New Possibilities of the Prevention and Treatment of Cardiovascular Pathologies. The Potential of Molecular Hydrogen in the Reduction of Oxidative Stress and its Consequences DOI Creative Commons
Ján Slezák, T Ravíngerová, Branislav Kura

et al.

Physiological Research, Journal Year: 2024, Volume and Issue: Suppl. 3, P. S671 - S684

Published: Dec. 31, 2024

Disproportion between reactive oxygen species (ROS) production and the body's antioxidant system can cause oxidative stress, which is considered a common denominator in various pathological conditions, including cardiovascular diseases, aging, cognitive disorders. The generation of free radicals, occurs through partial reduction oxygen, quickly overwhelm endogenous capacity cell. This causes lipid, protein, DNA RNA damage, inflammation, overall cell degeneration, be mitigated by antioxidants. However, their use human medicine did not bring expected effect. Molecular hydrogen (H2), due to its unique physical chemical properties, provides number benefits for alleviating stress. H2 superior conventional antioxidants as it selectively reduce (.)OH radicals while preserving important ROS that are otherwise used normal signaling. Key words Oxidative Cardiovascular hydrogen, ROS, Inflammation.

Language: Английский

Potential role of molecular hydrogen therapy on oxidative stress and redox signaling in chronic kidney disease DOI Open Access
Cai‐Mei Zheng, Yi‐Chou Hou, Min-Tser Liao

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116802 - 116802

Published: May 24, 2024

Oxidative stress plays a key role in chronic kidney disease (CKD) development and progression, inducing cell damage, inflammation, fibrosis. However, effective therapeutic interventions to slow down CKD advancement are currently lacking. The multifaceted pharmacological effects of molecular hydrogen (H2) have made it promising avenue. H2 is capable capturing harmful •OH ONOO- while maintaining the crucial reactive oxygen species (ROS) involved cellular signaling. NRF2-KEAP1 system, which manages redox balance, could be used treat CKD. activates this pathway, fortifying antioxidant defenses scavenging ROS counteract oxidative stress. can improve NRF2 signaling by using Wnt/β-catenin pathway indirectly activate mitochondria. Additionally, modulates NF-κB activity regulating status, inhibiting MAPK pathways, Trx levels. Treatment with also attenuates HIF neutralizing bolstering HIF-1α function. Furthermore, affects FOXO factors enhances enzymes. Despite encouraging results bench studies, clinical trials still limited require further investigation. focus review on hydrogen's treating renal diseases, specific regulation, discusses its potential applications.

Language: Английский

Citations

10
Deep Red Light Driven Hydrogen Evolution by Heterojunction Polymer Dots for Diabetic Wound Healing DOI

Feixue Mi,

Zhao Liu, Xinyu Wang

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(29)

Published: May 6, 2024

Abstract We describe small heterojunction polymer dots (Pdots) with deep‐red light catalyzed H 2 generation for diabetic skin wound healing. The Pdots donor/acceptor heterojunctions showed remarkably enhanced photocatalytic activity as compared to the donor or acceptor nanoparticles alone. encapsulate and ascorbic acid into liposomes form Lipo‐Pdots nanoreactors, which selectively scavenge ⋅OH radicals in live cells tissues under 650 nm illumination. antioxidant capacity of is ~10 times higher than that single‐component described previously. Under a total dose 360 J/cm , nanoreactors effectively scavenged suppressed expression pro‐inflammatory cytokines tissues, thereby accelerating healing wounds mice. This study provides feasible solution safe effective treatment foot ulcers.

Language: Английский

Citations

5
Therapeutic potential of hydrogen-rich water in zebrafish model of Alzheimer’s disease: targeting oxidative stress, inflammation, and the gut-brain axis DOI Creative Commons
Jiaxuan He,

Peiye Xu,

Ting Xu

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 7, 2025

Alzheimer's disease (AD) is a complex neurodegenerative disorder, with amyloid-beta (Aβ) aggregation playing key role in its pathogenesis. Aβ-induced oxidative stress leads to neuronal damage, mitochondrial dysfunction, and apoptosis, making antioxidative strategies promising for AD treatment. This study investigates the effects of hydrogen-rich water (HRW) zebrafish model. Zebrafish were exposed aluminum chloride induce AD-like pathology then treated HRW using nanobubble device. Behavioral assays, ELISA, Hematoxylin-eosin (H&E) staining, reactive oxygen species (ROS) neutrophil fluorescence labeling employed assess HRW's impact. Additionally, 16S rRNA sequencing analyzed effect on gut microbiota. can significantly improve cognitive impairment depression-like behavior model, reduce Aβ deposition (p < 0.0001), regulate liver Soluble epoxide hydrolase (sEH) levels 0.05), neuroinflammation, stress. Furthermore, reduced number harmful bacteria linked by restoring balance microbiota gut. These findings suggest that has potential as therapeutic strategy targeting stress, inflammation, gut-brain axis modulation.

