ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(17), С. 21415 - 21426
Опубликована: Март 6, 2024
Effective
tissue
regeneration
and
immune
responses
are
essential
for
the
success
of
biomaterial
implantation.
Although
interaction
between
synthetic
materials
biological
systems
is
well-recognized,
role
surface
topographical
cues
in
regulating
local
osteoimmune
microenvironment─specifically,
their
impact
on
host
cells,
dynamic
interactions─remains
underexplored.
This
study
addresses
this
gap
by
investigating
topography
osteogenesis
immunomodulation.
We
fabricated
MXene/hydroxyapatite
(HAP)-coated
surfaces
with
controlled
2.5D
nano-,
submicro-,
microscale
patterns
using
our
custom
bottom-up
patterning
method.
These
engineered
were
employed
to
assess
behavior
osteoblast
precursor
cells
macrophage
polarization.
Our
results
demonstrate
that
MXene/HAP-coated
crumpled
significantly
influence
osteogenic
activity
polarization:
these
notably
enhanced
cell
spreading,
proliferation,
differentiation
facilitated
a
shift
macrophages
toward
an
anti-inflammatory,
prohealing
M2
phenotype.
The
observed
indicate
physical
from
topographies,
combined
chemical
MXene/HAP
coatings,
synergistically
create
favorable
microenvironment.
presents
first
evidence
employing
MXene/HAP-multilayer
coated
finely
concurrently
facilitate
immunomodulation
improved
implant-to-tissue
integration.
tunable
topographic
coatings
coupled
facile
scalable
fabrication
process
make
them
widely
applicable
various
biomedical
purposes.
highlight
potential
multilayer
improve
vivo
performance
fate
implants
modulating
response
at
material
interface.
Bioactive Materials,
Год журнала:
2023,
Номер
27, С. 15 - 57
Опубликована: Март 27, 2023
Titanium
(Ti)
and
its
alloys
have
been
widely
used
as
orthopedic
implants,
because
of
their
favorable
mechanical
properties,
corrosion
resistance
biocompatibility.
Despite
significant
success
in
various
clinical
applications,
the
probability
failure,
degradation
revision
is
undesirably
high,
especially
for
patients
with
low
bone
density,
insufficient
quantity
or
osteoporosis,
which
renders
studies
on
surface
modification
Ti
still
active
to
further
improve
results.
It
discerned
that
physicochemical
properties
directly
influence
even
control
dynamic
interaction
subsequently
determines
rejection
implants.
Therefore,
it
crucial
endow
bulk
materials
specific
high
bioactivity
can
be
performed
by
realize
osseointegration.
This
article
first
reviews
characteristics
conventional
techniques
involving
mechanical,
physical
chemical
treatments
based
formation
mechanism
modified
coatings.
Such
methods
are
able
but
surfaces
static
state
cannot
respond
biological
cascades
from
living
cells
tissues.
Hence,
beyond
traditional
design,
responsive
avenues
then
emerging.
The
stimuli
sources
functionalization
originate
environmental
triggers
physiological
triggers.
In
short,
this
review
surveys
recent
developments
engineering
materials,
a
emphasis
advances
functionality,
provides
perspectives
improving
biocompatibility
Bioengineering,
Год журнала:
2023,
Номер
10(2), С. 204 - 204
Опубликована: Фев. 3, 2023
Over
the
last
few
years,
biopolymers
have
attracted
great
interest
in
tissue
engineering
and
regenerative
medicine
due
to
diversity
of
their
chemical,
mechanical,
physical
properties
for
fabrication
3D
scaffolds.
This
review
is
devoted
recent
advances
synthetic
natural
polymeric
scaffolds
bone
(BTE)
therapies.
The
comprehensively
discusses
implications
biological
macromolecules,
structure,
composition
used
BTE.
Various
approaches
fabricating
BTE
are
discussed,
including
solvent
casting
particle
leaching,
freeze-drying,
thermally
induced
phase
separation,
gas
foaming,
electrospinning,
sol–gel
techniques.
Rapid
prototyping
technologies
such
as
stereolithography,
fused
deposition
modeling,
selective
laser
sintering,
bioprinting
also
covered.
immunomodulatory
roles
utilized
applications
discussed.
