Advanced surface engineering of titanium materials for biomedical applications: From static modification to dynamic responsive regulation

Bioactive Materials, Год журнала: 2023, Номер 27, С. 15 - 57

Опубликована: Март 27, 2023

Titanium (Ti) and its alloys have been widely used as orthopedic implants, because of their favorable mechanical properties, corrosion resistance biocompatibility. Despite significant success in various clinical applications, the probability failure, degradation revision is undesirably high, especially for patients with low bone density, insufficient quantity or osteoporosis, which renders studies on surface modification Ti still active to further improve results. It discerned that physicochemical properties directly influence even control dynamic interaction subsequently determines rejection implants. Therefore, it crucial endow bulk materials specific high bioactivity can be performed by realize osseointegration. This article first reviews characteristics conventional techniques involving mechanical, physical chemical treatments based formation mechanism modified coatings. Such methods are able but surfaces static state cannot respond biological cascades from living cells tissues. Hence, beyond traditional design, responsive avenues then emerging. The stimuli sources functionalization originate environmental triggers physiological triggers. In short, this review surveys recent developments engineering materials, a emphasis advances functionality, provides perspectives improving biocompatibility

Язык: Английский

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A Review of 3D Polymeric Scaffolds for Bone Tissue Engineering: Principles, Fabrication Techniques, Immunomodulatory Roles, and Challenges

Bioengineering, Год журнала: 2023, Номер 10(2), С. 204 - 204

Опубликована: Фев. 3, 2023

Over the last few years, biopolymers have attracted great interest in tissue engineering and regenerative medicine due to diversity of their chemical, mechanical, physical properties for fabrication 3D scaffolds. This review is devoted recent advances synthetic natural polymeric scaffolds bone (BTE) therapies. The comprehensively discusses implications biological macromolecules, structure, composition used BTE. Various approaches fabricating BTE are discussed, including solvent casting particle leaching, freeze-drying, thermally induced phase separation, gas foaming, electrospinning, sol–gel techniques. Rapid prototyping technologies such as stereolithography, fused deposition modeling, selective laser sintering, bioprinting also covered. immunomodulatory roles utilized applications discussed. In addition, features challenges polymer fabricated using advanced additive manufacturing (rapid prototyping) addressed compared conventional subtractive Finally, applying scaffold-based treatments practice discussed in-depth.

Язык: Английский

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Surface Modification and Functionalities for Titanium Dental Implants

ACS Biomaterials Science & Engineering, Год журнала: 2023, Номер 9(8), С. 4442 - 4461

Опубликована: Июль 31, 2023

Dental implants have become the mainstream strategy for oral restoration, and implant materials are most important research hot spot in this field. So far, Ti dominate all kinds of implants. The surface properties play decisive roles osseointegration antibacterial performance. Surface modifications can significantly change micro/nanotopography composition implants, which will effectively improve their hydrophilicity, mechanical properties, performance, etc. These optimizations thus success service life. In paper, latest modification techniques dental systematically comprehensively reviewed. various biomedical functionalities discussed in-depth. Finally, a profound comment on challenges opportunities frontier is proposed, promising directions future were explored.

Язык: Английский

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Connection between Osteoarthritis and Nitric Oxide: From Pathophysiology to Therapeutic Target

Molecules, Год журнала: 2023, Номер 28(4), С. 1683 - 1683

Опубликована: Фев. 9, 2023

Osteoarthritis (OA), a disabling joint inflammatory disease, is characterized by the progressive destruction of cartilage, subchondral bone remodeling, and chronic synovitis. Due to prolongation human lifespan, OA has become serious public health problem that deserves wide attention. The development related numerous factors. Among factors, nitric oxide (NO) plays key role in mediating this process. NO small gaseous molecule widely distributed body, its synthesis dependent on synthase (NOS). an important various physiological processes such as regulation blood volume nerve conduction. Notably, acts double-edged sword diseases. Recent studies have shown redox derivatives might be closely both normal pathophysiological conditions. They can play vital roles cell-conditioning agents for osteoclasts, osteoblasts, chondrocytes. Moreover, they also induce cartilage catabolism cell apoptosis. Based different conditions, NO/NOS system act anti-inflammatory or pro-inflammatory agent OA. This review summarizes effects all joints well possible new treatment strategies targeting system.

Язык: Английский

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Functionally Tailored Metal–Organic Framework Coatings for Mediating Ti Implant Osseointegration

Advanced Science, Год журнала: 2023, Номер 10(29)

Опубликована: Сен. 13, 2023

Abstract Owing to their mechanical resilience and non‐toxicity, titanium implants are widely applied as the major treatment modality for clinical intervention against bone fractures. However, intrinsic bioinertness of Ti its alloys often impedes effective osseointegration implants, leading severe adverse complications including implant loosening, detachment, secondary damage. Consequently, new engineering strategies urgently needed improve after implantation. Remarkably, metalorganic frameworks (MOFs) a class novel synthetic material consisting coordinated metal species organic ligands, which have demonstrated plethora favorable properties modulating interfacial implants. This review comprehensively summarizes recent progress in development MOF‐coated highlights potential utility bio‐implant interface osseointegration, discussions outlined according physical traits, chemical composition, drug delivery capacity. A perspective is also provided this regarding current limitations future opportunities orthopedic applications. The insights may facilitate rational design more advanced with enhanced therapeutic performance safety.

