Recent Developments of Inorganic Nanosensitizers for Sonodynamic Therapy

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(22)

Опубликована: Апрель 18, 2023

As a noninvasive treatment, sonodynamic therapy (SDT) has been widely used in the treatment of tumors because its ability to penetrate deep tissue with few side effects. key factor SDT, it is meaningful design and synthesize efficient sonosensitizers. Compared organic sonosensitizers, inorganic sonosensitizers can be easily excited by ultrasound. In addition, stable properties, good dispersion, long blood circulation time, have great development potential SDT. This review summarizes possible mechanisms SDT (sonoexcitation ultrasonic cavitation) detail. Based on these mechanisms, synthesis nanosonosensitizers divided into three categories: traditional semiconductor enhanced cavitation-enhanced Subsequently, current construction methods are summarized including accelerated charge separation production reactive oxygen species through cavitation. Furthermore, advantages disadvantages different detailed strategies systematically discussed how enhance Hopefully, this could provide new insights nano-sonosensitizers for

Язык: Английский

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Engineered nanoparticles for precise targeted drug delivery and enhanced therapeutic efficacy in cancer immunotherapy

Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(8), С. 3432 - 3456

Опубликована: Май 13, 2024

The advent of cancer immunotherapy has imparted a transformative impact on treatment paradigms by harnessing the power immune system. However, challenge practical and precise targeting malignant cells persists. To address this, engineered nanoparticles (NPs) have emerged as promising solution for enhancing targeted drug delivery in immunotherapeutic interventions, owing to their small size, low immunogenicity, ease surface modification. This comprehensive review delves into contemporary research at nexus NP engineering immunotherapy, encompassing an extensive spectrum morphologies strategies tailored toward optimizing tumor augmenting therapeutic effectiveness. Moreover, it underscores mechanisms that NPs leverage bypass numerous obstacles encountered regimens probes combined potential when co-administered with both established novel modalities. Finally, evaluates existing limitations platforms which could shape path future advancements this field.

Язык: Английский

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Advanced Polymeric Nanoparticles for Cancer Immunotherapy: Materials Engineering, Immunotherapeutic Mechanism and Clinical Translation

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Abstract Cancer immunotherapy, which leverages immune system components to treat malignancies, has emerged as a cornerstone of contemporary therapeutic strategies. Yet, critical concerns about the efficacy and safety cancer immunotherapies remain formidable. Nanotechnology, especially polymeric nanoparticles (PNPs), offers unparalleled flexibility in manipulation‐from chemical composition physical properties precision control nanoassemblies. PNPs provide an optimal platform amplify potency minimize systematic toxicity broad spectrum immunotherapeutic modalities. In this comprehensive review, basics polymer chemistry, state‐of‐the‐art designs from physicochemical standpoint for encompassing vaccines, situ vaccination, adoptive T‐cell therapies, tumor‐infiltrating cell‐targeted antibodies, cytokine therapies are delineated. Each immunotherapy necessitates distinctively tailored design strategies nanoplatforms. The extensive applications PNPs, investigation their mechanisms action enhanced particularly focused on. profiles clinical research progress discussed. Additionally, forthcoming developments emergent trends nano‐immunotherapeutics poised transform treatment paradigms into clinics explored.

Язык: Английский

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Mechanically Triggered Protein Desulfurization

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

The technology of native chemical ligation and postligation desulfurization has greatly expanded the scope modern protein synthesis. Here, we report that ultrasonic energy can trigger robust clean desulfurization, developed an ultrasound-induced (USID) strategy is simple to use generally applicable peptides proteins. USID involves a cleaning bath easy-to-use easy-to-remove sonosensitizer, titanium dioxide. It features mild convenient reaction conditions excellent functional group compatibility, e.g., with thiazolidine (Thz) serotonin, which are sensitive other strategies. robust: without reoptimizing conditions, same procedure be used for broad range proteins one or more sulfhydryl groups, even in multi-hundred-milligram scale reactions. utility was demonstrated by one-pot synthesis bioactive cyclopeptides such as Cycloleonuripeptide E Segetalin F, well convergent functionally important histone H3.5 using Thz temporary protecting group. A mechanistic investigation indicated proceeds via radical-based mechanism promoted low-frequency low-intensity ultrasonication. Overall, our work introduces mechanically triggered approach potential become method general both academic industrial laboratories.