In
addition,
features
challenges
polymer
fabricated
using
advanced
additive
manufacturing
(rapid
prototyping)
addressed
compared
conventional
subtractive
Finally,
applying
scaffold-based
treatments
practice
discussed
in-depth.
ACS Biomaterials Science & Engineering,
Год журнала:
2023,
Номер
9(8), С. 4442 - 4461
Опубликована: Июль 31, 2023
Dental
implants
have
become
the
mainstream
strategy
for
oral
restoration,
and
implant
materials
are
most
important
research
hot
spot
in
this
field.
So
far,
Ti
dominate
all
kinds
of
implants.
The
surface
properties
play
decisive
roles
osseointegration
antibacterial
performance.
Surface
modifications
can
significantly
change
micro/nanotopography
composition
implants,
which
will
effectively
improve
their
hydrophilicity,
mechanical
properties,
performance,
etc.
These
optimizations
thus
success
service
life.
In
paper,
latest
modification
techniques
dental
systematically
comprehensively
reviewed.
various
biomedical
functionalities
discussed
in-depth.
Finally,
a
profound
comment
on
challenges
opportunities
frontier
is
proposed,
promising
directions
future
were
explored.
Molecules,
Год журнала:
2023,
Номер
28(4), С. 1683 - 1683
Опубликована: Фев. 9, 2023
Osteoarthritis
(OA),
a
disabling
joint
inflammatory
disease,
is
characterized
by
the
progressive
destruction
of
cartilage,
subchondral
bone
remodeling,
and
chronic
synovitis.
Due
to
prolongation
human
lifespan,
OA
has
become
serious
public
health
problem
that
deserves
wide
attention.
The
development
related
numerous
factors.
Among
factors,
nitric
oxide
(NO)
plays
key
role
in
mediating
this
process.
NO
small
gaseous
molecule
widely
distributed
body,
its
synthesis
dependent
on
synthase
(NOS).
an
important
various
physiological
processes
such
as
regulation
blood
volume
nerve
conduction.
Notably,
acts
double-edged
sword
diseases.
Recent
studies
have
shown
redox
derivatives
might
be
closely
both
normal
pathophysiological
conditions.
They
can
play
vital
roles
cell-conditioning
agents
for
osteoclasts,
osteoblasts,
chondrocytes.
Moreover,
they
also
induce
cartilage
catabolism
cell
apoptosis.
Based
different
conditions,
NO/NOS
system
act
anti-inflammatory
or
pro-inflammatory
agent
OA.
This
review
summarizes
effects
all
joints
well
possible
new
treatment
strategies
targeting
system.
Abstract
Owing
to
their
mechanical
resilience
and
non‐toxicity,
titanium
implants
are
widely
applied
as
the
major
treatment
modality
for
clinical
intervention
against
bone
fractures.
However,
intrinsic
bioinertness
of
Ti
its
alloys
often
impedes
effective
osseointegration
implants,
leading
severe
adverse
complications
including
implant
loosening,
detachment,
secondary
damage.
Consequently,
new
engineering
strategies
urgently
needed
improve
after
implantation.
Remarkably,
metalorganic
frameworks
(MOFs)
a
class
novel
synthetic
material
consisting
coordinated
metal
species
organic
ligands,
which
have
demonstrated
plethora
favorable
properties
modulating
interfacial
implants.
This
review
comprehensively
summarizes
recent
progress
in
development
MOF‐coated
highlights
potential
utility
bio‐implant
interface
osseointegration,
discussions
outlined
according
physical
traits,
chemical
composition,
drug
delivery
capacity.
A
perspective
is
also
provided
this
regarding
current
limitations
future
opportunities
orthopedic
applications.
The
insights
may
facilitate
rational
design
more
advanced
with
enhanced
therapeutic
performance
safety.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(24)
Опубликована: Фев. 19, 2024
Abstract
Bone
implant
biomaterials
are
among
the
most
used
materials
for
clinical
application.
Despite
significant
advances
in
biocompatibility
and
osteoconductivity,
conventional
lack
ability
to
cope
with
pathological
microenvironment
(inflammation,
infection,
residual
tumors,
etc.)
during
bone
repair.
