Physiological Research,
Год журнала:
2024,
Номер
Suppl. 3, С. S671 - S684
Опубликована: Дек. 31, 2024
Disproportion
between
reactive
oxygen
species
(ROS)
production
and
the
body's
antioxidant
system
can
cause
oxidative
stress,
which
is
considered
a
common
denominator
in
various
pathological
conditions,
including
cardiovascular
diseases,
aging,
cognitive
disorders.
The
generation
of
free
radicals,
occurs
through
partial
reduction
oxygen,
quickly
overwhelm
endogenous
capacity
cell.
This
causes
lipid,
protein,
DNA
RNA
damage,
inflammation,
overall
cell
degeneration,
be
mitigated
by
antioxidants.
However,
their
use
human
medicine
did
not
bring
expected
effect.
Molecular
hydrogen
(H2),
due
to
its
unique
physical
chemical
properties,
provides
number
benefits
for
alleviating
stress.
H2
superior
conventional
antioxidants
as
it
selectively
reduce
(.)OH
radicals
while
preserving
important
ROS
that
are
otherwise
used
normal
signaling.
Key
words
Oxidative
Cardiovascular
hydrogen,
ROS,
Inflammation.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
176, С. 116802 - 116802
Опубликована: Май 24, 2024
Oxidative
stress
plays
a
key
role
in
chronic
kidney
disease
(CKD)
development
and
progression,
inducing
cell
damage,
inflammation,
fibrosis.
However,
effective
therapeutic
interventions
to
slow
down
CKD
advancement
are
currently
lacking.
The
multifaceted
pharmacological
effects
of
molecular
hydrogen
(H2)
have
made
it
promising
avenue.
H2
is
capable
capturing
harmful
•OH
ONOO-
while
maintaining
the
crucial
reactive
oxygen
species
(ROS)
involved
cellular
signaling.
NRF2-KEAP1
system,
which
manages
redox
balance,
could
be
used
treat
CKD.
activates
this
pathway,
fortifying
antioxidant
defenses
scavenging
ROS
counteract
oxidative
stress.
can
improve
NRF2
signaling
by
using
Wnt/β-catenin
pathway
indirectly
activate
mitochondria.
Additionally,
modulates
NF-κB
activity
regulating
status,
inhibiting
MAPK
pathways,
Trx
levels.
Treatment
with
also
attenuates
HIF
neutralizing
bolstering
HIF-1α
function.
Furthermore,
affects
FOXO
factors
enhances
enzymes.
Despite
encouraging
results
bench
studies,
clinical
trials
still
limited
require
further
investigation.
focus
review
on
hydrogen's
treating
renal
diseases,
specific
regulation,
discusses
its
potential
applications.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(29)
Опубликована: Май 6, 2024
Abstract
We
describe
small
heterojunction
polymer
dots
(Pdots)
with
deep‐red
light
catalyzed
H
2
generation
for
diabetic
skin
wound
healing.
The
Pdots
donor/acceptor
heterojunctions
showed
remarkably
enhanced
photocatalytic
activity
as
compared
to
the
donor
or
acceptor
nanoparticles
alone.
encapsulate
and
ascorbic
acid
into
liposomes
form
Lipo‐Pdots
nanoreactors,
which
selectively
scavenge
⋅OH
radicals
in
live
cells
tissues
under
650
nm
illumination.
antioxidant
capacity
of
is
~10
times
higher
than
that
single‐component
described
previously.
Under
a
total
dose
360
J/cm
,
nanoreactors
effectively
scavenged
suppressed
expression
pro‐inflammatory
cytokines
tissues,
thereby
accelerating
healing
wounds
mice.
This
study
provides
feasible
solution
safe
effective
treatment
foot
ulcers.
Frontiers in Aging Neuroscience,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 7, 2025
Alzheimer's
disease
(AD)
is
a
complex
neurodegenerative
disorder,
with
amyloid-beta
(Aβ)
aggregation
playing
key
role
in
its
pathogenesis.
Aβ-induced
oxidative
stress
leads
to
neuronal
damage,
mitochondrial
dysfunction,
and
apoptosis,
making
antioxidative
strategies
promising
for
AD
treatment.
This
study
investigates
the
effects
of
hydrogen-rich
water
(HRW)
zebrafish
model.
Zebrafish
were
exposed
aluminum
chloride
induce
AD-like
pathology
then
treated
HRW
using
nanobubble
device.
Behavioral
assays,
ELISA,
Hematoxylin-eosin
(H&E)
staining,
reactive
oxygen
species
(ROS)
neutrophil
fluorescence
labeling
employed
assess
HRW's
impact.
Additionally,
16S
rRNA
sequencing
analyzed
effect
on
gut
microbiota.
can
significantly
improve
cognitive
impairment
depression-like
behavior
model,
reduce
Aβ
deposition
(p
<
0.0001),
regulate
liver
Soluble
epoxide
hydrolase
(sEH)
levels
0.05),
neuroinflammation,
stress.
Furthermore,
reduced
number
harmful
bacteria
linked
by
restoring
balance
microbiota
gut.
