Roles of flavonoids in ischemic heart disease: Cardioprotective effects and mechanisms against myocardial ischemia and reperfusion injury

Phytomedicine, Год журнала: 2024, Номер 126, С. 155409 - 155409

Опубликована: Фев. 2, 2024

Язык: Английский

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Hesperidin and hesperetin against heavy metal toxicity: Insight on the molecular mechanism of mitigation

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 149, С. 112914 - 112914

Опубликована: Апрель 4, 2022

Toxic heavy metals (THMs) are non-essential hazardous environmental pollutants with intractable health challenges in humans and animals. Exposure to lead (Pb), cadmium (Cd), mercury (Hg), arsenic (As), nickel (Ni), chromium (Cr) ubiquitous unavoidable due food contamination, mining, industrial mobilization. They triggers of tissue impairment aberrant signaling pathways that cascade into several toxicities pathologies. Each Pb, Cd, Hg, As, Ni, Cr aggravate oxidative inflammation, protein dysregulation, apoptotic induction, DNA damage, endocrine deficits, mitochondrial dysfunction contributing the pathophysiology diseases. Hesperidin (HSD) hesperetin (HST) flavonoids from citrus fruits, systematic investigations suggest their potential combat molecular alterations induced by THMs. mitigate metal toxicity via antioxidant, anti-inflammatory, anti-apoptotic effects scavenging free radicals modulation ATPases, cell cycle proteins, various cellular pathways, including Nrf2/HO-1/ARE, PI3K/mTOR/Akt, MAPK/caspase-3/Bax/Bcl-2, iNOS/NF-κB/TNF-α/COX-2. This review summarized mechanistic insights on mechanisms underlying mitigation HSD HST. for pathological networks associated Therefore, HST can be suggested as natural dietary agents blockers harmful

Язык: Английский

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Tanshinone I inhibits doxorubicin-induced cardiotoxicity by regulating Nrf2 signaling pathway

Phytomedicine, Год журнала: 2022, Номер 106, С. 154439 - 154439

Опубликована: Сен. 6, 2022

Язык: Английский

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Neuroprotective Effects and Therapeutic Potential of the Citrus Flavonoid Hesperetin in Neurodegenerative Diseases

Nutrients, Год журнала: 2022, Номер 14(11), С. 2228 - 2228

Опубликована: Май 26, 2022

Neurodegenerative disorders affect more than fifty million Americans each year and represent serious health threats as the population ages. Neuroinflammation oxidative stress are critical in onset, progression, pathogenesis of neurodegenerative diseases such Alzheimer's (AD), Parkinson's (PD), amyotrophic lateral sclerosis (ALS). A wide range natural compounds has been investigated because their antioxidant, anti-inflammatory, neuroprotective properties. The citrus flavonoid hesperetin (HPT), an aglycone hesperidin found oranges, mandarins, lemons, extensively reported to exert effects experimental models neurogenerative diseases. This review compiled multiple studies on HPT both vivo vitro study neurodegeneration. We focused modulatory release cellular anti-inflammatory antioxidative mediators. Additionally, this discusses effect maintaining levels microRNA (miRNA) modulating autophagy it relates hesperetin's protective mechanisms against Moreover, is providing data for potential a compound evidence that crosses blood-brain barrier. In summary, shows available literature indicate efficacy delaying onset

Язык: Английский

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Targeting Nrf2 in ischemia-reperfusion alleviation: From signaling networks to therapeutic targeting

Life Sciences, Год журнала: 2022, Номер 300, С. 120561 - 120561

Опубликована: Апрель 20, 2022

Язык: Английский

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Nrf2 signaling in diabetic nephropathy, cardiomyopathy and neuropathy: Therapeutic targeting, challenges and future prospective

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2023, Номер 1869(5), С. 166714 - 166714

Опубликована: Апрель 5, 2023

Язык: Английский

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The Potential Effects of Quercetin-Loaded Nanoliposomes on Amoxicillin/Clavulanate-Induced Hepatic Damage: Targeting the SIRT1/Nrf2/NF-κB Signaling Pathway and Microbiota Modulation

Antioxidants, Год журнала: 2023, Номер 12(8), С. 1487 - 1487

Опубликована: Июль 25, 2023

Amoxicillin/clavulanate (Co-Amox), a commonly used antibiotic for the treatment of bacterial infections, has been associated with drug-induced liver damage. Quercetin (QR), naturally occurring flavonoid pleiotropic biological activities, poor water solubility and low bioavailability. The objective this work was to produce more bioavailable formulation QR (liposomes) determine effect its intraperitoneal pretreatment on amelioration Co-Amox-induced damage in male rats. Four groups rats were defined: control, liposomes (QR-lipo), Co-Amox, Co-Amox QR-lipo. Liver injury severity evaluated all through measurement serum enzymes, antioxidant status, proinflammatory mediators, microbiota modulation. results revealed that QR-lipo reduced hepatic rats, as indicated by reduction enzymes total capacity. In addition, upregulated transcription factors SIRT1 Nrf2 downregulated signatures, including IL-6, IL-1β, TNF-α, NF-κB, iNOS, upregulation anti-inflammatory one, IL10. also prevented gut dysbiosis favoring colonization Lactobacillus, Bifidobacterium, Bacteroides over Clostridium Enterobacteriaceae. These suggested ameliorates targeting SIRT1/Nrf2/NF-κB modulating microbiota.

Язык: Английский

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Hesperetin promotes diabetic wound healing by inhibiting ferroptosis through the activation of SIRT3

Phytotherapy Research, Год журнала: 2024, Номер 38(3), С. 1478 - 1493

Опубликована: Янв. 17, 2024

Abstract Hesperetin (HST) is a flavonoid compound naturally occurring in citrus fruits and widespread various traditional medicinal herbs such as grapefruit peel, orange tangerine peel. These plant materials are commonly used Chinese medicine to prepare herbal remedies. The study aimed investigate the potential molecular mechanisms through which HST reduces ferroptosis human umbilical vein endothelial cells (HUVECs) promotes angiogenesis wound healing. We employed network pharmacology predict downstream targets affected by HST. expression of markers related was assessed Western blot (WB) polymerase chain reaction. Intracellular levels ferroptosis‐related metabolism were examined using glutathione/oxidized glutathione (GSH/GSSG) malondialdehyde (MDA) assay kits. Mitochondrial status iron within investigated staining with Mitosox, FerroOrange, JC1 staining. Potential direct identified docking. Additionally, healing neovascularization site analyzed methods including HE staining, Masson's immunohistochemistry, Doppler hemodynamics assessment. effectively inhibits elevated intracellular stimulated ERASTIN. Furthermore, we observed that achieves this inhibition activating SIRT3. In diabetic rat model, significantly healing, reducing tissue ferroptosis, consistent our vitro findings. This demonstrates can inhibit progression protect physiological function HUVECs holds promise natural for promoting

Язык: Английский

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Low-dose deoxynivalenol exposure inhibits hepatic mitophagy and hesperidin reverses this phenomenon by activating SIRT1

Journal of Hazardous Materials, Год журнала: 2024, Номер 468, С. 133854 - 133854

Опубликована: Фев. 22, 2024

Язык: Английский

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Hesperidin alleviates endothelial cell inflammation and apoptosis of Kawasaki disease through inhibiting the TLR4/IĸBα/NF-ĸB pathway

Chemico-Biological Interactions, Год журнала: 2025, Номер 411, С. 111445 - 111445

Опубликована: Фев. 21, 2025

Язык: Английский

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