European Journal of Pharmaceutics and Biopharmaceutics,
Год журнала:
2024,
Номер
205, С. 114566 - 114566
Опубликована: Окт. 30, 2024
Arterial
thrombotic
disease
is
a
common
and
serious
clinical
medical
problem.
Nitric
oxide
(NO),
as
therapeutic
gas,
can
delay
the
progression
of
thrombosis
reduce
tissue
ischemia
hypoxia
damage.
However,
systemic
delivery
NO
causes
complications,
in
body
easily
cleared
by
hemoglobin
blood.
In
this
study,
we
designed
lipid
microbubble
carrying
(NO-MBs)
combined
with
ultrasound-targeted
destruction
(UTMD)
technology
to
achieve
targeted
under
real-time
contrast-enhanced
ultrasound
monitoring.
The
good
stability
NO-MBs
was
demonstrated
examining
changes
diameter,
concentration
intensity
time.
Moreover,
vivo
vitro
thrombolysis
experiments,
it
confirmed
that
combination
UTMD
could
accelerate
arterial
thrombolysis.
Meanwhile,
levels
inflammatory
factors,
superoxide
dismutase
(SOD)
malondialdehyde
(MDA)
vascular
after
treatment
were
detected,
which
showed
significantly
response
oxidative
stress
induced
thromboembolism.
addition,
so
to
evaluate
safety
strategy,
MTT
assay,
hemolysis
test,
detection
serum
biochemical
indicators,
H&E
staining
major
organs
performed.
results
strategy
had
excellent
biosafety.
conclusion,
has
great
potential
diseases.
Pharmaceutics,
Год журнала:
2024,
Номер
16(2), С. 275 - 275
Опубликована: Фев. 15, 2024
Calcium
carbonate
(CaCO3),
a
natural
common
inorganic
material
with
good
biocompatibility,
low
toxicity,
pH
sensitivity,
and
cost,
has
widespread
use
in
the
pharmaceutical
chemical
industries.
In
recent
years,
an
increasing
number
of
CaCO3-based
nano-drug
delivery
systems
have
been
developed.
CaCO3
as
drug
carrier
utilization
efficient
Ca2+
CO2
donor
played
critical
role
tumor
diagnosis
treatment
explored
depth
breadth.
Starting
from
system,
this
paper
systematically
reviews
preparation
nanoparticles
mechanisms
therapeutic
effects
internal
external
environments
summarizes
latest
advances
application
therapy.
view
biocompatibility
vivo
mechanisms,
they
are
expected
to
become
advancing
biomedicine
field
treatment.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 23, 2024
Low-intensity
ultrasound-mediated
sonodynamic
therapy
(SDT),
which,
by
design,
integrates
sonosensitizers
and
molecular
oxygen
to
generate
therapeutic
substances
(e.g.,
toxic
hydroxyl
radicals,
superoxide
anions,
or
singlet
oxygen)
at
disease
sites,
has
shown
enormous
potential
for
the
effective
treatment
of
a
variety
diseases.
Nanoscale
play
crucial
role
in
SDT
process
because
their
structural,
compositional,
physicochemical,
biological
characteristics
are
key
determinants
efficacy.
In
particular,
advances
materials
science
nanotechnology
have
invigorated
series
optimization
strategies
augmenting
efficacy
nanosonosensitizers.
This
comprehensive
review
systematically
summarizes,
discusses,
highlights
state-of-the-art
studies
on
current
achievements
nanosonosensitizer
enhanced
treatment,
with
an
emphasis
general
design
principles
nanosonosensitizers
strategies,
mainly
including
organic
inorganic
Additionally,
recent
advancements
optimized
applications
aimed
treating
various
diseases,
such
as
cancer,
bacterial
infections,
atherosclerosis,
autoimmune
clarified
detail.
Furthermore,
effects
improved
versatile
thoroughly
discussed.
The
concludes
highlighting
challenges
future
opportunities
this
rapidly
evolving
research
field
expedite
its
practical
clinical
translation
application.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(6), С. 6689 - 6708
Опубликована: Фев. 1, 2024
Tumor
development
and
metastasis
are
closely
related
to
the
complexity
of
metabolism
network.
Recently,
reprogramming
strategies
have
attracted
much
attention
in
tumor
therapy.
Although
there
is
preliminary
success
therapy
agents,
their
therapeutic
effects
been
restricted
by
effective
reaching
sites
drugs.
Nanodelivery
systems
with
unique
physical
properties
elaborate
designs
can
specifically
deliver
tumors.
