Potencial terapéutico de la granada (Punica granatum) en la epilepsia

eNeurobiología, Год журнала: 2025, Номер 16(40)

Опубликована: Янв. 7, 2025

La epilepsia, que afecta a aproximadamente 65 millones de personas en todo el mundo, representa un desafío significativo la salud pública, particularmente porque cerca del 30% los casos son resistentes al tratamiento farmacológico convencional. En este contexto, búsqueda nuevas estrategias terapéuticas cobra una relevancia crucial. Entre las principales características epilepsi a, hiperexcitabilidad neuronal asociada crisis epilépticas genera aumento producción radicales libres y promueve procesos inflamatorios. Estos factores, conjunto, subrayan importancia desarrollar enfoques terapéu ticos controlen tanto estrés oxidativo como inflamación. escenario, agentes antioxidantes antiinflamatorios destacan por su capacidad para potenciar efectos neuroprotectores tratamientos anticrisis. granada ( Punica gra natum ) surge alternativa innovadora prometedora, gracias composición rica polifenoles, le confiere potentes propiedades antiinflamatorias. compuestos no solo neutralizan libres, sino también actúan restaurando equilibrio neurotransmisores clave funcionalidad sistema nervioso central (SNC). Además, acción antiinflamatoria amplifica potencial terapéutico. Por tanto, únicas abren perspectivas destacándola opción terapéutica gran interés, pacientes con resistencia convencionales.

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Pharmacodynamics, pharmacokinetics, and cell signaling pathways of pomegranate peel extract

Phytochemistry Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

Язык: Английский

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Green synthesis of gold nanoparticles from pomegranate juice ascertained by a combined approach based on MALDI FT-ICR MS and LC-ESI-MS/MS

Food Chemistry, Год журнала: 2025, Номер 476, С. 143427 - 143427

Опубликована: Фев. 15, 2025

Язык: Английский

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Pomegranate Seeds and Peel Ethanolic Extracts Anticancer Potentials and Related Genetic, Histological, Immunohistochemical, Apoptotic and Oxidative Stress Profiles: In vitro Study

Journal of Experimental Pharmacology, Год журнала: 2023, Номер Volume 15, С. 191 - 205

Опубликована: Апрель 1, 2023

Owing to their great quantity of hydrolyzable anthocyanins and tannins, the peel seeds pomegranate are edible possess potent anti-oxidant anti-inflammatory characteristics. This work aims trace seed ethanolic extracts' anticancer activity against liver cancer cell line, namely HepG2 related histopathological, immunohistochemical, genetic oxidative stress profile.In vitro study for both extract showed prevalence phenols, polyphenols acids, those have anti-proliferative potential line (HepG2) with 50% inhibitory concentration (IC50) significantly reduced that peel. Toxicity test extracts was dependent accompanied cycle arrest death at theG0/G1 S phases but not G2/M phase. Cell supplemented raised ROS, MDA decreased SOD, GSH Catalase.Apoptosis-related genes significant up-expression pro-apoptotic gene (P53), Cy-C, Bax, casp-3 down expression anti-apoptotic (Bcl-2). Also, Casp-3 P53 proteins were substantially expressed under effect extracts. Histopathological demonstrated untreated cells (control group) regular nuclear pleomorphism hyperchromatic nuclei, while extracts-treated necrosis, mixed euchromatin heterochromatin, intra-nuclear eosinophilic structures, burst membranes, shrunken apoptotic membranes irregular cells. Finally, PCNA detected by immunohistochemistry regulated treatment than in case medication extract.

Язык: Английский

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Synthesis and characterization of bio-fabricated silver nanoparticles as green catalysts for mitigation of synthetic dyes: A sustainable environmental remedial approach

Journal of Molecular Liquids, Год журнала: 2024, Номер 396, С. 124061 - 124061

Опубликована: Янв. 18, 2024

Язык: Английский

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Medicinal Plant Extracts against Cardiometabolic Risk Factors Associated with Obesity: Molecular Mechanisms and Therapeutic Targets

Pharmaceuticals, Год журнала: 2024, Номер 17(7), С. 967 - 967

Опубликована: Июль 21, 2024

Obesity has increasingly become a worldwide epidemic, as demonstrated by epidemiological and clinical studies. may lead to the development of broad spectrum cardiovascular diseases (CVDs), such coronary heart disease, hypertension, failure, cerebrovascular atrial fibrillation, ventricular arrhythmias, sudden cardiac death. In addition there are other cardiometabolic risk factors (CRFs) visceral adiposity, dyslipidemia, insulin resistance, diabetes, elevated levels fibrinogen C-reactive protein, others, all which increase CVD events. The mechanisms involved between obesity mainly include oxidative stress, inflammation, adipokine dysregulation, cause maladaptive structural functional alterations heart, particularly left-ventricular remodeling diastolic dysfunction. Natural products plants provide diversity nutrients different bioactive compounds, including phenolics, flavonoids, terpenoids, carotenoids, anthocyanins, vitamins, minerals, fibers, possess wide range biological activities antihypertensive, antilipidemic, antidiabetic, activities, thus conferring benefits. this review, we discuss main therapeutic interventions using extracts from herbs in preclinical trials with protective properties targeting CRFs. Molecular targets herb plant for prevention treatment CRFs also reviewed.

