Toxicon, Год журнала: 2024, Номер unknown, С. 107652 - 107652
Опубликована: Фев. 1, 2024
Язык: Английский
Food & Function, Год журнала: 2021, Номер 13(1), С. 198 - 212
Опубликована: Ноя. 27, 2021
Cerebral ischemia/reperfusion (I/R) injury is caused by blood flow recovery after an ischemic stroke, and effective treatments targeting I/R are still insufficient. Oxidative stress known to play a pivotal role in the pathogenesis of cerebral injury. Previous studies have revealed that diosmetin could protect against oxidative injury, but underlying mechanisms not been fully revealed. The present study was undertaken investigate effects action on In vivo, rats were orally gavaged with for seven days, middle artery occlusion (MCAO) established simulate neurological deficit score, infarct volume, cortical pathological lesions measured. vitro, PC12 cells exposed oxygen-glucose deprivation/reoxygenation (OGD/R). To clarify mechanism, SIRT1 inhibitor EX527 small interfering RNA (siRNA) used downregulate protein level, respectively. contents superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), malondialdehyde (MDA) determined commercial kits. expressions SIRT1, total Nrf2 (T-Nrf2), nucleus (N-Nrf2), NQO1 HO-1 measured western blotting. results showed pretreatment improved outcomes, decreased volume lesions, inhibited rats. cells, increased cell viability, reduced lactate dehydrogenase (LDH) release reactive oxygen species (ROS) stress. Besides, T-Nrf2, N-Nrf2, both vivo vitro. However, administration or silencing gene its siRNA eliminated beneficial diosmetin. Meanwhile, inhibition levels downstream antioxidants HO-1. conclusion, our data suggested attenuate inhibiting via SIRT1/Nrf2 signaling pathway.
Язык: Английский
Процитировано
55
Pharmaceutics, Год журнала: 2022, Номер 14(1), С. 94 - 94
Опубликована: Янв. 1, 2022
Hesperetin (HES) is a key biological active ingredient in citrus peels, and one of the natural flavonoids that attract attention researchers due to its numerous therapeutic bioactivities have been identified vitro. As bioenhancer, piperine (PIP) can effectively improve absorption insoluble drugs vivo. In present study, cocrystal HES PIP was successfully obtained through solution crystallization. The single-crystal structure illustrated comprehensive characterization conducted. formed by two drug molecules at molar ratio 1:1, which contained O-H-O hydrogen bonds between carbonyl ether oxygen phenolic hydroxyl group HES. addition, solubility experiment performed on powder simulated gastrointestinal fluid, result revealed improves dissolution behavior compared with pure substance. Furthermore, HES's bioavailability six times higher than pristine drugs. These results may provide an efficient oral formulation for
Язык: Английский
Процитировано
36
Frontiers in Pharmacology, Год журнала: 2022, Номер 13
Опубликована: Ноя. 22, 2022
Background and Purpose: Ciprofol (HSK3486), a novel 2,6-disubstituted phenol derivative, is new intravenous anesthetic compound with similar chemical structure to propofol. Animal studies have also shown that propofol plays protective role in variety of cardiovascular diseases, including myocardial infarction, ischemia-reperfusion injury takotsubo syndrome. However, whether ciprofol exerts cardioprotective effects on infarction remains unclear. Thus, the aim this work was explore potential mechanism isoproterenol (ISO)-induced infarction. Experimental Approach: In present study, male C57BL/6 mice were subjected subcutaneous injection ISO (100 mg/kg) for 2 consecutive days induce experimental Herein, we found could inhibit abnormal increase enzymes, area cardiac dysfunction ISO-treated mice. administration increased activity superoxide dismutase reduced levels NADPH oxidase malondialdehyde hearts. Additionally, markedly expression pro-inflammatory cytokines cardiomyocyte apoptosis. an vitro model, results confirmed ISO-induced oxidative damage, inflammatory response Moreover, can activate sirtuin1 (Sirt1)/nuclear factor erythroid 2-related (Nrf2) pathway Sirt1 Nrf2 inhibition almost abolished ciprofol-mediated effects. Interpretation: protects heart against by reducing stress,