Semiconductor
have
unique
electrical,
optical,
ultrasound,
thermal
response
properties,
which
facilitate
non‐invasively
controllably
dynamic
repair
of
defects.
In
this
review,
design
synthesis
a
new
generation
semiconductor‐driven
summarized,
mechanism
action
semiconductive
biomaterials'
functional
interfaces
process
tissues
discussed,
strategies
problems
encountered
osseointegration
is
provided.
Finally,
review
outlooks
future
implants
defect
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(3), С. 3171 - 3186
Опубликована: Янв. 11, 2024
Biomaterial
scaffolds,
including
bone
substitutes,
have
evolved
from
being
primarily
a
biologically
passive
structural
element
to
one
in
which
material
properties
such
as
surface
topography
and
chemistry
actively
direct
regeneration
by
influencing
stem
cells
the
immune
microenvironment.
Ti-6Al-4V(Ti6Al4V)
implants,
with
significantly
higher
elastic
modulus
than
human
bone,
may
lead
stress
shielding,
necessitating
improved
stability
at
bone–titanium
alloy
implant
interface.
Ti-24Nb-4Zr-8Sn
(Ti2448),
low
β-type
titanium
devoid
of
potentially
toxic
elements,
was
utilized
this
study.
We
employed
3D
printing
technology
fabricate
porous
scaffold
structure
further
decrease
stiffness
approximate
that
cancellous
bone.
Microarc
oxidation
(MAO)
modification
is
then
create
microporous
hydrophilic
oxide
ceramic
layer
on
interior
scaffold.
In
vitro
studies
demonstrated
MAO
treatment
enhances
proliferation,
adhesion,
osteogenesis
capabilities
surface.
The
chemical
composition
MAO-Ti2448
found
enhance
transcription
expression
osteogenic
genes
mesenchymal
(BMSCs),
related
enrichment
Nb2O5
SnO2
layer.
scaffold,
its
synergistic
activity
stiffness,
activates
anti-inflammatory
macrophage
phenotype,
creating
an
microenvironment
promotes
differentiation
BMSCs.
vivo
experiments
rabbit
model
significant
improvement
quantity
quality
newly
formed
trabeculae
within
under
contact
pattern
matched
modulus.
These
exhibit
robust
connections
external
accelerating
formation
interlocking
between
providing
implantation
stability.
findings
suggest
has
potential
defect
repair
regulating
osteoimmunomodulation
osseointegration.
This
study
demonstrates
optional
strategy
combines
mechanism
reducing
treatment,
thereby
extending
application
scope
alloy.
Regenerative Biomaterials,
Год журнала:
2024,
Номер
11
Опубликована: Янв. 1, 2024
Abstract
The
intricate
nature
of
oral-maxillofacial
structure
and
function,
coupled
with
the
dynamic
oral
bacterial
environment,
presents
formidable
obstacles
in
addressing
repair
regeneration
bone
defects.
Numerous
characteristics
should
be
noticed
repair,
such
as
irregular
morphology
defects,
homeostasis
between
hosts
microorganisms
cavity
complex
periodontal
structures
that
facilitate
epithelial
ingrowth.
Therefore,
necessitates
restoration
materials
adhere
to
stringent
specific
demands.
This
review
starts
exploring
these
particular
requirements
by
introducing
bones
then
summarizes
classifications
current
respect
composition
structure.
Additionally,
we
discuss
modifications
including
improving
mechanical
properties,
optimizing
surface
topography
pore
adding
bioactive
components
elements,
compounds,
cells
their
derivatives.
Ultimately,
organize
a
range
potential
optimization
strategies
future
perspectives
for
enhancing
materials,
physical
environment
manipulation,
microbial
modulation,
osteo-immune
regulation,
smart
stimuli-responsive
multifaceted
approach
poly-pathic
treatment,
hope
providing
some
insights
researchers
this
field.
In
summary,
analyzes
demands
especially
alveolar
bone,
concludes
corresponding
biomaterials
aims
inspire
research
pursuit
more
effective
treatment
outcomes.