel
avenues
advanced
strategies,
providing
prospects
innovative
applications.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 23, 2024
Osteoarthritis
(OA)
of
the
knee
is
most
prevalent
degenerative
joint
condition
that
places
a
substantial
financial
and
medical
burden
on
society.
However,
due
to
drawbacks
such
as
inefficiency,
adverse
effects,
brief
duration
action,
clinical
efficacy
current
major
therapies
for
OA
largely
restricted.
Therefore,
novel
medication
development
highly
required
address
these
issues.
Numerous
studies
in
recent
years
have
established
nanomaterials
can
be
potential
effective
way
overcome
challenges.
In
this
review,
anatomical
distinctions
between
healthy
joints,
well
advances
field
treatment
are
summarized.
The
limits
present
therapeutic
strategies
treating
also
highlighted,
prospects
future.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 21, 2025
Inflammation
is
a
natural
immune
response
triggered
by
harmful
external
or
internal
stimuli.
However,
when
inflammation
fails
to
resolve
and
restore
basal
homeostasis,
it
can
lead
various
inflammatory
diseases
such
as
rheumatoid
arthritis
(RA),
bowel
disease
(IBD),
diabetic
chronic
wound
(DCW).
The
modulation
of
follows
highly
complex
mechanism,
monotherapy
often
insufficient
for
treating
conditions.
Therefore,
developing
next-generation
nanocarriers
anti-inflammatory
drug
delivery
multi-target
combination
therapies
critical.
Metal-organic
frameworks
(MOFs),
class
porous
coordination
polymers
with
large
surface
areas
adaptable
porosity,
have
emerged
promising
systems
(DDS)
due
their
biodegradability,
high
loading
capacity,
stimuli-responsive
release,
ease
functionalization.
Over
the
past
five
years,
MOFs
shown
significant
promise
in
diseases,
either
DDS
intrinsic
anti-oxidative
agents.
Additionally,
hybrid
MOFs,
which
combine
nanozymes,
offer
multifunctional
platform
great
potential.
This
review
intends
provide
comprehensive
recent
development
MOF-based
nanomedicines
therapy
diseases.
challenges
future
directions
research
into
use
treatment
these
will
also
be
discussed.