Language: Английский

Citations

0
A critical review on emerging photothermal-photocatalytic materials composed of g-C3N4 for energy production and environmental remediation DOI

Fatemeh Seifikar,

Aziz Habibi‐Yangjeh,

Mahtab Jahed-Jaafargolikhanlo

et al.

Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 115812 - 115812

Published: Feb. 1, 2025

Language: Английский

Citations

0
Mechanism and application prospect of magnesium-based materials in cancer treatment DOI Creative Commons
Yutong Ma, Yi Wang, Siwei Song

et al.

Journal of Magnesium and Alloys, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Role and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases DOI Creative Commons
Fengjiao Wang, Guangjie Zhang, Qingfeng Zhai

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: April 23, 2025

Parkinson’s disease (PD) is a complex neurodegenerative disorder characterized by pathology that includes the aggregation of alpha-synuclein (α-syn), oxidative stress, and neuroinflammation. While existing treatments can alleviate motor symptoms, they have limited efficacy in slowing progression improving non-motor symptoms. In recent years, molecular hydrogen has been recognized for its potential neuroprotective effects, attributed to selective antioxidant anti-inflammatory properties. preclinical studies demonstrate promising results, clinical trials conducted thus far yielded mixed outcomes, with some reporting or no therapeutic benefit. This review systematically analyzes mechanisms action PD related disorders, emphasizing antioxidant, anti-inflammatory, anti-apoptotic By evaluating evidence from both studies, this paper explores attenuate modulate inflammatory responses, inhibit apoptosis neuronal cells, while also identifying key gaps current research. As novel agent, holds other diseases, but further well-designed are needed validate efficacy. Future should focus on elucidating through which exerts particularly concerning α-syn clearance pathways, as well Nrf2-mediated immunomodulation. Furthermore, large-scale, multicenter necessary establish benchmarks personalized delivery protocols.

Language: Английский

Citations

0
The Molecular Biological Mechanism of Hydrogen Therapy and Its Application in Spinal Cord Injury DOI Creative Commons
Quan Hu, Yingxiao Li,

Zhaochen Lin

et al.

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 1399 - 1414

Published: April 1, 2024

Abstract: Hydrogen, which is a novel biomedical molecule, currently the subject of extensive research involving animal experiments and in vitro cell experiments, it gradually being applied clinical settings. Hydrogen has been proven to possess anti-inflammatory, selective antioxidant, antiapoptotic effects, thus exhibiting considerable protective effects various diseases. In recent years, several studies have provided preliminary evidence for hydrogen on spinal cord injury (SCI). This paper provides comprehensive review potential molecular biology mechanisms therapy its application treating SCI, with an aim better explore medical value provide new avenues adjuvant treatment SCI. Keywords: hydrogen, injury, anti-inflammatory

Language: Английский

Citations

1
Therapeutic potential of hydrogen in sports orthopaedics and traumatology: A narrative review DOI
Alberto Boretti

Sports Orthopaedics and Traumatology, Journal Year: 2024, Volume and Issue: 40(2), P. 120 - 132

Published: March 16, 2024

Citations

0
Deep Red Light Driven Hydrogen Evolution by Heterojunction Polymer Dots for Diabetic Wound Healing DOI

Feixue Mi,

Zhao Liu,

Xinyu Wang

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 136(29)

Published: May 6, 2024

Abstract We describe small heterojunction polymer dots (Pdots) with deep‐red light catalyzed H 2 generation for diabetic skin wound healing. The Pdots donor/acceptor heterojunctions showed remarkably enhanced photocatalytic activity as compared to the donor or acceptor nanoparticles alone. encapsulate and ascorbic acid into liposomes form Lipo‐Pdots nanoreactors, which selectively scavenge ⋅OH radicals in live cells tissues under 650 nm illumination. antioxidant capacity of is ~10 times higher than that single‐component described previously. Under a total dose 360 J/cm , nanoreactors effectively scavenged suppressed expression pro‐inflammatory cytokines tissues, thereby accelerating healing wounds mice. This study provides feasible solution safe effective treatment foot ulcers.

Language: Английский

Citations

0
Hydrogen therapy from the initiation to its practical applications DOI Creative Commons
Shigeo Ohta

PULMONOLOGIYA, Journal Year: 2024, Volume and Issue: 34(5), P. 624 - 633

Published: Oct. 10, 2024

Molecular hydrogen (H 2 ) has emerged as a therapeutic and prophylactic agent devoid of adverse effects. H demonstrates multifaceted functionality across diverse cell types organs, attributable to its interaction with oxidized hemes fundamental molecular mechanism. Given the abundance various heme both intracellularly extracellularly, broad-ranging effects are comprehensible. Subsequent Pathways mediated by end-or modified- products lipid peroxide followed free radical chain reactions. Notably, confers benefits not only patients afflicted diseases but also individuals seeking enhance health wellness. The mission medicine encompasses addressing unresolved medical challenges, including cerebral infarction, post-cardiac arrest syndrome, advanced cancer, metabolic dementia. Transitioning from animal experiments clinical studies is imperative confront these formidable effectively.

Language: Английский

Citations

0