These
findings
suggest
that
has
potential
as
therapeutic
strategy
targeting
stress,
inflammation,
gut-brain
axis
modulation.
Frontiers in Neuroscience,
Год журнала:
2025,
Номер
19
Опубликована: Апрель 23, 2025
Parkinson’s
disease
(PD)
is
a
complex
neurodegenerative
disorder
characterized
by
pathology
that
includes
the
aggregation
of
alpha-synuclein
(α-syn),
oxidative
stress,
and
neuroinflammation.
While
existing
treatments
can
alleviate
motor
symptoms,
they
have
limited
efficacy
in
slowing
progression
improving
non-motor
symptoms.
In
recent
years,
molecular
hydrogen
has
been
recognized
for
its
potential
neuroprotective
effects,
attributed
to
selective
antioxidant
anti-inflammatory
properties.
preclinical
studies
demonstrate
promising
results,
clinical
trials
conducted
thus
far
yielded
mixed
outcomes,
with
some
reporting
or
no
therapeutic
benefit.
This
review
systematically
analyzes
mechanisms
action
PD
related
disorders,
emphasizing
antioxidant,
anti-inflammatory,
anti-apoptotic
By
evaluating
evidence
from
both
studies,
this
paper
explores
attenuate
modulate
inflammatory
responses,
inhibit
apoptosis
neuronal
cells,
while
also
identifying
key
gaps
current
research.
As
novel
agent,
holds
other
diseases,
but
further
well-designed
are
needed
validate
efficacy.
Future
should
focus
on
elucidating
through
which
exerts
particularly
concerning
α-syn
clearance
pathways,
as
well
Nrf2-mediated
immunomodulation.
Furthermore,
large-scale,
multicenter
necessary
establish
benchmarks
personalized
delivery
protocols.
Drug Design Development and Therapy,
Год журнала:
2024,
Номер
Volume 18, С. 1399 - 1414
Опубликована: Апрель 1, 2024
Abstract:
Hydrogen,
which
is
a
novel
biomedical
molecule,
currently
the
subject
of
extensive
research
involving
animal
experiments
and
in
vitro
cell
experiments,
it
gradually
being
applied
clinical
settings.
Hydrogen
has
been
proven
to
possess
anti-inflammatory,
selective
antioxidant,
antiapoptotic
effects,
thus
exhibiting
considerable
protective
effects
various
diseases.
In
recent
years,
several
studies
have
provided
preliminary
evidence
for
hydrogen
on
spinal
cord
injury
(SCI).
This
paper
provides
comprehensive
review
potential
molecular
biology
mechanisms
therapy
its
application
treating
SCI,
with
an
aim
better
explore
medical
value
provide
new
avenues
adjuvant
treatment
SCI.
Keywords:
hydrogen,
injury,
anti-inflammatory
Angewandte Chemie,
Год журнала:
2024,
Номер
136(29)
Опубликована: Май 6, 2024
Abstract
We
describe
small
heterojunction
polymer
dots
(Pdots)
with
deep‐red
light
catalyzed
H
2
generation
for
diabetic
skin
wound
healing.
The
Pdots
donor/acceptor
heterojunctions
showed
remarkably
enhanced
photocatalytic
activity
as
compared
to
the
donor
or
acceptor
nanoparticles
alone.
encapsulate
and
ascorbic
acid
into
liposomes
form
Lipo‐Pdots
nanoreactors,
which
selectively
scavenge
⋅OH
radicals
in
live
cells
tissues
under
650
nm
illumination.
antioxidant
capacity
of
is
~10
times
higher
than
that
single‐component
described
previously.
Under
a
total
dose
360
J/cm
,
nanoreactors
effectively
scavenged
suppressed
expression
pro‐inflammatory
cytokines
tissues,
thereby
accelerating
healing
wounds
mice.
This
study
provides
feasible
solution
safe
effective
treatment
foot
ulcers.
PULMONOLOGIYA,
Год журнала:
2024,
Номер
34(5), С. 624 - 633
Опубликована: Окт. 10, 2024
Molecular
hydrogen
(H
2
)
has
emerged
as
a
therapeutic
and
prophylactic
agent
devoid
of
adverse
effects.
H
demonstrates
multifaceted
functionality
across
diverse
cell
types
organs,
attributable
to
its
interaction
with
oxidized
hemes
fundamental
molecular
mechanism.
Given
the
abundance
various
heme
both
intracellularly
extracellularly,
broad-ranging
effects
are
comprehensible.
Subsequent
Pathways
mediated
by
end-or
modified-
products
lipid
peroxide
followed
free
radical
chain
reactions.
Notably,
confers
benefits
not
only
patients
afflicted
diseases
but
also
individuals
seeking
enhance
health
wellness.
The
mission
medicine
encompasses
addressing
unresolved
medical
challenges,
including
cerebral
infarction,
post-cardiac
arrest
syndrome,
advanced
cancer,
metabolic
dementia.
Transitioning
from
animal
experiments
clinical
studies
is
imperative
confront
these
formidable
effectively.