In
this
review,
we
first
summarize
research
progress
nanodelivery
based
on
enhance
therapies
depleting
glucose,
inhibiting
glycolysis,
lactic
acid,
lipid
metabolism,
glutamine
glutathione,
disrupting
metal
metabolisms
combined
other
therapies,
including
chemotherapy,
radiotherapy,
photodynamic
therapy,
etc.
We
further
discuss
detail
advantages
for
As
well
as
opportunities
challenges
integrating
into
analyze
outlook
these
emerging
areas.
This
review
expected
improve
our
understanding
modulating
enhanced
Metal
ions
such
as
iron,
zinc,
copper,
manganese,
and
calcium
are
essential
for
normal
cellular
processes,
including
DNA
synthesis,
enzyme
activity,
signaling,
oxidative
stress
regulation.
When
the
balance
of
metal
homeostasis
is
disrupted,
it
can
lead
to
various
pathological
conditions,
cancer.
Thus,
understanding
role
in
cancer
has
led
development
anti-tumor
strategies
that
specifically
target
imbalance.
Up
now,
diverse
small
molecule-based
chelators,
ionophores,
complexes,
metal-based
nanomaterials
have
been
developed
restore
metals
or
exploit
dysregulation
therapeutic
purposes.
They
hold
great
promise
inhibiting
tumor
growth,
preventing
metastasis,
enhancing
effectiveness
existing
therapies.
In
this
review,
we
aim
provide
a
comprehensive
summary
employed
modulate
therapy.
Their
modulation
mechanisms
succinctly
described,
their
recent
applications
field
therapy
discussed.
At
end,
limitations
these
approaches
addressed,
potential
avenues
future
developments
explored.
Materials Today Bio,
Год журнала:
2025,
Номер
unknown, С. 101666 - 101666
Опубликована: Март 1, 2025
Calcium
ion
therapy
has
shown
promise
for
cancer
treatment,
but
its
efficacy
is
limited
by
the
cellular
calcium
buffering
mechanism.
Herein,
an
homeostasis
disruptor
(PCCa)
was
synthesized
using
in
situ
mineralization
method.
The
surface
of
porphyrin-metal-organic
framework
PCN
coated
with
carbonate
(CaCO3),
aimed
at
causing
Ca2+
overload
and
disrupting
self-defense
mechanism
during
imbalance.
Upon
internalization
into
tumor
cells,
PCCa
undergoes
lysosomal
acidification-induced
CaCO3
decomposition,
leading
to
instantaneous
overload.
Simultaneously,
under
ultrasonic
irradiation,
meso-tetra-(4-carboxyphenyl)porphine
(TCPP)
within
generates
reactive
oxygen
species
(ROS),
which
impairs
capacity
amplifies
cell
damage
caused
In
addition,
could
also
induce
immunogenic
death,
release
tumor-associated
antigens
(TAA),
act
as
adjuvant,
thereby
promoting
dendritic
maturation
enhancing
antitumor
activity
CD8+
T
cells.
mouse
models,
not
only
led
significant
regression
subcutaneous
mammary
tumors
demonstrated
substantial
anti-metastatic
effects.
summary,
proposed
ultrasound-actuated
interference
strategy
promising
deactivate
maintenance
system,
contributing
attainment
splendid
treatment
outcome
reliable
biosafety,
may
provide
useful
insights
therapy.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 6, 2024
Abstract
Tumor
progress
and
tumor‐associated
osteolysis
are
two
key
issues
of
breast
cancer
bone
metastasis,
which
makes
it
challenging
for
metastasis
treatment.
To
settle
these
concurrently,
a
versatile
semiconducting
nanointegrator
(termed
as
SPN
CpG/Ca
)
containing
polymer
nanoparticle
(SPN),
Ca
2+
cytosine‐phosphate‐guanine
(CpG)
oligonucleotides
conjugated
on
the
surface
via
singlet
oxygen
(
1
O
2
)‐responsive
linker,
is
designed.
The
antitumor
effect
can
be
triggered
with
X‐ray
irradiation
an
adjuvant,
in
works
radiosensitizer
to
produce
radiotherapy
controlled
release
CpG
disrupting
‐responsive
linkers.
accumulation
delivering
causes
tumor
cell
death
released
activates
immune
response
realize
immunotherapy.
combinational
action
radiotherapy,
overloading,
immunotherapy
results
complete
clearance
metastatic
cells
4T1
cancer‐based
mouse
models.
Furthermore,
accelerate
osteogenesis
marrow
mesenchymal
stem
while
inhibits
osteoclast
differentiation
microenvironment
alleviate
osteolysis,
synergistically
contributes
repair
destruction.
represents
therapeutic
nanosystem
abilities
treat
destruction,
providing
new
tactic
therapy.
