Advances in experimental medicine and biology, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Chemical Engineering Journal, Год журнала: 2023, Номер 478, С. 147147 - 147147
Опубликована: Ноя. 7, 2023
Язык: Английский
Процитировано
9
Materials & Design, Год журнала: 2024, Номер 239, С. 112805 - 112805
Опубликована: Фев. 27, 2024
A novel nanocomposite hydrogel with photothermal therapeutic properties, which could enhance the healing of surgical wounds, was developed. The composite comprises functionalized silica nanoparticles (FSNs) loaded desferoxamine (DFO) as core and a dexamethasone (Dex) filled hyaluronic acid–chitosan (HA-CS) shell. Dex can effectively control inflammation at wound site, DFO is beneficial in proliferating skin cells. two drugs promote site. aim this approach to demonstrate hierarchical continuous release from FSNs@DFO-H@Dex system reduce healing. Furthermore, controlled be achieved by controlling near-infrared illumination. nano has response, accelerates reducing through regulating immunological response damaged tissue.
Язык: Английский
Процитировано
3
Journal of Polymers and the Environment, Год журнала: 2024, Номер 32(9), С. 4763 - 4776
Опубликована: Апрель 27, 2024
Язык: Английский
Процитировано
2
Polymer, Год журнала: 2024, Номер 306, С. 127207 - 127207
Опубликована: Май 25, 2024
Язык: Английский
Процитировано
2
Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12
Опубликована: Ноя. 13, 2024
The cornea acts as the eye foremost protective layer and is essential for its focusing power. Corneal blindness may arise from physical trauma or conditions like dystrophies, keratitis, keratoconus, ulceration. While conventional treatments involve medical therapies donor allografts—sometimes supplemented with keratoprostheses—these options are not suitable all corneal defects. Consequently, development of bioartificial tissue has emerged a critical research area, aiming to address global shortage human donors. Bioengineered corneas hold considerable promise substitutes, potential replace either specific layers entire thickness damaged corneas. This review first delves into structural anatomy cornea, identifying key attributes necessary successful bioengineering. It then examines various pathologies, current treatments, their limitations. Finally, outlines primary approaches in engineering, exploring cell-free, cell-based, scaffold-based three emerging strategies failure.
Язык: Английский
Процитировано
2
Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(12), С. 13281 - 13295
Опубликована: Ноя. 21, 2024
The limited availability of corneal tissue grafts poses significant challenges in the treatment blindness. Novel utilizes stem cell transplanted from healthy side cornea to damaged side. However, this procedure is only possible for those who have one-sided Human cells offer promising potential engineering, providing an alternative solution. Among different types cells, mesenchymal (MSCs) stand out due their abundance and ease isolation. MSCs can be derived bone marrow, adipose, umbilical cord tissues. Differentiating MSC toward achieved through several methods including chemical induction co-culture with adult such as human limbal epithelial (LESCs) (hTCEpi). Adipose-derived (ADSCs) are most common type that has been studied differentiation. Corneal targeted by researchers Chemical small molecules, especially morphogenetic protein 4 (BMP4), all-trans retinoic acid (ATRA), epidermal growth factor (EGF), gained more popularity This review highlights current progress utilizing differentiation studies, showcasing revolutionize treatments
Язык: Английский
Процитировано
2
International Journal of Pharmaceutics, Год журнала: 2024, Номер unknown, С. 125009 - 125009
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
2
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(13), С. 7053 - 7053
Опубликована: Июнь 27, 2024
Cell-based therapies using corneal stromal stem cells (CSSC), keratocytes, or a combination of both suppress scarring. The number quiescent keratocytes in the cornea is small; it difficult to expand them vitro quantities suitable for transplantation. This study examined therapeutic effect fibroblasts reversed into (rCF) mouse model mechanical injury. rCF was studied vivo (slit lamp, optical coherence tomography) and ex (transmission electron microscopy immunofluorescence staining). Injection injured accompanied by recovery thickness, improvement transparency, reduction type III collagen stroma, absence myofibroblasts, structural organization fibers. TEM results showed that 2 months after intrastromal injection cells, there decrease fibril density an increase diameter average distance between fibrils. fibrils were well ordered maintained short-range order nearest-neighbor fibrils, although averaged increased. Our demonstrated cell therapy from ReLEx SMILe lenticules promotes transparent stroma
Язык: Английский
Процитировано
1
Bioengineering, Год журнала: 2024, Номер 11(9), С. 859 - 859
Опубликована: Авг. 23, 2024
Corneal diseases, which can result in substantial visual impairment and loss of vision, are an important worldwide health issue. The aim this review was to investigate the novel application bioscaffolds stem cell regenerative treatments for treatment corneal disorders. current literature reports that organic artificial substances create imitate inherent structure cornea, facilitating attachment, growth, specialization cells. Sophisticated methods such as electrospinning, 3D bioprinting, surface modification have been reported enhance characteristics scaffold. These shown greatly improve survival cells facilitate regrowth tissue both laboratory live animal experiments. In addition, incorporation growth factors bioactive compounds within scaffolds promote a favorable milieu regeneration. To summarize, advancement these groundbreaking presents hopeful strategy regeneration has potential results individuals suffering from This study highlights possibility utilizing fields biomaterials science tackle medical demands not yet satisfied field ophthalmology.
Язык: Английский
Процитировано
1
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Сен. 24, 2024
ABSTRACT The scarcity of human donor corneal graft tissue worldwide available for transplantation necessitates the development alternative therapeutic strategies treating patients with blindness. Corneal stromal stem cells (CSSCs) have potential to address this global shortage by allowing a single cornea treat multiple patients. To directly deliver CSSCs defects within an engineered biomatrix, we developed UNIversal Orthogonal Network (UNION) collagen bioink that crosslinks in situ bioorthogonal, covalent chemistry. This cell-gel therapy is optically transparent, stable against contraction forces exerted CSSCs, and permissive efficient growth epithelial cells. Furthermore, remain viable UNION gel precursor solution under standard storage transportation conditions. approach promoted transparency re-epithelialization rabbit anterior lamellar keratoplasty model, indicating serves effectively as -forming, suture-free delivering wounds. TEASER. are delivered chemically crosslinked regenerative biomaterial therapy.
Язык: Английский
Процитировано
1