Язык: Английский

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Semiconductive Biomaterials for Pathological Bone Repair and Regeneration

Advanced Functional Materials, Год журнала: 2024, Номер 34(24)

Опубликована: Фев. 19, 2024

Abstract Bone implant biomaterials are among the most used materials for clinical application. Despite significant advances in biocompatibility and osteoconductivity, conventional lack ability to cope with pathological microenvironment (inflammation, infection, residual tumors, etc.) during bone repair. Semiconductor have unique electrical, optical, ultrasound, thermal response properties, which facilitate non‐invasively controllably dynamic repair of defects. In this review, design synthesis a new generation semiconductor‐driven summarized, mechanism action semiconductive biomaterials' functional interfaces process tissues discussed, strategies problems encountered osseointegration is provided. Finally, review outlooks future implants defect

Язык: Английский

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Synergistic Amelioration of Osseointegration and Osteoimmunomodulation with a Microarc Oxidation-Treated Three-Dimensionally Printed Ti-24Nb-4Zr-8Sn Scaffold via Surface Activity and Low Elastic Modulus

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(3), С. 3171 - 3186

Опубликована: Янв. 11, 2024

Biomaterial scaffolds, including bone substitutes, have evolved from being primarily a biologically passive structural element to one in which material properties such as surface topography and chemistry actively direct regeneration by influencing stem cells the immune microenvironment. Ti-6Al-4V(Ti6Al4V) implants, with significantly higher elastic modulus than human bone, may lead stress shielding, necessitating improved stability at bone–titanium alloy implant interface. Ti-24Nb-4Zr-8Sn (Ti2448), low β-type titanium devoid of potentially toxic elements, was utilized this study. We employed 3D printing technology fabricate porous scaffold structure further decrease stiffness approximate that cancellous bone. Microarc oxidation (MAO) modification is then create microporous hydrophilic oxide ceramic layer on interior scaffold. In vitro studies demonstrated MAO treatment enhances proliferation, adhesion, osteogenesis capabilities surface. The chemical composition MAO-Ti2448 found enhance transcription expression osteogenic genes mesenchymal (BMSCs), related enrichment Nb2O5 SnO2 layer. scaffold, its synergistic activity stiffness, activates anti-inflammatory macrophage phenotype, creating an microenvironment promotes differentiation BMSCs. vivo experiments rabbit model significant improvement quantity quality newly formed trabeculae within under contact pattern matched modulus. These exhibit robust connections external accelerating formation interlocking between providing implantation stability. findings suggest has potential defect repair regulating osteoimmunomodulation osseointegration. This study demonstrates optional strategy combines mechanism reducing treatment, thereby extending application scope alloy.

Язык: Английский

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Engineering Multifunctional Surface Topography to Regulate Multiple Biological Responses

Biomaterials, Год журнала: 2025, Номер unknown, С. 123136 - 123136

Опубликована: Янв. 1, 2025

Язык: Английский

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Immunomodulatory nanomedicine for osteoporosis: Current practices and emerging prospects

Acta Biomaterialia, Год журнала: 2024, Номер 179, С. 13 - 35

Опубликована: Март 16, 2024

Язык: Английский

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Advances in biomaterials for oral-maxillofacial bone regeneration: spotlight on periodontal and alveolar bone strategies

Regenerative Biomaterials, Год журнала: 2024, Номер 11

Опубликована: Янв. 1, 2024

Abstract The intricate nature of oral-maxillofacial structure and function, coupled with the dynamic oral bacterial environment, presents formidable obstacles in addressing repair regeneration bone defects. Numerous characteristics should be noticed repair, such as irregular morphology defects, homeostasis between hosts microorganisms cavity complex periodontal structures that facilitate epithelial ingrowth. Therefore, necessitates restoration materials adhere to stringent specific demands. This review starts exploring these particular requirements by introducing bones then summarizes classifications current respect composition structure. Additionally, we discuss modifications including improving mechanical properties, optimizing surface topography pore adding bioactive components elements, compounds, cells their derivatives. Ultimately, organize a range potential optimization strategies future perspectives for enhancing materials, physical environment manipulation, microbial modulation, osteo-immune regulation, smart stimuli-responsive multifaceted approach poly-pathic treatment, hope providing some insights researchers this field. In summary, analyzes demands especially alveolar bone, concludes corresponding biomaterials aims inspire research pursuit more effective treatment outcomes.

Язык: Английский

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