Potential Causes of Spread of Antimicrobial Resistance and Preventive Measures in One Health Perspective-A Review

Infection and Drug Resistance, Год журнала: 2023, Номер Volume 16, С. 7515 - 7545

Опубликована: Дек. 1, 2023

Abstract: Antimicrobial resistance, referring to microorganisms' capability subsist and proliferate even when there are antimicrobials is a foremost threat public health globally. The appearance of antimicrobial resistance can be ascribed anthropological, animal, environmental factors. Human-related causes include overuse misuse in medicine, antibiotic-containing cosmetics biocides utilization, inadequate sanitation hygiene settings. Prophylactic therapeutic overuse, using as feed additives, microbes resistant antibiotics genes animal excreta, residue found animal-origin food excreta animals related contributive factors for the antibiotic emergence spread. Environmental including naturally existing genes, improper disposal unused antimicrobials, contamination from waste settings, farms, pharmaceutical industries, use agricultural chemicals facilitatet its Wildlife has plausible role Adopting one-health approach involving properly humans, improving spaces implementing coordinated governmental regulations crucial combating resistance. Collaborative cooperative involvement stakeholders public, veterinary ecological sectors circumvent problem effectively. Keywords: one health, gene, environment, wildlife

Язык: Английский

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A holistic review on triclosan and triclocarban exposure: Epidemiological outcomes, antibiotic resistance, and health risk assessment

The Science of The Total Environment, Год журнала: 2023, Номер 872, С. 162114 - 162114

Опубликована: Фев. 9, 2023

Язык: Английский

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Insights into the role of extracellular polymeric substances (EPS) in the spread of antibiotic resistance genes

Environmental Pollution, Год журнала: 2023, Номер 343, С. 123285 - 123285

Опубликована: Дек. 31, 2023

Язык: Английский

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Unraveling the Role of Microalgae in Mitigating Antibiotics and Antibiotic Resistance Genes in Photogranules Treating Antibiotic Wastewater

Environmental Science & Technology, Год журнала: 2023, Номер 57(44), С. 16940 - 16952

Опубликована: Окт. 27, 2023

Harnessing the potential of specific antibiotic-degrading microalgal strains to optimize microalgal-bacterial granular sludge (MBGS) technology for sustainable antibiotic wastewater treatment and resistance genes (ARGs) mitigation is currently limited. This article examined performance bacterial (BGS) MBGS (of Haematococcus pluvialis, an microalga) systems in terms stability, nutrient removal, fate ARGs mobile genetic elements (MGEs) under multiclass loads. The exhibited excellent none 50 μg/L mixed antibiotics a decrease at higher concentration. showed superior potential, 53.9 mg/L/day chemical oxygen demand (COD) 5.2–8.2% improved notably refractory antibiotics, system removal capacity was predicted. Metagenomic analysis revealed lower levels MGEs effluent biomass compared BGS bioreactor. Particle association niche projection pursuit regression models indicated that microalgae may limit gene transfers among effluent, impeding ARG dissemination. Moreover, discrepancy found biomarkers due effect on microcommunity. Altogether, these findings deepened our understanding microalgae's value remediation propagation control.

Язык: Английский

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Mitigation of Triclocarban Inhibition in Microbial Electrolysis Cell-Assisted Anaerobic Digestion

Environmental Science & Technology, Год журнала: 2024, Номер 58(21), С. 9272 - 9282

Опубликована: Май 15, 2024

Triclocarban (TCC), as a widely used antimicrobial agent, is accumulated in waste activated sludge at high level and inhibits the subsequent anaerobic digestion of sludge. This study, for first time, investigated effectiveness microbial electrolysis cell-assisted (MEC-AD) mitigating inhibition TCC to methane production. Experimental results showed that 20 mg/L inhibited disintegration, hydrolysis, acidogenesis, methanogenesis processes finally reduced production from traditional by 19.1%. Molecular docking revealed potential inactivation binding key enzymes these processes. However, MEC-AD with 0.6 0.8 V external voltages achieved much higher controlled less than 5.8%. systems was adsorbed humic substances degraded dichlorocarbanilide, leading certain detoxification effect. Methanogenic activities were increased systems, accompanied complete VFA consumption. Moreover, applied voltage promoted cell apoptosis disintegration release biodegradable organics. Metagenomic analysis resistance electrode biofilms enriching functional microorganisms (syntrophic VFA-oxidizing electroactive bacteria hydrogenotrophic methanogens), acidification pathways, multidrug efflux pumps, SOS response.

Язык: Английский

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Performance of sewage sludge treatment for the removal of antibiotic resistance genes: Status and prospects

The Science of The Total Environment, Год журнала: 2023, Номер 907, С. 167862 - 167862

Опубликована: Окт. 20, 2023

Язык: Английский

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Insight into the evolution of microbial communities and resistance genes induced by sucralose in partial nitrification system with triclosan pre-exposure

Journal of Hazardous Materials, Год журнала: 2023, Номер 461, С. 132581 - 132581

Опубликована: Сен. 19, 2023

Язык: Английский

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The pH-specific response of soil resistome to triclocarban and arsenic co-contamination

Journal of Hazardous Materials, Год журнала: 2023, Номер 464, С. 132952 - 132952

Опубликована: Ноя. 7, 2023

Язык: Английский

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Personal Care Products as a Contributing Factor to Antimicrobial Resistance: Current State and Novel Approach to Investigation

Antibiotics, Год журнала: 2023, Номер 12(4), С. 724 - 724

Опубликована: Апрель 7, 2023

Antimicrobial resistance (AMR) is one of the world's industrialized nations' biggest issues. It has a significant influence on ecosystem and negatively affects human health. The overuse antibiotics in healthcare agri-food industries historically been defined as leading factor, although use antimicrobial-containing personal care products plays role spread AMR. Lotions, creams, shampoos, soaps, shower gels, toothpaste, fragrances, other items are used for everyday grooming hygiene. However, addition to primary ingredients, additives included help preserve product by lowering its microbial load provide disinfection properties. These same substances released into environment, escaping traditional wastewater treatment methods remaining ecosystems where they contact communities promote resistance. study antimicrobial compounds, which often solely researched from toxicological point view, must be resumed considering recent discoveries, highlight their contribution Parabens, triclocarban, triclosan among most worrying chemicals. To investigate this issue, more effective models chosen. Among them, zebrafish crucial system because it allows assessment both risks associated with exposure these well environmental monitoring. Furthermore, artificial intelligence-based computer systems useful simplifying handling antibiotic data speeding up drug discovery processes.

Язык: Английский

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The spread of different resistance genes fractions in nitrification system under chronic exposure to varying alkyl chain length benzalkyl dimethylammonium compounds

Bioresource Technology, Год журнала: 2023, Номер 371, С. 128588 - 128588

Опубликована: Янв. 7, 2023

Язык: Английский

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