Advanced Healthcare Materials,
Год журнала:
2022,
Номер
11(22)
Опубликована: Сен. 13, 2022
Abstract
Ulcerative
colitis
(UC)
is
a
prevalent
idiopathic
inflammatory
disease
which
causes
such
complications
as
intestinal
perforation,
obstruction,
and
bleeding,
thus
deleteriously
impacting
people's
normal
work
quality
of
life.
Hence,
accurate
diagnosis
UC
crucial
in
terms
planning
optimal
treatment
plan.
Herein,
pH/reactive
oxygen
species
(ROS)
dual‐responsive
nanosystem
(BM@EP)
developed
for
UC's
detection
therapy.
BM@EP
composed
chromophore‐drug
dyad
the
enteric
coating.
The
(BOD‐XT‐DHM)
synthesized
by
linking
chromophore
(BOD‐XT‐BOH)
flavonoid
drug
(dihydromyricetin
DHM)
through
boronate
ester
bond.
coating
includes
Eudragit
S100
poly(lactic‐
co
‐glycolic
acid)
(PLGA),
former
commonly
employed
pH‐dependent
polymer
excipient
so
to
attain
colon‐targeted
delivery,
latter
has
been
widely
used
an
controlled‐extended
release.
After
oral
administration,
delivers
into
colon
releases
molecules
being
triggered
alkaline
pH
t
colon,
thereafter
upon
stimulated
overexpressed
H
2
O
inflamed
bond
broken
down
correspondingly
DHM
released
therapy,
simultaneously
near‐infrared
second
window
(NIR‐II)
fluorescence
optoacoustic
imaging
recovery
evaluation.
ACS Nano,
Год журнала:
2023,
Номер
17(15), С. 14347 - 14405
Опубликована: Июль 24, 2023
Light
has
profoundly
impacted
modern
medicine
and
healthcare,
with
numerous
luminescent
agents
imaging
techniques
currently
being
used
to
assess
health
treat
diseases.
As
an
emerging
concept
in
luminescence,
aggregation-induced
emission
(AIE)
shown
great
potential
biological
applications
due
its
advantages
terms
of
brightness,
biocompatibility,
photostability,
positive
correlation
concentration.
This
review
provides
a
comprehensive
summary
AIE
luminogens
applied
structure
dynamic
physiological
processes,
disease
diagnosis
treatment,
detection
monitoring
specific
analytes,
followed
by
representative
works.
Discussions
on
critical
issues
perspectives
future
directions
are
also
included.
aims
stimulate
the
interest
researchers
from
different
fields,
including
chemistry,
biology,
materials
science,
medicine,
etc.,
thus
promoting
development
fields
life
health.
ACS Nano,
Год журнала:
2024,
Номер
18(11), С. 8437 - 8451
Опубликована: Март 4, 2024
Molecular
imaging
in
the
second
near-infrared
window
(NIR-II)
provides
high-fidelity
visualization
of
biopathological
events
deep
tissue.
However,
most
NIR-II
probes
produce
"always-on"
output
and
demonstrate
poor
signal
specificity
toward
biomarkers.
Herein,
we
report
a
series
hemicyanine
reporters
(HBCs)
with
tunable
emission
to
(715–1188
nm)
structurally
amenable
constructing
activatable
probes.
Such
manipulation
wavelengths
relies
on
rational
molecular
engineering
by
integrating
benz[c,d]indolium,
benzo[b]xanthonium,
thiophene
moieties
conventional
skeleton.
In
particular,
HBC4
HBC5
possess
bright
record
long
over
1050
nm,
enabling
improved
tissue
penetration
depth
superior
background
ratio
for
intestinal
tract
mapping
than
NIR-I
fluorophore
HC1.
An
inflammatory
reporter
(AIR-PE)
is
further
constructed
pH-triggered
site-specific
release
colon.
Due
minimized
interference,
oral
gavage
AIR-PE
allows
clear
delineation
irritated
intestines
assessment
therapeutic
responses
mouse
model
bowel
disease
(IBD)
through
real-time
NIRF-II
imaging.
