ACS Applied Polymer Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 19, 2025
Язык: Английский
Nature Reviews Methods Primers, Год журнала: 2024, Номер 4(1)
Опубликована: Янв. 4, 2024
Язык: Английский
Процитировано
200
Journal of Functional Biomaterials, Год журнала: 2023, Номер 14(7), С. 341 - 341
Опубликована: Июнь 27, 2023
The treatment of bone defects remains a challenging clinical problem with high reintervention rates, morbidity, and resulting significant healthcare costs. Surgical techniques are constantly evolving, but outcomes can be influenced by several parameters, including the patient’s age, comorbidities, systemic disorders, anatomical location defect, surgeon’s preference experience. most used therapeutic modalities for regeneration long include distraction osteogenesis (bone transport), free vascularized fibular grafts, Masquelet technique, allograft, (arthroplasty with) mega-prostheses. Over past 25 years, three-dimensional (3D) printing, breakthrough layer-by-layer manufacturing technology that produces final parts directly from 3D model data, has taken off transformed enabling personalized therapies highly porous 3D-printed implants tailored to patient. Therefore, reduce morbidities complications associated current regimens, efforts have been made in translational research toward scaffolds facilitate regeneration. Three-dimensional printed should not only provide osteoconductive surfaces cell attachment subsequent formation also physical support containment graft material during process, enhancing ingrowth, while simultaneously, orthopaedic supply mechanical strength rigid, stable external and/or internal fixation. In this perspective review, we focus on elaborating history defect methods assessing approaches as well recent developments, existing evidence advantages disadvantages Furthermore, it is evident regulatory framework organization financing evidence-based trials very complex, new challenges non-biodegradable biodegradable emerging yet sufficiently addressed, such guideline development specific surgical indications, clinically feasible design concepts needed multicentre international preclinical trials, medico-legal status, reimbursement. These underscore need intensive exchange open honest debate among leaders field. This goal addressed well-planned focused stakeholder workshop topic patient-specific regeneration, proposed review.
Язык: Английский
Процитировано
72
European Polymer Journal, Год журнала: 2024, Номер 215, С. 113251 - 113251
Опубликована: Июнь 19, 2024
Meeting the escalating demands in biomedical applications has spurred creation of diverse scaffolds, where selection materials and manufacturing techniques stands as a linchpin fostering bone tissue formation. These scaffolds provide fundamental structural framework that supports cell growth differentiation. It is vital for repair, addressing various biological requisites such biocompatibility, biodegradability, mechanical properties becomes imperative. This comprehensive review discusses recent advancements 3D tailored specifically engineering applications. Stereolithography, fused deposition modelling, selective laser sintering, binder jetting, electron beam melting, bioprinting (including laser-based, inkjet extrusion bioprinting) are meticulously explored. Focusing on their respective applications, limitations, well advantages disadvantages within context regeneration. Furthermore, article underscores pivotal role material potential solution to address challenges associated with grafts. emphasizes need nuanced understanding significant considerations regardless type when designing or evaluating suitability integration into expansive realm engineering.
Язык: Английский
Процитировано
19
Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(40), С. 9597 - 9629
Опубликована: Янв. 1, 2023
Polyesters based on polyols have emerged as promising biomaterials for various biomedical applications, such tissue engineering and drug delivery systems, due to their biocompatibility, biodegradability, versatile physicochemical properties.
Язык: Английский
Процитировано
37
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 256, С. 128364 - 128364
Опубликована: Ноя. 22, 2023
Язык: Английский
Процитировано
28
Acta Biomaterialia, Год журнала: 2023, Номер 172, С. 16 - 37
Опубликована: Окт. 4, 2023
Bone scaffolds play a crucial role in bone tissue engineering by providing mechanical support for the growth of new while enduring static and fatigue loads. Although polymers possess favourable characteristics such as adjustable degradation rate, tissue-compatible stiffness, ease fabrication, low toxicity, their relatively strength has limited use load-bearing applications. While numerous studies have focused on assessing polymeric scaffolds, little research been conducted properties. The current review presents comprehensive study behaviour scaffolds. failure is discussed impact material properties, topological features, loading conditions, environmental factors are also examined. present provides insight into damage evolution within drawing comparisons to observed natural bone. Additionally, effect polymer microstructure, incorporating reinforcing materials, introduction hydrodynamic/corrosive body fluids life discussed. Understanding these parameters enhancing resistance holds promise expanding application clinical settings structural biomaterials. STATEMENT OF SIGNIFICANCE: Polymers promising advantages engineering, including rates, compatibility with native toxicity. However, hindered prior addressed performance lacking. This explores this gap, addressing characteristics, mechanisms, influence like factors. It examines reinforcement pore architectures, fluids, ingrowth effects behaviour. A significant emphasis placed understanding progression comparing it
Язык: Английский
Процитировано
26
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(7), С. 3836 - 3836
Опубликована: Март 29, 2024
Presently, millions worldwide suffer from degenerative and inflammatory bone joint issues, comprising roughly half of chronic ailments in those over 50, leading to prolonged discomfort physical limitations. These conditions become more prevalent with age lifestyle factors, escalating due the growing elderly populace. Addressing these challenges often entails surgical interventions utilizing implants or grafts, though treatments may entail complications such as pain tissue death at donor sites for along immune rejection. To surmount challenges, engineering has emerged a promising avenue injury repair reconstruction. It involves use different biomaterials development three-dimensional porous matrices scaffolds, alongside osteoprogenitor cells growth factors stimulate natural regeneration. This review compiles methodologies that can be used develop are important replacement Biomaterials orthopedic implants, several scaffold types production methods, well techniques assess biomaterials’ suitability human use—both laboratory settings within living organisms—are discussed. Even researchers have had some success, there is still room improvements their processing techniques, especially ones make scaffolds mechanically stronger without weakening biological characteristics. Bone therefore area rise bone-related injuries.
Язык: Английский
Процитировано
14
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 278, С. 134615 - 134615
Опубликована: Авг. 10, 2024
Язык: Английский
Процитировано
14
Materials Today Chemistry, Год журнала: 2024, Номер 37, С. 102016 - 102016
Опубликована: Апрель 1, 2024
Tissue-engineered constructs can replicate the structural and physiological properties of natural tissues. The be designed to address transplantation issues affected by shortage donor tissues organs. One major concerns in tissue engineering is design development structures that improve interaction between materials cells provide an ideal platform for form functional tissue. Several contributing factors need considered fabricate constructs, including biomaterials, biological, topographical, biophysical, morphological either alone or combination. Here, we review application, advancement, future directions these essential designing developing regeneration. In particular, focus on original approaches tools construct parameters engineering.
Язык: Английский
Процитировано
13
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials, Год журнала: 2024, Номер 156, С. 106581 - 106581
Опубликована: Май 13, 2024
Язык: Английский
Процитировано
10