Язык: Английский
Процитировано
28
Journal of Pharmaceutical Analysis, Год журнала: 2023, Номер 14(2), С. 157 - 176
Опубликована: Сен. 27, 2023
Heart failure (HF) is a highly morbid syndrome that seriously affects the physical and mental health of patients generates an enormous socio-economic burden. In addition to cardiac myocyte oxidative stress apoptosis, which are considered mechanisms for development HF, alterations in energy metabolism pathological autophagy also contribute abnormalities ultimately HF. Silent information regulator 1 (Sirt1) adenosine monophosphate-activated protein kinase (AMPK) nicotinamide adenine dinucleotide (NAD
Язык: Английский
Процитировано
18
Molecules, Год журнала: 2023, Номер 28(6), С. 2759 - 2759
Опубликована: Март 18, 2023
Sepsis is a severe inflammatory condition that can cause organ dysfunction, including acute kidney injury (AKI). Hesperetin flavonoid aglycone has potent antioxidant and anti-inflammatory properties. However, the effect of hesperetin on septic AKI not yet been fully investigated. This study examined whether renoprotective lipopolysaccharide (LPS)-induced AKI. treatment ameliorated histological abnormalities renal dysfunction in LPS-injected mice. Mechanistically, attenuated LPS-induced oxidative stress, as evidenced by suppression lipid DNA oxidation. beneficial was accompanied downregulation pro-oxidant NADPH oxidase 4, restoration glutathione levels, activation enzymes. compound also inhibited apoptotic cell death via p53-dependent caspase-3 pathway. Furthermore, alleviated Toll-like receptor 4-mediated cytokine production macrophage infiltration. Our findings suggest ameliorates structural functional through suppressing apoptosis, inflammation.
Язык: Английский
Процитировано
16
Diabetes & Metabolic Syndrome Clinical Research & Reviews, Год журнала: 2024, Номер 18(2), С. 102947 - 102947
Опубликована: Янв. 24, 2024
Язык: Английский
Процитировано
6
NeuroToxicology, Год журнала: 2024, Номер 101, С. 117 - 127
Опубликована: Фев. 28, 2024
Язык: Английский
Процитировано
6
Journal of Ethnopharmacology, Год журнала: 2024, Номер 333, С. 118503 - 118503
Опубликована: Июнь 26, 2024
Язык: Английский
Процитировано
5
Pharmaceuticals, Год журнала: 2024, Номер 17(9), С. 1144 - 1144
Опубликована: Авг. 30, 2024
Hesperidin (Hes) functions as a strong antioxidant and anti-inflammatory to guard against damage the heart, liver, kidneys. Nevertheless, due its restricted solubility bioavailability, delivery method is required for it reach specific organ. In this study, ion gelation was used synthesize chitosan/hesperidin nanoformulation. Numerous characterization techniques, such zeta potential, particle size, XRD, TEM, SEM, FTIR analyses, were corroborate synthesis of hesperidin nanoparticles (Hes-NPs). Male albino mice given pretreatment dose 100 mg/kg, PO, Hes or Hes-NPs, which administered daily 14 days before induction doxorubicin nephrotoxicity on 12th day. Kidney function (urea creatinine levels) measured. Lipid peroxidation (MDA) enzyme (CAT SOD) activities estimated. TNF-α, IL-1β, VEGF content; histopathological examination kidney tissue; immunohistochemical staining NF-κB, Caspase-3, BAX, Bcl-2, TGF-β1 evaluated. The gene expressions
Язык: Английский
Процитировано
5
Archives of Dermatological Research, Год журнала: 2025, Номер 317(1)
Опубликована: Март 12, 2025
Язык: Английский
Процитировано
0