Benefiting
from
its
high
fecal
clearance
efficiency
(>90%),
can
also
detect
IBD
evaluate
effectiveness
colitis
treatments
via
vitro
optical
fecalysis,
which
outperforms
typical
clinical
assays
including
occult
blood
testing
histological
examination.
This
study
thus
presents
scaffolds
that
are
not
only
applicable
developing
versatile
early
diagnosis
prognostic
monitoring
deeply
seated
diseases
but
hold
promise
future
translations.
Chemical Reviews,
Год журнала:
2024,
Номер
124(20), С. 11242 - 11347
Опубликована: Окт. 9, 2024
Biopsy,
including
tissue
and
liquid
biopsy,
offers
comprehensive
real-time
physiological
pathological
information
for
disease
detection,
diagnosis,
monitoring.
Fluorescent
probes
are
frequently
selected
to
obtain
adequate
on
processes
in
a
rapid
minimally
invasive
manner
based
their
advantages
biopsy.
However,
conventional
fluorescent
have
been
found
show
aggregation-caused
quenching
(ACQ)
properties,
impeding
greater
progresses
this
area.
Since
the
discovery
of
aggregation-induced
emission
luminogen
(AIEgen)
promoted
advancements
molecular
bionanomaterials
owing
unique
high
quantum
yield
(QY)
signal-to-noise
ratio
(SNR),
Coordination Chemistry Reviews,
Год журнала:
2023,
Номер
482, С. 215070 - 215070
Опубликована: Фев. 24, 2023
The
brain
is
the
central
control
hub
of
whole
body.
Hence,
consequences
diseases
can
be
lethal.
Despite
progress
in
fundamental
and
clinical
research,
several
key
obstacles
remain
to
addressed.
As
an
emerging
science,
aggregation-induced
emission
(AIE)
has
attracted
great
interest
past
few
years
owing
overwhelming
advantages
AIE
luminogens
(AIEgens),
including
their
wavelength,
quantum
yield,
spatial
resolution,
photosensitivity,
photostability,
signal-to-noise
ratio,
biocompatibility.
Herein,
we
provide
a
comprehensive
summary
AIEgen
applications
health
evaluation,
disease
detection,
diagnosis,
imaging,
therapeutics.
review
been
summarized
into
five
sections:
i)
Penetration
AIEgen-based
nanomaterials
across
biological
barriers;
ii)
Detection
diagnosis
with
AIEgen;
iii)
Bioimaging
structure
iv)
Therapeutics
for
specific
using
v)
Future
outlooks
surrounding
AIEgens
brain.
We
hope
that
this
will
promote
deeper
understanding
use
neuroscience
community
inspire
additional
research
aimed
at
improving
current
situation
clinic.
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(14), С. 17664 - 17674
Опубликована: Апрель 3, 2023
Acute
kidney
injuries
(AKI)
have
serious
short-term
or
long-term
complications
with
high
morbidity
and
mortality
rate,
thus
posing
great
health
threats.
Developing
high-performance
NIR-II
probes
for
noninvasive
in
situ
detection
of
AKI
via
fluorescent
optoacoustic
dual-mode
imaging
is
significance.
Yet
chromophores
often
feature
long
conjugation
hydrophobicity,
which
prevent
them
from
being
renal
clearable,
limiting
their
applications
the
diseases.
To
fully
exploit
advantageous
features
heptamethine
cyanine
dye,
while
overcoming
its
relatively
poor
photostability,
to
strive
design
a
probe
imaging,
herein,
we
developed
PEG3-HC-PB,
water
soluble,
biomarker
activatable
has
good
photostability.
As
probe,
fluorescence
(900-1200
nm)
quenched
due
existence
electron-pulling
phenylboronic
group
(responsive
element),
it
exhibits
weak
absorption
peak
at
830
nm.
Meanwhile,
presence
overexpressed
H2O2
region
case
AKI,
converted
phenylhydroxy
group,
enhances
emission
(600-900
eventually
produces
conspicuous
signals
imaging.
This
enables
contrast-agent-induced
ischemia/reperfusion-induced
mice
using
real-time
3D-MSOT
response
H2O2.
Hence,
this
can
be
used
as
practicable
tool
detecting
AKI;
additionally,
strategy
could
provide
insight
into
other
large-conjugation
multifarious
biological
applications.
