Oleandrin inhibits osteoclast differentiation by targeting the LRP4/MAPK/NF-κB signalling pathway to treat osteoporosis

International Immunopharmacology, Год журнала: 2025, Номер 148, С. 114073 - 114073

Опубликована: Янв. 18, 2025

Язык: Английский

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The Role of Osteoprotegerin in Breast Cancer: Genetic Variations, Tumorigenic Pathways, and Therapeutic Potential

Cancers, Год журнала: 2025, Номер 17(3), С. 337 - 337

Опубликована: Янв. 21, 2025

Introduction: Osteoprotegerin (OPG), encoded by the TNFRSF11B gene, is linked to development of breast cancer via several pathways, including interactions with receptor activator nuclear factor-κB (RANK) ligands, apoptosis-inducing proteins like TRAIL, and genetic variations such as single nucleotide polymorphisms (SNPs), directly altering gene expression. This review aims investigate role OPG expression in cancer. Methods: A comprehensive literature search was conducted using PubMed Medline, Google Scholar, ScienceDirect. Only full-text English publications from inception September 2024 were included. Results: Studies have demonstrated that certain SNPs specifically rs3102735 rs2073618, are a higher risk development. Additionally, OPG’s function TRAIL decoy may inhibit death cells. Furthermore, serum its BRCA mutations being investigated for their potential influence on progression. found promotes tumorigenesis enhancing cell proliferation, angiogenesis, aneuploidy normal mammary epithelial Moreover, mediates tumor-promoting effects interleukin-1 beta serve biomarker risk, particularly BRCA1 mutation carriers, through dysregulated RANK signaling. Lastly, use recombinant mouse models has been exert anti-tumor effects. Conclusions: In this review, examined. multifaceted exerts TNF-related ligand (TRAIL), modulation pro-tumorigenic microenvironment survival, metastasis. dual tumor suppressor promoter serves possible therapeutic target enhance apoptosis, limit bone metastasis, modulate microenvironment. Whilst much now known, further studies necessary fully delineate OPG.

Язык: Английский

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IgSF11-mediated phosphorylation of pyruvate kinase M2 regulates osteoclast differentiation and prevents pathological bone loss

Bone Research, Год журнала: 2023, Номер 11(1)

Опубликована: Март 16, 2023

Osteoclasts are primary bone-resorbing cells, and receptor-activated NF-kB ligand (RANKL) stimulation is the key driver of osteoclast differentiation. During late-stage differentiation, osteoclasts become multinucleated enlarged (so-called "maturation"), suggesting their need to adapt changing metabolic demands a substantial increase in size. Here, we demonstrate that immunoglobulin superfamily 11 (IgSF11), which required for differentiation through an association with postsynaptic scaffolding protein PSD-95, regulates by controlling activity pyruvate kinase M isoform 2 (PKM2). By using system directly induces activation IgSF11 controlled manner, identified PKM2 as major IgSF11-induced tyrosine-phosphorylated protein. activates multiple Src family tyrosine kinases (SFKs), including c-Src, Fyn, HcK, phosphorylate thereby inhibit activity. Consistently, IgSF11-deficient cells show higher defective Furthermore, inhibiting activities specific inhibitor Shikonin rescues impaired activating activator TEPP46 suppresses wild-type cells. Moreover, further osteoclastic bone loss without affecting formation vivo. Taken together, these results controls activity, switch necessary optimal maturation.

Язык: Английский

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Acute coronavirus infection triggers a TNF-dependent osteoporotic phenotype in mice

Life Sciences, Год журнала: 2023, Номер 324, С. 121750 - 121750

Опубликована: Май 2, 2023

Язык: Английский

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Novel Biomarkers of Bone Metabolism

Nutrients, Год журнала: 2024, Номер 16(5), С. 605 - 605

Опубликована: Фев. 22, 2024

Bone represents a metabolically active tissue subject to continuous remodeling orchestrated by the dynamic interplay between osteoblasts and osteoclasts. These cellular processes are modulated complex of biochemical mechanical factors, which instrumental in assessing bone remodeling. This comprehensive evaluation aids detecting disorders arising from imbalances formation reabsorption. Osteoporosis, characterized reduction mass strength leading heightened fragility susceptibility fractures, is one more prevalent chronic diseases. Some epidemiological studies, especially patients with kidney disease (CKD), have identified an association osteoporosis vascular calcification. Notably, low mineral density has been linked increased incidence aortic calcification, shared molecules, mechanisms, pathways two processes. Certain molecules emerging these can serve as biomarkers for metabolism. Detecting evaluating alterations early crucial, requiring identification that reliable intervention. While traditional calcification exist, they suffer limitations such specificity, sensitivity, conflicting results across studies. In response, efforts underway explore new, specific detect at earlier stages. The aim this review comprehensively examine some metabolism their correlation density, fracture risk, well potential use clinical practice.