Язык: Английский

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Potential Anticancer Activity of Pomegranate (Punica granatum L.) Fruits of Different Color: In Vitro and In Silico Evidence

Biomolecules, Год журнала: 2022, Номер 12(11), С. 1649 - 1649

Опубликована: Ноя. 7, 2022

Pomegranate (PMG; Punica granatum L.) fruits possess a well-balanced nutrient/phytochemical composition, with proven adjuvant benefits in experimental cancer chemotherapy; however, such bioactivity could be affected by PMG’s phenogenotype (varietal). Here, the chemical and phytochemical (UPLC-DAD-MS2) antioxidant capacity anticancer potential [in vitro (MTT assay) silico (foodinformatics)] of three PMG different aryl color [red (cv. Wonderful), pink Molar de Elche), white Indian)] were evaluated. The macro/micronutrient (ascorbic acid, tocols, carotenoids), organic acid (citric/malic), polyphenol content changed varietal total activity (ABTS, alcoholic > hexane extract) order red white. However, their cytotoxicity was same (IC50 200 μg.mL−1) against normal (retinal) (breast, lung, colorectal) cell lines. Sixteen major phytochemicals tentatively identified, four them high GI absorption/bioavailability score [Ellagic (pink), vanillic (red), gallic (white) acids, D-(+)-catechin (white)] multiple molecular targets (52) (32) (23)] associated (at initiation promotion stages) activity. fruit is phenogenotype-specific, although it more effective nutraceutical formulations (concentrates).

Язык: Английский

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Punica granatum L. (Pomegranate) Extracts and Their Effects on Healthy and Diseased Skin

Pharmaceutics, Год журнала: 2024, Номер 16(4), С. 458 - 458

Опубликована: Март 26, 2024

The aim of this review is to provide a summary the botany, phytochemistry and dermatological effects Punica granatum (PG), with special emphasis on therapeutic mechanisms in various skin conditions. PG peel contains highest levels chemical compounds. Due high abundance polyphenolic compounds, including phenolic acids, anthocyanins flavonoids, exhibiting strong antioxidant properties, possesses significant health-promoting effects. Up until now, different parts form extracts, fixed seed oil or individual active compounds have been investigated for conditions vitro vivo studies, such as antioxidant, anti-inflammatory, antimicrobial, chemoprotective antiaging effects, well positive striae distensae, repair mechanisms, erythema, pigmentation psoriasis. Therefore, formulations containing used skincare diseased healthy skin. Only few confirmed human subjects. Based encouraging results obtained animal studies about numerous substantial future perspectives should incorporate more investigations volunteers. This approach can aid identifying optimal concentrations that would be most efficacious addressing specific

Язык: Английский

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Pomegranate seeds: a comprehensive review of traditional uses, chemical composition, and pharmacological properties

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Июль 11, 2024

Pomegranate seeds (PS) are the dried derived from pomegranate fruit, accounting for approximately 20% of fruit’s total weight, and a by-product juice extraction. These hold significance in traditional medicine among Uyghurs Tibetan cultures, featuring diverse clinical applications within Chinese medicine. include management gastric coldness acidity, abdominal distension, liver gallbladder fever, pediatric enteritis. PS demonstrates properties such as stomach tonicity, qi regulation, analgesia, anti-inflammatory effects. Extensive research underscores richness various phytochemical compounds metabolites, notably unsaturated fatty acids (particularly linolenic acid linoleic acid), phenolic tocopherols, proteins, volatile oils. Notably, these bioactive compounds, punicic (PA), found PS, potential prevention treatment cancers, diabetes, obesity, other ailments. Despite extensive literature on botanical entity, comprehensive review focusing specifically chemical composition pharmacological effects remains elusive. Therefore, this aimed to consolidate knowledge regarding medicinal summarizing its composition, uses, treating diseases, thereby laying foundation advancement application field pharmacology.

Язык: Английский

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Herb-Drug Interactions

Опубликована: Янв. 1, 2025

Язык: Английский

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