Язык: Английский

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Nanomedicine-Enabled Concurrent regulations of ROS Generation and Copper Metabolism for Sonodynamic-Amplified Tumor Therapy

Biomaterials, Год журнала: 2025, Номер unknown, С. 123137 - 123137

Опубликована: Янв. 1, 2025

Язык: Английский

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Sono‐Piezo Dynamic Therapy: Utilizing Piezoelectric Materials as Sonosensitizer for Sonodynamic Therapy

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 8, 2025

Sonodynamic therapy (SDT) represents a promising approach for cancer treatment. Compared to photodynamic therapy, SDT offers increased penetration depth and higher precision. However, the practical application of is constrained by low water solubility, poor tumor specificity, metabolic susceptibility most sonosensitizers. Recent research has explored use piezoelectric materials as sonosensitizers in treatment inhibition bacterial growth. Upon ultrasound excitation, separation electron-hole (e--h+) pairs occurs within material. By improving crystal structure material or incorporating other nanoparticles prevent rapid recombination e--h+ pairs, accumulates charges conduction band valence band, achieving redox potential O2/·O2 -. This enables serve sonosensitizer, leading concept termed Sono-Piezo Dynamic Therapy (SPDT). review aims define SPDT, provide systematic overview historical development SDT, elucidate mechanisms which act Importantly, various will be discussed terms their feasibility, advantages, disadvantages sonosensitizers, offering new perspectives identifying

Язык: Английский

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Current advances in metal–organic frameworks for cancer nanodynamic therapies

Coordination Chemistry Reviews, Год журнала: 2023, Номер 497, С. 215434 - 215434

Опубликована: Сен. 17, 2023

Язык: Английский

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Sonodynamic therapy-based nanoplatforms for combating bacterial infections

Ultrasonics Sonochemistry, Год журнала: 2023, Номер 100, С. 106617 - 106617

Опубликована: Сен. 23, 2023

The rapid spread and uncontrollable evolution of antibiotic-resistant bacteria have already become urgent global to treat bacterial infections. Sonodynamic therapy (SDT), a noninvasive effective therapeutic strategy, has broadened the way toward dealing with biofilms, which base on ultrasound (US) sonosensitizer. Sonosensitizer, based small organic molecules or inorganic nanoparticles, is essential SDT process. Thus, it meaningful design sonosensitizer-loaded nanoplatform synthesize an efficient effect. In this review, we initially summarize probable SDT-based antibacterial mechanisms systematically discuss current advancement in different (including for small-molecule sonosensitizer delivery as sonosensitizer) infection therapy. addition, biomedical applications SDT-involved multifunctional nanoplatforms are also discussed. We believe innovative would highly next-generation tool combating infection.

Язык: Английский

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Nanosonosensitizer Optimization for Enhanced Sonodynamic Disease Treatment

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 23, 2024

Low-intensity ultrasound-mediated sonodynamic therapy (SDT), which, by design, integrates sonosensitizers and molecular oxygen to generate therapeutic substances (e.g., toxic hydroxyl radicals, superoxide anions, or singlet oxygen) at disease sites, has shown enormous potential for the effective treatment of a variety diseases. Nanoscale play crucial role in SDT process because their structural, compositional, physicochemical, biological characteristics are key determinants efficacy. In particular, advances materials science nanotechnology have invigorated series optimization strategies augmenting efficacy nanosonosensitizers. This comprehensive review systematically summarizes, discusses, highlights state-of-the-art studies on current achievements nanosonosensitizer enhanced treatment, with an emphasis general design principles nanosonosensitizers strategies, mainly including organic inorganic Additionally, recent advancements optimized applications aimed treating various diseases, such as cancer, bacterial infections, atherosclerosis, autoimmune clarified detail. Furthermore, effects improved versatile thoroughly discussed. The concludes highlighting challenges future opportunities this rapidly evolving research field expedite its practical clinical translation application.

Язык: Английский

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Engineering Sonosensitizer‐Derived Nanotheranostics for Augmented Sonodynamic Therapy

Small, Год журнала: 2024, Номер 20(44)

Опубликована: Июль 6, 2024

Abstract Sonodynamic therapy (SDT), featuring noninvasive, deeper penetration, low cost, and repeatability, is a promising approach for deep‐seated tumors. However, the general or only utilization of SDT shows efficiency unsatisfactory treatment outcomes due to complicated tumor microenvironment (TME) process. To circumvent issues, three feasible approaches enhancing SDT‐based therapeutic effects, including sonosensitizer optimization, strategies conquering hypoxia TME, combinational are summarized, with particular focus on combination other modalities, chemodynamic therapy, photodynamic photothermal chemotherapy, starvation gas immunotherapy. In end, current challenges in tumors discussed enhanced effects provided. It envisioned that this review will provide new insight into strategic design high‐efficiency sonosensitizer‐derived nanotheranostics, thereby augmenting accelerating potential clinical transformation.

Язык: Английский

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