Язык: Английский

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Association between Bone Turnover Markers and Fracture Healing in Long Bone Non-Union: A Systematic Review

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(8), С. 2333 - 2333

Опубликована: Апрель 17, 2024

Background: Fracture healing is a very complex and well-orchestrated regenerative process involving many cell types molecular pathways. Despite the high efficiency of this process, unsatisfying outcomes, such as non-union, occur for approximately 5–10% long bone fractures. Although there an obvious need to identify markers monitor predict potential failure in callus formation heal fracture, circulating turnover markers’ (BTMs) utility biomarkers association with radiographic clinical examination still lacks evidence so far. Methods: A systematic review on between BTMs changes fracture non-union was performed following PRISMA guidelines. The research papers were identified via PubMed, Cochrane, Cinahl, Web Science, Scopus, Embase databases. Studies which associated osteoporosis or genetic disorders not included. Results: total 172 studies collected and, given inclusion criteria, 14 manuscripts included review. Changes levels detected during across groups (healed vs. patients healthy non-union). However, we found heterogeneity patients’ characteristics (fracture site, gender, age) sample scheduling, made it impossible perform meta-analysis. Conclusions: Clinical findings features remain two important components diagnosis We suggest improving blood standardization data collection future lay foundations effective use tools diagnosing non-union.

Язык: Английский

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On Peri-Implant Bone Loss Theories: Trying To Piece Together the Jigsaw

Cureus, Год журнала: 2023, Номер unknown

Опубликована: Янв. 1, 2023

This review aims to explore the plausibility of new theories on etiopathogenesis marginal bone loss (MBL) and peri-implantitis (PI) discuss possible underlying pathogenic mechanisms. The former concept osteointegration dental implants can now be conceptualized as a foreign body response histologically characterized by bony demarcation in combination with chronic inflammation. Different risk factors provoke additional inflammation and, therefore, pro-inflammatory cytokine release soft tissues bone, leading an overpass threshold peri-implant defensive regenerative capacity. Progressive observed MBL PI is ultimately due localized imbalance receptor activator nuclear factor kappaB ligand (RANKL)/Receptor κ B (RANK)/osteoprotegerin (OPG) pathway favor increased catabolic activity. genetic background severity duration could explain differences between individuals needed reach imbalanced scenario. pathogenesis better explained “inflammation-immunological balance” theory rather than solely “infectious disease” conception. link effect biofilm other lies osteoclast differentiation activation pathways (over)stimulation.

Язык: Английский

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Integrated osteoimmunomodulatory strategies based on designing scaffold surface properties in bone regeneration

Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(29), С. 6718 - 6745

Опубликована: Янв. 1, 2023

Those who have used traditional biomaterials as bone substitutes always regarded the immune response an obstacle leading to implant failure. However, cumulative evidence revealed that blindly minimizing host reactions cannot induce successful regeneration. With emergence of new concept osteoimmunology, intimate mutual effects between skeletal system and been gradually recognized, promoting innovation with osteoimmunomodulatory properties. By tuning surface properties, can precisely manipulate osteoimmune environment favoring In this review, we first reviewed show importance immunomodulation on Subsequently, summarize recent developments in modification strategies terms physicochemical properties coatings explain how these work.

Язык: Английский

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Association of chronic liver disease with bone diseases and muscle weakness

Journal of Bone and Mineral Metabolism, Год журнала: 2024, Номер 42(4), С. 399 - 412

Опубликована: Фев. 1, 2024

Язык: Английский

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The interplay between osteoarthritis and osteoporosis: Mechanisms, implications, and treatment considerations – A narrative review

Experimental Gerontology, Год журнала: 2024, Номер 197, С. 112614 - 112614

Опубликована: Окт. 23, 2024

Язык: Английский

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